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SUMMARY:Prof. Jue Wang\, University of Wisconsin-Madison and Mercator Fell
 ow of GRK 2937: Themes and Variations of Stress-Signaling Alarmones
DTSTART;TZID=Europe/Berlin:20250107T090000
DTEND;TZID=Europe/Berlin:20250107T100000
DTSTAMP:20260509T165647Z
UID:9198d1cad33e4876bdddec43aeb5318e@www.uni-marburg.de
CREATED:20241205T124814Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/jue-wang-wisconsin-madison\nSpeaker Series. About the Wang Lab:
  Bacterial stress responses allow cells to survive fluctuating environment
 s\, antibiotic treatments\, and host defenses. My current research aims to
  answer the following fundamental questions: how do bacteria utilize stres
 s-induced small molecules to adapt to their specific environmental niches?
  How do bacteria enter a metabolically dormant persister state that is int
 rinsically tolerant to a broad array of antibiotic treatments? How do stre
 ssed bacteria mitigate potential conflicts between their DNA replication a
 nd transcription machineries to ensure survival? What are the molecular me
 chanisms of bacterial evolution to fit their specific niches? We combine m
 etabolomics\, transcriptomics\, and proteomics with biochemical and evolut
 ionary approaches to answer these questions. We study these processes in t
 he Gram-positive bacterium Bacillus subtilis and the Gram-negative bacteri
 um Escherichia coli. These organisms grow fast and are highly amenable to 
 genetic manipulation. Because the fundamentals of information processing m
 echanisms are conserved across all domains of life\, our work in bacteria 
 is broadly applicable to other\, less tractable\, systems.
LAST-MODIFIED:20241219T091513Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/jue-wang-wisconsin-madison
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