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SFB TR84

Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia.

Leading Institution:
Charité - Universitätsmedizin Berlin

Research Network between:
Charité - Universitätsmedizin Berlin
Justus - Liebig -Universität Giessen
Philipps - Universität Marburg
Freie Universität Berlin
Robert-Koch-Institut
Helmholtz Zentrum München
Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Universitätsklinikum Erlangen

Funding and runtime:
Deutsche Forschungsgemeinschaft
01 July 2010 - 31 December 2023

Subproject C1 - RNA-mediated regulatory networks in Legionella pneumophila pneumonia

We have obtained for the first time full coverage of protein-coding and non-coding RNA from the important pneumonia pathogen Legionella pneumophila (mRNA, sRNA) and human macrophages (mRNA, miRNA, lncRNA, circRNA) during infection by a dual RNA-Seq approach. We will exploit these data to develop an in vivo applicable therapeutic compound: We will identify suitable candidates by advanced computational network and experimental analysis, validate them in explanted human lung tissue and data of existing clinical cohorts, and finally translate them in mouse infection models, with the final goal of an in vivo applicable cell-permeable inhibitor of RNA function.

Cooperation Partner:
Prof. Dr. Annalisa Marsico
Helmholtz Zentrum München
Institute of Computational Biology
Ingolstädter Landstraße 1
85764 Neuherberg