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SUMMARY:Dr. Maria Duca\, Université Côte d’Azur\, Nice (FR): Design of
  multifunctional conjugates for the targeting of non-coding RNAs: anticanc
 er and antimicrobial applications
DTSTART;TZID=Europe/Berlin:20241203T090000
DTEND;TZID=Europe/Berlin:20241203T100000
DTSTAMP:20260510T084338Z
UID:b1f291a5e73d4038a0de20cbed3000d8@www.uni-marburg.de
CREATED:20240229T101517Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/speaker-series-maria-duca\nSpeaker Series. Abstract: RNA is one
  of the most intriguing and promising biological targets for the discovery
  of innovative drugs in a large number of pathologies and various biologic
 ally relevant RNAs that could serve as drug targets have already been iden
 tified. Among the most important ones\, it is worth to mention prokaryotic
  ribosomal RNA which is the target of a number of currently employed antib
 iotics\, viral RNAs such as TAR\, RRE and DIS RNA of HIV-1 or oncogenic mi
 croRNAs that are tightly involved in the development and progression of va
 rious cancers. However\, difficulties in the rational design of strong and
  specific small-molecule ligands renders this kind of molecules relatively
  rare. In this presentation\, we will show our recent results about the st
 ructure-based design of new RNA ligands targeting oncogenic RNAs that led 
 us to the identification of new compounds bearing a promising biological a
 ctivity but also to a better understanding of the formed interactions towa
 rd the design of optimized compounds. In parallel to the design of bioacti
 ve compounds\, we also perform the screening of chemical library thus incr
 easing the available chemical tools for the development of efficient and s
 pecific RNA binders for a wide number of therapeutic applications. We will
  finally show the validation of a new antibacterial target and the design 
 of original compounds bearing potential antimicrobial activity against res
 istant bacterial strains.
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LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/speaker-series-maria-duca
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