Hypothalamic Neurons |
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Integrative Functions of Hypothalamic Neurons The experimental work at present continues with electrophysiological recordings from hypothalamic neurons, mainly in the preoptic/anterior hypothalamus (POAH) and the supraoptic/paraventricular nuclei (SON/PVN), to examine neuronal control of vital autonomous functions (neurosecretion, osmo- and thermoregulation) with special regard on immunomodulatory mechanisms. |
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Particular emphasis is laid on the examination of nonlinear neuromodulatory effects which, for example, occur when immune substances like cytokines are interacting with systemic signal parameters like temperature and/or osmoregulatory substances like Angitensin II. The paper "Dewald M, Anthes N, Vedder H, Voigt K, Braun HA (1999): Phasic bursting activity of paraventricular neurons is modulated by temperature and angiotensin II. J Thermal Biol 24: 339-345" received the organisers award of the 1999 congress of Pharmacology of Thermoregulation. |
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Selected references: (for a more detailed publication list see Publications) Dewald M, Anthes N, Vedder H, Voigt K, Braun HA (1999): Phasic bursting activity of paraventricular neurons is modulated by temperature and angiotensin II. J Thermal Biol 24: 339-345. Dewald M, Braun HA, Huber MT, Zwingmann D, Roth J, Voigt K (2002): Interactions of temperature and angiotensin II in paraventricular neurons of rats in vitro. Pflügers Arch: 444: 117- 125 |
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