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SUMMARY:Prof. Andrea Rentmeister\, Ludwig-Maximilians-Universität Münche
 n: Harnessing Click Chemistry and Light for Precise Analysis and Control o
 f mRNA
DTSTART;TZID=Europe/Berlin:20241217T090000
DTEND;TZID=Europe/Berlin:20241217T100000
DTSTAMP:20260312T175534Z
UID:5a2550083ad14c2f8ba1ce4ec236ddcb@www.uni-marburg.de
CREATED:20240208T102514Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/speaker-series-andrea-rentmeister\nSpeaker Series. \nMessenger 
 RNAs (mRNAs) enable the production of almost any functional protein/peptid
 e in the human body as a vaccine or therapeutic agent. The translation of 
 mRNA is a fundamental process in gene expression\, and controlling transla
 tion is crucial for regulating the production of proteins in cells. In add
 ition\, internal modifications of mRNA have emerged as widespread and vers
 atile regulatory mechanism to control gene expression at the post-transcri
 ptional level. Most of these modifications are methyl groups\, making S-ad
 enosyl-L-methionine (SAM) a central metabolic hub.\nWe established metabol
 ic labeling with a clickable metabolic precursor of SAM that enables detec
 tion and identification of various methylation sites. Integration into nex
 t generation sequencing enabled mapping of N6-methyladenosine (m6A) and 5-
 methylcytidine (m5C) sites in mRNA with single nucleotide precision and in
 dependent of antibodies.\nIn a different project\, we aimed to control tra
 nslation of mRNA by light as external stimulus. We synthesized 5′ cap an
 alogues with photo-cleavable groups (FlashCaps) that prohibit binding to t
 he eukaryotic translation initiation factor eIF4E. These compounds are com
 patible with the general and efficient production of mRNAs by in vitro tra
 nscription. FlashCaps offer a route to regulate the expression of any give
 n mRNA in vitro and in cells and may provide an approach to dose mRNA ther
 apeutics with spatio-temporal control.
LAST-MODIFIED:20241206T101615Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/speaker-series-andrea-rentmeister
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