The focus in our lab is on arginine methylation of histones and chromatin-associated proteins. Arginine methylation is a posttranslational modification, which has only recently been shown to play an important role in transcriptional control. Since many transcriptional regulators are deregulated in cancer and other diseases, we are interested in characterising

• the gene regulatory pathways that are in control of arginine methyltransferases in mammalian cells
  
• the molecular mechanisms by which arginine methylation affects transcription
  
• how the enzymatic activitiy of arginine methyltransferases can be regulated
  
• diseases which show mutation, misexpression or deregulation of these enzymes and their targets.