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We are sad to have to report that Prof. Dr. Klaus Lingelbach passed away on 03.09.2015. He will be sorely missed by both family, friends, colleagues and many generations of students. 

 

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Klaus

 

 

 

 

 

Please address any inquiries to:

Dr. Stefan Baumeister
Tel.: ++49 6421 28 23421
Fax: ++49 6421 28 21531
baumeist@staff.uni-marburg.de

 

apl. Prof. Jude Przyborski
Contact details below


Veröffentlichungen


Forschungsschwerpunkte

Viele intrazelluläre Parasiten können nur dann in ihren Wirtszellen überleben, wenn sie diese modifizieren. Wir befassen uns mit den zellbiologischen Grundlagen der Wirt-Parasit-Interaktion, insbesondere mit den Veränderungen physiologischer Eigenschaften von Wirtszellen durch intrazelluläre Parasiten. Als Modellsysteme dienen Plasmodium falciparum , der Erreger der Malaria tropica, und Babesia divergens, der Erreger der Babesiose.

 

Schwerpunkte

  • Biogenese definierter Parasiten-Kompartimente
  • Infektionsbedingte Modifikationen der Wirtszellmembran
  • Proteomanalyse von Zellkompartimenten infizierter Zellen

 

Die experimentellen Ansätze bei allen Projekten sind Methoden der molekularen Zellbiologie, insbesondere Zellfraktionierung, Proteinbiochemie (Proteomics) und rekombinante DNA Technologie.

 

apl-Prof. Dr. Jude M Przyborski

Kontakt

apl.Prof. Dr. Jude Przyborski
Tel.: ++49 6421 28 26596
Fax: ++49 6421 28 21531
przybors@staff.uni-marburg.de

Skype: judepr

Publications

 

Research: Apicomplexan Cell Biology

The malaria parasite P. falciparum invades and replicate within human erythrocytes. Malaria parasites export several hundred proteins to their host cell, where they mediate a number of significant biochemical, physiological and structural modifications. Of particular importance in disease progression is the parasite-induced phenomenon termed cytoadherence, in which infected cells adhere to endothelium within the body. This leads to a reduction of blood flow to numerous tissues, and causes pathology in the human host. Cytoadherance is mediated by a parasite-encoded protein, PfEMP1, which is synthesised within the parasite, transported to, and inserted into the plasma membrane of the host cell. Transport of parasite proteins through the erythrocyte is a unique situation in eukaryotic cell biology. It appears that the parasite “installs” a protein transport system within the host erythrocyte to enable transport of (for example) PfEMP1 to the cell surface. As such, this transport system is an attractive target for therapeutic intervention.

It is our long-term goal to understand the molecular mechanisms underlying protein transport to-and through the host erythrocyte. Additionally we are interested in both protein transport and organelle biogenesis in the related apicomplexan Toxoplasma gondii.

 

Topics

·       The role of chaperone/co-chaperones in protein traffic in the malaria-infected erythrocyte.

·       The role of PfSBP1 in trafficking of PfEMP1

·       Trafficking of proteins to the apicoplast of P. falciparum and T. gondii.

·       Biogenesis of peroxisomes in T. gondii.

 

To study these parasites we use a variety of methods including molecular biology, generation of transgenic parasite lines, protein biochemistry, and both live and fixed cell imaging.

 

 

 


 


 


 

 

 

 

Zuletzt aktualisiert: 08.09.2015 · lingelba

 
 
 
Fb. 17 - Biologie

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