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SUMMARY:Prof. Fernando Moreno-Herrero\, Universidad Autónoma de Madrid\, 
 Spain: Single-molecule approaches to study protein machines involved in DN
 A metabolism
DTSTART;TZID=Europe/Berlin:20260119T160000
DTEND;TZID=Europe/Berlin:20260119T170000
DTSTAMP:20260407T072205Z
UID:9a505ca26c9b4e9fa722368378ae200f@www.uni-marburg.de
CATEGORIES:()
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_fernando-moreno-herrero\nSpeaker Series.
  Abstract: DNA metabolism is essential for the proper functioning of the c
 ell. It encompasses processes that preserve the stability\, structure\, an
 d integrity of the genome\, including DNA repair mechanisms and higher-ord
 er DNA organization. These tasks are performed by complex\, specialized pr
 otein machineries composed of low-copy number components that operate in a
  coordinated and often sequential manner. Many of these processes are inhe
 rently mechanical\, proceeding through a series of events that are exquisi
 tely regulated by force. Traditional biochemical methods provide ensemble-
 averaged measurements\, lack single-molecule resolution\, and offer limite
 d access to physical parameters such as force and directionality. As a res
 ult\, they can obscure rare or atypical molecular behaviors that may be cr
 ucial for proper cellular function.\nIn this talk\, I will introduce two s
 ingle-molecule techniques – Magnetic Tweezers and Optical Tweezers – t
 hat enable us to study protein machines involved in DNA processing one mol
 ecule at a time. Moreover\, by combining these approaches with fluorescenc
 e microscopy\, we can correlate the biological activity of molecular motor
 s with their spatial localization along the DNA. I will highlight several 
 ongoing projects\, including investigations of helicases and molecular mot
 ors implicated in bacterial and eukaryotic double-strand break repair\, as
  well as studies of ParB and ParB-like proteins involved in bacterial chro
 mosome segregation and gene regulation of multi-drug resistance plasmids.
LAST-MODIFIED:20260109T083305Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_fernando-moreno-herrero
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TZID:Europe/Berlin
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DTSTART:20251026T020000
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TZOFFSETFROM:+0200
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