Projects in SFB593
Project group A aims to increase our knowledge on the cellular compartmentalization of metabolites, metals, proteins, lipids and nucleic acids. In addition, work is focussed on the components and mechanisms of membrane trafficking within the different compartments of a eukaryotic cell. A special topic of project group A is the analysis of the sub-cellular organisation of multi-protein complexes which are involved in transport, signal transduction and assembly processes in various biological membranes or compartments.
Project group B focuses on the impact of endosymbionts and pathogens on the compartmentalization of their respective host and target cells. The biological systems include (highly pathogenic) viruses, secondary endosymbionts acquired by algae, filamentous fungi, and parasites. A particular focus of the work in project group B is on the importance of compartment-specific interactions of these pathogens for their own reproductivity and for host cell toxicity.
Project group A |
Mechanisms and regulation of membrane transport |
|
| A1 |
Prof. Dr. Roland Lill | The role of mitochondria in the maturation of cytosolic and nuclear iron-sulfur proteins |
| A2 |
PD Dr. Ulrich Mühlenhoff | Mechanisms and regulation of the cellular comparmentalization of iron between mitochondria and cytosol. |
| A4 |
Prof. Dr. Dr. Jürgen Daut | Intracellular traffic of potassium channels |
| A9 |
Prof. Dr. Ralf Jacob | Identification of vesicle components involved in apical protein transport |
| A11 |
Prof. Dr. Joachim Hoyer | Endothelial caveolae are functional microcompartments and target structures in hypertension and renal failure |
| A12 |
Prof. Dr. Dominik Oliver | Compartment-specific phosphoinositide dynamics in a central neuron |
| A13 |
Prof. Dr. Moritz Bünemann | Spatiotemporal and structural aspects of G protein-mediated signal transduction |
| A14 |
Prof. Dr. Robert Grosse | Nuclear localization and regulation through protein modification of SCAI |
| A15 |
Prof. Dr. Gerhard Schratt | Molecular mechanisms underlying dendritic transport and processing of neuronal microRNAs |
Project group B |
Pathogen-induced alterations of the sub-cellular compartmentation. |
|
| B1 | Prof. Dr. Hans Dieter Klenk | Interactions of the influenza virus polymerase and hemagglutinin with host factors and their roles in pathogenesis and host adaptation |
| B2 | Prof. Dr. Wolfgang Garten | Proteases of the respiratory tract activating influenza viruses: Identification, characterization and cellular compartmentalization |
| B7 | Prof. Dr. Klaus Lingelbach | Biogenesis of the parasitophorous vacuole of apicomplexan parasites in human erythrocytes. |
| B9 | Prof. Dr. Uwe-G. Maier | Protein transport into complex plastids |
| B10 | Prof. Dr. Regine Kahmann | The role of secreted Ustilago maydis proteins during pathogenesis. |
| B11 | Prof. Dr. Andrea Maisner | Role of the endosomal compartment in Nipah virus replication |
| B12 | Prof. Dr. Stephan Becker | Morphogenesis and transport of filovirus nucleocapsids |
| B13 | Prof. Dr. Friedemann Weber | Disturbance of the nuclear and nucleolar compartments by a viral interferon antagonist |
Project group N |
Independent Junior Research Group |
|
| N1 |
Coming soon |
|
Project group Z |
Central projects of the Collaborative Research Centre 593 |
|
| Z2 |
Prof. Dr. Klaus Lingelbach | Protein analytics |
