Winiarska A., Ramírez-Amador F., Hege D., Gemmecker Y., Prinz S., Hochberg G., Heider J., Szaleniec M., Schuller J. M. (2023) A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire. bioRxiv 2023. DOI: 10.1101/2023.01.23.525143

Andrys-Olek J., Heider J., Borowski T. (2023) Molecular Dynamics simulations for the Michaelis complex of Ectoine Synthase (EctC). Catalysts 13, 124. DOI: 10.3390/catal13010124


Lo H.-Y., Matinéz-Lavanchy P., Goris T., Heider J., Boll M., Kaster A.-K. & Müller J. A. (2022) IncP-type plasmids carrying genes for antibiotic resistance or for aromatic compound degradation are prevalent in sequenced Aromatoleum and Thauera strains. Environ. Microbiol. 24, 6411-6425. DOI: 10.1111/1462-2920.16262

Chistyakova P. A., Chistyakov A. V., Nikolaev S. A., Bagdatov R. A., Tsodikov M. V., Heider J. & Netrusov A. I. (2022) Conversion of ethanol and fusel oils over Au-M/MFI/Al2O3 calalysts. Petrol. Chem. 62, 1107-1125. DOI: 10.1134/S0965544122090018

Steinhilper R., Höff G., Heider J., Murphy B. J. (2022) Structure of the membrane-bound formate hydrogen lyase complex from Escherichia coli. Nature Comm. 13, 5395. DOI: 10.1101/2022.03.21.484881

Winiarska A., Hege D., Gemmecker Y., Kryściak-Czerwenka J., Seubert A., Heider J., Szaleniec M. (2022) A tungsten enzyme using hydrogen as an electron donor to reduce carboxylic acids and NAD+. ACS Catalysis 12, 8707-8717. DOI: 10.1021/acscatal.2c02147

Weidenweber S., Schühle K., Lippert M.-L., Mock J., Seubert A., Demmer U., Ermler U. & Heider J. (2022) Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyses the final step of anaerobic toluene metabolism. FEBS J. 289, 5599-5616. DOI: 10.1111/febs.16443

von Horsten S., Lippert M.-L., Geisselbrecht Y., Schühle K., Schall I., Essen L.-O., Heider J. (2022) Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation. FEBS J. 289, 1023-1042. DOI: 10.1111/febs.16216

Hagel C., Blaum B., Friedrich T. & Heider J. (2022) Characterisation of the redox centers of ethylbenzene dehydrogenase. J. Biol. Inorg. Chem. 27, 143-154. DOI: 10.1007/s00775-021-01917-0


Andrys J., Heider J., Borowski T. (2021) Comparison of different approaches to derive classical bonded force-field parameters for a transition metal cofactor. A case study for non-heme iron site of ectoine synthase. Theor. Chem. Acc. 140, 115. DOI: 10.1007/s00214-021-02796-z

Schühle K., Saft M., Vögeli B., Erb T. J., Heider J. (2021) Benzylmalonyl-CoA dehydrogenase, an enzyme involved in bacterial auxin degradation. Arch Microbiol. accepted. DOI: 10.21203/rsa.3.5s-466161/v1

Salii I., Szaleniec M., Alhaj Zein A., Seyhan D., Sekula A., Schühle K., Kaplieva-Dudek I., Linne U., Meckenstock R. U. & Heider J. (2021) Determinants for substrate recognition in the glycyl radical enzyme benzylsuccinate synthase revealed by targeted mutagenesis. ACS Catal.11, 3361-3370. DOI: 10.1021/acscatal.0c04954


Borowiecki P., Teltycka N., Tataruch M., Żądło-Dobrowolska A., Reiter T., Schühle K., Heider J., Szaleniec M., Kroutil W. (2020) Biocatalytic asymmetric reduction of γ‐keto esters to access optically active γ‐aryl‐γ‐butyrolactones. Adv. Synth. Catal. 362, 2012-2029. DOI: 10.1002/adsc.201901483


Vogt M. S., Kölzer S., Schühle K., Peschke P., Schall I., Chowdhury N. P., Buckel W., Kleinsorge D., Essen L.-O., Heider J. (2019) Diversity of electron transferring flavoproteins: structure and function of a paralogue involved in anaerobic toluene metabolism. J. Bacteriol. 201, 00326-19. DOI: 10.1128/JB.00326-19

Schmitt G., Saft M., Arndt F., Kahnt J., Heider J. (2019) Two different quinohemoprotein amine dehydrogenases initiate anaerobic degradation of aromatic amines in Aromatoleum aromaticum EbN1. J. Bacteriol. 201, e00281-19. DOI: 10.1128/JB.00281-19

Arndt F., Schmitt G., Winiarska A., Saf M.t, Seubert A., Kahnt J., Heider J. (2019) Characterisation of an aldehyde oxidoreductase from the mesophilic bacterium Aromatoleum aromaticum, a member of a new subfamily of tungsten-containing enzymes. Front. Microbiol. 10, 71. DOI: 10.3389/fmicb.2019.00071

Czech L., Höppner A., Kobus S., Seubert A., Riclea R., Dickschat J. S., Heider J., Smits S. H. J. & Bremer E. (2019) Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis. Nature Sci. Rep. 9, 364. DOI: 10.1038/s41598-018-36247-w

Özcan A., Pausch P., Linden A., Wulf A., Schühle K., Heider J., Urlaub H., Heimerl T., Bange G, and Randau L. (2019) Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum. Nature Microbiol. 4, 89-96. DOI: 10.1038/s41564-018-0274-8


León M. J., Hoffmann T., Sánchez-Porro C., Heider J., Ventosa A. & Bremer E. (2018) Compatible solute synthesis and import by the moderate halophile Spiribacter salinus: physiology and genomics. Front. Microbiol. 9, 108. DOI: 10.3389/fmicb.2018.00108


Schulz A., Hermann L., Freibert S.-A., Bönig T., Hoffmann T., Ricela R., Dickschat J. S., Heider J. Bremer E. (2017) Transcriptional regulation of ectoine catabolism in response to multiple metabolic and environmental cues. Environ. Microbiol. 19, 4599-4619. DOI: 10.1111/1462-2920.13924

Warkentin E., Weidenweber S., Schühle K., Demmer U., Heider J. & Ermler U. (2017) A rare polyglycine type II-like helix motif in naturally occurring proteins. Proteins 85, 2017-2023. DOI: 10.1002/prot.25355

Schmitt G., Arndt F., Kahnt J., Heider J. (2017) Adaptations to a loss-of-function mutation in the betaproteobacterium Aromatoleum aromaticum: recruitment of alternative enzymes for anaerobic phenylalanine degradation. J. Bacteriol. 199, e00383-17. DOI: 10.1128/JB.00383-17

Schulz A.,  Stöveken N., Binzen I. M., Hoffmann T., Heider J. Bremer E. (2017) Feeding on compatible solutes: a substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR. Environ. Microbiol. 19, 926-946. DOI: 10.1111/1462-2920.13414

 Weidenweber S., Schühle K., Demmer U., Warkentin E., Ermler U. & Heider J. (2017) Structure of the acetophenone carboxylase core complex: prototype of a new class of ATP-dependent carboxylases/hydrolases. Nature Sci. Rep. 7, 39674. DOI: 10.1038/srep39674


Schühle K., Nies J. & Heider J. (2016) An indoleactate-CoA ligase and a phenylsuccinate CoA-transferase involved in anaerobic indoleacteate metabolism. Environ. Microbiol. 18, 3120-3132. DOI: 10.1111/1462-2920.13347

Seyhan D., Friedrich P., Szaleniec M., Hilberg M., Golding B. T., Buckel W. & Heider J. (2016) Elucidating the Stereochemistry of Enzymatic Benzylsuccinate Synthesis with Chirally Labeled Toluene. Angew. Chemie Int. Ed. 55, 11664-11667. DOI: 10.1002/anie.201605197

Seyhan D., Friedrich P., Szaleniec M., Hilberg M., Golding B. T., Buckel W. & Heider J. (2016) Stereochemischer Verlauf der enzymatischen Synthese von Benzylsuccinat mit chiral markiertem Toluol. Angew. Chemie 128, 11832-11835. DOI: 10.1002/ange.201605197

Szaleniec  M. & Heider J. (2016) Modeling of the reaction mechanism of enzymatic radical C-C coupling by benzylsuccinate synthase. Int. J. Mol. Sci. 17,514. DOI: 10.3390/ijms17040514

Widderich N., Kobus S., Hoeppner A., Riclea R., Seubert A., Dickschat J., Heider J., Smits S. H. J. & Bremer E. (2016) Biochemistry and crystal structure of the ectoine synthase: a metal-containing member of the cupin superfamily. PLoS One, 11, e0151285. eCollection 2016. DOI: 10.1371/journal.pone.0151285

Muhr E., Leicht O., González Sierra S., Thanbichler M. & Heider J. (2016) A fluorescent bioreporter for acetophenone and 1-phenylethanol derived from a specifically induced catabolic operon. Front. Microbiol. 6, 1561. DOI: 10.3389/fmicb.2015.01561

Widderich N., Czech L., Elling F. J., Könneke M., Stöveken N., Pittelkow M., Riclea R., Dickschat J., Heider J. & Bremer E. (2016) Strangers in the archaeal world: osmostress-responsive biosynthesis of ectoine and hydroxyectoine by the marine thaumarchaeon Nitrosopumilus maritimus. Environ. Microbiol. 18, 1227-1248. DOI: 10.1111/1462-2920.13156


Dudzik A., Snoch W., Borowiecki P., Opalinska-Piskorz J., Witko M., Heider J., Szaleniec M. (2015) Asymmetric reduction of ketones and β-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum. Appl. Microbiol. Biotechnol. 99, 5055-5069. DOI: 10.1007/s00253-014-6309-z

Muhr E., Schühle K., Clermont L., Sünwoldt K., Kleinsorge D., Seyhan D., Kahnt J., Schall I., Cordero P. R., Schmitt G. & Heider J. (2015) Enzymes of anaerobic ethylbenzene and p-ethylphenol catabolism in Aromatoleum aromaticum: differentiation and differential induction. Arch. Microbiol. 197, 1051-1062. DOI: 10.1111/1462-2920.13414

Kalimuthu P., Heider J., Knack D. & Bernhardt P. V. (2015) Electrocatalytic hydrocarbon hydroxylation by ethylbenzene dehydrogenase from Aromatoleum aromaticum. J. Phys. Chem. B 119, 3456-3463. DOI: 10.1012/jp512562k


Debnar-Daumler C., Seubert A., Schmitt G. & Heider J. (2014) Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism. J. Bacteriol. 196, 483-492. DOI: 10.1128/JB.00980-13

Szaleniec M., Dudzik A., Kozik B.,  Borowski T., Heider J. & Witko M. (2014) Mechanistic basis for the enantioselectivity of anaerobic hydroxylation of alkylaromatic compounds by  ethylbenzene dehydrogenase. J. Inorgan. Biochem. 139, 9-20. DOI: 10.1016/j.jinorgbio.2014.05.006

Tataruch M., Bryjak J., Nowak P., Knack D., Czerniak A., Liesiene J., Heider J. & Szaleniec M. (2014) Suitability of the hydrocarbon-hydroxylating molybdenum-enzyme ethylbenzene dehydrogenase for industrial chiral alcohol production. J. Biotechnol. 192, 400-409. DOI: 10.1016/j.jbiotec.2014.06.021

Widderich N., Höppner A., Pittelkow M., Heider J., Smits S. H. J. & Bremer E. (2014) Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLOS One 9, e93809. DOI: 10.1371/journal.pone.0093809


Dudzik A., Kozik B., Tataruch M., Wójcik A., Knack D., Borowski T., Heider J., Witko M. & Szaleniec M. (2013) The reaction mechanism of chiral hydroxylation of p-OH and p-NH2 substituted compounds by ethylbenzene dehydrogenase. Can J. Chem. 91, 775-786. DOI: 10.1139/cjc-2012-0504

Knack D. H, Marshall J. L., Harlow G. P., Dudzik A., Szaleniec M., Liu S.-Y. & Heider J. (2013) BN/CC-isosterische Verbindungen als Enzyminhibitoren: Hemmung der Hydroxylierung von Ethylbenzol durch N - und B -Ethyl-1,2-azaborin als nichtkonvertierbare Substratanaloga.,Angew. Chemie 125, 2660 –2662. DOI: org/10.1002/ange.201208351

Knack D. H, Marshall J. L., Harlow G. P., Dudzik A., Szaleniec M., Liu S.-Y. & Heider J. (2013) BN/CC isosteric compounds as enzyme inhibitors: N- and B-ethyl-1,2-azaborine inhibit ethylbenzene hydroxylation as nonconvertible substrate analogs. Angew. Chemie Int. Ed. 52, 2599-2601. DOI: 10.1002/anie.201208351

Kümmel S., Kuntze K., Vogt C., Boll M., Heider J. & Richnow H. H. (2013) Evidence for benzylsuccinate synthase subtypes by stable isotope tools. J. Bacteriol. 195, 4660-4667. DOI: 10.1128/JB.00477-13


Ebenau-Jehle C., Thomas M., Scharf G., Kockelkorn D., Knapp B., Schühle K., Heider J. & Fuchs G. (2012) Anaerobic Metabolism of Indoleacetate. J. Bacteriol. 194, 2894-2903. DOI: 10.1128/JB.00250-12

Hilberg M., Pierik A. J., Bill E., Friedrich T., Lippert M.-L. & Heider J. (2012) Identification of FeS-clusters in the glycyl radical enzyme benzylsuccinate synthase via EPR and Mössbauer spectroscopy. J. Biol. Inorg. Chem. 17, 49-56. DOI: 10.1007/s0075-011-0828-1

Knack D., Hagel C., Szaleniec M., Dudzik A., Salwinski A. & Heider J. (2012) Substrate and inhibitor spectrum of ethylbenzene dehydrogenase: implications on application potential and enzyme mechanism. Appl. Environ. Microbiol. 78, 6475-6482. DOI: 10.1128/AEM.01551-12

Schühle K. & Heider J. (2012) Acetone and butanone metabolism of the denitrifying bacterium “Aromatoleum aromaticum” demonstrates novel biochemical properties of an ATP-dependent aliphatic ketone carboxylase. J. Bacteriol. 194, 131-141. DOI: 10.1128/JB.05898-11

Szaleniec M., Salwinski A., Borowski T., Heider J. & Witko M. (2012) Quantum chemical modeling studies of ethylbenzene dehydrogenase activity. Intl. J. Quant. Chem. 112, 1990-1999. DOI: org/10.1002/qua.23143


Rabus R., Jarling R., Lahme S., Kühner S., Heider J., Widdel F. & Wilkes H. (2011) Co-metabolic conversion of toluene in anaerobic n-alkane-degrading bacteria. Environ. Microbiol. 13, 2576-2586. DOI: 10.1111/j.1462-2920.2011.02529.x

Stöveken N., Pittelkow M., Sinner T., Jensen R. A., Heider J. & Bremer E. (2011) A specialized aspartokinase enhances the biosynthesis of the osmoprotectants ectoine and hydroxyectoine in Pseudomonas stutzeri A1501. J. Bacteriol. 193, 4456-4468. DOI: 10.1128JB.00345-11


Jobst B., Schühle K., Linne U. & Heider J. (2010) ATP-dependent carboxylation of acetophenone by a novel type of carboxylase. J. Bacteriol. 192, 1387-1394. DOI: 10.1128/JB.01423-09

Müller F. D., Treuner-Lange A., Heider J., Huntley S. M., Higgs P. I. (2010) Global transcriptome analysis of spore formation in Myxococcus xanthus reveals a locus necessary for cell differentiation. BMC Genomics 11, 264. DOI: 10.1186/1471-2164-11-264

Szaleniec M., Borowski T., Schühle K., Witko M. & Heider  J. (2010) Ab initio modelling of ethylbenzene dehydrogenase reaction mechanism. J. Amer. Chem. Soc. 132, 6014-6024. DOI: 10.1021/ja907208k


Grundmann O., Behrends A., Rabus R., Amann J., Halder T., Heider J. & Widdel F. (2008) Genes encoding a tentative enzyme for anaerobic activation of n-alkanes in the denitrifying bacterium, strain HxN1. Environ. Microbiol. 10, 376-385. DOI: 10.1111/j.1462-2920.2007.01458.x

Szaleniec M., Witko M & Heider J. (2008) Quantum chemical modelling of C-H cleavage mechanism in oxidation of ethylbenzene and its derivates by ethylbenzene dehydrogenase. J. Molec. Catal. A, 286, 128-136. DOI: org./10.1016/j.molcata.2008.02.016


Szaleniec M., Hagel C., Menke M., Nowak P., Witko M. & Heider J. (2007) Kinetics and mechanism of oxygen-independent hydrocarbon-hydroxylation by ethylbenzene dehydrogenase. Biochemistry 46, 7637-7646. DOI: 10.1021/bi700633c


Höffken H. W., Duong M., Friedrich T., Breuer M., Hauer B., Reinhardt R., Rabus R., Heider J. (2006) Crystal structure and enzyme kinetics of the (S)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain EbN1. Biochemistry, 45, 82-93. DOI: 10.1021/bi051596b

Kloer D. P., Hagel C., Heider J. & Schulz, G. E. (2006) Crystal Structure of Ethylbenzene dehydrogenase from Aromatoleum aromaticum. Structure 14, 1377-1388. DOI: 10.1016j.str.2006.07.001


Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F. & Reinhard R. (2005) The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1. Arch. Microbiol. 183, 27-36. DOI: 10.1007/s00203-004-0742-9


Kube M., Heider J., Amann J., Hufnagel P., Kühner S., Beck A., Reinhardt R. & Rabus R. (2004) Genes involved in the anaerobic degradation of toluene in a denitrifying bacterium, strain EbN1. Arch. Microbiol. 181, 182-194. DOI: 10.1007/s00203-003-0627-3

Verfürth K., Pierik A. J., Leutwein C., Zorn S. & Heider J. (2004) Substrate specificities and electron paramagnetic resonance properties of benzylsuccinate synthases in anaerobic toluene- and m-xylene-metabolism. Arch. Microbiol. 181, 155-162. DOI: 10.1007/s00203-003-0642-4


Duboc-Toia C., Hassan A. K., Mulliez E., Ollagnier-de Choudens S., Fontecave M., Leutwein C. & Heider J. (2003) Very high field EPR studies of glycyl radical enzymes. J. Amer. Chem. Soc. 125, 38-39. DOI: 10.1021/ja026690j

Szaleniec M., Jobst B. & Heider J. (2003) Ethylbenzene dehydrogenase: oxidation of hydrocarbons without oxygen. Ann. Pol. Chem.Soc. 2003, 240-245. 


Hermuth K., Leuthner B. & Heider J. (2002) Operon structure and expression of the genes for benzylsuccinate synthase in Thauera aromatica strain K172. Arch. Microbiol. 177, 132-138. DOI: 10.1007/s00203-001-0375-1

Leutwein C. & Heider J. (2002) (R)-Benzylsuccinyl-CoA dehydrogenase from Thauera aromatica: a new acyl-CoA dehydrogenase involved in anaerobic toluene catabolism. Arch. Microbiol. 178, 517-524. DOI: 10.1007/s00203-002-0484-5

Mohamed M. E., Ismail W., Heider J. & Fuchs G (2002) Aerobic metabolism of phenylacetic acids in Azoarcus evansii. Arch. Microbiol. 178, 180-192. DOI: 10.1007/s00203-002-0438-y


Kniemeyer O. & Heider J. (2001) Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme. J. Biol. Chem. 276, 21381-21386. DOI: 10.1074/jbc.M101679200  

Kniemeyer O. & Heider J. (2001) (S)-1-Phenylethanol dehydrogenase of Azoarcus sp. strain EbN1, an enzyme of anaerobic ethylbenzene catabolism. Arch. Microbiol. 176, 129-135. DOI: 10.1007/s002030100303

Leutwein C. & Heider J. (2001) Succinyl-CoA: (R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria. J. Bacteriol. 183, 4288-4295. DOI: 10.1128/JB.183.14.4288-4295.2001


Leuthner B. & Heider J. (2000) Anaerobic toluene catabolism of Thauera aromatica: a toluene-induced operon codes for the enzymes of b-oxidation of the intermediate benzylsuccinate. J. Bacteriol. 182, 272-277. DOI: 10.1128/jb.182.2.272-277.2000


Leutwein C. & Heider J. (1999) Anaerobic toluene catabolic pathway in denitrifying Thauera aromatica: activation and b-oxidation of the first intermediate, (R)-(+)-benzylsuccinate. Microbiol. 145, 3265- 3271. DOI: 10.1099/0021287-145-11-3265

Zengler K., Heider J., Rosselló-Mora R. & Widdel F. (1999) Phototrophic utilisation of toluene under anoxic conditions by a new strain of Blastochloris sulfoviridis. Arch. Microbiol. 172, 204-212. DOI: 10.1007/s002030050761


Heider J., Boll M., Breese K., Breinig S., Ebenau-Jehle C., Feil U., Gad’on N., Laempe D., Leuthner B., Mohamed M., Schneider S., Burchhardt G. & Fuchs G. (1998) Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica. Arch. Microbiol. 170, 120-131. DOI: 10.1007/s002030050623

Leuthner B. & Heider J. (1998) A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica. FEMS Microbiol. Lett. 166, 35-41. DOI: 10.1111/j.1574-6968.1998.tb13180.x

Leuthner B., Leutwein C., Schulz H., Hörth P., Haehnel H., Schiltz E., Schägger H. & Heider J. (1998) Biochemical and genetic characterisation of benzylsuccinate synthase from Thauera aromatica: a new glycyl-radical enzyme catalysing the first step in anaerobic toluene metabolism. Molec. Microbiol. 28, 615-628. DOI: 10.1046/j.1365-2958.1998.00826.x

 Rabus R. & Heider J. (1998) Initial reactions of anaerobic metabolism of alkylbenzenes in denitrifying and sulfate-reducing bacteria. Arch. Microbiol. 170, 377-384. DOI: org/10.1007/s002030050656


Müller S., Heider J. & Böck A. (1997) The path of unspecific incorporation of selenium in Escherichia coli. Arch. Microbiol. 168, 421-427. DOI: 10.1007/s002030050517


Biegert T., Fuchs G. & Heider J. (1996) Evidence that anaerobic oxidation of toluene in the denitrifying bacterium Thauera aromatica is initiated by formation of benzylsuccinate from toluene and fumarate, Eur. J. Biochem. 238, 661-668. DOI: 10.1111/j.1432-1033.1996.0661w.x

Heider J., Mai X. & Adams M. W. W. (1996) Characterisation of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A dependent enzyme involved in peptide fermentation by hyperthermophilic archaea. J. Bacteriol. 178, 780-787. DOI: 10.1128/jb.178.3.780-787.1996

Hüttenhofer A., Heider J. & Böck A. (1996) Interaction of the Escherichia coli fdhF hairpin promoting selenocysteine incorporation with the ribosome. Nucl. Acids Res. 24, 3903-3910. DOI: 10.1093/nar/24.20.3903


Heider J., Ma K. & Adams M. W. W. (1995) Purification, characterisation and metabolic function of tungsten-containing aldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Thermococcus strain ES-1. J. Bacteriol. 177, 4757-4764. DOI: 10.1128/jb.177.16.4757-4764.1995

Ma K., Loessner H., Heider J., Johnson M. K. & Adams M. W. W. (1995) Effects of elemental sulfur on the metabolism of the deep-sea hyperthermophilic archaeon Thermococcus strain ES-1: characterisation of a sulfur-regulated, non-heme iron alcohol dehydrogenase. J. Bacteriol. 177, 4748-4756. DOI: 10.1128/jb.177.16.4748-4756.1995


Tormay P., Wilting R., Heider J. & Böck A. (1994) Genes coding for the selenocysteine-inserting tRNA species from Desulfomicrobium baculatum and Clostridium thermoaceticum: structural and evolutionary implications. J. Bacteriol. 176, 1268-1274. DOI: 10.1128jb.176.5.1268-1274.1994


Baron C., Heider J. & Böck A. (1993) Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA. Proc. Natl. Acad. Sci. USA 90, 4181-4185. DOI: 10.1073/pnas.90.9.4181


Heider J., Baron C. & Böck A. (1992) Coding from a distance: dissection of the mRNA determinants required for the incorporation of selenocysteine into protein. EMBO J. 11, 3759-3766. PMCID: doi.org/10.1002/j.1460-2075.1992.tb05461.x

Heider J. & Böck A. (1992) Targeted insertion of selenocysteine into the a-subunit of formate dehydrogenase from Methanobacterium formicicum. J. Bacteriol. 174, 659-663. DOI: 10.1128/jb.174.3.659-663.1992


Berg B. L., Li J., Heider J. & Stewart V. (1991) Nitrate-inducible formate dehydrogenase in Escherichia coli K-12: I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine. J. Biol. Chem. 266, 22380-22385. DOI: org/10.1016/S0021-9258(18)54583-X

Heider J., Forchhammer K., Sawers G. & Böck A. (1991) Interspecies compatibility of selenoprotein biosynthesis in Enterobacteriaceae. Arch. Microbiol. 155, 221-228. DOI: 10.1128/jb.173.16.4983-4993.1991

Sawers G., Heider J., Zehelein E. & Böck A. (1991) Expression and operon structure of the sel genes of Escherichia coli and identification of a third selenium-containing formate dehydrogenase isoenzyme. J. Bacteriol. 173, 4983-4993. DOI: 10.1128/jb.173.16.4983-4993.1991


Baron C., Heider J. & Böck A. (1990) Mutagenesis of selC, the gene for the selenocysteine-inserting tRNA-species in E. coli: effects on in vivo function. Nucl. Acids Res. 18, 6761-6766. DOI: 10.1093/nar/18.23.6761

Zinoni F., Heider J. & Böck A. (1990) Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine. Proc. Natl. Acad. Sci. USA 87, 4660-4664. DOI: 10.1073/pnas.87.12.4660


Heider J., Leinfelder W. & Böck A. (1989) Occurrence and functional compatibility of a tRNA species which inserts selenocysteine into protein. Nucl. Acids Res. 17, 2529-2540. DOI: 10.1093/nar/17.7.2529



Seelmann C. S., Willistein M., Heider, J. & Boll M. (2020) Tungstoenzymes: occurrence, catalytic diversity and cofactor synthesis. Inorganics 8, 44. DOI: 10.3390/inorganics8080044


Czech L., Hermann L., Stöveken N., Richter A. A., Höppner A., Smits S. H. J., Heider J., Bremer E. (2018) Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry and structural analysis. Genes 9, E177. DOI: 10.3390/genes9040177

Boll M., Estelmann S. & Heider J. (2018) Catabolic pathways and enzymes involved in the anaerobic degradation of monocyclic aromatic compounds. In: Boll M. (ed) Anaerobic Utilization of Hydrocarbons, Oils, and Lipids. Handbook of Hydrocarbon and Lipid Microbiology. Springer, Cham. DOI: 10.1007/978-3-319-33598-8_6-1

Boll M., Estelmann S. & Heider J. (2018) Anaerobic Degradation of Hydrocarbons: Mechanisms of Hydrocarbon Activation in the Absence of Oxygen. In: Boll M. (ed) Anaerobic Utilization of Hydrocarbons, Oils, and Lipids. Handbook of Hydrocarbon and Lipid Microbiology. Springer, Cham. DOI: 10.1007/978-3-319-33598-8_2-1


Rabus R., Boll M., Heider J., Meckenstock R. U., Buckel W., Einsle O., Ermler U.,   Golding B. T.,  Gunsalus R., Kroneck P. M. H., Krüger M., Lueders T., Martins B. M.,  Musat F., Richnow H. H., Schink B., Seifert J., Szaleniec M., Treude T., Ullmann G. M., Vogt C.,  von Bergen M. & Wilkes H. (2016) Anaerobic Microbial Degradation of Hydrocarbons  -  From Enzymatic Reactions to the Environment. J. Mol. Microbiol. Biotechnol. 26, 5-28. DOi: 10.1159/000443997

Heider J., Szaleniec M., Martins B. M., Seyhan D., Buckel W. & Golding B. T. (2016) Structure and function of benzylsuccinate synthase and related fumarate-adding glycyl radical enzymes. J. Mol. Microbiol. Biotechnol. 26, 29-44. DOI: 10.1159/000441656

Heider J., Szaleniec M., Sünwoldt K. & Boll M. (2016) Ethylbenzene dehydrogenase and related molybdenum enzymes involved in oxygen-independent alkyl chain hydroxylation. J. Mol. Microbiol. Biotechnol. 26, 45-62. DOI: 10.1159/000441357

Heider J., Schühle K., Frey J. & Schink B. & (2016) Activation of acetone and other ketones in anaerobic bacteria. J. Mol. Microbiol. Biotechnol. 26, 152-164. DOI: 10.1159/000441500


Heider J. & Fuchs G. (2015) Thauera. In: Bergey's Manual of Systematics of Archaea and Bacteria (W. B. Whitman ed.), John Wiley & Sons, Inc., in association with Bergey's Manual Trust. DOI: 10.1002/9781118960608.gbm01004


Heider J. & Schühle K. (2013) Anaerobic biodegradation of hydrocarbons including methane. In: The Prokaryotes: Prokaryotic Physiology and Biochemistry., 4th ed. (Rosenberg E., DeLong E.F., Thompson F., Lory S., Stackebrandt E. eds), Chapter 80, pp. 601-630, Springer-Verlag, Heidelberg. DOI: 10.1007/978-3-642-30141-4_80


Fuchs G., Boll M. & Heider J. (2011) Microbial degradation of aromatic compounds – from one strategy to four. Nature Rev. Microbiol. 9, 803-816. DOI: 10.1038/nrmicro2652 


Boll M. & Heider J. (2009) Anaerobic Degradation of Hydrocarbons: Mechanisms of C-H-bond activation in the absence of oxygen. In: Handbook of Hydrocarbon and Lipid Microbiology (K. N. Timmis ed.),  pp. 1011-1024, Springer-Verlag, Heidelberg. DOI: 10.1007/978-3-540-77587-4_71


Heider J. (2008) Bakterieller Kohlenwasserstoff-Abbau—es geht auch ohne Sauerstoff. Biospektrum 14, 28-31

Heider J. & Rabus R. (2008) Genomic insights in the anaerobic biodegradation of organic pollutants. In: Microbial biodegradation: Genomics and molecular biology (E. Diaz ed.), pp. 25-54, Caister academic press, Norfolk, UK


Heider J. (2007) Adding handles to unhandy substrates: anaerobic hydrocarbon activation mechanisms. Curr. Opin. Chem. Biol. 11, 188-194. DOI: 10.1016/j.cbpa.2007.02.027


Selmer T., Pierik A. J., Heider J. (2005) New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria. Biol. Chem. 386, 981-988. DOI: 10.1515/BC.2005.114

Heider J. & Fuchs G. (2005) Genus Thauera. In: Bergey’s Manual of Systematic Bacteriology (2nd ed); Vol. 2, part C (G. Garitty, ed.), pp. 907-913, Springer Verlag, Berlin


Boll M., Fuchs G. & Heider J. (2002) Anaerobic oxidation of aromatic compounds and hydrocarbons. Curr. Opin. Chem. Biol. 6, 604-611. DOI: 10.1016/s1367-5931(02)00375-7


Heider J. (2001) A new family of CoA-transferases. FEBS Lett. 509, 345-349. DOI: 10.1016/s0014-5793(01)03178-7


Heider J. (2000) Toluol-Stoffwechsel ohne Sauerstoff: eine (Glycyl-)radikale Lösung. Biospektrum 6, 280-281


Heider J., Spormann, A. M., Beller H. R. & Widdel, F. (1998) Anaerobic bacterial metabolism of hydrocarbons. FEMS Microbiol. Rev. 22, 459-473. DOI: 10.1111/j.1574-6976.1998.tb00381.x


Heider J. & Fuchs G. (1997) Anaerobic metabolism of aromatic compounds, Eur. J. Biochem. 243, 577-596. DOI: 10.1111/j.1432-1033.1997.00577.x

Heider J. & Fuchs G. (1997) Microbial anaerobic aromatic metabolism, Anaerobe 3, 1-22. DOI: 10.1006/anae.1997.0073 


Heider J. & Böck A. (1993) Selenium metabolism in micro-organisms. Adv. Microb. Physiol. 35, 71-109. DOI: 10.1016/s0065-2911(08)60097-1


Böck A., Forchhammer K., Heider J. & Baron C. (1991) Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem. Sci. 16, 463-467. DOI: 10.1016/0968-0004(91)90180-4

Böck A., Forchhammer K., Heider J., Leinfelder W., Sawers G., Veprek B. & Zinoni F (1991) Selenocysteine: the 21st amino acid. Molec. Microbiol. 5, 515-520. DOI: 10.1111/j.1365-2958.1991.tb00722.x


Böck A., Baron C., Forchhammer K., Heider J., Leinfelder W., Sawers G., Veprek B., Zehelein E. & Zinoni F. (1990) From nonsense to sense: UGA encodes selenocysteine in formate dehydrogenase and other selenoproteins. In: 41. Colloquium Mosbach: The molecular basis of bacterial metabolism (G. Hauska & R. Thauer eds.), pp. 61-68, Springer Verlag, Berlin