The availability of human induced pluripotent stem cells (iPSC) and the great variety of neural differentiation protocols open new perspectives in the field of disease modelling and pharmacological drug development. We are applying iPSC derived human neural model systems to investigate synaptic mechanisms underlying neurodegenerative and neuropsychiatric phenotypes. How disease mechanisms, acting at the molecular level of single synapses, affect the activity within human synaptic networks is addressed by the help of multi electrode arrays. Our combinatorial approach will deliver a valuable tool to indentify targets in a human background and to screen for molecules that act on human synaptic networks and potentially “cure” disease related synaptic deficits.
- human iPSC culture
- small molecule directed neural differentiation
- multi electrode arrays