Research activities

Research Group Stephan Becker

Prof. Dr. Stephan Becker Tel. 06421/28 66253/54

Fields of activity:

• Structure and function of filoviral proteins

Research Group Wolfgang Garten

• Glycoproteins of enveloped viruses
  
  • Hemagglutinin of influenza viruses
  • Lassavirus glycoprotein
  • Borna disease virus (BDV) glycoprotein

• Host cell proteases processing viral glycoproteins
  
  • Furin and other proprotein convertases
  • SKI-1/S1P (subtilisin/Kexin isoenzyme-1/site 1 protease)
  • Human airway trypsin-like protease (HAT) and TMPRSS2

• Protease inhibitors targeted to block propagation of enveloped viruses
  
  • decanoyl-RVKR-chloromethylketone (decRVKRcmk)
  • decanoyl-RRLL-chloromethylketone (decRRLLcmk)
  • modified alpha-1-antitrypsins

• Structure and assembly of proteins of enveloped RNA viruses
  
  • Borna disease virus: nucleo-, phosphoprotein, matrix protein, glycoprotein
  • Lassa virus: glycoprotein and matrix protein

Research Group Hans-Dieter Klenk

Prof. Dr. Hans-Dieter Klenk Tel.: 06421/28 66191

Fields of activity:

• Human and avian influenza viruses
• Determinants of pathogenicity of influenza viruses
  
• Determinants of interspecies transmission and host range of influenza viruses
  
• Evolution of influenza viruses
  

Research Group Andrea Maisner

Prof. Dr. Andrea Maisner Tel.: 06421/28 65360

Fields of activity:

• Transport and Processing of Measles Virus and Nipah Virus Envelope Proteins
• Measles and Nipah virus infection of polarized epithelial cells
• Nipah virus infection of endothelial cells
  
• Endosomal trafficking and proteoltyic activation of the Nipah virus fusion protein
  

Research Group Mikhail Matrosovich

Dr. Mikhail Matrosovich  Tel. 06421/28 65166

Fields of activity:

• Influenza virus interactions with cellular receptors: molecular mechanisms, and role in pathogenicity
• Hemagglutinin (HA) and neuraminidase (NA) of influenza virus

Research Group Ralph T. Schwarz

• Parasitologie

Research Group Friedemann Weber

• Reverse genetics and molecular biology of bunyaviruses

• SARS-coronavirus and the antiviral type I interferon system

• Induction and inhibition of intracellular pathways triggering interferon induction

Associated Research Group

Prof. Dr. Jan ter Meulen

Fields of activity:

• Epidemiology of Hanta and Lassa virus infections in Guinea, West  Africa

• Industrial vaccine research (Merck Research Laboratories)