Publikationen

Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M. Seasonal leptin resistance is associated with impaired signalling via JAK2- STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. J Comp. Physiol. B. 2011 Dec. (in press)

Koch C, Augustine RA, Steger J, Ganjam GK, Benzler J, Pracht C, Lowe C, Schwartz MW, Shepherd PR, Anderson GM, Grattan DR, Tups A. Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity. J Neurosci. 2010 Dec 1. PMID: 21123564

Tups A, Anderson GM, Rizwan M, Augustine RA, Chaussade C, Shepherd PR, Grattan DR. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. J Neuroendocrinol. 2010 Mar 2. PMID: 20236230

Tups A. Physiological models of leptin resistance. J Neuroendocrinol. 2009 Nov;21(11):961-71. Epub 2009 Sep 1. Review. PMID: 19732287

Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M. Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus). J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jul;195(7):631-42. Epub 2009 Apr 5. PMID: 19347341

Ladyman SR, Tups A, Augustine RA, Swahn-Azavedo A, Kokay IC, Grattan DR. Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. J Neuroendocrinol. 2009 May;21(5):449-56. PMID: 19302191

Quennell JH, Mulligan AC, Tups A, Liu X, Phipps SJ, Kemp CJ, Herbison AE, Grattan DR, Anderson GM. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology. 2009 Jun;150(6):2805-12. Epub 2009 Jan 29. PMID: 19179437

Król E, Tups A, Archer ZA, Ross AW, Moar KM, Bell LM, Duncan JS, Mayer C, Morgan PJ, Mercer JG, Speakman JR. Altered expression of SOCS3 in the hypothalamic arcuate nucleus during seasonal body mass changes in the field vole, Microtus agrestis. J Neuroendocrinol. 2007 Feb;19(2):83-94. PMID: 17214870

Helwig M, Khorooshi RM, Tups A, Barrett P, Archer ZA, Exner C, Rozman J, Braulke LJ, Mercer JG, Klingenspor M. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol. 2006 Jun;18(6):413-25. PMID: 16684131

Tups A, Helwig M, Stöhr S, Barrett P, Mercer JG, Klingenspor M. Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R643-50. Epub 2006 Apr 6. PMID: 16601260

Tups A, Barrett P, Ross AW, Morgan PJ, Klingenspor M, Mercer JG. The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus. J Neuroendocrinol. 2006 Feb;18(2):139-45 PMID: 16420283

Tups A, Helwig M, Khorooshi RM, Archer ZA, Klingenspor M, Mercer JG. Circulating ghrelin levels and central ghrelin receptor expression are elevated in response to food deprivation in a seasonal mammal (Phodopus sungorus). J Neuroendocrinol. 2004 Nov;16(11):922-8. PMID: 15584933

Tups A, Ellis C, Moar KM, Logie TJ, Adam CL, Mercer JG, Klingenspor M. Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Endocrinology. 2004 Mar;145(3):1185-93. Epub 2003 Nov 26. PMID: 14645119

Mercer JG, Tups A. Neuropeptides and anticipatory changes in behaviour and physiology: seasonal body weight regulation in the Siberian hamster. Eur J Pharmacol. 2003 Nov 7;480(1-3):43-50. Review. PMID: 14623349