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Translational Neuroimaging

Principal Investigator

Foto: Judith Straube

 Prof. Dr. Benjamin Straube

The Translational Neuroimaging group in Marburg (TNM-Lab; www.tmn-lab.com) is an interdisciplinary workgroup linking experimental psychology, neuroimaging and the clinical neurosciences at the Philipps-Universität Marburg (UMR). The aim of the TNM-Lab is to fill the need for translating basic research from experimental psychology and neuroimaging to clinical investigations in patients with mental disorders, in particular schizophrenia and anxiety disorders.

The Heisenberg Professorship is focused on three overarching themes, namely 1) the neural correlates of action-perception circuits, 2) dysfunctional multisensory integration and 3) the aberrant functional connectivity as general pathophysiological mechanism. The specific focus of the TNM-Lab is on predictive neural mechanisms in a multisensory environment as well as adaptive behavior reflected in learning, adaptation, memory and neuro-functional plasticity (e.g., in context of psychotherapy).

Additionally, the TNM-Lab is concerned with interdisciplinary research questions of how the human brain gives rise to complex processes such as ToM, social interactions and communication. In this sense the TNM-Lab combines multidisciplinary fields from speech science, social, cognitive and clinical psychology with experimental neurosciences.

The main method used in the TNM-Lab is functional magnetic resonance imaging (fMRI). Complementary to fMRI we also apply electroencephalography (EEG), brain stimulation techniques (tDCS) as well as behavioral experiments.

The TNM-Lab collaborates with different research consortia as well as national and international researchers. In particular, the TNM-Lab is associated to current DFG consortia in Marburg and Giessen regarding the neuroscientific investigation of action (IRTG 1901; Title: The Brain in Action, www.uni-marburg.de/fb13/forschungsgruppen/neurophysik/brainact/), perception (SFB/TRR 135; Title: Cardinal Mechanisms of Perception; http://www.allpsych.uni-giessen.de/sfb/projects.html) and their dysfunctions in psychiatric disorders (FOR 2107; Title: Neurobiology of Affective Disorders; www.FOR2107.de). Furthermore, the group is involved in the BMBF consortia (www.protect-ad.de) investigating the neural plasticity of psychotherapy. Using fear conditioning, extinction and semantic priming paradigms before and after cognitive behavioral therapy (CBT) we try to shed light on neural changes of basic learning mechanisms due to therapeutic intervention. This work is complemented by research on the development of targeted interventions to improve social functioning, speech-gesture communication and action outcome monitoring in patients with schizophrenia spectrum disorder.

The main method used in the experimental neuroscience group is functional magnetic resonance imaging (fMRI). Complementary to fMRI we also apply electroencephalography (EEG), brain stimulation techniques (tDCS) as well as behavioral experiments.

Focus of Research:

Action and perception
Multisensory integration
Learning and adaptation
Connectivity
Clinical investigations: Schizophrenia, Major Depression, Anxiety disorders

Research Group:

  • Dr. rer. nat.  Bianca van Kemenade, M.Sc. (Neuroscience)
  • Dr. Yifei He, M.Sc. (doctoral candidate, Linguist)
  • Dipl.-Psych. Yunbo Yang, (doctoral candidate, Psychologist)
  • Philipp Berger, M.Sc. (doctoral candidate, Psychologist)
  • Florian Bitsch, M.Sc. (doctoral candidate, Psychologist)  
  • Lukas Uhlmann, M.Sc. (doctoral candidate, Psychologist)
  • Belkis Ezgi Arikan, M.Sc. (doctoral candidate, Psychologist)
  • Miriam Steines, B.A. (doctoral candidate, Linguist)
  • Gizem Neziroglu, M.Sc. (doctoral candidate, Psychologist)
  • Adrian Wroblewski, M.Sc. (doctoral candidate, Neuroscience)

For all group members, see www.tnm-lab.com.

Publications

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