Maestre-Reyna M, Wang PH, Nango E, Hosokawa Y, Saft M, Furrer A, Yang CH, Gusti Ngurah Putu EP, Wu WJ, Emmerich HJ, Caramello N, Franz-Badur S, Yang C, Engilberge S, Wranik M, Glover HL, Weinert T, Wu HY, Lee CC, Huang WC, Huang KF, Chang YK, Liao JH, Weng JH, Gad W, Chang CW, Pang AH, Yang KC, Lin WT, Chang YC, Gashi D, Beale E, Ozerov D, Nass K, Knopp G, Johnson PJM, Cirelli C, Milne C, Bacellar C, Sugahara M, Owada S, Joti Y, Yamashita A, Tanaka R, Tanaka T, Luo F, Tono K, Zarzycka W, Müller P, Alahmad MA, Bezold F, Fuchs V, Gnau P, Kiontke S, Korf L, Reithofer V, Rosner CJ, Seiler EM, Watad M, Werel L, Spadaccini R, Yamamoto J, Iwata S, Zhong D, Standfuss J, Royant A, Bessho Y, Essen LO, Tsai MD. Visualizing the DNA repair process by a photolyase at atomic resolution. Science. 2023 Dec;382(6674):eadd7795. doi: 10.1126/science.add7795. Epub 2023 Dec 1. PMID: 38033054.

Korf L, Ye X, Vogt MS, Steinchen W, Watad M, van der Does C, Tourte M, Sivabalasarma S, Albers S-V, Essen L-O. Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis. mBio. 2023 Nov 14;14(6):e0085923. doi: 10.1128/mbio.00859-23. Epub ahead of print. PMID: 37962382; PMCID: PMC10746158.

Hasenjäger S, Bologna A, Essen LO, Spadaccini R, Taxis C. C-terminal sequence stability profiling in Saccharomyces cerevisiae reveals protective protein quality control pathways. J Biol Chem. 2023 Sep;299(9):105166. doi: 10.1016/j.jbc.2023.105166. Epub 2023 Aug 16. PMID: 37595870; PMCID: PMC10493509.

Bezold F, Scheffer J, Wendering P, Razaghi-Moghadam Z, Trauth J, Pook B, Nußhär H, Hasenjäger S, Nikoloski Z, Essen LO, Taxis C. Optogenetic control of Cdc48 for dynamic metabolic engineering in yeast. Metab Eng. 2023 Sep;79:97-107. doi: 10.1016/j.ymben.2023.06.013. Epub 2023 Jul 7. PMID: 37422133.

Werel L, Farmani N, Krol E, Serrania J, Essen LO, Becker A. Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein. mBio. 2023 Apr 25;14(2):e0302822. doi: 10.1128/mbio.03028-22. Epub 2023 Apr 5. PMID: 37017526; PMCID: PMC10127613.

Moldenhauer, M., Tseng, H.W., Kraskov A., Tavraz, N.N., Yaroshevich, I.A., Hildebrandt. P., Sluchanko, N.N., Hochberg, G.A., Essen, L.-O., Budisa, N., Korf, L., Maksimov, E.G., Friedrich, T. (2023). Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems. Front. Mol. Biosci., 10: 1072606.

Emmerich, H.-J., Schneider, L.-O., Essen, L.-O. (2023). Structural and Functional Analysis of a Prokaryotic (6-4) Photolyase from the Aquatic Pathogen Vibrio Cholerae. Photochem. Photobiol., doi: 10.1111/php.13783.


Maestre-Reyna, M., Yang, C.-H., Nango, E., Huang, W.-C. Putra Gusti Ngurah Putu, E., Wu, W.-J., Wang, P.-H., Franz-Badur, S., Saft, M., Emmerich, H.-J., Wu, H.-Y., Lee, C.-C., Huang, K.-F., Chang, Y.-K., Liao, J.-H., Weng, J.-H., Gad, W., Chang, C.-W., Pang, A.-H., Sugahara, M., Owada, S., Hosokawa, Y., Joti, Y., Yamashita, A., Tanaka, R., Tanaka, T., Fangjia, L., Tono, K., Hsu, K.-C., Kiontke, S., Schapiro, I., Spadaccini, R., Royant, A., Yamamoto, J., Iwata, S., Essen, L.-O., Bessho, Y., Tsai, M.-D. (2022). Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme. Nature Chemistry 14: 677-685.

Schulz, V., Basu, S., Webert, H., Boß, L., Freibert, S.-A., Mühlenhoff, U., Pierrel, F., Bernhardt, R., Essen, L.-O., Booker, S., Stehling, O., Lill, R. (2022). Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2. Nature Chemical Biology, 19: 206-214

Schöppner, P., Lutz, A. P., Lutterbach, B. J., Brückner, S., Essen, L.-O., Mösch, H.-U. (2022). Structure of the Yeast Cell Wall Integrity Sensor Wsc1 Reveals an Essential Role of Surface-Exposed Aromatic Clusters. J. Fungi 8: 379.

Albert, L., Steinchen, W., Werel, L., Nagpal, J., Djokovic, N., Ruzic, D., Hoffarth, M., Xu, J., Royant, A., Bange, G., Nikolic, K., Ryu, S., Dou, Y., Essen, L.-O., Vázquez, O. (2022). Bistable photoswitch for in vivo control of hematopoiesis. ACS Central Science 8: 57-66.

von Horsten, S., Lippert, M.-L., Geisselbrecht, Y., Schühle, K., Schall, I., Essen, L.-O.†, Heider, J. (2022). Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation. FEBS J 289: 1023-1042.

Gramazio, S., Trauth, J., Bezold, F., Essen, L.-O., Taxis, C. (2022). Light-induced fermenter production of derivatives of the sweet protein monellin is maximized in prestationary Saccharomyces cerevisiae cultures. Biotechnology J., 17: 2100676.


Pook, B., Goenrich, J., Hasenjäger, S., Essen, L.-O., Spadaccini, R., Taxis, C. (2021). An Optogenetic Toolbox for Synergistic Regulation of Protein Abundance. ACS Synth Biol 10: 3411-3421.

Oppermann, S., Mertins, B., Meissner, L., Crasel, K., Psakis, G., Reiss, P., Dolga, A., Plesnila, N., Bünemann, N., Essen, L.-O., Culmsee, C. (2021). Interaction of Bid and VDAC1 determines mitochondrial demise and cell death. BioXriv, doi 10.1101/2021.09.14.460262

Fischer, T., van Wilderen, L., Gnau, P., Bredenbeck, J., Essen, L.-O., Wachtveitl, J., Slavov, C. (2021). Ultrafast photoconversion dynamics of the knotless phytochrome SynCph2. Int J Mol Sci 22: 10690.

von Horsten, S., Essen, L.-O. (2021). Structural base for acid control of phytochrome-associated protein phosphatase 5. Frontiers Plant. doi: 10.3389/fpls.2021.733069

Lacombat, F., Espagne, A., Dozova, N., Plaza, P., Müller, P., Emmerich, H.-J., Saft, M., Essen, L.-O. (2021). Ultrafast Photoreduction Dynamics of a New Class of CPD Photolyases. Photochem Photobiol 20: 733-746.

Vogt, M.S., Ngouoko, R. R., Mohr, M. K. F., Albers, S.-V., Essen, L.-O., Banerjee, A. (2021). The archaeal triphosphate tunnel metalloenzyme SaTTM defines structural determinants for the diverse activities in the CYTH protein family. JBC 297: 100820.

Reithofer, V., Fernández-Pereira, J., Alvarado, M., de Groot, P., Essen, L.-O. (2021). A novel class of Candida glabrata cell wall proteins with β-helix fold mediates adhesion in clinical isolates. PloS Pathogens 17: e1009980.


Vogt MS, Schmitz GF, Silva-Varon D, Mösch HU, Essen LO (2020). Structural base for the transfer of GPI-anchored glycoproteins into fungal cell walls. PNAS 117: 22061-22067.

Emmerich, H.-J., Saft, M., Schneider, L., Kock, D., Batschauer, A., Essen, L.-O. (2020). A topologically distinct class of photolyases specific for UV lesions within single-stranded DNA. Nucl Acids Res 48: 12845-12857.

Essen LO, Vogt MS, Mösch HU (2020). Diversity of GPI-anchored fungal adhesins. Biol Chem 401:1389-1405.

Hoffmann D, Diderrich R, Reithofer V, Friederichs S, Kock M, Essen LO, Mösch HU (2020). Functional reprogramming of Candida glabrata epithelial adhesins: the role of conserved and variable structural motifs in ligand binding. JBC 295:12512-12524.

Brückner S, Schubert R, Kraushaar T, Hartmann R, Hoffmann D, Müller D, Essen LO, Mösch HU (2020). Kin discrimination in social yeasts is mediated by cell surface receptors of the Flo11 adhesin family. eLife 9: e55587

Hepp S, Trauth J, Hansenjäger S, Essen LO, Taxis C (2020). AuPAC: an engineered optogenetic tool to control cAMP levels in budding yeast. J Mol Biol. 432: 1880-1890

Hong G, Pachter R, Essen LO, Ritz T (2020). Electron transfer and spin dynamics of the radical-pair in the cryptochrome from Chlamydomonas reinhardtii by computational analysis. J Chem Phys. 152: 065101

Ye X, Vogt MS, van der Does C, Bildl W, Schulte U, Essen LO, Albers SV (2020). The phosphatase PP2A interacts with ArnA and ArnB to regulate the oligomeric state and the stability of the ArnA/B complex. Frontiers in Microbiology 11: 1849.


Lacombat F, Espagne A, Dozova N, Plaza P, Müller P, Brettel K, Franz-Badur S, Essen LO (2019) Ultrafast Oxidation of a Tyrosine by Proton-Coupled Electron Transfer Promotes Light Activation of an Animal-like Cryptochrome. J Am Chem Soc. 141: 13394-13409

Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M (2019) Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization. Microbiology 165: 1095-1106

Franz-Badur S, Penner A, Straß S, von Horsten S, Linne U, Essen LO (2019) Structural changes within the bifunctional cryptochrome/photolyase CraCRY upon blue light excitation. Sci Rep. 9: 9896

Hasenjäger S, Trauth J, Hepp S, Goenrich J, Essen LO, Taxis C (2019) - Optogenetic Downregulation of Protein Levels with an Ultrasensitive Switch. ACS Synth. Biol. 8: 1026-1036

Albert L, Peñalver A, Djokovic N, Werel L, Hoffarth M, Ruzic D, Xu J, Essen LO, Nikolic K, Dou Y, Vázquez O (2019) - Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches. Chembiochem 20: 1-14.

Golonka D, Fischbach P, Jena SG, Kleeberg JRW, Essen LO, Toettcher JE, Zurbriggen MD, Möglich A (2019) - Deconstructing and repurposing the light-regulated Interplay between Arabidopsis phytochromes and interacting factors. Commun Biol. 2: 448

Vogt MS, Schühle K, Kölzer S, Peschke P, Chowdhury NP, Kleinsorge D, Buckel W, Essen LO, Heider J (2019) Structural and Functional Characterization of an Electron Transfer Flavoprotein Involved in Toluene Degradation in Strictly Anaerobic Bacteria. J Bacteriol. 201: 326-319

Hoffmann L, Anders K, Bischof LF, Ye X, Reimann J, Khadoumas S, Pham TK, van der Does C, Wright PC, Essen LO, Albers SV (2019) - Structure and interactions of the archaeal motility repression module ArnA-ArnB that modulates archaellum gene expression in Sulfolobus acidocaldarius. J. Biol. Chem. 294: 7460-7471

Muszkieta L, Fontaine T, Beau R, Mouyna I, Vogt MS, Trow J, Cormack BP, Essen LO, Jouvion G, Latgé JP (2019) The Glycosylphosphatidylinositol-Anchored DFG Family Is Essential for the Insertion of Galactomannan into the β-(1,3)-Glucan-Chitin Core of the Cell Wall of Aspergillus fumigatus. mSphere 4: 397-319


Assafa TE, Anders K, Linne U, Essen LO, Bordignon E (2018) - Light-Driven Domain Mechanics of a Minimal Phytochrome Photosensory Module Studied by EPR. Structure 26: 1534-1545.

Helizon H, Rösler-Dalton J, Gasch P, von Horsten S, Essen LO, Zeidler M (2018) - Arabidopsis phytochrome A nuclear translocation is mediated by a far-red elongated hypocotyl 1–importin complex. Plant J. DOI: 10.1111/tpj.14107.

Kock M, Brückner S, Wozniak N, Maestre-Reyna M, Veelders M, Schlereth J, Mösch HU, Essen LO (2018) - Structural and Functional Characterization of PA14/Flo5-Like Adhesins From Komagataella pastoris. Front Microbiol. 9: 2581.

Vogt MS, Völpel SL, Albers SV, Essen LO, Banerjee A (2018) - Crystal structure of an Lrs14-like archaeal biofilm regulator from Sulfolobus acidocaldarius. Acta Crystallogr D Struct Biol. 74: 1105-1114.

Lacombat F, Espagne A, Dozova N, Plaza P, Ignatz E, Kiontke S, Essen LO (2018) - Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases. Phys Chem Chem Phys. 20: 25446-25457.

Maestre-Reyna M, Yamamoto J, Huang WC, Tsai MD, Essen LO, Bessho Y (2018) - Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA. IUCrJ 5: 608-618.

Kahlstatt J, Reiß P, Halbritter T, Essen LO, Koert U, Heckel A (2018) - A light-triggered transmembrane porin. Chem. Commun. 54: 9623-9626.

Franz S, Ignatz E, Wenzel S, Zielosko H, Putu EPGN, Maestre-Reyna M, Tsai MD, Yamamoto J, Mittag M, Essen LO (2018) - Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii. Nucleic Acids Research 46: 8010-8022.

Ignatz E, Geisselbrecht Y, Kiontke S, Essen LO (2018) - Nicotinamide Adenine Dinucleotides Arrest Photoredction of Class II DNA Photolyases in FADH.-State. Photochem. Photobiol. 94: 81-87.


Müller P, Ignatz E, Kiontke S, Brettel K, Essen LO (2017) - Sub-nanosecond tryptophan radical deprotonation mediated by a protein-bound water cluster in class II DNA photolyases. Chem. Sci. 9: 1200-1212.

Essen LO, Franz S, Banerjee A (2017) - Structural and evolutionary aspects of algal blue light receptors of the cryptochrome and aurechrome type. J. Plant Physiol. 217: 27-37.

Orth C, Niemann N, Hennig L, Essen LO, Batschauer A (2017) - Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding site. J. Biol. Chem. 292: 12906-12920.

Ma H, Zhang F, Ignatz E, Suehnel M, Xue P, Scheerer P, Essen LO, Krauß N, Lamparter T (2017) - Divalent Cations Increase DNA Repair Activities of Bacterial (6-4) Photolyases. Photochem Photobiol. 93: 323-330.

Velázquez Escobar F, Buhrke D, Fernandez Lopez M, Shenkutie SM, von Horsten S, Essen LO, Hughes J, Hildebrandt P (2017) - Structural communication between the chromophore-binding pocket and the N-terminal extension in plant phytochrome phyB. FEBS Lett. 591: 1258-1265.

Angerer V, Essen LO, Wilde A (2017) - Analysis of c-di-GMP Levels Synthesized by a Photoreceptor Protein in Response to Different Light Qualities Using an In Vitro Enzymatic Assay. Methods Mol. Biol. 1657: 187-204.

Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bildl W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV (2017) - Wing phosphorylation is a major functional determinant of the Lrs14-type biofilm and motility regulator AbfR1 in Sulfolobus acidocaldarius. Mol. Microbiol. 105: 777-793.


Banerjee A, Herman E, Serif M, Maestre-Reyna M, Hepp S, Pokorny R, Kroth PG, Essen LO, Kottke T (2016) - Allosteric communication between DNA-binding and light-responsive domains of diatom class I aureochromes. Nucleic Acids Res. 44: 5957-70.

Banerjee A, Herman E, Kottke T, Essen LO (2016) - Structure of a Native-like Aureochrome 1a LOV Domain Dimer from Phaeodactylum tricornutum. Structure 24: 171-8.

von Horsten S, Straß S, Hellwig N, Gruth V, Klasen R, Mielcarek A, Linne U, Morgner N, Essen LO (2016) - Mapping light-driven conformational changes within the photosensory module of plant phytochrome B. Sci Rep. 6: 34366.

von Zadow A, Ignatz E, Pokorny R, Essen LO, Klug G (2016) - Rhodobacter sphaeroides CryB is a bacterial cryptochrome with (6-4) photolyase activity. FEBS J. 283: 4291-4309.

Nohr D, Franz S, Rodriguez R, Paulus B, Essen LO, Weber S, Schleicher E (2016) - Extended Electron-Transfer in Animal Cryptochromes Mediated by a Tetrad of Aromatic Amino Acids. Biophys J. 111: 301-311.

Oldemeyer S, Franz S, Wenzel S, Essen LO, Mittag M, Kottke T (2016) - Essential Role of an Unusually Long-lived Tyrosyl Radical in the Response to Red Light of the Animal-like Cryptochrome aCRY. J Biol Chem. 291:14062-14071.

Krol E, Klaner C, Gnau P, Kaever V, Essen LO, Becker A (2016) - Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology 162: 1840-1856.

Dümmer M, Michalski C, Essen LO, Rath M, Galland P, Forreiter C (2016) - EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana. J Plant Physiol. 206: 114-124.


Kraushaar T, Brückner S, Veelders M, Rhinow D, Schreiner F, Birke R, Pagenstecher A, Mösch HU, Essen LO (2015) - Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands. Structure 23:1005-1017.

Velazquez Escobar F, von Stetten D, Günther-Lütkens M, Keidel A, Michael N, Lamparter T, Essen LO, Hughes J, Gärtner W, Yang Y, Heyne K, Mroginski MA, Hildebrandt P (2015) - Conformational heterogeneity of the Pfr chromophore in plant and cyanobacterial. Front. Mol. Biosci. 10:2:37.

Diderrich R, Kock M, Maestre-Reyna M, Keller P, Steuber H, Rupp S, Essen LO, Mösch HU (2015) - Structural Hotspots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family. J. Biol. Chem. 290: 19597-19613.

Anders K, Essen LO (2015) - The family of phytochrome-like photoreceptors: diverse, complex and multi-colored, but very useful. Curr Opin Struct Biol. 35: 7-16.

Engelhard C, Wang X, Robles D, Moldt J, Essen LO, Batschauer A, Bittl R, Ahmad M (2014) - Cellular Metabolites Enhance the Light Sensitivity of Arabidopsis Cryptochrome through Alternate Electron Transfer Pathways. Plant Cell 26:4519-31.

Usherenko S, Stibbe H, Muscò M, Essen LO, Kostina EA, Taxis C (2014) - Photo-sensitive degron variants for tuning protein stability by light. BMC Syst Biol. 18: 8:128.

Mertins B, Psakis G, Essen LO (2014) VDAC: the wizard of mitochondrial OM. Biol Chem.

Anders K, Gutt A, Gärtner W, Essen LO (2014)- Phototransformation of the red light sensor cyanobacterial phytochrome 2 from synechocystis species depends on its tongue motifs. J. Biol Chem. 289: 25590-25600.

Grosse W, Psakis G, Mertins B, Reiss P, Windisch D, Brademann F, Bürck J, Ulrich A, Koert U, Essen LO (2014) - Structure-based engineering of a minimal porin reveals loop-independent channel closure. Biochemistry 53: 4826-4838

Kiontke S, Gnau P, Haselsberger R, Batschauer A, Essen LO (2014) - Structural and Evolutionary Aspects of Antenna Chromophore Usage by Class II Photolyases. J. Biol. Chem.

Samel S A, Czodrowski P, Essen LO (2014) - Structure of the epimerization domain of tyrocidine synthetase A. Acta Cryst D

Sineshchekov V, Mailliet J, Psakis G, Feilke K, Kopycki J, Zeidler M, Essen LO, Hughes J (2014) - Tyrosine 263 in Cyanobacterial Phytochrome Cph1 Optimizes Photochemistry at the prelumi-R→lumi-R Step. Photochem. Photobiol.

Anders K, Daminelli-Widany G, Mroginski MA, von Stetten D, Essen LO (2013) - Structure of the cyanobacterial phytochrome 2 photosensor implies a tryptophan switch  for phytochrome signaling. J. Biol. Chem. 288: 35714-35725.

Renicke C, Schuster D, Usherenko S, Essen LO, Taxis C (2013) - A LOV2 Domain-Based Optogenetic Tool to Control Protein Degradation and Cellular Function. Chemistry & Biology 20: 619–626.

Mertins B, Psakis G, Grosse W, Back K, Salisowski A, Reiss P, Koert U, Essen LO (2012) - Flexibility of the N-terminal mVDAC1 segment controls the channel’s gating behavior. PloS one 7: e47938.

Maestre-Reyna M, Diderrich R, Veelders M, Eulenburg G, Kalugin V, Brückner S, Keller P, Rupp S, Mösch HU, Essen LO (2012) - Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia. PNAS 109: 16864–16849.

Veelders M, Essen LO (2012) - Complex gadolinium-oxo clusters formed along concave protein surfaces. ChemBioChem DOI: 10.1002/cbic.201200441

Blanck S, Geisselbrecht Y, Kräling K, Middel S, Mietke T, Harms K, Essen LO, Meggers E (2012) - Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition. Dalton Trans. 41: 9337-9348.

Savakis P, De Causmaecker S, Angerer V, Ruppert U, Anders K, Essen LO , Wilde A (2012) - Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803. Mol. Microbiol. 85: 239-251.

Kiekebusch D, Michie KA, Essen LO, Löwe J, Thanbichler M (2012) - Localized Dimerization and Nucleoid Binding Drive Gradient Formation by the Bacterial Cell Division Inhibitor MipZ. Mol. Cell 46: 245-259.

Song C, Essen LO, Gärtner W, Hughes J, Matysik J (2012) - Solid-state NMR spectroscopic study of chromophore-protein interactions in the pr ground state of plant phytochrome A. Mol. Plant 5: 172-189.

Geisselbrecht Y, Frühwirth S, Schroeder S, Pierik AJ, Klug G, Essen LO (2012) - CryB from Rhodobacter sphaeroides: a unique class of cryptochromes with new cofactors. EMBO Reports 13: 223-229.


Kiontke S, Geisselbrecht Y, Pokorny R, Carell T, Batschauer A and Essen LO  (2011) - Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA. EMBO J. 30: 4437-4449.

Chaves I, Pokorny R, Byrdin M, Hoang N, Ritz T, Brettel K, Essen LO, van der Horst GTJ, Batschauer A and Ahmad M (2011) - The Cryptochromes: Blue Light Photoreceptors in Plants and Animals. Annu. Rev. Plant Biol. 62: 335-364.

Vinzenz X, Grosse W, Linne U, Meissner B, Essen LO (2011) - Chemical engineering of Mycobacterium tuberculosis dodecin hybrids. Chem. Commun. 47: 11071-11073.

Anders K, von Stetten D, Mailliet J, Kiontke S, Sineshchekov VA, Hildebrandt P, Hughes J, Essen LO  (2011) - Spectroscopic and Photochemical Characterization of the Red-Light Sensitive Photosensory Module of Cph2 from Synechocystis PCC 6803. Photochem. Photobiol. 87: 160-173.

Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kräling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen L-O, Meggers E (2011) - Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors. J Am Chem Soc, 133, 5976–5986.

Grosse W, Essen LO , Koert U (2011) - Strategies and Perspectives in Ion-Channel Engineering. ChemBioChem, 12, 830-839.

Malliet J, Psakis G, Sineshchekov V, Essen LO , Hughes J (2011) - Spectroscopy and a high-resolution crystal structure of Tyr-263 mutants of cyanobacterial phytochrome Cph1. J. Mol. Biol. 413: 115-127.

Psakis G, Mailliet J, Lang C, Teufel L, Essen LO, Hughes J (2011) - Signalling kinetics of cyanobacterial phytochrome cph1, a light regulated histidine kinase. Biochemistry 50: 6178-6188.

Mroginski M A, Kaminski S, von Stetten D, Ringsdorf S, Gärtner W, Essen LO, Hildebrandt P (2011) - Structure of the chromophore binding pocket in the Pr state of plant phytochrome phyA. J. Phys. Chem. B 115: 1220-1231.

Weber S, Schroeder C, Kacprzak S, Mathes T, Kowalczyk R M, Essen LO, Hegemann P, Schleicher E, Bittl R (2011) - Light-generated paramagnetic intermediates in BLUF-domains. Photochem. Photobiol. 87: 574-583.

Johnson A, Schlegel M, Meggers E, Essen LO , Wiest O (2011). On the Structure and Dynamics of Duplex GNA.J Org Chem, 76, 7964-7974.

Veelders M, Brückner S, Ott D, Unverzagt C, Mösch H-U, Essen LO (2010) - Structural basis of flocculin-mediated social behavior in yeast. Proc Natl Acad Sci USA, 107, 22511-22516.

Grosse W, Reiss P, Reitz S, Cebi M, Lubben W, Koert U, Essen LO (2010) - Structural and functional characterization of a synthetically modified OmpG. Bioorg Med Chem, 18, 7716-7723.

Eckhardt B, Grosse W, Essen LO , Geyer A (2010) - Structural characterization of a beta-turn mimic within a protein-protein interface. Proc Natl Acad Sci USA, 107, 18336-18341. (Radio Report Deutschlandfunk)

Schleicher E, Wenzel R, Ahmad M, Batschauer A, Essen LO, Hitomi K, Getzoff ED, Bittl R, Weber S, Okafuji A (2010). The Electronic State of Flavoproteins: Investigations with Proton Electron-Nuclear Double Resonance. Appl Magn Reson, 37, 339-352.

Schlegel M K, Essen LO , Meggers E (2010). Atomic resolution duplex structure of the simplified nucleic acid GNA. Chem Commun, 46, 1094-1096.

Mailliet J, Psakis G, Schroeder C, Kaltofen S, Durrwang U, Hughes J, Essen LO  (2009) - Dwelling in the dark: procedures for the crystallography of phytochromes and other photochromic proteins. Acta Cryst D, 65, 1232-1235.

Reitz S, Essen LO  (2009) - alpha-Helical Cytolysins: Molecular Tunnel-Boring Machines in Action. ChemBioChem, 10, 2305-2307.

Kress D, Bruegel D, Schall I, Linder D, Buckel W and Essen LO  (2009) - An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases. J Biol Chem, 284, 28401-28409.

Moldt J, Pokorny R, Orth C, Linne U, Geisselbrecht Y, Marahiel MA, Essen L-O, Batschauer A (2009) - Photoreduction of the folate cofactor in members of the photolyase family. J Biol Chem, 284, 21670-21683.

Zirak P, Penzkofer A, Moldt J, Pokorny R, Batschauer A, Essen L-O (2009). Photocycle dynamics of the E149A mutant of cryptochrome 3 from Arabidopsis thaliana. J Photochem Photobiol, 97, 94-108.

Mroginski M A, von Stetten D, Escobar F V, Strauss H M, Kaminski S, Scheerer P, Günther M, Murgida D H, Schmieder P, Bongards C, Gärtner W, Mailliet J, Hughes J, Essen L-O, Hildebrandt P (2009) - Chromophore Structure of Cyanobacterial Phytochrome Cph1 in the Pr State: Reconciling Structural and Spectroscopic Data by QM/MM Calculations. Biophys J, 96, 4153-4163.

Helmetag V, Samel S A, Thomas M G, Marahiel MA, Essen LO  (2009) - Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J, 276, 3669-3682.

Peukert F, Miethke M, Albrecht A, Essen LO, Marahiel MA (2009) - Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew Chemie Int Ed, 48, 7924-7927.

Marahiel M A, Essen LO (2009) - Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods Enzymol, 458, 337-351.

Reitz S, Cebi M, Reiss P, Studnik G, Linne U, Koert U, Essen, LO  (2009) - On the Function und Structure of Synthetically Modified Porins. Angew Chem Int Ed, 48, 4853-4857.

Reitz S, Cebi M, Reiss P, Studnik G, Linne, U, Koert U, Essen, LO  (2009) - Zur Funktion und Struktur synthetisch modifizierter Porine. Angew Chem, 121, 4947-4951.

Psakis G, Saidijam M, Shibayama K, Polaczek J, Bettaney K E, Baldwin J M, Baldwin SA, Hope R, Essen LO, Essenberg R C, Henderson P J (2009) - The sodium-dependent D-glucose transport protein of Helicobacter pylori. Mol Microbiol, 71, 391-403.

Psakis G, Polaczek J, Essen LO  (2008) - AcrB et al.: Obstinate contaminants in a picogram scale. One more bottleneck in the membrane protein structure pipeline. J Struct Biol, 166, 107-111.

Pokorny R, Klar T., Hennecke U, Carell T, Batschauer A, Essen L-O (2008) - Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome. Proc Natl Acad Sci USA, 105, 21023-21027.

Rohmer T, Lang C, Hughes J, Essen L-O, Gärtner W, Matysik J (2008) - Light-induced chromophore activity and signal transduction in phytochromes observed by 13C and 15N magic-angle spinning NMR. Proc Natl Acad Sci, 105, 15229-15234.

Essen L-O , Mailliet J, Hughes J (2008) - The structure of a complete phytochrome sensory module in the Pr ground state. Proc Natl Acad Sci USA, 105, 14709-14714.

Schroeder C, Werner K, Otten H, Krätzig S, Schwalbe H, Essen L-O (2008) - Influence of a Joining Helix on the BLUF Domain of the YcgF Photoreceptor from Escherichia coli. ChemBioChem, 9, 2463 - 2473.

Kress D, Alhapel A, Pierik A J, Essen L-O  (2008) - The Crystal Structure of Enamidase: a bifunctional Enzyme of the Nicotinate Catabolism. J Mol Biol, 384, 837-847. 

Reitz S, Alhapel A, Essen L-O, Pierik A J (2008) - Structural and Kinetic Properties of a β−Hydroxyacid Dehydrogenase involved in Nicotinate Fermentation. J Mol Biol, 382, 802-811.

Essen L-O  and Koert U (2008) - Ion-channel engineering. Review. Annu Rep Prog Chem, Sect C: Phys Chem, 104, 165-188.

Tanovic A, Samel S A , Essen L-O , Marahiel M A (2008) - Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase. Science, 321 (5889), 659-663.

Schlegel M K, Essen L-O , Meggers E (2008) - Duplex Structure of a Minimal Nucleic Acid. J Am Chem Soc, 130, 8158-8159.

Samel S A, Marahiel M A, Essen L-O  (2008) - How to tailor non-ribosomal peptide products-new clues about the structures and mechanisms of modifying enzymes. Molecular Biosystems, 4, 387-393.
Strieker M, Essen LO, Walsh CT, Marahiel MA. (2008) - Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. ChemBioChem, 9, 374-376.
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Samel S A, Schoenafinger G, Knappe, T A, Marahiel, M A, Essen, L-O  (2007) - Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure, 15, 781-792.

Strieker M, Kopp F, Mahlert C, Essen L-O , Marahiel M A (2007) - Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-depentent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol, 2, 187-196.

Psakis G, Nitschkowski S, Holz C, Kreß D, Maestre-Reyna M, Polaczek J, Illing G, Essen L-O  (2007) - Expression screening of integral membrane proteins from Helicobacter pylori 26695. Protein Science, 16, 2667-2676.

Meissner B, Schleicher E, Weber S, Essen L-O  (2007) - The Dodecin from Thermus thermophilus, a Bifunctional Cofactor Storage Protein. J Biol Chem, 282, 33142-33154.

Bosch J, Tamura T, Tamura N, Baumeister W, Essen, L-O  (2007) - The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology. Acta Cryst D, 63, 179-187.

Klar T, Pokorny R, Moldt J, Batschauer A, Essen, L-O  (2007) - Cryptochrome 3 from Arabidopsis thaliana: Structural and functional analysis of its complex with a folate light antenna. J Mol Biol, 366, 954-964.

Klar T, Kaiser G, Hennecke U, Carell T, Batschauer A, Essen L-O  (2006) - Natural and non-natural antenna chromophores in the DNA photolyase from Thermus thermophilus. ChemBioChem, 7, 1798-1806.

Essen L-O , Klar T (2006) - Light-driven DNA repair by photolyases Cellular and Molecular Life Sciences, 63, 1266-1277.

Schönafinger A, Morbitzer A, Kreß D, Essen L-O, Noll F, Hampp N (2006) - Morphology of dry solid supported protein monolayers in dependence on substrate and protein surface properties. Langmuir, 22, 7185-7191.

Song S-H, Dick B, Penzkofer A, Pokorny R, Batschauer A, Essen L-O (2006) - Absorption and fluorescence spectroscopic characterization of cryptochrome 3 from Arabidopsis thaliana. J Photochem Photobiol B, 85, 1-16.

Samel S, Wagner B, Marahiel M A, Essen L-O (2006) - Crystal structure of the thioesterase domain of the fengycin biosynthesis cluster. J Mol Biol 359, 876-889.

Essen L-O  (2006) - Photolyases and cryptochromes: common mechanisms of DNA repair and light-driven signaling? Curr Opin Struct Biol, 16, 51-59.

Pokorny R, Klar T, Essen L-O, Batschauer A (2005) - Crystallization and preliminary X-ray analysis of cryptochrome 3 from Arabidopsis thaliana. Acta Cryst F, 61, 935-938.

Sakasegawa S-I, Hagemeier C, Thauer R, Essen L-O , Shima S  (2004) - Structural and functional analysis of the putative gpsA gene product of Archaeoglobus fulgidus: A glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference. Protein Science, 13, 3161-3171.

Mees A, Klar T, Gnau P, Hennecke U, Eker A P M, Carell T,  Essen, L-O  (2004) - Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair. Science, 306, 1789-1793.

Zeth K, Offermann S, Essen L-O , Oesterhelt D  (2004) - Iron-oxo clusters biomineralizing on protein surfaces – structural analysis of H. salinarum DpsA in its low and high iron states. Proc Natl Acad Sci USA, 101, 13780-13785.

Mofid M R, Finking R, Essen L-O, Marahiel M A (2004) - Mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry, 43, 4128-4134.

Kunz S, Kloeckner T, Essen L-O, Seebeck T, Boshart M (2004) - TbPDE1, a novel class I phosphodiesterase from Trypanosoma brucei. Eur J Biochem, 271, 637-647.


Bieger B, Essen LO , Oesterhelt D  (2003) - Crystal structure of halophilic dodecin: A novel, dodecameric riboflavin-binding protein from Halobacterium salinarum. Structure, 11, 375-385.

Essen LO , Harrenga A, Ostermeier C, Michel H (2003) - 1.3 Å X-ray structure of an antibody Fv-fragment used for enforced membrane protein crystallization. Acta Cryst D, 59, 677-687.

Essen LO (2002) - Halorhodopsin: light-driven ion pumping made simple? Curr Opin Struct Biol, 12, 516-522.

Essen  LO  (2002) - Structural genomics of "non-standard" proteins: a chance for membrane proteins? Gene, Function & Disease, 3, 39-48.

Bosch J, Tamura T, Bourenkov G P, Baumeister W, Essen, LO  (2001) - Purification, crystallization and preliminary X-ray diffraction analysis of the Tricorn protease hexamer from Thermoplasma acidophilum. J Struct Biol, 134, 83-87.

Bieger B,  Essen LO  (2001) - Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from E. coli. J Mol Biol, 307, 1-8.

Bieger B,  Essen LO  (2001) - Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J, 20, 433-445 (Corrigendum in EMBO J, 20, 5302).

Essen  LO  (2001) - G-protein-coupled receptors (GPCR) for light: The 3D-structure of rhodopsin. ChemBioChem, 2, 513-516.

Bosch G, Baumeister W,  Essen LO  (2000) - Crystal structure of the b-apical domain of the thermosome reveals structural plasticity in protrusion region. J Mol Biol, 301, 19-25.

Kolbe M, Besir H, Essen LO , Oesterhelt D  (2000) - Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution. Science, 288, 1390-1396.

Bieger B,  Essen, LO  (2000) - Crystallization and preliminary X-ray analysis of the catalytic domain of the adenylate cyclase GRESAG4.1 from Trypanosoma brucei. Acta Cryst D, 56, 359-362.

Bieger B,  Essen, LO  (2000) - Crystallization and preliminary X-ray analysis of the catalytic core of the alkylhydroperoxide reductase component AhpF from E. coli. Acta Cryst D, 56, 92-94.

Gutsche I,  Essen, LO, Baumeister W  (1999) - Group II chaperonins: new TRiC(k)s and turns of a protein folding machine. J Mol Biol, 293, 295-312.

Essen LO , Siegert R, Lehmann W D, Oesterhelt D  (1998) - Lipid patches in membrane protein oligomers: Crystal structure of the bacteriorhodopsin-lipid complex. Proc Natl Acad Sci USA, 95, 11673-11678.

Essen LO, Oesterhelt D  (1998) - A cold break for photoreceptors. Nature, 392,131-132.

Heinz D , Essen LO, Williams R L (1998) - Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C. J Mol Biol, 275, 635-650.

Nitsch M, Walz J, Typke D, Klumpp M, Essen LO, Baumeister W  (1998) - Archaeal group II chaperonin in an open conformation: the thermosome from Thermoplasma acidophilum examined by cryo-electron tomography. Nature Structural Biology, 5, 855-857.


Klumpp M, Baumeister W,  Essen, LO (1997) - Structure of the substrate-binding domain of the thermosome, an archaeal groupII chaperonin. Cell, 91, 263-270.

Essen  LO, Perisic O, Roberts M, Katan M, Williams R L (1997) - Structural mapping of the catalytic mechanism of a mammalian phosphoinositide-specific phospholipase Cd. Biochemistry, 36, 1704-1718.

Essen  LO, Perisic O, Lynch D, Katan M, Williams R L (1997) - A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-d1. Biochemistry, 36, 2753-2762.

Essen LO, Perisic O, Cheung R, Katan M, Williams R L  (1996) - Crystal structure of a mammalian phosphoinositide-specific phospholipase Cd. Nature, 380, 595-602.

Grobler J A, Essen LO, Williams R L, Hurley J H  (1996) - C2 domain conformational changes in phospholipase C-delta 1. Nature Structural Biology, 3, 788-795.

Voss R-H, Ermler U, Essen LO, Wenzl G, Kim Y-M, Flecker P  (1996) - Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28 nm resolution. Eur J Biochem, 242, 121-131.

Ostermeier C, Essen LO, Michel, H  (1995) - Crystals of an antibody Fv fragment against an integral membrane protein diffracting to 1.28 A resolution. Proteins, 21, 74-77.

Essen  LO, Skerra A (1994) - The de novo design of an antibody combining site. Crystallographic analysis of the VL domain confirms the structural model. J Mol Biol, 238, 226-44.

Essen  LO, Skerra A (1993) - Single-step purification of a bacterially expressed antibody Fv fragment by immobilized metal affinity chromatography in the presence of betaine. Journal of Chromatography A, 657, 55-61.

Gloor S, Nasse K, Essen LO, Appel F (1992) - Production and secretion in CHO cells of the extracellular domain of AMOG/beta 2, a type-II membrane protein. Gene, 120, 307-312.

Book Section

Marahiel M A, Essen LO (2009) - Non-ribosomal peptide synthetases: Mechanistic and structural aspects of essential domains. In Methods of Enzymology, 458, 337-351.

Essen LO , Offermann S, Oesterhelt D & Zeth K (2004) - Iron-oxo clusters and the onset of biomineralization on protein surfaces: Lessons from an archaeal ferritin. In Biomineralization, edited by E. Bäuerlein, VCH.
Essen LO† (2004) - Structural base of halide transport through biological membranes. In Encyclopedia of Nanoscience and Nanotechnology, edited by J. A. Schwarz, Contescu, C., & Putyera, K., Marcel Dekker, 3697-3711.

Essen LO, Brownlie P, Perisic O, Katan M, Williams R L (1998) - Structural analysis of the catalysis and membrane association of PLC-d1 from rat. edited by K. Bruzik, Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications (ACS Symp. Series 718, 121-136), Washington DC, American Chemical Society.


Bahar I, Buck M, Citterich H, Dahm A, Essen LO, Fariselli P, Finkelstein A, Hooft R, Hubbard T, Koebnik R, Kuroda Y, Lesk A M, Luo J, Mayr L M, Moult J, Mueller K, Ortigao F R, Osuna J, Reinhardt A, Sander C, Tramontano A, Vallone B, Vriend G (1994) - ProDes94: Protein design on computers. BIOcomputing Technical Document 8, EMBL Heidelberg