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SUMMARY:Prof. Michal Hocek\, Charles University\, Prague (CZ): Base-modifi
 ed nucleotides and nucleic acids for chemical biology\, medicinal chemistr
 y and diagnostics
DTSTART;TZID=Europe/Berlin:20241105T090000
DTEND;TZID=Europe/Berlin:20241105T100000
DTSTAMP:20260407T142111Z
UID:e5b22c8eac874f879765498f20e79799@www.uni-marburg.de
CREATED:20240212T111223Z
DESCRIPTION:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-
 and-events/speaker-series-michal-hocek\nSpeaker Series. The Hocek group is
  interested in synthetic\, bioorganic and medicinal chemistry of nucleic a
 cids and their components. Novel types of modified derivatives and analogu
 es of nucleobases\, nucleosides\, nucleotides and nucleic acids are design
 ed and prepared for applications in all areas of biomedicinal sciences (me
 dicinal chemistry\, biochemistry\, chemical biology\, bioanalysis etc.). B
 asic developments of methodology for the synthesis of these modified biomo
 lecules are performed largely using modern methods (including metal- or en
 zyme-catalyzed reactions).\nBiological activity (antitumor\, antiviral etc
 .) of the novel nucleobases\, nucleosides and nucleotides is systematicall
 y studied in collaboration with several groups both in academia and in pha
 rmaceutical industry\, including mechanism of action and preclinical devel
 opment of promising new cytostatics.\nEnzymatic synthesis of functionalize
 d nucleic acids bearing diverse interesting and useful substituents is dev
 eloped and the modified oligonucleotides or nucleic acids are applied in b
 ioanalysis (redox labelling for electrochemical detection or environment-s
 ensitive fluorescence labelling for fluorescent microscopy) or in chemical
  biology (regulation of gene expression or cross-linking of DNA probes wit
 h proteins).
LAST-MODIFIED:20240926T120134Z
LOCATION:SYNMIKRO Lecture Hall
URL:https://www.uni-marburg.de/en/synmikro/grk2937/whats-on/dates-and-even
 ts/speaker-series-michal-hocek
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TZID:Europe/Berlin
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DTSTART:20241027T020000
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TZOFFSETFROM:+0200
TZOFFSETTO:+0100
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