Our research focuses on ligand-receptor systems, which control epithelial cell communication in development, homeostasis, regeneration and cancer. A particular emphasis lies on semaphorins, a family of axon guidance cues, and their receptors, plexins. In a translational approach, we aim to identify new drug targets leading to the development of novel drugs.
Worzfeld, T., Offermanns, S. (2014).
Semaphorins and plexins as therapeutic targets.
Nature Reviews Drug Discovery 13, 603-621
Worzfeld, T., Pogge von Strandmann, E., Huber, M., Adhikary, T., Wagner, U., Reinartz, S., Müller, R. (2017).
The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Frontiers in Oncology 7, 24