Publikationen
| Publications |
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Publications
Geisselbrecht Y, Frühwirth S, Schroeder S, Pierik AJ, Klug G, Essen L-O (2012) - CryB from Rhodobacter sphaeroides: a unique class of cryptochromes with new cofactors, EMBO Reports, online, doi:10.1038/embor.2012.22011
Kiontke S, Geisselbrecht Y, Pokorny R, Carell T, Batschauer A and Essen L-O (2011) - Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA. EMBO J, 30, 4437 - 4449
Chaves I, Pokorny R, Byrdin M, Hoang N, Ritz T, Brettel K, Essen L-O,
van der Horst GTJ, Batschauer A and Ahmad M (2011) - The
Cryptochromes: Blue Light Photoreceptors in Plants and Animals. Annu
Rev Plant Biol, 62, 335-364
Anders K, von Stetten D, Mailliet J, Kiontke S, Sineshchekov VA, Hildebrandt P, Hughes J, Essen L-O (2011) - Spectroscopic and Photochemical Characterization of the Red-Light Sensitive Photosensory Module of Cph2 from Synechocystis PCC 6803. Photochem Photobiol, 87 (1), 160-173
Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kräling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen L-O, Meggers E (2011) - Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors. J Am Chem Soc, 133 (15), 5976–5986
Grosse W, Essen L-O, Koert U (2011) - Strategies and Perspectives in Ion-Channel Engineering. ChemBioChem, 12 (6), 830-839
2010
Veelders M, Brückner S, Ott D, Unverzagt C, Mösch H-U, Essen L-O (2010) - Structural basis of flocculin-mediated social behavior in yeast. Proc Natl Acad Sci USA, 107 (52), 22511-22516
Grosse W, Reiss P, Reitz S, Cebi M, Lubben W, Koert U, Essen L-O (2010) - Structural and functional characterization of a synthetically modified OmpG. Bioorg Med Chem, 18 (22), 7716-7723
Eckhardt B, Grosse W,
Essen L-O, Geyer A (2010) - Structural characterization of a
beta-turn mimic within a protein-protein interface. Proc Natl Acad
Sci USA, 107 (43), 18336-18341
Schleicher E, Wenzel R, Ahmad M, Batschauer A, Essen L-O, Hitomi K, Getzoff ED, Bittl R, Weber S, Okafuji A - (2010). The Electronic State of Flavoproteins: Investigations with Proton Electron-Nuclear Double Resonance. Appl Magn Reson, 37(1-4), 339-352
Schlegel MK, Essen LO, Meggers E - (2010). Atomic resolution duplex structure of the simplified nucleic acid GNA. Chem Commun, 46(7), 1094-1096
2009
Mailliet J, Psakis G, Schroeder C, Kaltofen S, Durrwang U, Hughes J, Essen L-O - (2009). Dwelling in the dark: procedures for the crystallography of phytochromes and other photochromic proteins. Acta Cryst D, 65(11), 1232-1235
Reitz S, Essen L-O - (2009). a-Helical Cytolysins: Molecular Tunnel-Boring Machines in Action. ChemBioChem, 10(14), 2305-2307
Kress D, Bruegel D, Schall I, Linder D, Buckel W and Essen L-O - (2009). An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases. J Biol Chem, 284(41), 28401-28409
Moldt J, Pokorny R, Orth C, Linne U, Geisselbrecht Y, Marahiel MA, Essen L-O, Batschauer A – (2009). Photoreduction of the folate cofactor in members of the photolyase family. J Biol Chem, 284(32), 21670-21683.
Mroginski MA, von Stetten D, Escobar FV, Strauss HM, Kaminski S, Scheerer P, Günther M, Murgida DH, Schmieder P, Bongards C, Gärtner W, Mailliet J, Hughes J, Essen L-O, Hildebrandt P - (2009). Chromophore Structure of Cyanobacterial Phytochrome Cph1 in the Pr State: Reconciling Structural and Spectroscopic Data by QM/MM Calculations. Biophys J, 96(10), 4153-4163Helmetag V, Samel SA, Thomas MG, Marahiel MA, Essen L-O - (2009). Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J, 276(13), 3669-3682
Marahiel MA, Essen L-O - (2009). Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods Enzymol, 458, 337-351.
Reitz S, Cebi M, Reiss P, Studnik G, Linne U, Koert U,
Essen, L-O - (2009). On the Function und Structure of Synthetically
Modified Porins. Angew Chem Int Ed, 48,
4853-4857.
Reitz S, Cebi M, Reiss P, Studnik G, Linne, U, Koert U,
Essen, L-O - (2009). Zur Funktion und Struktur synthetisch
modifizierter Porine. Angew Chem, 121,
4947-4951.
Psakis G, Saidijam M, Shibayama K, Polaczek J, Bettaney KE, Baldwin JM, Baldwin SA, Hope R, Essen L-O, Essenberg RC, Henderson PJ. - (2009). The sodium-dependent D-glucose transport protein of Helicobacter pylori. Mol Microbiol, 71(2), 391-403.
2008
Psakis G., Polaczek J., Essen L.-O. - (2008). AcrB et al.: Obstinate contaminants in a picogram scale. One more bottleneck in the membrane protein structure pipeline. Journal of Structural Biology, 166(1), 107-111.
Pokorny R., Klar T., Hennecke U, Carell T, Batschauer A., Essen L.-O. - (2008). Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome. PNAS, 105(52), 21023-21027.Rohmer T., Lang C., Hughes J., Essen L.-O., Gärtner W., Matysik J. – (2008). Light-induced chromophore activity and signal transduction in phytochromes observed by 13C and 15N magic-angle spinning NMR. PNAS, 105(40), 15229-15234.
Essen L.-O., Mailliet J., Hughes J. – (2008). The structure of a complete phytochrome sensory module in the Pr ground state. PNAS, 105(38), 14709-14714.Schroeder C., Werner K., Otten H., Krätzig S., Schwalbe H., Essen L.O. – (2008). Influence of a Joining Helix on the BLUF Domain of the YcgF Photoreceptor from Escherichia coli. Chembiochem, 9(15), 2463 - 2473.
Kress D., Alhapel A., Pierik A.J., Essen, L.-O. – (2008). The Crystal Structure of Enamidase: a bifunctional Enzyme of the Nicotinate Catabolism. Journal of Molecular Biology, 384, 837-847.Reitz, S., Alhapel, A., Essen, L.-O. & Pierik, A.J. - (2008). Structural and Kinetic Properties of a β − Hydroxyacid Dehydrogenase involved in Nicotinate Fermentation. Journal of Molecular Biology, 382, 802-811.
Essen L.-O. and Koert U. - (2008). Ion-channel engineering. Review. Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 104, 165-188.
Tanovic A., Samel S.A., Essen L.O., Marahiel M.A. - (2008). Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase. Science, 321 (5889), 659-663.
Schlegel M.K., Essen L.O., Meggers E. - (2008). Duplex Structure of a Minimal Nucleic Acid. JACS, 130 (26), 8158-8159.
Samel S.A., Marahiel M.A., Essen L.O. - (2008). How to tailor non-ribosomal peptide products-new clues about the structures and mechanisms of modifying enzymes. Molecular Biosystems, 4(5), 387-393.Strieker M, Essen LO, Walsh CT, Marahiel MA. - (2008). Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. Chembiochem, 9(3), 374-376.
Psakis G., Nitschkowski S., Holz C., Kreß D., Maestre-Reyna M., Polaczek J., Illing G., Essen L.-O. - (2007). Expression screening of integral membrane proteins from Helicobacter pylori 26695. Protein Science, 16(12), 2667-2676.
Meissner, B., Schleicher E., Weber S., Essen L.-O.† (2007). The Dodecin from Thermus thermophilus, a Bifunctional Cofactor Storage Protein. J. Biol. Chem., 282(45), 33142-33154.Samel, S. A., Schoenafinger, G., Knappe, T. A., Marahiel, M. A.,† and Essen, L.-O.† (2007). Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure 15(7), 781-792.
Strieker, M., Kopp, F., Mahlert, C., Essen, L.-O.† , Marahiel, M. A.† (2007). Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-depentent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol. 2(3), 187-196.
Bosch, J., Tamura, T., Tamura, N., Baumeister, W., Essen, L.-O.† (2007). The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology. Acta Cryst D 63(Pt 2), 179-187.
Klar, T., Pokorny, R., Moldt, J., Batschauer, A.† and Essen, L.-O.† (2007). Cryptochrome 3 from Arabidopsis thaliana: Structural and functional analysis of its complex with a folate light antenna. J. Mol. Biol. 366(3), 954-964.
2006
Klar, T., Kaiser, G., Hennecke, U., Carell, T., Batschauer, A., Essen, L.-O.† (2006). Natural and non-natural antenna chromophores in the DNA photolyase from Thermus thermophilus. ChemBioChem 7(11), 1798-1806.
Essen, L.-O.† Klar, T. (2006). Light-driven DNA repair by photolyases Cellular and Molecular Life Sciences 63, 1266-1277.
Schönafinger, A., Morbitzer, A., Kreß, D., Essen, L.-O., Noll, F. & Hampp, N.† (2006). Morphology of dry solid supported protein monolayers in dependence on substrate and protein surface properties. Langmuir 22, 7185-7191.
Song, S.-H., Dick, B., Penzkofer, A.† , Pokorny, R., Batschauer, A. & Essen, L.-O. (2006). Absorption and fluorescence spectroscopic characterization of cryptochrome 3 from Arabidopsis thaliana. J. Photochem. Photobiol. B 85(1), 1-16.
Samel, S., Wagner, B., Marahiel, M. A., & Essen, L.-O.† (2006). Crystal structure of the thioesterase domain of the fengycin biosynthesis cluster. J. Mol. Biol. 359(4), 876-889.
2005
2004
Mees, A., Klar, T., Gnau, P., Hennecke, U., Eker, A. P. M., Carell, T.† & Essen, L.-O.† (2004). Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair. Science, 306, 1789-1793.
Zeth, K., Offermann, S. Essen, L.-O.† & Oesterhelt, D. † (2004). Iron-oxo clusters biomineralizing on protein surfaces – structural analysis of H. salinarum DpsA in its low and high iron states. Proc. Natl. Acad. Sci. U.S.A., 101, 13780-13785.
Mofid, M. R., Finking, R., Essen, L.-O. & Marahiel, M. A.† (2004). Mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry,43, 4128-4134.
Kunz, S., Kloeckner, T., Essen, L.-O., Seebeck, T.† & Boshart, M.† (2004). TbPDE1, a novel class I phosphodiesterase from Trypanosoma brucei. Eur. J. Biochem., 271, 637-647.
2003
Bieger, B., Essen, L.-O.† , & Oesterhelt, D. † (2003). Crystal structure of halophilic dodecin: A novel, dodecameric riboflavin-binding protein from Halobacterium salinarum. Structure, 11, 375-385.
Essen, L.-O.† , Harrenga, A., Ostermeier, C. & Michel, H. (2003). 1.3 Å X-ray structure of an antibody Fv-fragment used for enforced membrane protein crystallization. Acta Cryst., D59, 677-687.
2002
Essen, L.-O.† (2002). Halorhodopsin: light-driven ion pumping made simple? Curr Opin. Struct. Biol., 12, 516-522.
Essen , L.-O.† (2002). Structural genomics of "non-standard" proteins: a chance for membrane proteins? Gene, Function & Disease, 3, 39-48.
2001
Bosch, J., Tamura, T., Bourenkov, G. P., Baumeister, W. & Essen, L.-O.† (2001). Purification, crystallization and preliminary X-ray diffraction analysis of the Tricorn protease hexamer from Thermoplasma acidophilum. J. Struct. Biol., 134, 83-87.
Bieger, B., & Essen, L.-O.† (2001). Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from E. coli. J. Mol. Biol., 307, 1-8.
Bieger, B., & Essen, L.-O.† (2001). Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 433-445 (Corrigendum in EMBO J. 20, 5302).
Essen , L.-O.† (2001). G-protein-coupled receptors (GPCR) for light: The 3D-structure of rhodopsin. Chembiochem, 2, 513-516.
2000
Bosch, G., Baumeister, W. & Essen, L.-O.† (2000). Crystal structure of the b-apical domain of the thermosome reveals structural plasticity in protrusion region. J. Mol. Biol., 301, 19-25.
Kolbe, M., Besir, H., Essen, L.-O.† & Oesterhelt, D. † (2000). Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution. Science, 288, 1390-1396.
Bieger, B. & Essen, L.-O.† (2000). Crystallization and preliminary X-ray analysis of the catalytic domain of the adenylate cyclase GRESAG4.1 from Trypanosoma brucei. Acta Cryst., D56, 359-362.
Bieger, B., & Essen, L.-O.† (2000). Crystallization and preliminary X-ray analysis of the catalytic core of the alkylhydroperoxide reductase component AhpF from E. coli. Acta Cryst., D56, 92-94.
1999
Gutsche, I., Essen, L.-O. & Baumeister, W. † (1999). Group II chaperonins: new TRiC(k)s and turns of a protein folding machine. J. Mol. Biol., 293, 295-312.
1998
Essen, L.-O.† , Siegert, R., Lehmann, W. D. & Oesterhelt, D. † (1998). Lipid patches in membrane protein oligomers: Crystal structure of the bacteriorhodopsin-lipid complex. Proc. Natl. Acad. Sci. USA, 95, 11673-11678.
Essen, L.-O. & Oesterhelt, D. † (1998). A cold break for photoreceptors. Nature, 392,131-132.
Heinz, D. † ,Essen, L.-O. & Williams, R. L. (1998). Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C. J. Mol. Biol., 275, 635-650.
Nitsch, M., Walz, J., Typke, D., Klumpp, M., Essen, L.-O. & Baumeister, W. † (1998). Archaeal group II chaperonin in an open conformation: the thermosome from Thermoplasma acidophilum examined by cryo-electron tomography. Nature Structural Biology, 5, 855-857.
<1998
Essen , L.-O., Perisic, O., Lynch, D., Katan, M. & Williams, R. L.† (1997). A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-d1. Biochemistry, 36, 2753-2762.
Essen , L.-O., Perisic, O., Roberts, M., Katan, M. & Williams, R. L.† (1997). Structural mapping of the catalytic mechanism of a mammalian phosphoinositide-specific phospholipase Cd. Biochemistry, 36, 1704-1718.
Klumpp, M., Baumeister, W. † & Essen, L.-O. (1997). Structure of the substrate-binding domain of the thermosome, an archaeal groupII chaperonin. Cell, 91, 263-270.
Essen, L.-O., Perisic, O., Cheung, R., Katan, M. & Williams, R. L. † (1996). Crystal structure of a mammalian phosphoinositide-specific phospholipase Cd. Nature, 380, 595-602.
Grobler, J. A., Essen, L.-O., Williams, R. L. & Hurley, J. H. † (1996). C2 domain conformational changes in phospholipase C-delta 1. Nature Structural Biology, 3, 788-795.
Voss, R.-H., Ermler, U., Essen, L.-O., Wenzl, G., Kim, Y.-M. & Flecker, P. † (1996). Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28 nm resolution. Eur. J. Biochem., 242, 121-131.
Ostermeier, C., Essen, L.-O. & Michel, H. † (1995). Crystals of an antibody Fv fragment against an integral membrane protein diffracting to 1.28 A resolution. Proteins, 21, 74-77.
Essen , L.-O. & Skerra, A.† (1994). The de novo design of an antibody combining site. Crystallographic analysis of the VL domain confirms the structural model. Journal of Molecular Biology, 238, 226-44.
Essen , L.-O. & Skerra, A. (1993). Single-step purification of a bacterially expressed antibody Fv fragment by immobilized metal affinity chromatography in the presence of betaine. Journal of Chromatography A, 657, 55-61.
Gloor, S., Nasse, K., Essen, L.-O. & Appel, F.† (1992). Production and secretion in CHO cells of the extracellular domain of AMOG/beta 2, a type-II membrane protein. Gene, 120, 307-312.
Book section
Essen, L.-O., Offermann, S., Oesterhelt, D. & Zeth, K. (2004). Iron-oxo clusters and the onset of biomineralization on protein surfaces: Lessons from an archaeal ferritin. In Biomineralization, edited by E. Bäuerlein, VCH.
Essen, L.-O. (2004). Structural base of halide transport through biological membranes. In Encyclopedia of Nanoscience and Nanotechnology, edited by Schwarz, J. A, Contescu, C., & Putyera, K., Marcel Dekker, 3697-3711.
Essen, L.-O., Brownlie, P., Perisic, O., Katan, M., & Williams, R. L. (1998). Structural analysis of the catalysis and membrane association of PLC-d1 from rat. In K. Bruzik (Ed.), Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications (ACS Symp. Series 718, 121-136), Washington DC, American Chemical Society.
Other
Essen, L.-O, Kolbe, M., Besir, H., Oesterhelt, D. (2000). The light-driven chloride pump halorhodopsin: Equivalent mechanisms for proton and chloride transport ? ESRF Highlights 2000
Skerra, A.† , Essen, L.-O., Schmidt, T., & Warderberg, C. (1994). Engineering of antibody fragments produced in bacteria: solutions to the purification problem. Progr. Biotechnol., 9, 167-170.
† corresponding authors
