Main Content
Publications
2025
Fehse L, Tajabadi M, Martin R, Holzmann H, Heider D. gLinDA: A privacy-preserving, swarm learning toolbox for differential abundance analysis of microbiomes. Comput Struct Biotechnol J. 2025 Jul; doi: 10.1016/j.csbj.2025.07.031.
Niedermaier T, Alter P, Jörres R, Vogelmeier C, Holle R. Parametric estimation of age-, sex-, and spirometry grade-specific mortality in a cohort of COPD patients from Germany: Results from COSYCONET. Respiratory Med. 2025 October; DOI: j.rmed.2025.108280
Konietzke P, Weinheimer O, Triphan SMF, Nauck S, Wuennemann F, Konietzke M, Jobst BJ, Jörres RA, Vogelmeier CF, Heussel CP, Kauczor H-U, Biederer J, Wielpütz MO; COSYCONET study group: GOLD-Grade Specific Disease Characterization and Phenotyping of COPD Using Quantitative Computed Tomography in the Nationwide COSYCONET Multicenter Trial in Germany. Respir Int Rev Thorac Dis 2025 Aug.; DOI: 10.1159/000540781
Reingruber J, Krämer MJ, Bigge J, Dasmeh P, Grover S, Heilmann-Heimbach S, Nöthen MM, Kreuser N, Gockel I, Veits L, Vieth M, Jank P, Denkert C, Maj C, Hess T, Schumacher J. Assessing the suitability of formalin-fixed paraffin-embeded (FFPE) tissue for genome-wide association studies (GWAS). BMC Res Notes. 2025 July 18(1); DOI: 10.1186/s13104-025-07306-z
Fahrenberg C, Niedermaier T, Alter P, Jörres RA, Vogelmeier CF, Holle R. Analysis of change in health-related quality of life in patients with COPD over 6 years, including information on dropouts: Results from the German COSYCONET cohort. Respiratory Med. 2025 May; DOI: 10.1016/j.rmed.2025.108153
Zhu L, Li Q, von Stackelberg O, Triphan SMF, Biederer J, Weinheimer O, Eichinger M, Vogelmeier CF, Jörres RA, Kauczor H-U, Heußel CP, Jobst BJ, Yu H, Wielpütz MO. Longitudinal MRI in comparison to low-dose CT for follow-up of incidental pulmonary nodules in patients with COPD—a nationwide multicenter trial. Eur. Radiol. 2025 Apr. 13; https://doi.org/10.1007/s00330-025-11567-4
Pott H, Weckler B, Gaffron S, Martin R, Maier D, Alter P, Biertz F, Speicher T, Bertrams W, Jung AL, Laakmann K, Heider D, Wouters M, Vogelmeier CF, Schmeck B. Diffusion capacity and static hyperinflation as markers of disease progression predict 3-year mortality in COPD: Results from COSYCONET. Respirology. 2025 Feb. 30(2); DOI: 10.1111/resp.14843
Konietzke P, Weinheimer O, Triphan SMF, Nauck S, Wuennemann F, Konietzke, M. Jobst BJ, Jörres RA, Vogelmeier CF, Heussel CP, Kauczor H-U, Wielpütz MO, Biederer J; COSYCONET study group. GOLD grade-specific characterization of COPD in the COSYCONET multi-center trial: comparison of semiquantitative MRI and quantitative CT. Eur Radiol. 2025 Jan. 35:3842-3857; DOI: 10.1159/000540781
2024
Khan SA, Brenner T, Link A-C, Reudenbach C, Bendix J, Weckler BC, Kutzinski M, Rupp J, Witzenrath M, Rohde G, Pletz MW, Bertrams W, Schmeck B. Impact of absolute values and changes in meteorological and air quality conditions on community-acquired pneumonia in Germany. Int J Biometeorol. 2024 Dec. doi: 10.1007/s00484-024-02839-7
Pott H, Weckler B, Gaffron S, Martin R, Maier D, Alter P, Biertz F, Speicher T, Bertrams W, Jung A L, Laakmann K, Heider D, Wouters M, Vogelmeier C F, Schmeck B; COSYCONET Study Group. Diffusion capacity and static hyperinflation as markers of disease progression predict 3-year mortality in COPD: Results from COSYCONET. Respirology, 2024 Oct 24. doi: 10.1111/resp.14843.
Weckler B C, Pott H, Race A, Jugkaeo N, Karki K, Ringshandl S, Seidemann C, Schöndorf I, Renz H, Fähndrich S, Jung AL, Bertrams W, Makoudjou A, Zöller D, Finotto S, Schild S, Seuchter SA, Rohde G, Trinkmann F, Greulich T, Schmeck B (2024) Eosinopenia as Predictor of Disease Severity in Patients with Community-Acquired Pneumonia: An Observational Study. CHEST. DOI: 10.1016/j.chest.2024.05.041
Krause FF, Mangold KI , Ruppert A-L, Leister H, Hellhund-Zingel A , A Lopez Krol, Pesek J, Watzer B , Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, WA, Taudte RV, Bertrams W, Schmeck B, A Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Gut Microbes, 2024 Oct. 14; doi: 10.1080/19490976.2024.2412669.
Nauck S, Pohl M, Jobst BJ, Melzig C, Meredig H, Weinheimer O, Triphan S, von Stackelberg O, Konietzke P, Kauczor HU, Heußel CP, Wielpütz, MO, Biederer J. Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial. Eur Radiol. 2024 Sep 34 (9): 5597 - 5609; doi: 10.1007/s00330-024-10610-0.
Konietzke P, Weinheimer O, Triphan SMF, Nauck S, Wuennemann F, Konietzke M, Jobst BJ, Jörres RA, Vogelmeier CF, Heussel CP, Kauczor HU, Biederer J, Wielpütz MO. GOLD-Grade Specific Disease Characterization and Phenotyping of COPD Using Quantitative Computed Tomography in the Nationwide COSYCONET Multicenter Trial in Germany. Respir Int Rev Thorac Dis. 2024 Aug 22;1–17; doi: 10.1159/000540781.
Almeida SD, Norajitra T, Lüth CT, Wald T, Weru V, Nolden M, Jäger PF, von Stackelberg O, Heußel CP, Weinheimer O, Biederer J, Kauczor HU, Maier-Hein K. How do deep-learning models generalize across populations? Cross-ethnicity generalization of COPD detection. Insights Imaging. 2024 Aug 7;15(1):198.
Trudzinski FC, Jörres RA, Alter P, Watz H, Vogelmeier CF, Kauczor HU, Thangamani S, Debis M, Welte T, Behr J, Kahnert K, Bals R, Herr C, Heußel CP, Biederer J, von Stackelberg O, Fähndrich S, Wouters, EFM, Waschki B, Rabe KF, Herth FJF, Palm V. Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD). Respir Res. 2024 Jul 13;25(1):274. doi: 10.1186/s12931-024-02902-2.
Giel A-S, Bigge J, Schumacher J, Maj C, Dasmeh P. Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes. Mol Biol Evol., 2024 Jul 3;41(7):msae115. doi: 10.1093/molbev/msae115.
Dasmeh, P, Zheng, J, Erdogan, A, Tokuriki, N, Wagner, P. Rapid evolutionary change in trait correlations of single proteins. Nature Communications. 2024 15(1): 3327. DOI: 10.1038/s41467-024-46658-1.
Bertrams W, Wilhelm J, Veeger P-M, Hanko C, auf dem Brinke K, Klabunde B, Pott H, Weckler B, Greulich T, Vogelmeier C F, Schmeck B. A mRNA panel for differentiation between acute exacerbation or pneumonia on COPD patients. Front. Med. 2024 March 22. doi: 10.3389/fmed.2024.1234068
Almeida SD, Norajitra T, Lüth CT, Wald T, Weru V, Nolden M, Jäger PF, von Stackelberg O, Heußel CP, Weinheimer O, Biederer J, Kauczor HU, Maier-Hein K. Capturing COPD heterogeneity: anomaly detection and parametric response mapping comparison for phenotyping on chest computed tomography. Front Med. 2024 Mar 1;11:1360706.
Schmutzer M., Dasmeh, P., Wagner, A. (2024). Frustration can limit the adaptation of promiscuous enzymes through gene duplication and specialization. Journal of molecular Evolution, 92(2): 104. doi: 10.1007/s00239-024-10161-4.
Zöller D, Haverkamp C, Makoudjou A, Sofack G, Kiefer S, Gebele D, Pfaffenlehner M, Boeker M, Binder J, Karki K, Seidemann C, Schmeck B, Greulich T, Renz H, Schild S, Seuchter SA, Tibyampansha D, Buhl R, Rohde G, Trudzinski, F, Bals R, Janciauskiene S, Stolz D, Fähndrich S. Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning. Respir Res. 2024 Jan. 18. doi: 10.1186/s12931-023-02607-y
Maj, C, Eberts, A, Schumacher, J, Dasmeh, P. Single-cell analysis reveals the spatial-temporal expression of genes associated with esophageal malformations. Scientific Reports 2024, 14(1), 3752.
2023
Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B. Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study. Front Med. 2023 June 5. doi: 10.3389/fmed.2023.1180746.
Jung AL, Møller Jørgensen M, Bæk R, Artho M, Griss K, Han M, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Heider D, Suttorp N, Schmeck B. Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria. Infection. 2023 Mar 24.
Laakmann K, Eckersberg JM, Hapke M, Wiegand M, Bierwagen J, Beinborn I, Preußer C, Pogge von Strandmann E, Heimerl T, Schmeck B, Jung AL. Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells. Cell Commun Signal. 2023 May 15;21(1):111. doi: 10.1186/s12964-023-01131-2. PMID: 37189117; PMCID: PMC10184351.
Vidakovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Ben-Moshe NB, Aznaourova M, Nosho K, Drescher A, Schmeck B, Schulte LN, Persat A, Avraham R, Drescher K. Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae. Cell. 2023 Jun 8;186(12):2690-2704.e20. doi: 10.1016/j.cell.2023.05.008. Epub 2023 Jun 8. PMID: 37295405; PMCID: PMC10256282.
Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed EM, Laakmann K, Jung AL, Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A, Völker U, Vollmeister E, Benedikter BJ, Schmeck B. NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections. Nat Commun. 2023 Oct 2;14(1):5818. doi: 10.1038/s41467-023-41372-w. PMID: 37783679; PMCID: PMC10545792.
Pandi A, Adam D, Zare A, Trinh VT, Schaefer SL, Burt M, Klabunde B, Bobkova E, Kushwaha M, Foroughijabbari Y, Braun P, Spahn C, Preußer C, Pogge von Strandmann E, Bode HB, von Buttlar H, Bertrams W, Jung AL, Abendroth F, Schmeck B, Hummer G, Vázquez O, Erb TJ. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat Commun. 2023 Nov 8;14(1):7197. doi: 10.1038/s41467-023-42434-9. PMID: 37938588; PMCID: PMC10632401.
Klabunde B, Wesener A, Bertrams W, Ringshandl S, Halder LD, Vollmeister E, Schmeck B, Benedikter BJ. Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner. Cell Commun Signal. 2023 Aug 17;21(1):208. doi: 10.1186/s12964-023-01233-x. PMID: 37592354; PMCID: PMC10436572.
2022
Oestreich MA, Seidel K, Bertrams W, Müller HH, Sassen M, Steinfeldt T, Wulf H, Schmeck B. Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs. PLoS One. 2022 Dec 7;17(12): e0278766. doi: 10.1371/journal.pone.0278766. PMID: 36476845; PMCID: PMC9728855.
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B. Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones. Virulence. 2022 Nov 21.
Presentation at Conferences
2025
Secure Multi-centric Data Management: Experiences from PerMed-COPD – Talk at the PerMed-COPD Symposium 2025 - L. Dulz
COPD and Multimorbidity: Personalized Medicine through Body Composition Phenotyping in Correlation with Osteoporosis - Talk at the PerMed-COPD Symposium 2025 - A. Wagner
Polygenic Risk Scores for the Prediction of COPD Disease Activity in COSYCONET - Talk at the PerMed-COPD Symposium 2025 - H. Pott
An Updated German Decision Model for Long-term Projection of COPD Based on COSYCONET Data - Talk at the PerMed-COPD Symposium 2025 - T. Niedermaier
Secure Multi-centric Data Management: Experiences from PerMed-COPD - Talk at the PerMed-COPD Symposium 2025 - L. Dulz
The CDSS on the Way to the Clinical Trial for PerMed-COPD - Talk at the PerMed-COPD Symposium 2025 - T. Schleicher
COPD and Multimorbidity: Personalized Medicine through Body Composition Phenotyping in Correlation with Osteoporosis - Talk at the PerMed-COPD Symposium 2025 - A. Wagner
AI-Driven Chest CT Body Composition Analysis for Sarcopenia Risk Assessment in COPD – a multicentric Study on COSYCONET Patients – Poster at the DZL Annual Meeting 2025, Heidelberg - B Budai
KI-basierte Body Composition Analyse der CT-Scans von COPD Patienten – eine multizentrische Studie – Talk at the Deutscher Röntgen Kongress - S. Hettinger
Systematic update of a health economic Markov model for COPD using recent German cohort data - Poster presentation at the DGGÖ Annual Conference 2025 - T. Niedermaier
AI-based Body Composition Analysis of COPD Patients‘ CT Scans – a Mulitcentric Study – Talk at the ECR Congress 2025, Wien - B. Budai
2024
Eosinophil counts as potential biomarker for progranosis in community-acquired pneumonia - Talk at the German Conference on Bioinformatics 2024 - R. Martin, B. Weckler, P. Ahnert, D. Heider, S. Ringshandl, C. Vogelmeier, B. Schmeck
Pitfalls and challenges in decentralized differential abundance analysis for microbiome data - Talk at the German Conference on Bioinformatics 2024 - L. Fehse, M. Tahabadi, R. Martin, D. Heider
Estimation of lung function decline from the longitudinal COSYCONET cohort: does drop-out information matter? – Poster presentation at the ERS Congress 2024 - R. Holle, T. Niedermaier, C. Vogelmeier
Systematic update of a health economic Markov model for COPD using recent German cohort data – Talk at the Meeting of the EuHEA Conference 2024 - T. Niedermaier, R. Holle
2023
Reproducibility and outcomes of comorbidity clusters in patients with COPD (2023) Poster presentation at the annual meeting of the German Center for Lung Research (Deutsches Zentrum für Lungenforschung, DZL) - B. Schmeck, P. Alter, C. Vogelmeier
Mit System zum therapeutischen Erfolg – Kann uns künstliche Intelligenz dabei helfen? (2023) Talk at zjr 63th Congress of the German Respiratory Society (Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin, DGP e. V.) – B. Schmeck
COSYCONET and DZL: Where do we stand, where are we going - Talk at the PerMed-COPD Symposium 2023 - C. Vogelmeier
Studien Setup - Talk at the PerMed-COPD Symposium 2023 - M. Wittenberg, S. Söhler
CDSS und Datenintegration - Talk at the PerMed-COPD Symposium 2023 - D. Maier
Imaging Methoden und Anforderung an die Studienzentren - Talk at the PerMed-COPD Symposium 2023 - O. Stackelberg, J. Biederer
