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Renz Group

The center of research activities of the AG Renz is the immuno-pathogenesis of chronic inflammatory diseases as exemplified in the area of allergies and asthma.

The research unit focuses on the following research areas:

• Chronic inflammatory diseases such as allergies and asthmas are triggered and controlled through heterogeneous panel of inflammatory processes. These inflammatory signatures are called “endotypes”. One classical endotype is defined as the allergic, eosinophilic, Th2-triggered inflammatory response. The research group is interested in unrevealing further endotypes and to define novel biomarkers which would help to stratify patients for selected (and novel) therapeutic strategies.

• Allergies and asthma are prototypical diseases in the area of precision medicine. It is the goal to develop endotype-specific new therapies. The research group has pioneered the development of novel antisense strategies which also resulted in founding companies such as sterna biologicals and SECARNA pharmaceuticals.

• The development of chronic inflammatory diseases is the result of complex gene X environment actions. The research group is heavily involved in unrevealing allergy protective and allergy-risk components from lifestyle and living conditions. One important component in these regards are environmental bacteria. The group is involved in research developing novel mechanistic understanding of the role and function of such microbes. Furthermore, the group is interested in translational aspects of this research leading to better modes of allergy prevention and therapy.

• Biomathematical modelling plays an increasing role in the development of better understanding chronic diseases. This includes artificial intelligence and other approaches. The group works closely together with the research consortium MIRACUM and plays a leading role in use case 2 which is aimed to apply these novel tools and technologies to asthma and COPD patients. It is the goal to develop novel pathobiochemical networks and pathways in the area of precision medicine.

Academic group members:

A list of students and scientists currently working in the AG can be found here.

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