Publikationen der AG Stoffwechselphysiologie

Publikationen 2010 -

Polymeropoulos ET, Heldmaier G, Frappell PB, McAllan BM, Withers KW, Klingenspor M, White CR, Jastroch M. (2012) Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak. Proc Biol Sci. 279:185-93

Bouma HR, Verhaag EM, Otis JP, Heldmaier G, Swoap SJ, Strijkstra AM, Henning RH, Carey HV (2012) Induction of torpor: Mimicking natural metabolic suppression for biomedical applications. J Cell Physiol. 227: 1285-1290

Heldmaier G (2011). Physiology. Life on low flame in hibernation. Science. 331: 866-867

Meyer CW, Willershäuser M, Jastroch M, Rourke BC, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M. (2010) Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. Am J Physiol Regul Integr Comp Physiol. 299: R1396-406

Oelkrug R, Heldmaier G, Meyer CW (2011) Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice. J Comp Physiol B. 181:137-145

Braulke LJ, Heldmaier G, Berriel Diaz M, Rozman J, Exner C (2010) Seasonal changes of myostatin expression and its relation to body Mass acclimation in the Djungarian hamster, Phodopus sungorus. J Exp Zool A 313: 548-556

Oelkrug R, Kutschke M, Meyer CW, Heldmaier G, Jastroch M (2010) Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J Biol Chem. 285: 21961-21968

Quarta C, Bellocchio L, Mancini G, Mazza R, Cervino C, Braulke LJ, Fekete C, Latorre R, Nanni C, Bucci M, Clemens LE, Heldmaier G, Watanabe M, Leste-Lassere T, Maitre M, Tedesco L, Fanelli F, Reuss S, Klaus S, Srivastava RK, Monory K, Valerio A, Grandis A, De Giorgio R, Pasquali R, Nisoli E, Cota D, Lutz B, Marsicano G, Pagotto U (2010) CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab. 11: 273-285

Hesse D, Dunn M, Heldmaier G, Klingenspor M, Rozman J (2010) Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity. Physiol Behav. 99: 370-380

Keipert S, Klaus S, Heldmaier G, Jastroch M (2010) UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochim Biophys Acta. 1797: 324-330

Braulke LJ, Heldmaier G (2010)Torpor and ultradian rhythms require an intact signalling of the sympathetic nervous system. Cryobiology. 60: 198-203

Publikationen 2009 - 07

Knauf S, Exner C, Hospes R, Heldmaier G, Wehrend A (2009) Transabdominal ultrasonography as a monitoring tool for pregnancy in Alpine marmots (Marmota marmota). J Zoo Wildl Med. 40: 796-798

Clemens LE, Heldmaier G, Exner C (2009) Keep cool: memory is retained during hibernation in Alpine marmots. Physiol Behav. 98: 78-84

Meyer CW, Wagener A, Rink N, Hantschel C, Heldmaier G, Klingenspor M, Brockmann GA (2009) High energy digestion efficiency and altered lipid metabolism contribute to obesity in BFMI mice. Obesity 17: 1988-1993

Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M. (2009) Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus). J Comp Physiol A 195: 631-642

Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Mörth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Klopstock T, Kremmer E, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH (2009). Systemic first-line phenotyping. Methods Mol Biol. 530: 463-509.

Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M (2009) The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 10: 236-243.

Dausmann KH, Glos J, Heldmaier G (2009) Energetics of tropical hibernation. J Comp Physiol B. 179: 345-357

Trzcionka M., Withers K.W., Klingenspor M., and Jastroch M. : The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad, Bufo marinus. Accepted in J Exp Biol.(2008) pubmed

Klingenspor M., Fromme T., Hughes D.A., Manzke L., Polymeropoulos E., Riemann T., Trzcionka M., Hirschberg V., and Jastroch M. : An ancient look at UCP1. Epub ahead of print. (2008) pubmed

Jastroch M, Withers KW, Taudien S, Frappell PB, Helwig M, Fromme T, Hirschberg V, Heldmaier G, McAllan BM, Firth BT, Burmester T, Platzer M, Klingenspor M. : Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics. 2008 Jan 17;32(2):161-9. Epub 2007 Oct 30. pubmed

Fromme T., Reichwald K., Platzer M., Li X.S., Klingenspor M. : Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. BMC Mol Biol. 2007 Jan 4;8:1. pubmed

Fromme T., Klingenspor M. : Rapid single step subcloning procedure by combined action of type II and type IIs endonucleases with ligase. J Biol Eng 2007, 1:7 pubmed

Mzilikazi N., Jastroch M., Meyer C., and Klingenspor M. : The molecular and biochemical basis of nonshivering thermogenesis in a phylogenetically ancient eutherian mammal, the rock elephant shrew, Elephantulus myurus. Am J Physiol Regul Integr Comp Physiol 2007 pubmed

Nau K., Fromme T., Meyer C.W., von Praun C., Heldmaier G., Klingenspor M. : Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes. J Comp Physiol [B]. 2007 Nov 7 pubmed

Wuertz S., Nitsche A., Jastroch M., Gessner J., Klingenspor M., Kirschbaum F., and Kloas W. The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758. Gen Comp Endocrinol. 150(1), 140-50, 2007 pubmed

Publikationen 2006 - 03

Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. : Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737, 2006 Pubmed

Helwig M, Khorooshi RM, Tups A, Barrett P, Archer ZA, Exner C, Rozman J, Braulke LJ, Mercer JG, Klingenspor M. : PC1/3 and PC2 Gene Expression and Post-Translational Endoproteolytic Pro-Opiomelanocortin Processing is Regulated by Photoperiod in the Seasonal Siberian Hamster (Phodopus sungorus). J Neuroendocrinol 18: 413-425, 2006 Pubmed

Tups A, Helwig M, Stohr S, Barrett P, Mercer JG, Klingenspor M. : Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am J Physiol Regul Integr Comp Physiol , 2006 Pubmed

Tups A, Barrett P, Ross AW, Morgan PJ, Klingenspor M, Mercer JG. : The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus. J Neuroendocrinol 18: 139-145, 2006 Pubmed

Dausmann KH. : Measuring body temperature in the field - evaluation of external vs. implanted transmitters in a small mammal. J therm Biol 30: 195-202, 2005 Pubmed

Dausmann KH, Glos J, Ganzhorn JU, Heldmaier G. : Hibernation in the tropics: lessons from a primate. J Comp Physiol [B] 175: 147-155, 2005 Pubmed

Ehrhardt N, Heldmaier G, Exner C. : Adaptive mechanisms during food restriction in Acomys russatus: the use of torpor for desert survival. J Comp Physiol [B] 175: 193-200, 2005 Pubmed

Elvert R, Heldmaier G. : Cardiorespiratory and metabolic reactions during entrance into torpor in dormice, Glis glis. J Exp Biol 208: 1373-1383, 2005 Pubmed

Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Muller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, De Angelis MH. Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods 2: 403-404, 2005 Pubmed

Jastroch M, Wuertz S, Kloas W, Klingenspor M. : Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics 22: 150-156, 2005 Pubmed

Kanzleiter T, Schneider T, Walter I, Bolze F, Eickhorst C, Heldmaier G, Klaus S, Klingenspor M. : Evidence for NR4A1 as a cold-induced effector of brown fat thermogenesis. Physiol Genomics Epub ahead of print; doi:10.1152/physiolgenomics.00204.2005: 2005 Pubmed

Khorooshi RM, Klingenspor M. : Neuronal distribution of melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus). J Chem Neuroanat 29: 137-148, 2005 Pubmed

Schuhmann B, Dietrich A, Sel S, Hahn C, Klingenspor M, Lommatzsch M, Gudermann T, Braun A, Renz H, Nockher WA. : A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol 163: 15-23, 2005 Pubmed

Berriel-Diaz M, Lange M, Heldmaier G, Klingenspor M. : Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus). J Comp Physiol [B] 174: 495-502, 2004 Pubmed

Dausmann KH, Glos J, Ganzhorn JU, Heldmaier G. : Physiology: hibernation in a tropical primate. Nature 429: 825-826, 2004 Pubmed

Fietz J, Schlund W, Dausmann KH, Regelmann M, Heldmaier G. : Energetic constraints on sexual activity in the male edible dormouse (Glis glis). Oecologia 138: 202-209, 2004 Pubmed

Heldmaier G, Ortmann S, Elvert R. : Natural hypometabolism during hibernation and daily torpor in mammals. Respir Physiol Neurobiol 141: 317-329, 2004 Pubmed

Jastroch M., Stoehr S., Withers K.W., and Klingenspor M. : A quest for the origin of three mammalian uncoupling proteins. In Life in the cold: Evolution, Mechanisms, Adaptation, and Application, edited by Brian M. Barnes and Hannah V. Carey, pp. 417 - 426 (2004)

Jastroch M, Withers K, Klingenspor M. : Uncoupling protein 2 and 3 in marsupials: identification, phylogeny, and gene expression in response to cold and fasting in Antechinus flavipes. Physiol Genomics 17: 130-139, 2004 Pubmed

Liebig M, von Praun C, Heldmaier G, Klingenspor M. : Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis. Physiol Biochem Zool 77: 116-126, 2004 Pubmed

Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, De Angelis MH, Nehls M. : A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 145: 2531-2541, 2004 Pubmed

Meyer CW, Klingenspor M, Rozman J, Heldmaier G. : Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice. Obes Res 12: 1509-1518, 2004 Pubmed

Tups A, Helwig M, Khorooshi RM, Archer ZA, Klingenspor M, Mercer JG. : Circulating ghrelin levels and central ghrelin receptor expression are elevated in response to food deprivation in a seasonal mammal ( Phodopus sungorus). J Neuroendocrinol 16: 922-928, 2004 Pubmed

Tups A, Ellis C, Moar KM, Logie TJ, Adam CL, Mercer JG, Klingenspor M. : Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Endocrinology 145: 1185-1193, 2004 Pubmed

Archer ZA, Rayner DV, Rozman J, Klingenspor M, Mercer JG. Normal distribution of body weight gain in male sprague-dawley rats fed a high-energy diet. Obes Res 11: 1376-1383, 2003 Pubmed

Exner C, Wehrend A, Hospes R, Einspanier A, Hoffmann B, Heldmaier G. Hormonal and behavioural changes during the mating season and pregnancy in Alpine marmots (Marmota marmota). Reproduction 126: 775-782, 2003 Pubmed

Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, Remschmidt H, Herpertz-Dahlmann B, Klingenspor M. Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav 79: 25-37, 2003 Pubmed

Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148, 2003 Pubmed

Glueck SB, Heldmaier G. Settling down for a long winter's nap: focus on "coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal". Physiol Genomics 8: 3-4, 2002 Pubmed

Rousseau K, Atcha Z, Cagampang FR, Le Rouzic P, Stirland JA, Ivanov TR, Ebling FJ, Klingenspor M, Loudon AS. Photoperiodic regulation of leptin resistance in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 143: 3083-3095, 2002 Pubmed

Weber K, Bruck P, Mikes Z, Kupper JH, Klingenspor M, Wiesner RJ. Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143: 177-184, 2002 Pubmed