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SUMMARY:Prof. Beatrix Süß\, TU Darmstadt: RNA aptamers as genetic contro
 l devices – the potential of synthetic riboswitches for regulating gene 
 expression
DTSTART;TZID=Europe/Berlin:20250603T090000
DTEND;TZID=Europe/Berlin:20250603T100000
DTSTAMP:20260407T142110Z
UID:c60eb50364c2432082d204647da43cb7@www.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_beatrix-suess\nSpeaker Series. Abstract:
  RNA utilises many different mechanisms to control gene expression. Among 
 the regulatory elements that respond to external stimuli\, riboswitches ar
 e a prominent and elegant example. Riboswitches consist solely of RNA. The
 y are characterised by binding of a small molecule ligand to the so-called
  aptamer domain\, which results in a conformational change of the downstre
 am expression platform that determines the output of the system. The modul
 ar organisation of riboswitches has resulted in the adoption of engineered
  riboswitches as artificial genetic control devices and a number of exciti
 ng proof-of-concept studies have been published. It should be noted that t
 he majority of these studies were performed with the theophylline aptamer.
  Overall\, there is no shortage of small molecule-binding aptamers. Howeve
 r\, only a small fraction of them are suitable for RNA engineering since a
  classical SELEX protocol selects only for high-affinity binding but not f
 or conformational switching. We now implemented RNA Capture-SELEX in our r
 iboswitch developmental pipeline to integrate the required selection for h
 igh-affinity binding with the equally necessary RNA conformational switchi
 ng. We consider this integrated approach a breakthrough in riboswitch deve
 lopment\, as suitable sensor domains for RNA-based devices can now be deve
 loped quickly and easily against any ligand of choice.
LAST-MODIFIED:20250527T075938Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_beatrix-suess
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