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Dr. Christof Wegscheid-Gerlach
Dr. Christof Wegscheid-Gerlach

Philipps-Universität Marburg
Department of Pharmacy
Vice-Director “Chemikum-Marburg” e.V.
Wilhelm-Roser-Str. 2 35032 Marburg

Phone: +49 6421 28-25843
E-mail: dehnen@chemie.uni-marburg.de
www: http://www.chemikum-marburg.de/

Position: Department Coordinator
Expertise: Pharmaceutical chemistry, computer aided molecular design, molecular modelling, pharmaceutical and chemical education

Project Ö: Public Relations

University Education

2006 Doctoral degree in Pharmaceutical Chemistry (Dr. rer. nat.), Philipps-Universität Marburg, "Privileged structures for the inhibition of serine proteases – docking and directed design in the protein binding pocket", thesis advisor: Prof. Dr. Gerhard Klebe
2002 State licensed pharmacist
1997-01 Studies of Pharmacy, Philipps-Universität Marburg

Professional Experience

2013- Permanent position as "Akademischer Rat"
2010-13 Permanent position as scientific staff scientist
2007-09 Lab Head computational chemistry, Bayer Health Care, Berlin
2006-07 Postdoc computational chemistry, Lilly Pharma, Hamburg
2003-06 Stipend of the DFG-research training group "Protein function at the atomic level"
2002 Practical training for pharmacists, Apotheke am Brommygrün, Wilhelmshaven
2001-02 Practical training for pharmacists, Hoffmann La-Roche, Basel

Honours, Awards and other Proofs of Qualification

2016-17 Co-Organisation of the Studium Generale on Emil von Behring (12 Lectures)
2014- Member of the academic senate at Philipps-Universität Marburg
2011- Deputy executive director Chemikum Marburg e.V.
2011- Member of the examination board "Industriemeister Pharmazie" of the Kassel-Marburg Chamber of Industry and Commerce
2012-13 Co-Organisation of the Studium Generale on Drug Devlopment and the conflicts thereof (12 Lectures)
2009 Co-Editior for the special issue "The Medicinal Chemistry of Protease Inhibitors" Journal Current Topics in Medicinal Chemistry
2007-08 Associated member of the EU FP7 Marie Curie Research Training Network "Chromatin Plasticity"

Selected Publications

  1. H. Steuber, M. Zentgraf, C. Gerlach, C. A. Sotriffer, A. Heine, G. Klebe Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions J. Mol. Biol. 363 (1), 174 (2006).
  2. C. Gerlach, M. Smolinski, H. Steuber, C. A. Sotriffer, A. Heine, D. G. Hangauer, G. Klebe Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons Angew. Chem. Int. Ed. 46 (44), 8511 (2007).
  3. C. Gerlach, M. Münzel, B. Baum, H. D. Gerber, T. Craan, W. E. Diederich, G. Klebe KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding Angew. Chem. Int. Ed. 46 (47), 9105 (2007).
  4. C. Gerlach, H. Broughton, A. Zaliani FTree query construction for virtual screening: a statistical analysis J. Comput. Aided Mol. Des. 22 (2), 111 (2008).
  5. J. Degen, C. Wegscheid-Gerlach, A. Zaliani, M. Rarey On the art of compiling and using "drug-like" chemical fragment spaces Chem. Med. Chem. 3 (10), 1503 (2008).
  6. B. Baum, M. Mohamed, M. Zayed, C. Gerlach, A. Heine, D. Hangauer, G. Klebe More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the S1 pocket of thrombin J. Mol. Biol. 390 (1), 56 (2009).
  7. T. Brandt, N. Holzmann, L. Muley, M. Khayat, C. Wegscheid-Gerlach, B. Baum, A. Heine, D. Hangauer, G. Klebe Congeneric but still distinct: how closely related trypsinligands exhibit different thermodynamic and structural properties J. Mol. Biol. 405 (5), 1170 (2011).
  8. S. Oppermann, F. C. Schrader, K. Elsässer, A. M. Dolga, A. L. Kraus, N. Doti, C. Wegscheid-Gerlach, M. Schlitzer, C. Culmsee Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity J. Pharmacol. Exp. Ther. 350 (2), 273 (2014).
  9. M. T. Barho, S. Oppermann, F. C. Schrader, I. Degenhardt, K. Elsässer, C. Wegscheid-Gerlach, C. Culmsee, M. Schlitzer N-acyl-derivatives of 4-pheoxyaniline as neuroprotective agents Chem. Med. Chem. 9 (10), 2260 (2014).


  1. M. Koppitz, V.Schulze, D. Kosemund, H. Schirok, B. Bader, P. Lienau, T. Marquardt, C. Wegscheid-Gerlach, G. Siemeister, S. Prechtl, A. M.Wengner, U. Bömer, Triazolopyridin-Derivate (EP 2507236 B1 (2010)).
  2. J. Hübner, C. Wegscheid-Gerlach, O. Panknin, S. Ring, S. Bäurle, C. Huwe, K. Nowak, R. Nubbemeyer, H.-P. Muhn, Pyridinone derivatives and pharmaceutical compositions thereof (WO 2011076687 A1 (2009)).
  3. M. Koppitz, B. Bader, U. Bömer, B. Kreft, P. Lienau, T. Marquardt, S. Prechtl, G. Siemeister, C. Wegscheid-Gerlach, Substituted imidazoquinoxalines (US 8729082 B2 (2009)).
  4. B. Bader, U. Bömer, S. Ince, M. Koppitz, P. Lienau, T. Marquardt, D. Nguyen, S. Prechtl, G. Siemeister, C. Wegscheid-Gerlach, Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors (US 20120263708 A1 (2009)).

Zuletzt aktualisiert: 16.03.2018 · armbrusn

Philipps-Universität Marburg

Sonderforschungsbereich 1083, Philipps-Universität Marburg, Renthof 5, 35032 Marburg, Germany
Tel. +49 6421 28-24223, Fax +49 6421 28-24218, E-Mail: info@uni-marburg.de

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