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Recent Joint/smART Publications

2026

Kaltenschnee N, Dietz MS, Kessler LF, Li Y, Kaufmann J, Heckel A, Heilemann M. Wash‐Free Multi‐Target Super‐Resolution Microscopy With Photocaged DNA Labels. Angewandte Chemie International Edition. 65, e26137 (2026). doi.org/10.1002/anie.202526137 (Open Access)

Schlundt A, von Ehr J, Sethumadhavan S, Schubert F, Korn S, Meixner N, Oberstrass L, Simon B, Weigand J, Hummer G, Müller-McNicoll M. The structural basis of SRSF6-mediated splicing decisions governed by tandem-domain RNA recognition and RS domain tuning. Research Square (2026). doi.org/10.21203/rs.3.rs-9953096/v1 (Open Access)

Schwalbe H, Wachtveitl J, Heckel A, Buhr F, Toews S, Schimmer TM. The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence. Angewandte Chemie International Edition. 65, e23427 (2026). doi.org/10.1002/anie.202523427 (Open Access)

Schoth JB, Schwedt I, Philipp S, Toews S, Schübel L, Wacker A, Schwalbe H, Weigand JE. Structure and sequence characteristics of 5′-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variants. Nucleic Acids Research. 54 (2026). doi.org/10.1093/nar/gkag364 (Open Access)

Kessler LF, Berrevoets ES, Balakrishnan A, Okuda EK, Müller-McNicoll M, Rieger B, Stallinga S, Heilemann M. Structural cell biology with smart STED microscopy. Single Molecule Spectroscopy and Superresolution Imaging XIX (2026). doi.org/10.1117/12.3084913

Zhang L, Djokovic N, Herr A, Wacker A, Hay ES, Santana D, Hargrove AE, Schwalbe H, Nikolic K, Abendroth F, Vázquez O. Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion. Chemistry – A European Journal. 32 (2026). doi.org/10.1002/chem.71371 (Open Access)

Dalwigk JF, Kerkhoff K, Knittelfelder O, Ross RL, Petrella MC, Kuśnierczyk A, Bhandari T, Attina A, Burkard A, Brás-Costa C, DeMott MS, Johnson K, Kerkhoff-Bernaciak X, Kist J, Kögel K, Krämer M, Moreno-Ballesteros R, Podoprygorina G, Simcox K, Simsir Ö, Skriba A, Wein S, Cahova H, Garcia BA, Helm M, David A, Höfer K, Leidel S, Limbach PA, Novoa E, Sabidó E, Schneider S, Wolff P, Dedon P, Cheung V, Kaiser S. Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification. bioRxiv (Cold Spring Harbor Laboratory) (2026). doi.org/10.64898/2026.07.17.739095 (Open Access)

Wirmer‐Bartoschek J, Ferner J, Heckel A, Schwalbe H. Dissecting the Chemical and Thermal Stabilities of Tetrads in G‐Quadruplexes to Derive a Structure‐Activity Relation for a Thrombin‐Binding DNA G‐Quadruplex Aptamer. ChemBioChem. 27, e202500743 (2026). doi.org/10.1002/cbic.202500743 (Open Access)

Weckler BC, Martin R, Kutzinski M, Bertrams W, Jung AL, Pott H, Laakmann K, Schulte L, Ahnert P, Heider D, Ringshandl S, Seidemann C, Suttorp N, Witzenrath M, Wildberg C, Lehmann M, Rohde G, Greulich T, Vogelmeier CF, Schmeck B. Blood eosinopenia (≤30/µL) as an early predictor of respiratory failure in community-acquired pneumonia: A prospective multicentre study. Pulmonology. 32, 2611215 (2026). doi.org/10.1080/25310429.2025.2611215 (Open Access)

Westermann AJ, Schock A, Ashour DAD, Wende S, Skevaki C, Mack E, Schmeck B, Linne U, Herrmann T, Antonakos N, Florou H, Giamarellos-Bourboulis EJ, Weis S, Vogel J, Schulte LN. A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense. Proceedings of the National Academy of Sciences. 123, e2520205123 (2026). doi.org/10.1073/pnas.2520205123 (Open Access)

2025

Bertrams W, Roessler FK, Bæk R, Jung AL, Laakmann K, Jørgensen MM, Lehmann M, Weckler B, Schulte LN, Rohde G, Bar N, Barten G, Schmeck B, . Surface proteome of plasma extracellular vesicles differentiates between SARS-CoV-2 and influenza infection. Virulence. 17, 2590305 (2025). doi.org/10.1080/21505594.2025.2590305 (Open Access)

Burkhart I, McKenney VR, Wirmer-Bartoschek J, Grün JT, Heckel A, Schwalbe H. Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter. ACS Chemical Biology. 20, 1417-1425 (2025). doi.org/10.1021/acschembio.5c00226 (Open Access)

Berrevoets ES, Kessler LF, Balakrishnan A, Okuda EK, Müller-McNicoll M, Rieger B, Stallinga S, Heilemann M. Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body. Nature Communications. 16, 10689 (2025). doi.org/10.1038/s41467-025-65723-x (Open Access)

Okuda EK, Kessler LF, Arnold B, Riegger RJ, Hernández Cañás MC, Zebrowska E, Bakisoglu C, Rudigier M, Krost C, Nagasse HY, Keiten-Schmitz J, Müller S, Stanek D, Dormann D, Zarnack K, Heilemann M, Müller-McNicoll M. Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckle–paraspeckle crosstalk during cellular stress. Nucleic Acids Research. 53 (2025). doi.org/10.1093/nar/gkaf713 (Open Access)

Christe L, Haessler A, Gier S, Schmeck B, Jung N, Windbergs M. Raman spectroscopy reveals growth phase-dependent molecular differences in bacterial membrane vesicles. Journal of Bacteriology. 208, e0041025 (2025). doi.org/10.1128/jb.00410-25 (Open Access)

Elsayed EM, Stukenberg D, Meier D, Schmeck B, Becker A. RECKLEEN is a lambda Red/CRISPR-Cas9 based single plasmid platform for enhanced genome editing in Klebsiella pneumoniae. Communications Biology. 8, 1509 (2025). doi.org/10.1038/s42003-025-08934-8 (Open Access)

Ceylan B, Adam J, Toews S, Kaiser F, Dörr J, Scheppa D, Tants J, Smart A, Schoth J, Philipp S, Stirnal E, Ferner J, Richter C, Sreeramulu S, Caliskan N, Schlundt A, Weigand JE, Göbel M, Wacker A, Schwalbe H. Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2. Angewandte Chemie International Edition. 64, e202417961 (2025). doi.org/10.1002/anie.202417961 (Open Access)

Yilmaz Demirel N, Mumcuoglu I, Malengo G, Schmeck B, Jung AL, Höfer K. Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction. bioRxiv (Cold Spring Harbor Laboratory) (2025). doi.org/10.1101/2025.07.11.664405 (Open Access)

Schmerer N, Janga H, Aillaud M, Hoffmann J, Aznaourova M, Wende S, Steding H, Halder LD, Uhl M, Boldt F, Stiewe T, Nist A, Jerrentrup L, Kirschbaum A, Ruppert C, Rossbach O, Ntini E, Marsico A, Valasarajan C, Backofen R, Linne U, Pullamsetti SS, Schmeck B, Schulte LN. A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages. Nature Communications. 16, 4733 (2025). doi.org/10.1038/s41467-025-60084-x (Open Access)