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SUMMARY:Dr. Olivier Duss\, European Molecular Biology Laboratory (EMBL) He
 idelberg: Dynamic RNA biology at the single-molecule level: Watching how i
 nterconnected processes work in real-time
DTSTART;TZID=Europe/Berlin:20250218T090000
DTEND;TZID=Europe/Berlin:20250218T100000
DTSTAMP:20260407T120210Z
UID:7106f907ed984e0a86bbb491ae2c2a9d@www.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_olivier-duss\nSpeaker Series. A central 
 question in biology is how macromolecular machines function cooperatively.
  \nIn the first part\, I will show our recent work investigating how bacte
 rial transcription and translation cooperate. We have reconstituted a comp
 lete and active transcription-translation system and developed multi-color
  single-molecule fluorescence microscopy experiments to directly and simul
 taneously track transcription elongation\, translation elongation and the 
 physical and functional coupling between the ribosome and the RNAP in real
 -time (Qureshi & Duss\, Nature\, 2025). A main finding is that the ribosom
 e and the RNAP can communicate with each other by mRNA looping\, providing
  an alternative explanation on how the ribosome can efficiently rescue RNA
 P from frequent pausing without requiring collisions by a closely trailing
  ribosome. \nIn the second part\, I will discuss our work on understanding
  how the bacterial rRNA transcription antitermination complex (rrnTAC) coo
 rdinates early co-transcriptional rRNA processing. By directly tracking rr
 nTAC assembly and co-transcriptional RNase III cleavage in real-time\, we 
 show how the presence of the completely assembled rrnTAC facilitates RNase
  III cleavage by bringing 5’- and 3’-end of the rRNA spatially close\,
  thereby chaperoning the long-range RNA helix which is the substrate for R
 Nase III. This is the first direct experimental evidence of coupling betwe
 en rRNA transcription and processing in bacterial ribosome assembly mediat
 ed by long-range rRNA looping. \nDepending on time\, I may also show some 
 work on our efforts to understand eukaryotic RNA biology\, specifically ho
 w m6A gets introduced into RNA by the Mettl3/14 complex and read in real-t
 ime by the YTHDC1 reader protein.
LAST-MODIFIED:20250127T112132Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_olivier-duss
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TZID:Europe/Berlin
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DTSTART:20241027T020000
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