Main Content Publications 2024
Khan SA, Brenner T, Link A-C, Reudenbach C, Bendix J, Weckler BC, Kutzinski M, Rupp J, Witzenrath M, Rohde G, Pletz MW, Bertrams W, Schmeck B . Impact of absolute values and changes in meteorological and air quality conditions on community-acquired pneumonia in Germany. Int J Biometeorol. 2024 Dec. doi: 10.1007/s00484-024-02839-7.
Gao Y, Zandieh K, Zhao K, Khizanishvili N, Di Fazio P, Yu X, Schulte L , Aillaud M , Chung H-R, Ball Z, Meixner M, Bauer U-M, Bartsch DK, Buchholz M, Lauth M, Nimsky C, Cook L, Bartsch JW . The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis. Cellular Oncology, 2024, Oct 16. doi: 10.1007/s13402-024-01001-0.
Wagner M, Döhlemann J, Geisel D, Sobetzko P, Serrania J, Lenz P, Becker A . Engineering a Sinorhizobium meliloti Chassis with Monopartite, Single Replicon Genome Configuration. ACS Synth Biol. 2024 Aug 16;13(8):2515-2532. doi: 10.1021/acssynbio.4c00281.
Krause FF, Mangold KI , Ruppert A-L, Leister H, Hellhund-Zingel A , A Lopez Krol, Pesek J, Watzer B , Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, WA, Taudte RV, Bertrams W, Schmeck B , A Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Gut Microbes, 2024 Oct. 14; doi: 10.1080/19490976.2024.2412669.
Weckler BC, Pott H, Race A, Nattika Jugkaeo N, Karki K, Ringshandl S, Seidemann C, Schöndorf I, Renz H, Fähndrich S, Jung AL , Bertrams W, Makoudjou A, Zöller D, Finotto S, Schild S, Seuchter SA, Rohde G, Trinkmann F, Greulich T, Vogelmeier CF, Schmeck B . Eosinopenia as predictor of disease severity in patients with community-acquired pneumonia: an observational study. Chest , 2024, Jul 5: S0012-3692(24)04580-X. doi: 10.1016/j.chest.2024.05.041.
Burt M , Angelidou G, Mais CN, Preußer C, Glatter T, Heimerl T, Groß R, Serrania J, Boosarpu G, Pogge von Strandmann E, Müller JA, Bange G , Becker A , Lehmann M , Jonigk D, Neubert L, Freitag H, Paczia N, Schmeck B , Jung AL . Lipid A in outer membrane vesicles shields bacteria from polymyxins. J Extracell Vesicles. 2024 May;13(5):e12447.Ross PA, Xu W, Jalomo-Khayrova E, Bange G , Gumerov VM, Bradley PH, Sourjik V , Zhulin IB. Framework for exploring the sensory repertoire of the human gut microbiota. mBio. 2024 May 17:e0103924.
Benz F, Camara-Wilpert S, Russel J, Wandera KG, Čepaitė R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, Mestre MR, Cuénod A, Aguilà-Sans M, Maccario L, Egli A, Randau L , Pausch P, Rocha EPC, Beisel CL, Madsen JS, Bikard D, Hall AR, Sørensen SJ, Pinilla-Redondo R. Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans. Cell Host Microbe. 2024 May 7:S1931-3128(24)00135-5.
Dörner PJ, Anandakumar H, Röwekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, Sellmaier J, Brüning U, Fritsche-Guenther R, Pfannkuch L, Kurth F, Milek M, Igbokwe V, Löber U, Gutbier B, Holstein M, Heinz GA, Mashreghi MF, Schulte LN , Klatt AB, Caesar S, Wienhold SM, Offermanns S, Mack M, Witzenrath M, Jordan S, Beule D, Kirwan JA, Forslund SK, Wilck N, Bartolomaeus H, Heimesaat MM, Opitz B. Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung. Nat Commun. 2024 Mar 30;15(1):2788.
Bertrams W, Wilhelm J, Veeger PM, Hanko C, Brinke KAD, Klabunde B, Pott H, Weckler B, Greulich T, Vogelmeier CF, Schmeck B . A mRNA panel for differentiation between acute exacerbation or pneumonia in COPD patients. Front Med (Lausanne). 2024 Mar 22;11:1234068.
Möbs C, Jung AL . Extracellular vesicles: Messengers of allergic immune responses and noval theraputic strategy. Eur J Immunol, 2024; https://doi.org/10.1002/eji.202350392
2023
Gomes-Filho JV, Breuer R, Morales-Filloy HG, Pozhydaieva N, Borst A, Paczia N, Soppa J, Höfer K , Jäschke A, Randau L . Identification of NAD-RNA species and ADPR-RNA decapping in Archaea. Nat Commun. 2023 Nov 21;14(1):7597. doi: 10.1038/s41467-023-43377-x.
Pandi A, Adam D, Zare A, Trinh VT, Schaefer SL, Burt M , Klabunde B, Bobkova E, Kushwaha M, Foroughhijabbari Y, Braun P, Spahn C, Preußer C, Pogge von Standmann E, Bode HB, von Buttlar H, Bertrams W, Jung AL , Abendroth F, Schmeck, B , Hummer G, Vázquez O, Erb TJ. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat. Commun. 2023 Nov 8; 14(1): 7197. doi: 10.1038/s41467-023-42434-9.
Mohebali N, Weigel M, Hain T , Sütel M, Bull J, Kreikemeyer B, Breitrück A. Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity. Biomed Pharmacother. 2023 Nov;167:115568.
Xu W, Cerna-Vargas JP, Tajuelo A, Lozano-Montoya A, Kivoloka M, Krink N, Monteagudo-Cascales E, Matilla MA, Krell T, Sourjik V . Systematic mapping of chemoreceptor specificities for Pseudomonas aeruginosa. mBio. 2023 Oct 31;14(5):e0209923.
Malainou C, Abdin SM, Lachmann N, Matt U , Herold S . Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting. J Clin Invest. 2023 Oct 2;133(19):e170501. (Review)
Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed EM , Laakmann K, Jung AL , Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A , Völker U, Vollmeister E, Benedikter B J, Schmeck B . NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections. Nat. Commun. 2023 Oct. 2; 14(1):5818
Klabunde B, Wesener A, Bertrams W, Ringshandl S, Halder LD, Vollmeister E, Schmeck B , Benedikter BJ. Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner. Cell. Commun. Signal. 2023 Aug 17;21(1):208.
Vidacovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Bossel Ben-Moshe N, Aznaourova M, Nosho K, Drescher A, Schmeck B , Schulte LN , Persat A, Avraham R, Drescher K . Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae. Cell. 2023 June 8, 186:2690-2704.e20.
Jung AL , Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D , Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B . Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study. Front Med. 2023 June 5. doi: 10.3389/fmed.2023.1180746.Bierwagen J, Wiegand M , Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN , Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B , Jung AL . Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis. Cell Commun Signal. 2023 Mar 28;21(1):65. doi: 10.1186/s12964-023-01086-4.
Laganenka L, Lee J-W, Malfertheiner L, Dieterich CL, Fuchs L, Piel J, von Mering C, Sourjik V , Hardt W-D. Chemotaxis and autoinducer-2 signalling mediate colonization and contribute to co-existence of Escherichia coli strains in the murine gut. Nat Microbiol. 2023 Feb;8(2):204-217.
Jung AL , Møller Jørgensen M, Bæk R, Artho M, Griss K, Han M, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Heider D , Suttorp N, Schmeck B . Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria. Infection. 2023 Mar 24. doi: 10.1007/s15010-023-02022-x. 2022
Bertrams W*, Hönzke K*, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B *, Hocke AC* (*contributed equally). Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus. Sci Rep. 2022 Nov 29;12(1):20608.
Herbel SM, Moyon L, Christ M, Elsayed EM , Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL , Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A , Wagner S, Bange G , Völker U, Bertrams W, Marsico A, Schmeck B . Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones. Virulence. 2022 Nov 21. doi: 10.1080/21505594.2022.2149973.
Guo X, Sanchez-Londono M, Gomes-Filho JV, Hernandez-Tamayo R, Rust S, Immelmann LM, Schäfer P, Wiegel J, Graumann PL, Randau L . Characterization of the self-targeting Type IV CRISPR interference system in Pseudomonas oleovorans. Nat Microbiol. 2022 Sep 29. doi: 10.1038/s41564-022-01229-2.
Romero R, Zarzycka A, Preussner M, Fischer F, Hain T , Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U. Selected commensals educate the intestinal vascular and immune system for immunocompetence. Microbiome. 2022 Sep 28;10(1):158.
Monteagudo-Cascales E, Martín-Mora D, Xu W, Sourjik V , Matilla MA, Ortega A, Krell T. The pH Robustness of Bacterial Sensing. mBio. 2022 Sep 26;e0165022.
Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B , Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A. Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells. EMBO Rep. 2022 Oct 10:e54685.
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B , Schulte LN . Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2120680119.
Stricker S, Hain T , Chao CM, Rudloff S. Respiratory and Intestinal Microbiota in Pediatric Lung Diseases-Current Evidence of the Gut-Lung Axis. Int J Mol Sci. 2022 Jun 18;23(12):6791. (Review)
Matilla MA, Velando F, Tajuelo A, Martín-Mora D, Xu W, Sourjik V, Gavira JA, Krell T. Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine. mBio. 2022 Apr 26;13(2):e0345821.
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S , Suttorp N, Schmeck B , Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870.
2021
Beinecke J & Heider D . Gaussian noise up-sampling is better suited than SMOTE and ADASYN for clinical decision making. BioData Min. 2021 Nov 29;14(1):49.
Breitrück A, Weigel M, Hofrichter J, Sempert K, Kerkhoff C, Mohebali N, Mitzner S, Hain T , Kreikemeyer B. Smectite as a Preventive Oral Treatment to Reduce Clinical Symptoms of DSS Induced Colitis in Balb/c Mice. Int J Mol Sci. 2021 Aug 13;22(16):8699.
Schulz-Weidner N, Weigel M, Turujlija F, Komma K, Mengel JP, Schlenz MA, Bulski JC, Krämer N, Hain T . Microbiome Analysis of Carious Lesions in Pre-School Children with Early Childhood Caries and Congenital Heart Disease. Microorganisms. 2021 Sep 8;9(9):1904.
Jung AL , Schmeck B , Wiegand M, Bedenbender K, Benedikter BJ. The clinical role of host and bacterial-derived extracellular vesicles in pneumonia. Adv Drug Deliv Rev. 2021 May 19:S0169-409X(21)00185-X.Schmerer N, Schulte LN . Long noncoding RNAs in bacterial infection. Wiley Interdiscip Rev RNA. 2021 May 14:e1664.
