Wegener Lab - Dr. Christian Wegener
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My main scientific interest is in peptidomics,
architecture, and regulation of peptidergic signaling systems in
insects. I aim to understand how the small insect nervous system
regulates the activity of peptidergic signaling systems and the release
of peptide hormones. Our studies will help to understand the
evolutionary development of peptidergic system. |
Address |
Office Location |
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| Dr. Christian Wegener Philipps-University Marburg Department of Biology - Neurobiology/Ethology Karl-von-Frisch-Str. 8 35032 Marburg, Germany |
Block: D 0 Room number: 0031 Visiting Time: on agreement |
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Contact |
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| Email:
wegener[at]biologie.uni-marburg[dot]de Telefon: +49 (0)6421 28-23411 Fax: +49 (0)6421 28-28941 |
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Publications
- Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac RE, Wegener C
2011
Peptidomics and peptide hormone processing in the Drosophila midgut
J Proteome Res 10: 1881-1892
PMID: 21214272
- Wegener C, Herbert H, Kahnt J, Bender M, Rhea JM
Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila
J Neurochem [epub ahead of print]
PMID: 21138435
- Rhea JM, Wegener C, Bender M 2010
The proprotein convertase encoded by amontillado(amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH
PLoS Genetics 6:e1000967
PMID: 18717992 download open access article
- Sidyelyeva G, Wegener C, Schoenfeld BP, Bell AJ, Baker NE, McBride
SM, Fricker LD 2010
Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior
Cell Mol Life Sci 67: 2991-3004
PMID: 20386952
- Nässel DR, Enell LE, Santos JG, Wegener C, Johard HA 2008
A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions
BMC Neurosci 9:90
PMID: 18803813 download open access article
- Wegener C, Gorbashov A 2008
Molecular evolution of neuropeptides in the genus Drosophila.
Genome Biol 9:R131
PMID: 18717992 download open access article
- Vömel M, Wegener C 2008
Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster
PLoS ONE 3(3):e1848
PMID: 18365004 download open access article -
- Bader R, Wegener C, Pankratz M 2007
Comparative neuroanatomy and genomics of hugin and pheromone biosynthesis activating neuropeptide (PBAN)
FLY 1(4):228-231
download open access article
PMID: 18820431
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- Santos JG, Vömel M, Struck R, Homberg U, Nässel DR, Wegener C
2007
Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster.
PLoS ONE 2(8):e695
download open access article
PMID: 17668072 -
- Vömel M, Wegener C 2007
Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila
Dev Neurobiol 67(6):792-808
PMID: 17443825 -
- Utz S, Huetteroth W, Wegener C, Kahnt J, Predel R, Schachtner J
2007
Direct peptide profiling of lateral cell groups of the antennal lobes of Manduca sexta reveals specific composition and changes in neuropeptide expression during development
Dev Neurobiol 67(6):764-777
PMID: 17443823
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- Fastner S, Predel R, Kahnt J, Schachtner J, Wegener C 2007
A simple purification protocol for the detection of peptide hormones in the hemolymph of individual insects by MALDI-TOF mass spectrometry
Rapid Communications in Mass Spectrometry 21(1):23-28
PMID: 17125155 -
- Wegener C, Reinl T, Jänsch L, Predel R 2006
Direct mass spectrometric profiling and fragmentation in larval peptide hormone release sites of Drosophila melanogaster reveals tagma-specific peptide expression and differential processing
J Neurochem 96(5):1362-1374
PMID: 16441518
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- Santos JG, Pollák E, Rexer KH, Molnár L, Wegener C 2006
Morphology and metamorphosis of the peptidergic Va neurons and the median nerve system of the fruit fly, Drosophila melanogaster
Cell Tissue Res 326(1):187-99
PMID: 16685531
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- Hamasaka Y, Wegener C, Nässel DR 2005
GABA modulates Drosophila circadian clock neurons via GABAB receptors and decreases in calcium
J Neurobiol 65(3):225-240
PMID: 16118795
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- Hamasaka Y, Mohrherr C, Predel R, Wegener C 2005
Chronobiological quantification and mass spectrometric characterisation of PDF-immunoreactive material in the cockroach Leucophaea maderae
J Insect Sci 5:43
Download PDF -
- Wegener C, Hamasaka Y, Nässel DR 2004
Acetylcholine increases intracellular Ca2+ via nicotinic receptors in cultured PDF-containing clock neurons
J Neurophysiol 91(2):912-923
PMID: 14534288
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- Predel R, Wegener C, Russell WK, Tichy SE, Russell DH, Nachman RJ
2004
Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies
J Comp Neurol 474(3):379-92
PMID: 15174081
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- Wegener C, Herbert Z, Predel R, Eckert M 2002
The periviscerokinin (PVK) peptide family in insects: Evidence for the inclusion of CAP2b as a PVK family member
Peptides 23:605-611
PMID: 11897378
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- Wegener C, Linde D, Eckert M 2001
Periviscerokinins in cockroaches: release, distribution and a taxon-restricted myotropic effect of Pea-periviscerokinin-1
Gen Comp Endocrinol 121:1-12
PMID: 11161765
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- Wegener C, Nässel DR 2000
Peptide-induced Ca2+ movements in a tonic insect muscle: the effect of proctolin and periviscerokinin-2
J Neurophysiol 84(6):3056-3066
PMID: 11110832
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- Wegener C, Predel R, Eckert M 1999
Quantification of periviscerokinin-1 in the nervous system of the American cockroach, Periplaneta americana: an insect neuropeptide with unusual distribution
Arch Insect Biochem Physiol 40:203-211
PMID: 10330720
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Reviews and Book Chapters
- Nässel DR, Wegener C 2011
A comparative review of short and long neuropeptide F signaling in invertebrates: any similarities to vertebrate neuropeptide Y signaling?
Peptides 32:1335-1355
PMID: 21440021 -
- Wegener C, Neupert S, Predel R 2010
Direct MALDI-TOF mass spectrometric peptide profiling in neuroendocrine tissue of Drosophila.
In: Soloviev [Ed] "Peptidomics". Methods in Molecular Biology 615: 117-127. Humana Press. USA
http://www.springerlink.com/content/g170212543714318/
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- Schachtner J, Wegener C, Neupert S, Predel R 2010
Direct peptide profiling of brain tissue by MALDI-TOF mass spectrometry.
In: Soloviev [Ed] "Peptidomics". Methods in Molecular Biology 615: 129-135. Humana Press. USA
http://www.springerlink.com/content/t5771qt5641t0445/
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- Predel R, Wegener C 2006
Biology of the CAPA peptides in insects
Cell Mol Life Sci 63(21):2477-2490
PMID: 16952053
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Other Publications
- Wegener C 2011
Zur Wanzenfauna (Insecta: Heteroptera) des Naturschutzgebiets "Kleine Lummersbach" bei Marburg an der Lahn/Mittelhessen
Philippia: in press
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- Wegener C 2005
Massenansammlung von Wanzen, vor allem der Familie Acanthosomatidae, am Nordstrand von Usedom mit einem Erstnachweis von Sciocoris homalonotus FIEBER für Mecklenburg-Vorpommern
Heteropteron 20:11-14
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- Wegener C, Roth S 1999
Die Wanzen des Naturschutzgebietes "Grosser Gleisberg" im Mittleren Saaletal (Insecta: Heteroptera)
Thüringer Faunistische Abhandlungen 6:111-120
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- Wegener C, Peter H-U 1999
Forschung für einen bedrohten Lebensraum - Internationale Expedition an die Küste des Ochotskischen Meeres im Fernen Osten Russlands
Forschungsmagazin Friedrich- Schiller-Universität Jena 8:34-37
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- Wegener C 1998
Predation on the grassbug Notostira elongata (Heteroptera: Miridae: Stenodemini) by Nabidae (Heteroptera) and selected non-webbuilding spiders (Araneae) in a grassland system
Entomologia Generalis 22:295-304
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- Wegener C 1998
Termination der Diapause von Notostira elongata (Heteroptera: Miridae)
Mitteilungen des Thüringer Entomologen-Verbandes 4:4-6
