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Prof. Gerhard Schratt, PhD  

Philipps-Universität Marburg, Fachbereich Medizin

Institut für Physiologische Chemie

Karl-von-Frisch-Straße 1, 35032 Marburg

Phone: +49 6421 – 2865020, Fax: +49 6421 – 2868797

Email: schratt@staff.uni-marburg.de

Homepage

 Schratt

Research focus
Molecular and cellular mechanisms of synaptic development and plasticity in mammals; Synaptic protein synthesis and local translation; Function and targets of neuronal microRNAs; Neurodevelopmental (Autism-spectrum disorders) and neuropsychiatric (schizophrenia, depression) diseases.


Techniques

-    Cell cultures of primary hippocampal and cortical neurons

-    Small RNA isolation and analysis (Northern, qPCR, microarray, next-generation sequencing)

-    High-resolution fluorescence confocal microscopy (neuronal dendrites and spines)

-    Transgenic and knockout mouse models  

-    Recombinant adeno-associated virus (rAAV) production and brain delivery

-    Electrophysiology (patch-clamp)

-    Standard methods of molecular cloning, molecular biology and protein biochemistry

 

Publications (10 selected Publications since 2006)

1. Saba, R., Störchel, P.H., Aksoy-Aksel, A., Kepura, F., Lippi, G., Plant, T.D. and Schratt, G. (2012) The dopamine-regulated microRNA, miR-181a, controls GluA2 surface expression in hippocampal neurons. Mol Cell Biol. 32(3):619-32.

2. Berkel S, Tang W, Treviño M, Vogt M, Obenhaus HA, Gass P, Scherer SW, Sprengel R, Schratt G, Rappold GA (2012) Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology. Hum Mol Genet. 15;21(2):344-57.

3. Siegel, G., Saba R. and Schratt G., (2011) microRNAs in neurons: manifold regulatory roles at the synapse. Curr Opin Genet Dev. 21(4):491-7.

4. Lippi G, Steinert JR, Marczylo EL, D'Oro S, Fiore R, Forsythe ID, Schratt G, Zoli M, Nicotera P, Young KW. (2011) Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology. J Cell Biol. 19;194(6):889-904.

5. Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Richter J, Duebel J, Bicker S, Fehling HJ, Schübeler D, Oertner TG, Schratt G, Bibel M, Roska B and Filipowicz W. (2010) Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell, 14;141(4):618-31.

6. Christensen, M., Larsen, L.A., Kauppinen, S. & Schratt G. (2010) Recombinant adeno-associated virus-mediated microRNA delivery into the postnatal mouse brain reveals a role for miR-134 in dendritogenesis in vivo. Frontiers in Neural Circuits,3:16.

7. Siegel G.*, Obernosterer G.*, Fiore R., Oehmen, M., Bicker, S., Christensen M., Khudayberdiev, S., Leuschner, P., Busch, C., Kane, C., Hübel K., Dekker, F., Hedberg, C., Rengarajan, B., Drepper, C., Waldmann H., Kauppinen S., Greenberg M.E., Draguhn, A., Rehmsmeier M., Martinez J. and Schratt G.  (2009) A functional microRNA screen implicates miR-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nature Cell Biology, 11(6):705-716.

8. Fiore R.*, Khudayberdiev S.*, Christensen M., Siegel G., Flavell S., Kim T.K., Greenberg M.E. and Schratt G. (2009) Mef2-dependent activation of the miR-379-410 cluster promotes dendritic outgrowth by fine-tuning protein levels of the translational repressor Pumilio2. EMBO J.18;28(6):697-710.

9. Schratt, G. (2009) microRNAs at the synapse. Nat Rev Neurosci. 10(12): 842-9.

10. Schratt G, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M and Greenberg ME. (2006) A brain-specific microRNA regulates dendritic spine development. Nature, 439(7074):283-9.

 

 

 

 

Zuletzt aktualisiert: 03.05.2013 · Busses

 
 
 
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