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SUMMARY:Prof. Michael Booth\, University College London: Nucleic acid conj
 ugates: remote control\, targeting\, and entirely new functions
DTSTART;TZID=Europe/Berlin:20250401T090000
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DTSTAMP:20260407T094750Z
UID:83a4f3618e7446d6b9c4520d5fb13ddf@www.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_michael-booth\nSpeaker Series. Abstract:
  We are entering the age of nucleic acid (DNA/RNA) technologies. DNA and R
 NA form the basis for many therapeutic and experimental technologies\, inc
 luding gene editing and silencing\, several aspects of nanotechnology\, ap
 tamers and their applications\, and cell-free gene expression. However\, t
 heir application is limited by the chemistry of nucleic acids. A major goa
 l of the Booth group is the generation of nucleic acid conjugates to overc
 ome current major challenges in their delivery and targeting\, and to prod
 uce entirely new functions to increase their therapeutic potential. Contro
 lling nucleic acid function would greatly expand their application in biol
 ogy and medicine\, by reducing toxic on/off-target effects. To this end\, 
 we have generated remote-controlled nucleic acids under the control of ort
 hogonal wavelengths of light (JACS\, Chem. Sci.) and magnetism (BioRxiv). 
 These controllable nucleic acids have also been applied in synthetic cells
  to control their communication with living cells (Nat. Chem. Biol.). Anti
 sense oligonucleotides\, short single stranded synthetic oligos\, are the 
 predominant form of nucleic acid therapeutics in the clinic. However\, des
 pite their success\, approved ASOs target a narrow spectrum of diseases an
 d their key mechanisms of action are predominantly localised within the nu
 cleus. We have attached a nuclear importer to improve their activity in th
 e nucleus (ChemRxiv) and developed a new mechanism of action for targeted 
 mRNA degradation in the cytoplasm (unpublished). These nucleic acid conjug
 ates will form the basis of a whole new suite of targeted therapeutics and
  technologies for basic research.
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LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_michael-booth
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