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Prof. Dr. Johann Heider

Original Publications

Seyhan, D., Friedrich, P., Szaleniec, M., Hilberg, M., Buckel, W., Golding, B.T., and Heider, J. (2016)
Elucidating the stereochemistry of enzymatic benzylsuccinate synthesis with chirally labeled toluene. Angew. Chem. Int. Ed. Engl. 55, 11664-11667.

Schulz, A., Stöveken, N., Binzen, I.M., Hoffmann, T., Heider, J., and Bremer, E. (2016)
Feeding on compatible solutes: A substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR. Environ Microbiol, doi: 10.1111/1462-2920.13414. [Epub ahead of print]

Schühle, K., Nies, J., and Heider, J. (2016)
An indolacetate-CoA ligase and a phenylsuccinyl-CoA transferase involved in anaerobic metabolism of auxin. Environ Microbiol, doi: 10.1111/1462-2920.13347. [Epub ahead of print]

Szaleniec, M., and Heider, J. (2016)
Modeling of the reaction mechanism of enzymatic radical C-C coupling by benzylsuccinate synthase. Int. J. Mol. Sci. 17, 514

Widderich, N., Kobus, S., Höppner, A., Riclea, R., Seubert, A., Dickschat, J.S., Heider, J., Smits, S.H., and Bremer, E. (2016)
Biochemistry and crystal structure of ectoine synthase: A metal-containing member of the cupin superfamily. PLoS One 11, doi: 10.1371/journal.pone.0151285. eCollection. 

Muhr, E., Leicht, O., González Sierra, S., Thanbichler, M., and Heider, J. (2015) A fluorescent bioreporter for acetophenone and 1-phenylethanol derived from a specifically induced catabolic operon. Front Microbiol, doi: 10.3389/fmicb.2015.01561. eCollection 2015.

Widderich, N., Czech, L., Elling, F.J., Könneke, M., Stöveken, N., Pittelkow, M., Riclea, R., Dickschat, J.S., Heider, J., and Bremer, E. (2015) Strangers in the archaeal world: osmostress-responsive biosynthesis of ectoine and hydroxyectoine by the marine thaumarchaeon Nitrosopumilus maritimus. Environ Microbiol, doi: 10.1111/1462-2920.13156. [Epub ahead of print]

Muhr, E., Schühle, K., Clermont, L., Sünwoldt, K., Kleinsorge, D., Seyhan, D., Kahnt, J., Schall, I., Cordero, P.R., Schmitt, G., and Heider, J. (2015) Enzymes of anaerobic ethylbenzene and p-ethylphenol catabolism in 'Aromatoleum aromaticum': differentiation and differential induction. Arch Microbiol 197, 1051-1062.

Kalimuthu, P., Heider, J., Knack, D. and Bernhardt, P. V. (2015) Electrocatalytic hydrocarbon hydroxylation by ethylbenzene dehydrogenase from Aromatoleum aromaticum. J. Phys. Chem. B. 119, 3456-63.

Dudzik, A., Snoch, W., Borowiecki, P., Opalinska-Piskorz, J., Witko, M., Heider, J. and Szalenic, M. (2015) Asymmetric reduction of ketones and ß-keto esters by (S)-1-pehnylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum. Appl. Microbiol. Biotechnol. 99,5055-5069.

Tataruch, M., Heider, J., Bryjak, J., Nowak, P., Knack, D., Czerniak, A., Liesiene, J. and Szalenic, M. (2014) Suitability of the hydrocarbon-hydroxylating molybdenum-enzyme ethylbenzene dehydrogenase for industrial chiral alcohol production. J. Biotechnol. 192, 400-409.

Widderich, N., Hoeppner, A., Pittelkow, M., Heider, J., Smits, S. H. J. and Bremer, E. (2014) Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLoS One 9(4): e93809.

Szaleniec M., Dudzik A., Kozik B.,   Borowski T., Heider J. & Witko M. (2014) Mechanistic basis for the enantioselectivity of anaerobic hydroxylation of alkylaromatic compounds by  ethylbenzene dehydrogenase. J. Inorgan. Biochem. (epub ahead of print).

Debnar-Daumler C., Seubert A., Schmitt G. &, Heider J. (2014) Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism. J. Bacteriol. 196, 483-492.

Kümmel S., Kuntze K., Vogt C., Boll M., Heider J. & Richnow H. H. (2013) Evidence for benzylsuccinate synthase subtypes by stable isotope tools. J. Bacteriol. 195, 4660-4667

Dudzik A., Kozik B., Tataruch M., Wójcik A., Knack D., Borowski T., Heider J., Witko M. & Szaleniec M. (2013) The reaction mechanism of chiral hydroxylation of p-OH and p-NH2 substituted compounds by ethylbenzene dehydrogenase. Can J. Chem. 91, 775-786

Knack D. H, Marshall J. L., Harlow G. P., Dudzik A., Szaleniec M., Liu S.-Y. & Heider J. (2012) Biological role of azaborines as enzyme inhibitors: N- and B-ethyl-1,2-azaborine are non-convertible substrate analogs of ethylbenzene dehydrogenase, Angew. Chemie, 52, 2599-2601

Knack D., Hagel C., Szaleniec M., Dudzik A., Salwinski A. & Heider J. (2012) Substrate and inhibitor spectrum of ethylbenzene dehydrogenase: implications on application potential and enzyme mechanism. Appl. Environ. Microbiol. 78, 6475-6482

Ebenau-Jehle C., Thomas M., Scharf G., Kockelkorn D., Knapp B., Schühle K., Heider J. & Fuchs G. (2012) Anaerobic Metabolism of Indoleacetate. J. Bacteriol. 194, 2894-2903

Schühle, K. & Heider, J. (2012) Acetone and butanone metabolism of the denitrifying bacterium Aromatoleum aromaticum demonstrates novel biochemical properties of an ATP-dependent aliphatic ketone carboxylase. J. Bacteriol. 194, 131-141

H ilberg, M., Pierik, A. J., Bill, E., Friedrich, T., Lippert, M.-L., & Heider, J. (2012) Identification of FeS clusters in the glycyl-radical enzyme benzylsuccinate synthase via EPR and Mössbaur spectroscopy. J. Biol. Inorg. Chem. 17, 49-56

Szaleniec M., Salwinski A., Borowski T., Heider J. & Witko M. (2011) Quantum chemical modeling studies of ethylbenzene dehydrogenase activity. Intl. J. Quant. Chem. DOI 10.1002/qua23143

Stöveken, N., Pittelkow. M., Sinner, T., Jensen, R.A., Heider, J. & Bremer, E. (2011) A specialized aspartokinase enhances the biosynthesis of the osmoprotectans ectoine and hydroxyectoine in Pseudomonas stutzeri A1501. J. Bacteriol. 17, 4456-4468

Rabus, R., Jarling, R., Lahme, S., Kühner, S., Heider, J., Widdel, F. & Wilkes, H. (2011) Co-metabolic conversion of toluene in anaerobic n-alkane-degrading bacteria. Environ. Microbiol., 9, 2576-2586

Jobst B., Schühle K., Linne U. & Heider J. (2010) ATP-Dependent Carboxylation of Acetophenone by a Novel Type of Carboxylase. J. Bacteriol. 192, 1387-1394

Szaleniec M., Borowski T., Schühle K., Witko M. and Heider J. (2010) Ab initio modelling of ethylbenzene dehydrogenase reaction mechamism. J. Amer. Chem. 132, 6014-6024

Müller F. D., Treuner-Lange A., Heider J., Huntley S. M., Higgs P. I. (2010) Global transcriptome analysis of spore formation in Myxococcus xanthus reveals a locus necessary for cell differentiation. BMC Genomics11, 264

Szaleniec M., Witko M & Heider J. (2008) Quantum chemical modelling of C-H cleavage mechanism in oxidation of ethylbenzene and its derivates by ethylbenzene dehydrogenase. J. Molec. Catal. A, 286, 128-136

Grundmann O., Behrends A., Rabus R., Amann J., Halder T., Heider J. & Widdel F. (2008) Genes encoding a tentative enzyme for anaerobic activation of n-alkanes in the denitrifying bacterium, strain HxN1. Environ. Microbiol., 10, 376-385

Breuer M., Rabus R. and Heider J. (2008) Method for production of optically active alcohols using Azoarcus sp. EbN1 dehydrogenase. Pub. No. WO/2008/1545302; Intl. Appl. No. PCT/EP2008/057522

Szaleniec M., Hagel C., Menke M., Nowak P., Witko M. & Heider J. (2007) Kinetics and mechanism of oxygen-independent hydrocarbon-hydroxylation by ethylbenzene dehydrogenase. Biochemistry 46, 7637-7646

Kloer D. P., Hagel C., Heider J. & Schulz, G. E. (2006) Crystal Structure of Ethylbenzene dehydrogenase from Aromatoleum aromaticum. Structure 14, 1377-1388

Höffken H. W., Duong M., Friedrich T., Breuer M., Hauer B., Reinhardt R., Rabus R., Heider J. (2006) Crystal structure and enzyme kinetics of the (S)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain EbN1. Biochemistry, 45, 82-93

Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F. & Reinhard R. (2005) The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1. Arch. Microbiol. 183, 27-36

Verfürth K., Pierik A. J., Leutwein C., Zorn S. & Heider J. (2004) Substrate specificities and electron paramagnetic resonance properties of benzylsuccinate synthases in anaerobic toluene- and m-xylene-metabolism. Arch. Microbiol. 181, 155-162

Kube M., Heider J., Amann J., Hufnagel P., Kühner S., Beck A., Reinhardt R. & Rabus R. (2004) Genes involved in the anaerobic degradation of toluene in a denitrifying bacterium, strain EbN1. Arch. Microbiol. 181, 182-194

Szaleniec M., Jobst B. & Heider J. (2003) Ethylbenzene dehydrogenase: oxidation of hydrocarbons without oxygen. Ann. Pol. Chem.Soc. 2003, 240-245

Duboc-Toia C., Hassan A. K., Mulliez E., Ollagnier-de Choudens S., Fontecave M., Leutwein C. & Heider J. (2003) Very high field EPR studies of glycyl radical enzymes. J. Amer. Chem. Soc. 125, 38-39

Hermuth K., Leuthner B. & Heider J. (2002) Operon structure and expression of the genes for benzylsuccinate synthase in Thauera aromatica strain K172. Arch. Microbiol. 177, 132-138

Mohamed M. E., Ismail W., Heider J. & Fuchs G (2002) Aerobic metabolism of phenylacetic acids in Azoarcus evansii. Arch. Microbiol. 178, 180-192

Leutwein C. & Heider J. (2002) (R)-Benzylsuccinyl-CoA dehydrogenase from Thauera aromatica: a new acyl-CoA dehydrogenase involved in anaerobic toluene catabolism. Arch. Microbiol. 178, 517-524

Leutwein C. & Heider J. (2001) Succinyl-CoA: (R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria. J. Bacteriol. 183, 4288-4295

Kniemeyer O. & Heider J. (2001) Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme. J. Biol. Chem. 276, 21381-21386

Kniemeyer O. & Heider J. (2001) (S)-1-Phenylethanol dehydrogenase of Azoarcus sp. strain EbN1, an enzyme of anaerobic ethylbenzene catabolism. Arch. Microbiol. 176, 129-135

Leuthner B. & Heider J. (2000) Anaerobic toluene catabolism of Thauera aromatica: a toluene-induced operon codes for the enzymes of ß-oxidation of the intermediate benzylsuccinate. J. Bacteriol. 182, 272-277

Zengler K., Heider J., Rosselló-Mora R. & Widdel F. (1999) Phototrophic utilisation of toluene under anoxic conditions by a new strain of Blastochloris sulfoviridis. Arch. Microbiol. 172, 204-212

Leutwein C. & Heider J. (1999) Anaerobic toluene catabolic pathway in denitrifying Thauera aromatica: activation and ß-oxidation of the first intermediate, (R)-(+)-benzylsuccinate. Microbiol. 145, 3265- 3271

Leuthner B., Leutwein C., Schulz H., Hörth P., Haehnel H., Schiltz E., Schägger H. & Heider J. (1998) Biochemical and genetic characterisation of benzylsuccinate synthase from Thauera aromatica: a new glycyl-radical enzyme catalysing the first step in anaerobic toluene metabolism. Molec. Microbiol. 28, 615-628

Heider J., Boll M., Breese K., Breinig S., Ebenau-Jehle C., Feil U., Gad’on N., Laempe D., Leuthner B., Mohamed M., Schneider S., Burchhardt G. & Fuchs G. (1998)
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica. Arch. Microbiol. 170, 120-131

Leuthner B. & Heider J. (1998) A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica. FEMS Microbiol. Lett. 166, 35-41

Rabus R. & Heider J. (1998) Initial reactions of anaerobic metabolism of alkylbenzenes in denitrifying and sulfate-reducing bacteria. Arch. Microbiol. 170, 377-384

Müller S., Heider J. & Böck A. (1997) The path of unspecific incorporation of selenium in Escherichia coli. Arch. Microbiol. 168, 421-427

Biegert T., Fuchs G. & Heider J. (1996) Evidence that anaerobic oxidation of toluene in the denitrifying bacterium Thauera aromatica is initiated by formation of benzylsuccinate from toluene and fumarate, Eur. J. Biochem. 238, 661-668

Heider J., Mai X. & Adams M. W. W. (1996) Characterisation of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A dependent enzyme involved in peptide fermentation by hyperthermophilic archaea. J. Bacteriol. 178, 780-787

Hüttenhofer A., Heider J. & Böck A. (1996) Interaction of the Escherichia coli fdhF hairpin promoting selenocysteine incorporation with the ribosome. Nucl. Acids Res. 24, 3903-3910

Ma K., Loessner H., Heider J., Johnson M. K. & Adams M. W. W. (1995) Effects of elemental sulfur on the metabolism of the deep-sea hyperthermophilic archaeon Thermococcus strain ES-1: characterisation of a sulfur-regulated, non-heme iron alcohol dehydrogenase. J. Bacteriol. 177, 4748-4756

Heider J., Ma K. & Adams M. W. W. (1995) Purification, characterisation and metabolic function of tungsten-containing aldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Thermococcus strain ES-1. J. Bacteriol. 177, 4757-4764

Tormay P., Wilting R., Heider J. & Böck A. (1994) Genes coding for the selenocysteine-inserting tRNA species from Desulfomicrobium baculatum and Clostridium thermoaceticum: structural and evolutionary implications. J. Bacteriol. 176, 1268-1274

Baron C., Heider J. & Böck A. (1993) Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA. Proc. Natl. Acad. Sci. USA 90, 4181-4185

Heider J. & Böck A. (1992) Targeted insertion of selenocysteine into the alpha-subunit of formate dehydrogenase from Methanobacterium formicicum. J. Bacteriol. 174, 659-663

Heider J., Baron C. & Böck A. (1992) Coding from a distance: dissection of the mRNA determinants required for the incorporation of selenocysteine into protein. EMBO J. 11, 3759-3766

Heider J., Forchhammer K., Sawers G. & Böck A. (1991) Interspecies compatibility of selenoprotein biosynthesis in Enterobacteriaceae. Arch. Microbiol. 155, 221-228

Sawers G., Heider J., Zehelein E. & Böck A. (1991) Expression and operon structure of the sel genes of Escherichia coli and identification of a third selenium-containing formate dehydrogenase isoenzyme. J. Bacteriol. 173, 4983-4993

Berg B. L., Li J., Heider J. & Stewart V. (1991) Nitrate-inducible formate dehydrogenase in Escherichia coli K-12: I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine. J. Biol. Chem. 266, 22380-22385

Zinoni F., Heider J. & Böck A. (1990) Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine. Proc. Natl. Acad. Sci. USA 87, 4660-4664

Baron C., Heider J. & Böck A. (1990) Mutagenesis of selC, the gene for the selenocysteine-inserting tRNA-species in E. coli: effects on in vivo function. Nucl. Acids Res. 18, 6761-6766

Heider J., Leinfelder W. & Böck A. (1989) Occurrence and functional compatibility of a tRNA species which inserts selenocysteine into protein. Nucl. Acids Res. 17, 2529-2540


Rabus, R., Boll, M., Heider, J., Meckenstock, R.U., Buckel, W., Einsle, O., Ermler, U., et al. (2016)
Anaerobic microbial degradation of hydrocarbons: From enzymatic reactions to the environment. J. Mol. Microbiol. Biotechnol. 26, 5-28

Heider, J., Szaleniec, M., Martins, B.M., Seyhan, D., Buckel, W., and Golding, B.T. (2016) Structure and function of benzylsuccinate synthase and related fumarate-adding glycyl radical enzymes. J Mol Microbiol Biotechnol 26, 29-44
Heider, J., Szaleniec, M., Sünwoldt, K., and Boll, M. (2016) Ethylbenzene dehydrogenase and related molybdenum enzymes involved in oxygen-independent alkyl chain hydroxylation. J Mol Microbiol Biotechnol 26, 45-62

Heider, J., Schühle, K., Frey, J., and Schink, B. (2016) Activation of acetone and other simplle ketones in anaerobic bacteria. J Mol Microbiol Biotechnol 26, 152-164

Schühle K. & Heider J. (2013) Anaerobic biodegradation of hydrocarbons including methane. In:The prokaryotes-a handbook on the biology of bacteria, 4th ed. (Rosenberg E., DeLong E.F., Thompson F., Lory S., Stackebrandt E. eds), accepted, Springer-Verlag, Heidelberg

Fuchs, G., Boll, M. and Heider, J. (2011) Microbial degradation of aromatic compounds – from one strategy to four. Nat Rev Microbiol,9, 803-816

Boll M. & Heider J. (2009) Anaerobic Degradation of Hydrocarbons: Mechanisms of C-H-bond activation in the absence of oxygen. In. Handbook of Hydrocarbon and Lipid Microbiology (ed. K. N. Timmis), Springer-Verlag, Heidelberg

Heider J. (2008)
Bakterieller Kohlenwasserstoff-Abbau—es geht auch ohne Sauerstoff. Biospektrum 14, 28-31

Heider J. & Rabus R. (2007) Genomic insights in the anaerobic biodegradation of organic pollutants. In: Microbial biodegradation: Genomics and molecular biology (E. Diaz ed.), pp. 25-54, Caister academic press, Norfolk, UK

Heider J. (2007) Adding handles to unhandy substrates: anaerobic hydrocarbon activation mechanisms. Curr. Opin. Chem. Biol. 11, 188-194

Selmer T., Pierik A. J., Heider J. (2005) New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria. Biol. Chem. 386, 981-988

Heider J. & Fuchs G. (2005) Genus Thauera. In: Bergey’s Manual of Systematic Bacteriology (2nd ed); Vol. 2, part C (G. Garitty, ed.), pp. 907-913, Springer Verlag, Berlin

Boll M., Fuchs G. & Heider J. (2002) Anaerobic oxidation of aromatic compounds and hydrocarbons. Curr. Opin. Chem. Biol. 6, 604-611

Heider J. (2001) A new family of CoA-transferases. FEBS Lett. 509, 345-349

Heider J. (2000) Toluol-Stoffwechsel ohne Sauerstoff: eine (Glycyl-)radikale Lösung. Biospektrum 6, 280-281

Heider J., Spormann, A. M., Beller H. R. & Widdel, F. (1999) Anaerobic bacterial metabolism of hydrocarbons. FEMS Microbiol. Rev. 22, 459-473

Heider J. & Fuchs G. (1997) Anaerobic metabolism of aromatic compounds, Eur. J. Biochem. 243, 577-596

Heider J. & Fuchs G. (1997) Microbial anaerobic aromatic metabolism, Anaerobe 3, 1-22

Heider J. & Böck A. (1993) Selenium metabolism in micro-organisms. Adv. Microb. Physiol. 35, 71-109

Böck A., Forchhammer K., Heider J., Leinfelder W., Sawers G., Veprek B. & Zinoni F (1991) Selenocysteine: the 21st amino acid. Molec. Microbiol. 5, 515-520

Böck A., Forchhammer K., Heider J. & Baron C. (1991) Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem. Sci. 16, 463-467

Böck A., Baron C., Forchhammer K., Heider J., Leinfelder W., Sawers G., Veprek B., Zehelein E. & Zinoni F. (1990) From nonsense to sense: UGA encodes selenocysteine in formate dehydrogenase and other selenoproteins. In: 41. Colloquium Mosbach: The molecular basis of bacterial metabolism (G. Hauska & R. Thauer eds.), pp. 61-68, Springer Verlag, Berlin

Textbook chapters

Heider J. (2013) Oxidation anorganischer Verbindungen: Chemolithotrophe Lebensweise. In: Allgemeine Mikrobiologie, 9. Aufl. (G. Fuchs  ed.), pp. §§§, Thieme Verlag, Stuttgart

Heider J. (2013) Mikrobielle Gärungen. In: Allgemeine Mikrobiologie, 9. Aufl. (G. Fuchs  ed.), pp. §§§, Thieme Verlag, Stuttgart

Heider J. (2013) Anaerobe Atmung. In: Allgemeine Mikrobiologie, 9. Aufl. (G. Fuchs  ed.), pp. §§§, Thieme Verlag, Stuttgart

Heider J. (2006) Oxidation anorganischer Verbindungen: Chemolithotrophe Lebensweise. In: Allgemeine Mikrobiologie, 8. Aufl. (G. Fuchs ed.), pp. 321-346, Thieme Verlag, Stuttgart

Heider J. (2006) Mikrobielle Gärungen. In: Allgemeine Mikrobiologie, 8. Aufl. (G. Fuchs ed.), pp. 347-378, Thieme Verlag, Stuttgart

Heider J. (2006) Anaerobe Atmung. In: Allgemeine Mikrobiologie, 8. Aufl. (G. Fuchs ed.), pp. 379-404, Thieme Verlag, Stuttgart

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