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2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 |
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2012 Flühe, L., Knappe, T.A., Gattner, M.J., Schäfer, A., Burghaus, O., Linne, U. and Marahiel, M.A. (2012) The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat. Chem. Biol. 8, 350-357. Bosello, M., Mielcarek, A., Giessen, T.W. and Marahiel, M.A. (2012) An enzymatic pathway for the biosynthesis of the formylhydroxyornithine required for rhodochelin iron coordination. Biochemistry 14, 3059-3066. Xie, X. and Marahiel, M.A. (2012) NMR as an effective tool for the structure determination of lasso peptides. Chembiochem 13, 621-625. Kraas, F.I., Giessen, T.W. and Marahiel, M.A. (2012) Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA. FEBS Lett. 586, 283-288. Yan, K.P., Li, Y., Zirah, S., Goulard, C., Knappe, T.A., Marahiel, M.A. and Rebuffat, S. (2012) Dissecting the maturation steps of the lasso peptide microcin J25 in vitro. Chembiochem 13, 1046-1052. |
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2011 Miethke, M., Hou, J. and Marahiel, M.A. (2011) The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry 50, 10951-10964. Albrecht, A.G., Landmann, H., Nette, D., Burghaus, O., Peuckert, F., Seubert, A., Miethke, M. and Marahiel, M.A. (2011) The frataxin homologue fra plays a key role in intracellular iron channeling in Bacilus subtilis. ChemBioChem 12, 2052-2061. Knappe, T.A., Manzenrieder, F., Mas-Moruno, C., Linne, U., Sasse, F., Kessler, H., Xie, X. and Marahiel, M.A. (2011) Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew. Chem. Int. Ed. Engl. 50, 8714-8717. Peuckert, F., Ramos-Vega, A.L. Miethke, M., Schwörer, C.J., Albrecht, A.G., Oberthür, M. and Marahiel, M.A. (2011) The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates. Chem. & Biol. 18, 907-919. Robbel, L., Helmetag, V., Knappe, T.A. and Marahiel, M.A. (2011) Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry 50, 6073-6080. Giessen, T.W., Kraas, F.I. and Marahiel, M.A. (2011) A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 50, 5680-5692. Hou, J., Robbel, L. and Marahiel, M.A. (2011) Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem. Biol. 18, 655-664. Bosello, M., Robbel, L., Linne, U., Xie, X. and Marahiel, M.A. (2011) Biosynthesis of the siderophore Rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococus jostii RHA1. J. Am. Chem.Soc. 133, 4587-4595. Miethke, M., Pierik, A.J., Peuckert, F., Seubert, A. and Marahiel, M.A. (2011) Identification and characterization of a novel-type ferric siderophore reductase from a Gram-positive extremophile. J. Biol. Chem. 286, 2245-2260. Albrecht, A.G., Peuckert, F., Landmann, H., Miethke, M., Seubert, A. and Marahiel, M. A. (2011) Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis. FEBS Lett. 585, 465-470. Zirah, S., Afonso, C., Linne, U., Knappe, T., Marahiel, M. Rebuffat, S. and Tabet, J.-C. (2011) Topoisomer differentiation of molecular knots by FTICR MS: Lessons from class II Lasso peptides. J. Am. Soc. Mass. Spectrom. 22, 467-479. Kuznedelov, K., Semenova, E., Knappe, T.A., Mukhamedyarov, D., Srivstava, A., Chatterjee, S., Ebright, R.H., Marahiel, M.A. and Severinov, K. (2011) The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J. Mol. Biol. 412, 842-848. van der Ploeg, R., Mäder, U., Homuth, G., Schaffer, M., Denham, E.L., Monteferrate, C.G., Miethke, M., Marahiel, M.A., Harwood, C.R., Winter, T., Hecker, M., Antelmann, H. and van Dijl, J.M. (2011) Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS one, in press. |
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2010 | ||
| Bugdahn, N., Peuckert, F., Albrecht, A.G., Miethke, M., Marahiel,
M.A. and Oberthür, M. (2010) Direct identification of a siderophore
import protein using synthetic petrobactin ligands.
Angew. Chem. Int. Ed. Engl. 49, 10210-10213. Robbel, L. and Marahiel, M.A. (2010) Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J. Biol. Chem. 285: 27501-27508. Kraas, F.I., Helmetag, V., Wittmann, M., Strieker, M. and Marahiel, M.A. (2010) Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem. Biol. 17: 872-880. see also: Chooi, Y.-H. and Tang, Y. (2010) Adding the lipo to lipopeptides: Do more with less. Chem. Biol. 17, 791-793. Chillappagari, S., Seubert, A., Trip, H., Kuipers, O.P., Marahiel, M.A. and Miethke, M. (2010) Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J. Bacteriol. 192: 2512-2524. Strieker, M., Tanovic, A. and Marahiel, M. (2010) Nonribosomal peptide synthetases: structures and dynamics. Curr Opin. Struct. Biol. 20: 234-240. Robbel, L., Knappe, T., Linne, U., Xie, X. and Marahiel, M. (2010) Erythrochelin - a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea. FEBS J. 277: 663-676. Albrecht, A.G., Netz, D.J., Miethke, M., Pierik, A.J., Burghaus, O., Peuckert, F., Lill, R. and Marahiel, M. (2010) SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. J. Bacteriol. 192: 1643-1651. Knappe, T.A., Linne, U., Xie, X. and Marahiel, M. (2010) The glucagon receptor antagonist I-32169 constitutes a new class of lasso peptides. FEBS Lett. 584: 785-789. Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2010) The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Org. Biomol. Chem. 8: 559-563. Winterberg, B., Uhlmann, S., Linne, U., Lessing, F., Marahiel, M.A., Eichhorn, H., Kahmann, R. and Schirawski (2010) Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Mol. Microbiol. 75: 1260-1271. |
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2009 | ||
| Knappe, T.A., Linne, U., Robbel, L. and Marahiel, M.A. (2009)
Insights into the biosynthesis and stability of the lasso peptide
capistruin. Chem. Biol. 16: 1290-1298. see also: Rosengren, K.J. and Craik, D.J. (2009) How bugs make lassos. Chem. Biol. 16: 1211-1212. Marahiel, M.A. (2009) Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis. J. Pept. Sci. 15: 799-807. Strieker, M., Nolan, E.M., Walsh, C.T. and Marahiel, M.A. (2009) Stereospecific synthesis of threo- and erythro-ß-hydroxyglutamic acid during kutzneride biosynthesis. J. Am. Chem. Soc. 131: 13523-13530. Peuckert, F., Miethke, M., Albrecht, A.G., Essen, L.-O. and Marahiel, M.A. (2009) Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew. Chem. Int. Ed. Engl. 48: 7924-7927. Marahiel, M. A. and Essen, L.-O. (2009) Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods Enzymol. 458: 337-351. Strieker, M. and Marahiel, M.A. (2009) The structural diversity of acidic lipopeptide antibiotics. ChemBioChem 10: 607-616. Robbel, L., Hoyer, M. and Marahiel, M.A. (2009) TioS T-TE - prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides. FEBS J. 276: 1641-1653. Chillappagari, S., Miethke, M., Trip, H., Kuipers, O.P. and Marahiel, M. (2009) Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. J. Bacteriol. 191: 2362-2370. Mendoza-Mendoza, A., Berndt, P., Djamei, A., Weise, C., Linne, U., Marahiel, M., Vranes, M., Kämper, J. and Kahmann, R. (2009) Physical-chemical plant-derived signals induce differentiation in Ustilago maydis. Mol. Microbiol. 71: 895-911. Duquesne, S., Destoumieux-Garzon, D., Zirah, S., Knappe, T.A., Goulard, C., Peduzzi, J., Marahiel, M.A. and Rebuffat, S. (2009) Post-translational modification and folding of a lasso-type gene-encoded antimicrobial peptide require two enzymes only in Escherichia coli. Adv. Exp. Med. Biol. 611: 35-36. Hur, G.H., Meier, J.L., Baskin, J., Codelli, J.A., Bertozzi, C.R., Marahiel, M.A., Burkart, M.D. (2009) Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem. Biol. 16: 372-381. Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A. and Essen, L.-O. (2009) Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J. 276: 3669-3682. Roberts, A.A., Copp, J.N., Marahiel, M.A. and Neilan, B.A. (2009) The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. ChemBioChem 10: 1869-1877. Moldt, J., Pokorny, R., Orth, C., Linne U., Geisselbrecht, Y., Marahiel, M.A., Essen, L.O. and Batschauer, A. (2009) Photoreduction of the folate cofactor in members of the photolyase family. J. Biol. Chem. 284: 21670-21783. |
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2008 | ||
| Tanovic, A., Samel, S.A., Essen, L.-O. and Marahiel, M.A. (2008)
Crystal structure of the termination module of a nonribosomal
peptide synthetase. Science 321: 659-663. see also: Everts, S. (2008) Peptide-producing powerhouses. C & EN 6: 48-51. Koglin, A., Löhr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Güntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A. and Dötsch, V. (2008) Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 454: 907-911. Knappe, T.A., Linne, U., Zirah, S., Rebuffat, S., Xie, X. and Marahiel, M.A. (2008) Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. J. Am. Chem. Soc. 130: 11446-11454. Kopp, F., Linne, U., Oberthür, M. and Marahiel, M.A. (2008) Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. J. Am. Chem. Soc. 130: 2656-2666. Miethke, M., Schmidt, S. and Marahiel, M. A. (2008) The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibaction secretion in Bacillus subtilis. J. Bacteriol. 190: 5143-5152. Strieker, M., Essen, L.-O., Walsh, C.T. and Marahiel, M.A. (2008) Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. ChemBioChem 9: 374-376. Wittmann, M., Linne, U., Pohlmann, V. and Marahiel, M.A. (2008) Role of DptE and DptF in the lipidation reaction of daptomycin. FEBS Journal 275: 5343-5354. Pohlmann, V. and Marahiel, M.A. (2008) delta-Amino group hydroxylation of l-ornithine during coelichelin biosynthesis. Org. Biomol. Chem. 6: 1843-1848. Samel, S.A., Marahiel, M.A. and Essen, L.O. (2008) How to tailor non-ribosomal peptide products - new clues about the structures and mechaisms of modifying enzymes. Mol. Biosyst. 4: 387-393. Yonus, H., Neumann, P, Zimmermann, S., May, J.J., Marahiel, M.A. and Stubbs, M.T. (2008) Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J. Biol. Chem. 283: 32484-32491. Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2008) The entropy balance of nostocyclopeptide macrocyclization analysed by NMR spectroscopy. ChemBioChem 9: 2597-2601. |
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2007 | ||
| Kopp, D. and Marahiel, M.A. (2007) Where chemistry meets biology:
the chemoenzymatiac synthesis of nonribosomal peptides and polyketides.
Curr. Op. Biotechnol. 18: 513-520. Fujimori, D., Hrvatin, S., Neumann, C., Strieker, M., Marahiel, M.A. and Walsh, C.T. (2007) Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc. Natl. Acad. Sci. USA 104: 16498-16503. Teichmann, B., Linne, U., Hewald, S., Marahiel, M.A. and Bölker, M. (2007) A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Mol. Microbiol. 66: 525-533. Mahlert, C., Kopp, F., Thirlway, J., Micklefield, J. and Marahiel, M.A. (2007) Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. J. Am. Chem. Soc. 129: 12011-12018. Miethke, M., and Marahiel, M.A. (2007) Siderophore-based iron acquisition and pathogen control. Microbiol. Mol. Biol. Rev. 71: 413-451. Kopp, F. and Marahiel, M.A. (2007) Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat. Prod. Rep. 24: 735-749. Samel, S.A., Schönafinger, G., Knappe, T.A., Marahiel, M.A. and Essen L.-O. (2007) Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure 15: 781-792. Wiegeshoff, F., Marahiel, M.A. (2007) Characterization of a mutation in the acetolactate synthase of Bacillus subtilis that causes a cold-sensitive phenotype. FEMS Microbiol. Lett. 272: 30-34. Azim-Zadeh, O., Hillebrecht, A., Linne, U., Marahiel, M.A., Klebe, G., Lingelbach, K. and Nyalwidhe, J. (2007) Use of biotin derivatives to probe conformational changes in proteins. J. Biol. Chem. 282: 21609-21617. Copp, J.N., Roberts, A.A., Marahiel, M.A., Neilan, B.A. (2007) Characterization of PPTNs, a cyanobacterial phosphopantetheinyl transferase from Nodularia spumigena NSOR10. J. Bacteriol. 189: 3133-3139 Strieker, M., Kopp, F., Mahlert, C., Essen, L.-O., Marahiel, M.A. (2007) Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol. 2: 187-196. Linne, U., Schäfer, A., Stubbs, M.T., Marahiel, M.A. (2007). Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains. FEBS Lett. 581: 905-910. Hoyer, K.M., Mahlert, C., Marahiel, M.A. (2007). The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem. Biol. 14: 13-22. Bisseret, P., Thielges, S., Bourg, S., Miethke, M., Marahiel, M. and Eustache, J. (2007) Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis. Tetrahedron Letters 48: 6080-6083. Paungmoung, P., Punya, J., Pongpattanakitshote, S., Jeamton, W., Vichisoonthonkul, T., Bhumiratana, S., Tanticharoen, M., Linne U., Marahiel, M.A. and Cheevadhararak, S. (2007) Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA. FEMS Microbiol. Lett. 274: 260-268. |
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2006 | ||
| Kopp, F., Mahlert, C., Grünewald, J., Marahiel, M.A. (2006) Peptide
macrocyclization: the reductase of the nostocyclopeptide synthetase
triggers the self-assembly of a macrocyclic imine. J. Am. Chem. Soc. 128: 16478-16479. |
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| Miethke, M., Westers, H., Blom, E.J., Kuipers, O.P. and Marahiel,
M.A. (2006) Iron starvation triggers the stringent response and induces
amino acid biosynthesis for bacillibactin production in Bacillus
subtilis. J. Bacteriol. 188: 8655-8657. |
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| Stein, D. B., Linne, U., Hahn, M. and Marahiel, M. A. (2006) Impact
of epimerization domains on the intermodular transfer of enzyme-bound
intermediates in nonribosomal peptide synthesis. ChemBioChem 7: 1807-1814. |
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| Kopp, F., Grünewald, J., Mahlert, C. and Marahiel, M. A. (2006)
Chemoenzymatic design of acidic lipopeptide hybrids: new insights into
the structure-activity relationship of daptomycin and A54145. Biochemistry 45: 10474-10481. |
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| Wagner, B., Schumann, D., Linne, U., Koert, U. and Marahiel, M. A.
(2006) Rational design of bacitracin A derivatives by incorporating
natural product derived heterocycles. J. Am. Chem. Soc. 128: 10513-10520. |
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| Miethke, M., Klotz, O., Linne, U., May, J. J., Beckering, C. L. and
Marahiel, M. A. (2006) Ferri-bacillibactin uptake and hydrolysis in
Bacillus subtilis. Mol. Microbiol. 61: 1413-1427. |
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| Hewald, S., Linne, U. Scherer, M. Marahiel, M. A., Kamper, J. and
Bolker, M. (2006) Identification of a gene cluster for biosynthesis of
mannosylerythritol lipids in the basidiomycetous fungus Ustilago
maydis. Appl. Environ. Microbiol. 72: 5469-5477. |
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| Samel, S.A., Wagner, B., Marahiel, M. A. and Essen, L. O. (2006)
The thioesterase domain of the fengycin biosynthesis cluster: a
structural base for the macrocyclization of a non-ribosomal
lipopeptide. J. Mol. Biol. 359: 876-889. |
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| Koglin, A., Mofid, M. R., Lohr, F., Schafer, B., Robov, V. V., Blum, M. M., Mittag, T., Marahiel, M. A., Bernhard, F. and Dotsch, V. (2006) Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 312: 273-276. | |||
| Grünewald, J., Mahlert, C., Kopp, F. and Marahiel, M. A. (2006) Chemoenzymatic pathways towards novel peptide antibiotics. Anti-Infective Agents in Medicinal Chemistry 5: 227-243. | |||
| Schoenafinger, G., Schracke, N., Linne, U. and Marahiel, M. A. (2006) Formylation domain: An essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. J. Am. Chem. Soc. 128: 7406-7407. | |||
| Wiegeshoff, F., Beckering, C. L., Debarbouille, M. and Marahiel, M. A. (2006) Sigma L is important for cold shock adaptation of Bacillus subtilis. J. Bacteriol. 188: 3130-3133. | |||
| Wagner, B., Sieber, S. A., Baumann, M. and Marahiel, M. A. (2006) Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 7: 595-597. | |||
| Grünewald, J. and Marahiel, M. A. (2006). Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol. Mol. Biol. Rev. 70: 121-146. | |||
| Miehtke, M., Bisseret, P., Beckering, C. L., Vignard, D., Eustache, J. and Marahiel, M. A. (2006) Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J. 273: 409-419. | |||
| Hunger, K., Beckering, C. L., Wiegeshoff, F., Graumann, P. L. and Marahiel, M. A. (2006) Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J. Bacteriol. 188: 240-248. | |||
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2005 | ||
| Grünewald, J., Kopp, F., Mahlert, C., Linne, U., Sieber, S. A. and
Marahiel, M. A. (2005) Fluorescence resonance energy transfer as a
probe of peptide cyclization catalyzed by nonribosomal thioesterase
domains. Chem. Biol. 12: 873-881.
Stein, D. B., Linne, U., and Marahiel, M. A. (2005) Utility of epimerization domains for the redesign of nonribosomal peptide synthetases. FEBS-J. 272: 4506-4520. Mahlert, C., Sieber, S. A., Grünewald, J. and Marahiel, M. A. (2005) Chemoenzymatic approach to enantiopure streptogramin B variants: Characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. J. Am. Chem. Soc. 127: 9571-9580. May, J., Finking, R., Wiegeshoff, F., Weber T., Bandur, N., Koert, U. and Marahiel, M. A. (2005) Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. FEBS Journal 272: 2993-3003. Schracke, N., Linne, U., Mahlert, C. and Marahiel, M. A. (2005) Synthesis of linear gramicidin requires the cooperation of two independent reductases. Biochemistry 44: 8507-8513. Sieber, S., and Marahiel, M. A. (2005) Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem. Rev. 105: 715-738. Dürfahrt, T. and Marahiel, M. A. (2005) Peptidantibiotika vom molekularen Fliessband. Nachrichten aus der Chemie 53: 507-513. Dürfahrt, T. and Marahiel, M. A. (2005) Functional and structural basis for targeted modification of non-ribosomal peptide synthetases. In: Biocombinatorial Approaches for Drug Finding. W. Wohlleben, T. Spellig, B. Müller-Tiemann (eds.), Ernst Schering Research Foundation, Workshop 51, 79-100, Springer-Verlag. |
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2004 | ||
| Grünewald, J., Sieber, S. A., Mahlert, C., Linne, U. and Marahiel,
M. A. (2004) Synthesis and derivatization of daptomycin: A
chemoenzymatic route to acidic lipopeptide antibiotics. J. Am. Chem. Soc. 126: 17025-17031.
Kundu, L. M., Linne, U., Marahiel, M. A. and Carell, T. (2004) RNA is more UV resistant than DNA: The formation of UV-induced DNA lesions is strongly sequence and conformation dependent. Chem. Eur. J. 10: 5697-5705. Finking, R. and Marahiel, M. A. (2004) Biosynthesis of nonribosomal peptides. Annu. Rev. Microbiol. 58: 453-488. Linne, U. and Marahiel, M. A. (2004) Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases. Methods Enzymol. 388: 293-315. Finking, R., Mofid, R. M. and Marahiel, M. A. (2004) Mutational analysis of peptidyl carrier protein and acyl carrier protein synthase unveils residues involved in protein-protein recognition. Biochemistry 43: 8946-8956. Garbe, D., Sieber, S. A., Bandur, N. G., Koert, U. and Marahiel, M. A. (2004) Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres. ChemBioChem 5: 1000-1003. Dürfahrt, T., Eppelmann, K., Müller, R. and Marahiel, M. A. (2004) Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem. Biol. 11: 261-271. Linne, U., Schwarzer, D., Schroeder, G. N. and Marahiel, M. A. (2004) Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis. Eur. J. Biochem. 271: 1536-1545. Mofid, M. R., Finking, R., Essen, L. O. and Marahiel, M. A. (2004) Structure-based mutational anaylsis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry 43: 4128-4136. Grünewald, J., Sieber, S. A. and Marahiel, M. A. (2004) Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry 43: 2915-2925. Sieber, S. A., Tao, J., Walsh, C. T. and Marahiel, M. A. (2004) Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angew. Chem. Int. Ed. 43: 493-498. Hunger, K., Beckering, C. L. and Marahiel, M. A. (2004) Genetic evidence for the temperature-sensing ability of the membrane domain of the Bacillus subtilis histidine kinase DesK. FEMS Microbiol. Lett. 230: 41-46. Kessler, N., Schuhmann, H., Morneweg, S., Linne, U. and Marahiel, M. A. (2004) The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains. J. Biol. Chem. 279: 7413-7419. |
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2003 | ||
| Sieber, S. A. and Marahiel, M. A. (2003) Learning from nature's
drug factories: nonribosomal synthesis of macrocyclic peptides. J. Bacteriol. 185: 7036-7043.
Sieber, S. A., Walsh, C. T. and Marahiel, M. A. (2003) Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. J. Am. Chem. Soc. 125: 10862-10866. Duerfahrt, T., Doekel, S., Sonke, T., Quaedflieg, P. J. L. M. and Marahiel, M. A. (2003) Construction of hybrid peptide synthetases for the production of alpha-L-aspartyl-L-phenylalanine, a precursor for the high-intensity sweetener aspartame. Eur. J. Biochem. 270: 4555-4563. Finking, R., Neumüller, A., Solsbacher, J., Konz, D., Kretzschmar, G., Schweitzer, M., Krumm, T. and Marahiel, M. A. (2003) Aminoacyl adenylate substrate analogues for the inhibition of adenylation domains of nonribosomal peptide synthetases. ChemBioChem 4: 903-906. Clugston, S. L., Sieber, S. A., Marahiel, M. A., and Walsh, C. T. (2003) Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: The C5 domain of tyrocidine synthetase is a DCL catalyst. Biochemistry 42: 12095-12104. Hicks, L., Weinreb, P., Konz, D., Marahiel, M. A., Walsh, C. T. and Kelleher, N. L. (2003) Fourier-transform mass spectrometry for detection of thioester-bound intermediates in unfractionated proteolytic mixtures of 80 and 191 kDa portions of bacitracin A synthetase. Analytica Chimica Acta 496: 217-224. Richardt, A., Kemme, T., Wagner, S., Schwarzer, D., Marahiel, M. A. and Hovemann, B. (2003) Ebony: A novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J. Biol. Chem. 278: 41160-41166. Schwarzer, D., Finking, R. and Marahiel, M. A. (2003) Nonribosomal peptides: from genes to products. Nat. Prod. Rep. 20: 275-287. Weber, M.H.W. and Marahiel, M. A. (2003) Bacterial cold shock responses. Science Progress 86: 9-75. Linne, U., Stein, D. B., Mootz, H. D. and Marahiel, M. A. (2003) Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry 42: 5114-5124. Hamoen, L. W., Kausche, D., Marahiel, M. A., van Sinderen, D., Venema, G. and Serror, P. (2003) The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol. Lett. 218: 299-304. Ingelfinger, D., Goethel, S. F., Marahiel, M. A., Reidt, U., Ficner, R., Lührmann, R. and Achsel, T. (2003) Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. Nucleic Acids Res. 31: 4791-4796. Sieber, S. A. and Marahiel, M. A. (2003) Antibiotika vom molekularen Fliessband: Modulare Peptidsynthetasen als Biokatalysatoren. Biospektrum 9: 474-477. Marahiel, M. A., Kessler, N. and Linne, U. (2003) Demain, des antibiotiques à façon? La Recherche 370: 54-58. |
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|
2002 | ||
| Schwarzer, D., Mootz, H. D., Linne, U. and Marahiel, M. A. (2002)
Regeneration of misprimed nonribosomal peptide synthetases by type II
thioesterases. Proc. Natl. Acad. Sci. USA 99: 14083-14088.
Wendrich, T. M., Blaha, G., Wilson, D. N., Marahiel, M. A. and Nierhaus, K. H. (2002) Dissection of the mechanism for the stringent factor RelA. Mol. Cell. 10: 779-788. Finking, R., Solsbacher, J., Konz, D., Schobert, M., Schafer, A., Jahn, D. and Marahiel, M. A. (2002) Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa J. Biol. Chem. 277: 50293-50302. Tseng, C. C., Bruner, S. D., Kohli, R. M., Marahiel, M. A., Walsh, C. T. and Sieber, S. A. (2002) Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry 41: 13350-13359. Beckering, C. L., Steil, L., Weber, M. H., Volker, U. and Marahiel, M. A. (2002) Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis. J. Bacteriol. 184: 6395-6402. Mootz, H. D., Schwarzer, D. and Marahiel, M. A. (2002) Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem 3: 490-504. Sieber, S., Linne, U., Hillson, N., Roche, E., Walsh, C. and Marahiel, M. A. (2002) Evidence for a monomeric structure of nonribosomal peptide synthetases. Chem. Biol. 9: 997. Mootz, H. D., Kessler, N., Linne, U., Eppelmann, K., Schwarzer, D. and Marahiel, M. A. (2002) Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes. J. Am. Chem. Soc. 124: 10980-10981. May, J. J., Kessler, N., Marahiel, M. A. and Stubbs, M. T. (2002) Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc. Natl. Acad. Sci. USA 99: 12120-12125. Weber, M. H. and Marahiel, M. A. (2002) Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis Philos. Trans. R. Soc. London B Biol. Sci. 357: 895-907. Eppelmann, K., Stachelhaus, T. and Marahiel, M. A. (2002) Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry 41: 9718-9726. Mootz, H. D., Schorgendorfer, K. and Marahiel, M. A. (2002) Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by compelementation of Saccharomyces cerevisiae lys5. FEMS Microbiol. Lett. 213: 51-57. Doekel, S., Eppelmann, K. and Marahiel, M. A. (2002) Heterologous expression of nonribosomal peptide synthetases in B. subtilis: construction of a bi-functional B. subtilis/E. coli shuttle vector system. FEMS Microbiol. Lett. 216: 185-191. Luo, L., Kohli, R. M., Onishi, M., Linne, U., Marahiel, M. A. and Walsh, C. T. (2002) Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry 41: 9184-9196. Klein, W. and Marahiel, M. A. (2002) Structure-function relationship and regulation of two Bacillus subtilis DNA-binding proteins, HBsu and AbrB. J. Mol. Microbiol. Biotechnol. 4: 323-329. Bruner, S. D., Weber, T., Kohli, R. M., Schwarzer, D., Marahiel, M. A., Walsh, C. T., Stubbs, M. T. (2002) Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure 10: 301-310. Mofid, M. R., Finking, R. and Marahiel, M. A. (2002) Recognition of hybrid PCP/ACP acyl carrier proteins in nonribosomal peptide synthetase modules by the 4'-phosphopantetheinyl transferases AcpS and Sfp. J. Biol. Chem. 277: 17023-17031. Bergendahl, V., Linne, U. and Marahiel, M. A. (2002) Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur. J. Biochem. 269: 620-629. Weber, M. H., Fricke, I., Doll, N. and Marahiel, M. A. (2002) CSDBase - An interactive database for cold shock domain containing proteins and the bacterial cold shock response. Nucl. Acids Res. 30: 375-378. |
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|
2001 | ||
| Linne, U., Doekel, S. and Marahiel, M. A. (2001) Portability of
epimerization domain and role of peptidyl carrier protein on
epimerization in nonribosomal peptide synthesis. Biochem. 40: 15824-15834.
Weber, M. H., Beckering, C. L. and Marahiel, M. A. (2001) Complementation of cold shock proteins by translation initiation factor IF1 in vivo. J. Bacteriol. 183: 7381-7386. Weber, M. H., Volkov, A. V., Fricke, I., Marahiel, M. A. and Graumann, P. L. (2001) Localization of cold shock proteins to cytosolic spaces surrounding nucleoids in Bacillus subtilis depends on active transcription. J. Bacteriol. 183: 6435-6443. Schwarzer, D., Mootz, H. D. and Marahiel, M. A. (2001) Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases. Chem. Biol. 10: 997-1010. Mootz, H. D., Finking, R. and Marahiel, M. A. (2001) 4'-Phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J. Biol. Chem. 276: 37289-37298. Eppelmann, K., Dökel, S. and Marahiel, M. A. (2001) Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate hostBacillus subtilis. J. Biol. Chem. 276: 34824-34831. Schwarzer, D. and Marahiel, M.A. (2001) Multimodular biocatalysts for natural product assembly. Naturwissenschaften 88: 93-101. Kohli, R. M., Trauger, J. W., Schwarzer, D., Marahiel, M. A. and Walsh, C. T. (2001) Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases. Biochemistry 40: 7099-7108. Neumüller, A. M., Konz, D. and Marahiel, M. A. (2001) The two-component regulatory system BacRS is associated with bacitracin 'self-resistance' of Bacillus licheniformis ATCC 10716. Eur. J. Biochem. 268: 3180-3189. Yazgan, A., Özcengiz, G., Özcengiz, E., Kilinc, K., Marahiel, M. A. and Alaeddinoglu, N. G. (2001) Bacilysin biosynthesis by a partially-purified enzyme fraction from Bacillus subtilis. Enzyme and Microb. Technol. 29: 400-406. Weber, T. and Marahiel, M. A. (2001) Exploring the domain structure of modular nonribosomal peptide synthetases. Structure (Camb.) 9: R3-9. Stachelhaus, T., Mootz, H. D. and Marahiel, M. A. (2001) Nonribosomal assembly of peptide antibiotics on modular protein templates. In: Bacillus subtilis and its closest relatives. From genes to cells. A. L. Sonenshein, J.A. Hoch and R. Losick (eds.). ASM Press, Washington D.C. Yazgan, A., Özcgeniz, G. and Marahiel, M. A. (2001) Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin. Biochim. Biophys. Acta 1518: 87-94. Weber, M. H., Klein, W., Müller, L., Niess, U. M. and Marahiel, M. A. (2001) Role of the Bacillus subtilis fatty acid desaturase in membrane adaptation during cold shock. Mol. Microbiol. 39: 1321-1329. Dökel, S. and Marahiel, M. A. (2001) Biosynthesis of natural products on modular peptide synthetases. Metab. Eng. 3: 64-77. May, J. J., Wendrich, T. M. and Marahiel, M. A. (2001) The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin. J. Biol. Chem. 276: 7209-7217. |
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|
2000 | ||
| Trauger, J., Kohli, R., Mootz, H. D., Marahiel, M. A. and Walsh, C.
T. (2000) Peptide cyclization catalyzed by the thioesterase domain of
tyrocidine synthetase. Nature 407: 215-218.
Wendrich, T. M., Beckering, C. and Marahiel, M. A. (2000) Characterization of the relA/spoT gene from Bacillus stearothermophilus. FEMS Microbiol. Lett. 190: 195-201. Klein, W., Winkelmann, D., Hahn, M., Weber, T. and Marahiel, M. A. (2000) Molecular characterization of the transition state regulator AbrB from Bacillus stearothermophilus. Biochim. Biophys. Acta 1493: 82-90. Linne, U. and Marahiel, M. A. (2000) Control of directionality in nonribosomal peptide synthesis: The role of condensation domain in preventing mis-initiation and timing of epimerization. Biochemistry 39: 10439-10437. Mootz, H. D., Schwarzer, D. and Marahiel, M. A. (2000) Construction of hybrid peptide synthetases by module and domain fusions. Proc. Natl. Acad. Sci. 97: 5848-5853. Dökel, S. and Marahiel, M. A. (2000) Dipeptide formatino on enigneered hybrid peptide synthetases. Chem. Biol. 7: 373-384. |
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|
1999 | ||
| Graumann, P. and Marahiel, M. A. (1999) Cold shock response in
Bacillus subtilis. In: Cold Shock, Response and Adaptation,
eds. M. Inouye and K. Yamanaka, Horizon Scientific Press, Norfolk, UK.,
27-40. J Mol Microbiol Biotechnol. 1:203-209.
Weber, T., Baumgartner, R., Renner, C., Marahiel, M. A. and Holak, T. A. (1999) Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Struct. Fold. Des. 8: 407-418. Reuter, K., Mofid, M.R., Marahiel, M.A., Ficner, R. (1999) Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily. EMBO J. Dec; 18(23): 6823-31. Mofid, M.R., Marahiel, M.A., Ficner, R. and K. Reuter (1999) Crystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetases. Acta Crystallogr. D. Biol. Crystallogr. May; 55(5): 1098-100. Göthel, S.F. and M.A. Marahiel (1999) Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell. Mol. Life. Sci. Mar; 55(3): 423-36. Stachelhaus, T., Mootz, H.D. and M.A. Marahiel (1999). The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol. Aug; 6(8): 493-505. Mootz, H.D. and M.A. Marahiel (1999) Design and application of multimodular peptide synthetases. Curr. Opin. Biotechnol. Aug; 10(4): 341-8. Klein, W., Weber, M.H.W. and M.A. Marahiel (1999) Cold Shock Response of Bacillus subtilis: Isoleucine-Dependent Switch in the Fatty Acid Branching Pattern for Membrane Adaptation to Low Temperatures. J. Bacteriol. Sep 1; 181(17): 5341-5349. Graumann, P. L. and Marahiel, M. A. (1999) Cold shock proteins CspB and CspC are major stationary-phase-induced proteins in Bacillus subtilis. Arch. Microbiol. 171(2): 135 - 138. Schindler, T., Graumann, P. L., Perl, D., Ma, S., Schmid, F.X., Marahiel, M.A. (1999) The family of cold shock proteins of Bacillus subtilis. Stability and dynamics in vitro and in vivo. J. Biol. Chem. 5, 274(6): 3407 - 3413. Konz, D. and Marahiel, M. A. (1999) How do peptide synthetases generate structural diversity ? Chem. Biol. 6(2): R39 - 48. Konz, D., Dökel, S. and Marahiel, M. A. (1999) Molecular and biochemical characterization of the protein template controlling the biosynthesis of the lipopeptide lichenysin of Bacillus licheniformis. J. Bacteriol. 181(1): 133 - 140. Peick, B, Graumann, P. L., Schmid, R., Marahiel, M. A. and Werner, D. (1999) Differenial pH induced proteins in Rhizobium tropici 899 and Rhizobium etlicia 611. Soil Biology and Biochemistry. 31, 189 - 194. Marahiel, M.A. and Zuber, P. (1999) Sporulation and cell differentiation. In: Biology of Prokaryotes. Lengeler, J. W., Drews, G. and Schlegel, H. G. (eds.), Thieme Verlag, Stuttgart, 586 - 601. |
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|
1998 | ||
| Köhler, P. and Marahiel, M. A. (1998) Mutational analysis of the
nucleoid-associated protein HBsu of Bacillus subtilis.
Mol. Gen. Genet. 260: 487 - 491.
Rajendran, N., Rompf, A., Marahiel, M. A. and Jahn, D. (1998) Isolation and characterization of a transposon mutant of Pseudomonas fluorescens AU63 deficient in antifungal activity against Pythium ultimum. Letters in Applied Microbiology. 27: 152 - 157. Graumann, P. L. and Marahiel, M. A. (1998) A superfamily of proteins that contain the cold-shock domain. Trends Biochem. Sci. 23: 286 - 290. Göthel, S., Scholz, C., Schmid, F. X. and Marahiel, M. A. (1998) Cyclophilin and trigger factor of Bacillus subtilis catalyze in vitro protein folding and are necessary for viability under starvation conditions. Biochemistry 37: 13392 - 13399. Stachelhaus, T., Mootz, H. D., Bergendahl, V. and Marahiel M. A. (1998) Peptide bond formation in nonribosomal peptide synthesis. Catalytic role of the condensation domain. J. Biol. Chem. 273: 22773-22781. Teigelkamp, S., Achsel, T., Mund, C., Göthel, S., Cronshagen, U., Lane, Marahiel, M. A., Lührmann, R. (1998) The 20kD protein of human (U4/U6.U5) tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. RNA 4: 127-141. Perl, D., Welker, C., Schindler, T., Schröder, K., Marahiel, M. A., Jaenicke, R. and Schmid, F. X. (1998) Conservation of rapid two-state folding in mesophilic, thermophilic, and hyperthermophilic cold shock proteins. Nature Structural Biology. 5: 229-235. Schneider, A. and Marahiel, M. A. (1998) Genetic evidence for the role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis. Arch. Microbiol. 169, 404-410. Chong, P. P., Podmore, S. M., Kieser, H., Redenbach, M., Turgay, K., Marahiel, M., Hopwood, D. A. and Colin, S. P. (1998) Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic of Streptomyces coelicolor A3(2). Microbiology 44: 193-199. Schneider, A., Stachelhaus, T. and Marahiel, M. A. (1998) Targeted alteration of substrate-specificity of peptide synthetases by rational modul-swapping. Molecular & General Genetics 257: 308-318. Schindler, T., Perl, D., Graumann, P. L., Sieber, V., Marahiel, M. A. and Schmid, F., X. (1998) Surface exposed phenylalanines in the RNP1/RNP2 motifs stabilize the cold shock protein CspB from Bacillus subtilis. Proteins, Structure, Function and Genetics 30: 401-406. |
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|
1997 | ||
| Konz, D., Klens, A., Schörgendorfer, K. and Marahiel, M. A. (1997)
The bacitracin biosynthesis operon of Bacillus licheniformis
ATCC10716: molecular characterization of three-modular peptide
synthetase.
Chemistry & Biology 4: 927-937.
Mootz, H. D. and Marahiel, M. A. (1997) Biosynthetic systems for non-ribosomal peptide antibiotic assembly. Current Opinion in Chemical Biology 4: 543-551. Marahiel, M. A. (1997) Protein templates for the biosynthesis of peptide antibiotics. Chemistry & Biology 4: 561-567. Mootz, H D. and Marahiel, M. A. (1997) The tyrocidine biosynthesis operon: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J. Bacteriol. 197: 6843-6850. Wendrich, T. M., Marahiel, M. A. (1997) Cloning and characterization of a relA/spoT homologue from Bacillus subtilis. Mol. Microbiol. 26: 65-79. Graumann, P. L., Wendrich, T. M., Weber, M. H. W., Schröder, K. and Marahiel, M. A. (1997) A family of cold shock proteins in Bacillus subtilis is essential for cellular growth and for efficient protein synthesis at optimal and low temperatures. Mol. Microbiol. 25: 741-756. Marahiel, M. A., Stachelhaus, T. and Mootz, H. D. (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev., 97(7): 2651-2674. Achenbach, T. V., Göthel, S. and Marahiel, M. A. (1997) Histidine 109 in prolyl isomerase of Bacillus subtilis plays an important role in cyclosporin A binding and prolyl isomeration. FEMS Microbiol. Lett. 154: 139-144. Conti, E., Stachelhaus, T., Marahiel, M. A. and Brick, P. (1997) Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S. EMBO J. 16: 4174-4183. Köhler, P. and Marahiel, M. A. (1997) Association of the histone-like protein HBsu with the nucleoid of B. subtilis. J. Bacteriol. 179: 2060-2064. Göthel, S., Schmid, R., Wipat, A., Carter, N.M., Emmerson, P. T., Harwood, C. R. and Marahiel, M. A. (1997) An internal FKPB 12 domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor. Eur. J. Biochem. 244: 59-65. Zuber, P. and Marahiel, M.A. (1997) Structure, function, and regulation of genes encoding multidomain peptide synthetases. In: Biotechnology of Industrial Antibiotics, Second Edition, W. Strohl (ed.). American Society for Microbiology Washington D.C., PP. 187-216. Graumann, P. L. and Marahiel, M. A. (1997) Effect of heterologous expression of CspB, the major cold shock protein of Bacillus subtilis on protein synthesis in Escherichia coli. Molecular & General Genetics 253: 745-752. |
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|
1996 | ||
| Rajendran, N., Stachelhaus, T. and Marahiel, M. A. (1996) Molecular
genetics of antimicrobial and chemotherapeutic agents. Recent Res.
Devel. in Antimicrob. Agents & Chemother. 1: 341-355.
Lambalot, R., Gehring, A. M., Flugel, R. S., Zuber, P., LaCelle, M., Marahiel, M. A., Reid, R., Khosla, C., Walsh, T. W. (1996) A new enzyme superfamily-The phosphpantetheinyl transferases. Chemistry & Biology 3: 923-936. Stachelhaus, T., Hüser, A. and Marahiel, M. A. (1996) Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of mutifunctional peptide synthetases. Chemistry & Biology 3: 913-921. Graumann, P. L., Marahiel, M.A. (1996) Some like it cold: response of microorganisms to cold shock. Arch. Microbiology 166: 293-300. Graumann, P. L. and Marahiel, M.A. (1996) A case of convergent evolution of nucleic acid binding modules. BioEssays 18: 309-315. Turgay, K., Bachmann, A. S., Marahiel, M.A. and Patil, S. (1996) Cloning of a putative peptide synthetase gene involved in the synthesis of phaseolotoxin. In: Pseudomonas synringae pathovars and related pathogens. Rudolph, K., ed., Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 248-254. Graumann, P. L., Schröder, K., Schmid R. and Marahiel, M. A. (1996) Cold shock induced proteins in Bacillus subtilis. J. Bacteriol. 178: 4611-4619. Stachelhaus, T., Schneider, A. and Marahiel, M. A. (1996) Engineered biosynthesis of peptide antibiotics. Biochemical Pharmacology 52: 177-186. Göthel, S., Herrler, M. and Marahiel, M. A. (1996) Peptidyl-prolyl cis-trans isomerase of B. subtilis: identification of residues involved in Cyclosporin A affinity and catalytic efficiency. Biochemistry 35: 3636-3640. |
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|
1995 | ||
| Stachelhaus, T., Schneider, A. and Marahiel, M. A. (1995) Rational
design of novel peptide antibiotics by targeted replacement of
bacterial and fungal domains.
Science 269: 69-72.
Schindler, T., Herrler, M., Marahiel, M.A. and Schmid, F.X. (1995) Extremely rapid folding in the absence of intermediates. Nature Structural Biolog 2: 663-675. Turgay, K. and Marahiel, M.A. (1995) The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis. DNA Sequence and Mapping 5: 283-290. Stachelhaus, T. and Marahiel, M.A. (1995) Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA. J. Biol. Chem. 270: 6163-6169. Stachelhaus, T. and Marahiel, M.A. (1995) Module structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis. FEMS Microbiol. Lett. 125: 3-14. Schröder, K., Graumann, P. L., Schnuchel, A., Holak, T. and Marahiel, M.A. (1995) Mutations in the putative nucleic acid binding surface of the major cold shock protein CspB revealed an essential role of aromatic and basic residues in binding to oligonucleotides containing the Y-box motif. Mol. Microbiol. 16: 699-708. |
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|
1994 | ||
| Makhatadze, G.I. and Marahiel, M.A. (1994) Effect of pH and
phosphate ions on self association properties of the major cold shock
protein from B. subtilis.
Protein Science 3: 2144-2147.
Turgay, K. and Marahiel, M.A. (1994) A general approach for identifying and cloning of peptide synthetase genes. Peptide Res. 7: 238-241. Graumann, P. L. and Marahiel, M.A. (1994) The major cold shock protein in B. subtilis CspB binds with high affinity to the ATTGG- and CCAAT sequences in single stranded oligonucleotides. FEBS Microbiol. Lett. 338: 157-160. Borchert, S., Stachelhaus, T. and Marahiel, M.A. (1994) Induction of surfactin production in B. subtilis by gsp, a gene located upstream of the 5'-end of the gramicidin S operon in B. brevis. J. Bacteriol. 176: 2458-2462. Rajendran, N., Jahn, D., Jayaraman, K. and Marahiel, M.A. (1994) Transposon Tn5 mutagenesis of Pseudomonas fluorescens to isolate mutants deficient in antibacterial activity. FEMS Microbiol. Lett. 115: 191-196. Herrler, M. Bang, H. and Marahiel, M.A. (1994) Cloning and characterization of ppiB, a Bacillus subtilis gene which encodes a peptidyl-prolyl cis-trans isomerase that is homologous to eukaryotic cyclophilin. Mol. Microbiol. 11: 1073-1084. Gocht, M. and Marahiel, M.A. (1994) Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by side directed mutagenesis. J. Bacteriol. 176: 2654-2662. Schindelin, H., Marahiel, M.A. and Heinemann, U. (1994) The cold shock domain: Crystal structure of the major cold shock protein of Bacillus subtilis. Structural Biology: The State of Art. R. H. Sarma and M. H. Sarma (eds.). Proceeding of the eighth conversation, Volume 1, State University of New York, Albany Adenine Press, pp 83-93. |
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|
1993 | ||
| Schröder, K., Zuber, P., Willimsky, G., Wagner, B. and Marahiel,
M.A. (1993) Mapping of Bacillus subtilis cspB gene and
molecular cloning of its homologs in thermophilic, mesophilic and
psychrotrophic Bacilli .
Gene 136: 277-280.
Schindelin, H., Marahiel, M.A. and Heinemann, U. (1993) Universal nucleic acid-binding domain revealed by the crystal structure of the B. subtilis major cold-shock protein. Nature (London) 364: 164-168. Schnuchel, A., Wiltscheck, R., Czisch, M., Herrler, M., Willimsky, G., Graumann, P. L., Marahiel, M.A. and Holak, T.A. (1993) Structure in solution of the major cold-shock protein from Bacillus subtilis. Nature (London) 364: 169-171. Zuber, P., Nakano, M.M. and Marahiel, M.A. (1993). Peptide antibiotics of Bacilli and other Gram-positive Bacteria. In: Bacillus subtilis and other Gram-positive Bacteria: Physiology, Biochemistry and Molecular Biology. A.L. Sonenshein, R. Losick, and J.A. Hoch (eds.) American Society for Microbiology, Washington D.C., 897-916. Marahiel, M.A., Nakano, M.M. and Zuber, P. (1993) Regulation of antibiotic production in Bacillus. Mol. Microbiol. 7: 631-636. |
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| Before 1993 |
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Marahiel, M.A. (1992) Multidomain enzymes involved in peptide synthesis. FEBS Microbiol. Lett. 307: 40-43. Herrler, M., Bang, H., Brune, K., R., Fischer, G. and Marahiel, M.A. (1992) Peptidyl-prolyl cis-trans isomerase from Bacillus subtilis: A prokaryotic enzyme that is highly sensitive to cyclosporin A. FEBS Microbiol. Lett. 309: 231-234. Willimsky, G., Bang, H., Fischer, G. and Marahiel, M.A. (1992) Characterization of cspB an inducible cold shock gene in Bacillus subtilis affecting cell viability at low temperatures. J. Bacteriol. 174: 6326-6335. Schindelin, H., Herrler, M., Willimsky, G., Marahiel, M.A. and Heinemann, U. (1992) Overproduction, crystallization and preliminary X ray diffraction studies of the major cold shock protein from Bacillus subtilis, CspB. Proteins: Structure, Function, Genetics 14: 120-124. Borchert, S., Patil, S.S. and Marahiel, M.A. (1992) Identification of putative multifunctional peptide synthetase genes using highly conserved oligonucleotide sequences derived from known synthetases. FEMS Microbiol. Lett. 92: 175-180 Micka, B. and Marahiel, M.A. (1992) The DNA binding protein HBsu is essential for normal growth and development in Bacillus subtilis. Biochimie 74: 641-650. Marahiel, M.A. (1992) Molekularbiologie und Regulationsmechanismen der Antibiotikaproduktion in Bacillus. Naturwissenschaften 97: 202-212. Turgay, K., Krause, M. and Marahiel, M.A. (1992) Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate forming enzymes. Mol. Microbiol. 6: 529-546. Schlumbohm, W., Stein, T., Ullrich, C., Vater, J., Krause, M., Marahiel, M.A., Kruft, V. and Wittman-Liebold, B. (1991) An active serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase. J. Biol. Chem. 266: 23135-23141.Fürbaß, R. and Marahiel, M.A. (1991) Mutant analysis of interaction of the Bacillus subtilis transcription regulator AbrB with the antibiotic biosynthesis gene tycA. FEBS Lett. 287: 153-156. Fürbaß, R., Gocht, M., Zuber, P. and Marahiel, M.A. (1991) Interaction of Abrb, a Bacillus subtilis transcription regulator with the promoter of the transition state activated genes tycA and spoVG. Mol. Gen. Genet. 225: 347-354. Micka, B., Groch, N., Heinemann, U. and Marahiel, M.A. (1991) Molecular cloning, nucleotide sequence and characterization of the B. subtilis gene encoding the DNA binding protein HBsu. J. Bacteriol. 173: 3191-3198. Von Döhren, H. and Marahiel, M.A. (1990) Antibiotics of Bacillus. In: Proceeding of the 6th International Symposium on Genetics of Industrial Microorganisms, Strasbourg, Vol. 2: 691-702 Marahiel, M.A., Fürbaß, R. and Gocht, M. (1990) Abrb, a regulator of stationary phase induced genes in Bacillus, neagatively affects transcription of the tyc-operon by direct interaction with the promoter DNA. In: Genetics and Biotechnology of Bacillus. (eds. A. T. Ganesan and J. A. Hoch) Academic Press, 269-275. Mittenhuber, G., Weckermann, R. and Marahiel, M.A. (1989) Gene cluster encoding the genes for tyrocidine synthetases 1 and 2 from B. brevis: Evidence for an operon. J. Bacteriol. 171: 4881-1887. Robertson, B.J., Gocht, M., Marahiel, M.A. and Zuber, P. (1989) AbrB a regular of gene expression in Bacillus, interacts with the transcription initiation region of a sporulation and an antibiotic biosynthesis gene. Proc. Natl. Acad. Sci. USA 86: 8457-8461. Krätzschmar, J., Krause, M. and Marahiel, M.A. (1989) Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases. J. Bacteriol. 171: 5477-5429. Mittenhuber, G., Krause, M. and Marahiel, M.A. (1989) Peptide antibiotic biosynthesis genes organization of the gramicidin S and tyrocidine biosynthesis genes from Bacillus brevis. In: Genetic transformation and expression. (ed. L.O. Butler) Intercept, Newcastle upon Tyne, 477-484. Weckermann, R., Fürbach, R. and Marahiel, M.A. (1988) Complete nucleotide sequence of the tycA gene coding the tyrocidine synthetase 1 from B. brevis. Nucleic Acids Res. 16: 11841. Zuber, P., Marahiel, M.A. and Robertson, J. (1988) Influence of the abrB locus on the transcription of the sporulation genes spoVG and spoOH of Bacillus subtilis. In: Genetics and biotechnology of Bacillus. Academic Press, 123-127. Krause, M. and Marahiel, M.A. (1988) Organization of the biosynthesis genes of the peptide antibiotic gramicidin S. J. Bacteriol. 170: 4669-4674. Nakano, M.M., Marahiel, M.A. and Zuber, P. (1988) Identification of a genetic locus required for biosynthesis of the lipopeptide antibiotic surfactin in Bacillus subtilis. J. Bacteriol. 170: 5662-5668. Marahiel, M.A., Zuber, P., Czekay, G. and Losick, R. (1987) Identification of the promoter for a peptide antibiotic biosynthesis gene from B. brevis and studies on its regulation in B. subtilis. J. Bacteriol. 169: 2215-2222. Marahiel, M.A., Krause, M. and Czekay, G. (1986) Cloning and expression of the tyrocidine synthetase 1 gene tycA. Biol. Chem. Hoppe-Seyler 367, 158. Marahiel, M.A., Krause, M. and Skarpied, H.J. (1985) Cloning of the tyrocidine synthetase 1 gene from B. brevis and its expression in E. coli. Mol. Gen. Genet. 201: 231-236. Krause, M., Marahiel, M.S., v. Döhren, H. and Kleinkauf, J. (1985) Molecular cloning of an ornithine activating fragment of the gramicidin S synthetase 2 gene from B. brevis and its expression in E. coli. J. Bacteriol. 162: 1120-1125. Modest, B., Marahiel, M.A., Pschorn, W. and Ristow, H.J. (1984) Peptide antibiotics and sporulation: Induction of sporulation in asporogenous and peptide negative mutants of B. brevis. J. Gen. Microbiol. 130: 747-755. Marahiel, M.A., Danders, W., Kraepelin, G. and Kleinkauf, H. (1982) Studies on the role of gramicidin S in the life cycle of its producer B. brevis ATCC 9999. In: Peptide antibiotics and bioactive peptides biosynthesis and function. (eds. H. Kleinkauf and H. von Döhren) Walter de Gruyter, Berlin, 375-380. Marahiel, M.A. and von Döhren, H. (1982) Survey of possible function of peptide antibiotics in the producer organisms. In: Peptide antibiotics and bioactive peptides biosynthesis and function (eds. Kleinkauf, H. and von Döhren, H.) Walter de Gruyter, Berlin, 375-380. Danders, W., Marahiel, M.A., Krause, M., Kosiu, N., Kato, T., Izumiya, N. and Kleinkauf. H. (1982).Antibacterial action of gramicidin S and tyrocidines in relation to active transport, in vitro transcription and spore outgrowth. Antimicrob. Agents and Chemotherapy 22: 785-790. Kurotsu, T., Marahiel, M.A., Müller, K.D. and Kleinkauf, H. (1982) Characterization of an intracellular serine protease from sporulating cells of B. brevis. J. Bacteriol. 151: 1466-1472. Marahiel, M.A., Lurz, R. and Kleinkauf, H. (1981) Characterization of plasmid from Bacillus brevis ATCC 9999. In: Advances in Biotechnology, Vol. III (ed. C. Venzina and K. Singh) Pergamon Press, 43-49. Marahiel, M.A., Lurz, R. and Kleinkauf, H. (1981) Characterization of chromosomal and membrane associated plasmid in B. brevis. J. Antibiotics 34: 323-330. Danders, W. and Marahiel, M.A. (1981) Control of RNA synthesis by gramicidin S during germination and outgrowth of Bacillus brevis spores. FEMS Microbiol. Lett. 10: 277-283. Marahiel, M.A., Danders, W., Krause, M. and Kleinkauf, H. (1979) Gramicidin S regulates spores outgrowth in Bacillus brevis. Hoppe-Seyler's Z. Physiol. Chem. 360: 324. Marahiel, M.A., Danders, W., Krause, M. and Kleinkauf, H. (1979) The biological role of gramicidin in spore functions. Eur. J. Biochem. 99: 49-55.Kleinkauf, H., Koischwitz, H., Vater, J., Zocher, R., Keller, U., Mahmutoglu, I., Bauer, K., Altmann, M. Kittelberger, R., Marahiel, M. and Salnikow, J. (1978) Non ribosomal biosynthesis of biologically active peptides. In: Regulation of secondary products and plants hormone metabolism (ed. Luckner, M. and Schreiber, K.), Pergamon Press, Vol. 55, 337-347. Marahiel, M.A., Imam, G., Nelson, P., Pieniazek, N., Stepien, P. and Küntzel, H. (1977) Identification of an intra mitochondrially synthesized proteolipid associated with the mitochondrial ATPase complex as the product of a mitochondrial gene determining oligomycin resistance in Aspergillus nidulans. Eur. J. Biochem. 76: 345-354. Küntzel, H., Marahiel, M.A., Leister, D.E. and Nelson, P. (1976) Polypeptide encoded by mitochondrial genes in ascomycetes. In: Genetics and Biogenesis of chloroplasts and mitochondria (ed. Th. Bucher et al.), Biochemical Press, 159-166.
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