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SUMMARY:Prof. Stephan Gruber\, University of Lausanne: SMC motors and swit
 ches in genome maintenance and DNA immunity
DTSTART;TZID=Europe/Berlin:20250520T090000
DTEND;TZID=Europe/Berlin:20250520T100000
DTSTAMP:20260407T094820Z
UID:9dfebfc5f2654bddbf477b20557f40ff@www.uni-marburg.de
CREATED:20241205T125047Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/grk2937_speaker-series_stephan-gruber\nSpeaker Series.  Abstrac
 t: SMC and SMC-like complexes are essential for chromosome organization an
 d genome maintenance across the domains of life. Recently\, they have also
  emerged as key players in cellular immunity against foreign DNA. In bacte
 ria and archaea\, the Wadjet and Lamassu systems function in anti-plasmid 
 and anti-phage defense\, while in humans\, the Smc5/6 and Rad50 complexes 
 contribute to antiviral immunity. This dual role presents an intriguing pa
 radox: how can the same\, or closely related\, complexes preserve chromoso
 mal DNA while also recognizing and restricting extrachromosomal DNA? I wil
 l discuss current insights into the role of these complexes in immunity\, 
 including how core principles of SMC(-like) function may enable them to di
 fferentiate and respond to linear or circular forms of invading DNA.
LAST-MODIFIED:20250512T084532Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/grk2937_speaker-series_stephan-gruber
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