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SUMMARY:Prof. Fabian Commichau\, University of Hohenheim: Heat brings ligh
 t into the lysogeny-lysis decision system of the Bacillus subtilis SPβ pr
 ophage
DTSTART;TZID=Europe/Berlin:20250923T090000
DTEND;TZID=Europe/Berlin:20250923T100000
DTSTAMP:20260411T111622Z
UID:a18b7a7fe7a1499d92e81d564a63e890@www.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_fabian-commichau\nSpeaker Series. Abstra
 ct: The temperate phage SPβinfects the endospore-forming Gram-positive ba
 cterium Bacillus subtilis and resides as a prophage in its genome. Culture
 s of B. subtilis that are lysogenic for SPβ release the glycopeptide subl
 ancin\, which inhibits the growth of SPβ-free B. subtilis strains by inte
 rfering with DNA replication and transcription. Thus\, SPβ is a host-bene
 fitting trait after the transfer to another B. subtilis strain lacking the
  prophage previously. Phages of the SPβgroup like phi3T use a peptide-bas
 ed communication system (termed the “arbitrium” system) to coordinate 
 lysis-lysogeny decisions. In the early stage of infection\, the number of 
 phages and the peptide concentration is low and a transcription antitermin
 ator protein allows the synthesis of an antitoxin. Consequently\, lytic tr
 anscripts are not degraded and SPβ remains in the lytic cycle. With incre
 asing peptide concentrations\, the peptide enters the cell and inactivates
  the transcription antiterminator protein. The lytic transcripts are degra
 ded\, and the phages enters the lysogenic state. Recently\, we have identi
 fied the master repressor of SPβ and a factor that acts downstream of the
  repressor and is critical for the activation of the lytic cycle. Although
  many additional components of the lysis-lysogeny decision system have alr
 eady been identified\, it is unclear how the lysogenic cycle\, particularl
 y in the case of the phage SPβ\, is activated. The current status of the 
 project is presented.
LAST-MODIFIED:20250820T074403Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_fabian-commichau
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