Publikationen Kissel - Philipps-Universität Marburg - Institut für Pharmazeutische Technologie & Biopharmazie

Publikationen 2009

M. Beck-Broichsitter, J. Gauss, C.B. Packhäuser, K. Lahnstein, T. Schmehl, W. Seeger, T. Kissel, T. Gessler:
Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model.
Int J Pharmaceutics 367 (2009), 169-178.
O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, M. Behe, T. Kissel:
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure.
Bioconjucate Chem 20 (2009), 174-182.
C. Packhäuser, K. Lahnstein, J. Sitterberg, T. Schmehl, T. Gessler, U. Bakowsky, W. Seeger, T. Kissel:
Stabilization of aerosolizable nano-carriers by freeze-drying.
Pharm Research 26 (2009), 129-138.
A. Malek, O. Merkel, L. Fink, F. Czubayko, T. Kissel, A. Aigner:
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.
Toxicology and Applied Pharmacology 236 (2009), 97-108.
A. Beyerle, S. Höbel, F. Czubayko, H. Schulz, T. Kissel, A. Aigner, T. Stoeger:
In vitro cytotoxic and immunomodulatory profiling of low molecular weight polyethylenimines for pulmonary application.
Toxicology in Vitro 23 (2009), 500-508.

Publikationen 2008

C. Cai, U. Bakowsky, E. Rytting, A.K. Schaper, T. Kissel:
Charged nanoparticles as protein delivery systems: A feasibility study using lysozyme as model protein.
Eur J Pharm Biopharm 69 (2008), 31-42.
O. Germershaus, S. Mao, J. Sitterberg, U. Bakowsky, T. Kissel:
Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure-activity relationships in vitro.
J Control Release 125 (2008), 145-154.
O. Germershaus, M. Neu, M. Behe, T. Kissel:
HER2 Targeted Polyplexes: The Effect of Polyplex Composition and Conjugation Chemistry on in vitro and in vivo Characteristics.
Bioconjucate Chem 19 (2008), 244-253.
S. Maretschek, A. Greiner, T. Kissel:
Electrospun biodegradable nanofiber nonwovens for controlled release of proteins.
J Control Release 127 (2008), 180-187.
A. Jintapattanakit, S. Mao, T. Kissel, V.B. Junyaprasert:
Physicochemical properties and biocompativility of N-trimethyl Chritosan: Effect of quaternization and dimethylation.
Eur J Pharm Biopharm 70 (2008), 563-571.
X. Wang, X. Xie, C. Cai, E. Rytting, T. Steele, T. Kissel:
Biodegradable branched polyesters poly(vinyl sulfonic-co-vinyl alcohol)-graft-P(D,L-lactic-co-glycolic acid) as negatively charged polyelectrolyte platform for drug delivery: synthesis and characterization.
Macromolecules 41 (2008), 2791-2799.
E. Rytting, X. Wang, J. Nguyen, T. Kissel:
Biodegradable Polymeric Nanocarriers for Pulmonary Drug Delivery.
Expert Opinion on Drug Delivery 5 (2008), 629-639.
W. Sun, S. Mao, D. Mei, T. Kissel:
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and enoxaparin.
Eur J Pharm Biopharm 69 (2008), 417-425.
D. Mei, S. Mao, W. Sun, Y. Wang, T. Kissel:
Effect of chitosan structure properties and molecular weight on th intranasal absorption of tetramethylpyrazine phosphate in rats.
Eur J Pharm Biopharm 70 (2008), 874-881.
J. Nguyen, X. Xie, M. Neu, R. Dumitrascu, R. Reul, J. Sitterberg, U. Bakowsky, R. Schermuly, L. Fink, T. Schmehl, T. Gessler, W. Seeger, T. Kissel:
Effects of cell-penetrating peptides and pegylation on transfection efficiency of PEI in mouse lungs.
J Gene Medicine 10 (2008), 1236-1246.
M. Mintzer, O. Merkel, T. Kissel, E.E. Simanek:
Dendrimers based on melamine can efficiently transfect cells in vitro.
Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008.
M. Mintzer, O. Merkel, T. Kissel, E.E. Simanek:
Dendrimers based on melamine can efficiently transfect cells in vitro.
PMSE Preprints 99 (2008), 132-133.
C. Cai, S. Mao, O. Germershaus, A. Schaper, E. Rytting, D. Chen, T. Kissel:
Influence of morphology and drug distribution on the release process of FITC-dextran loaded microspheres prepared with different types of PLGA.
Journal of Microencapsulation, published online 08 August 2008,
DOI: 10.1080/02652040802354707.
O. Germershaus, M. Neu, M. Behe, T. Kissel:
HER2 Targeted Polyplexes: The Effect of Polyplex Composition and Conjugation Chemistry on in vitro and in vivo Characteristics.
Bioconjucate Chem 19 (2008), 244-253.
J. Nguyen, T.W.J. Steele, O. Merkel, R. Reul, T. Kissel:
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy.
J Control Release 132 (2008), 243-251.
D. Mei, S. Mao, W. Sun, Y. Wang, T. Kissel:
Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.
Eur J Pharm Biopharm 70 (2008), 874-881.
J. Nguyen, X. Xie, M. Neu, R. Dumitrascu, R. Reul, J. Sitterberg, U. Bakowsky, R. Schermuly, L. Fink, T. Schmehl, T. Gessler, W. Seeger, T. Kissel:
Effects of cell-penetrating peptides and pegylation on transfection efficiency of PEI in mouse lungs.
J Gene Medicine 10 (2008), 1236-1246
F. Unger, M. Wittmar, F. Morell, T. Kissel:
Branched polyesters based on poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(D,L-lactide-co-glycolide): Effects of polymer structure on in vitro degradation behaviour.
Biomaterials 29 (2008), 2007-2014.

Publikationen 2007

M. Simon, I. Behrens, L.A. Dailey, M. Wittmar, T. Kissel:
Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters Poly[(vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-lactic acid): Protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity.
Eur J Pharm Biopharm 66 (2007), 165-172.
U. Westedt, M. Kalinowski, M. Wittmar, T. Merdan, F. Unger, U. Bakowsky, H.-J. Wagner, T. Kissel:
Poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment.
J Control Release 119 (2007), 41-51.
M. Neu, O. Germershaus, S. Mao, J. Nguyen, K-H. Voigt, M. Behe, T. Kissel:
Crosslinked nanocarrieres based upon Poly(ethylene imine) for systemic plasmid delivery: in vitro characterization and in vivo studies in mice.
J Control Release (2007), 370-380.
C.B. Packhäuser, T. Kissel:
On the design of in-situ forming biodegradable parenteral depot systems based on insulin loaded dialkylaminopropyl-amine-poly(vinyl alcohol)-g-poly(lactide-co-glycolide) nanoparticles.
J Control Release 123 ( 2007), 131-140.
M. Neu, O. Germershaus, M. Behe, T. Kissel:
Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo.
J Control Release 124 (2007), 69-80.
S. Mao, C. Augsten, K. Mäder, T. Kissel:
Characterization of chitosan and its derivatives using asymmetrical Flow Field-Flow-Fractionation: a comparison with traditional methods.
J Pharm Biomed Anal 45 (2007), 736-741.
F. Unger, U. Westedt, P. Hanefeld, R. Wombacher, S. Zimmermann, A. Greiner, M. Ausborn, T. Kissel
Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings?.
J Control Release 117 (2007), 312-321
E. Kleemann, T. Schmehl, T. Gessler, U. Bakowsky, T. Kissel, W. Seeger
Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability.
Pharmaceut Res 24 (2007), 277-287
F. Unger, M. Wittmar, T. Kissel
Branched Polyesters based on Poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(D,L-lactide-co-glycolide): Effects of polymer structure on cytotoxicity.
Biomaterials 28 (2007), 1610-1619
S. Mao, J. Xu, C. Cai, O. Germershaus, A. Schaper, T. Kissel
Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres.
Int J Pharm 334 (2007), 137-148
V. Hengst, C. Oussoren, T. Kissel, G. Storm
Bone targeting potential of bisphosphonate-targeted liposomes: Preparation, characterization and hydroxyapatite binding in vitro.
Int J Pharm 331 (2007), 224-227

Publikationen 2006

M. Moghimi, T. Kissel:
Particulate nanomedicines.
Adv Drug Deliver Rev 58 (2006), 1451-1455.
C. G. Oster, M. Wittmar, U. Bakowsky, T. Kissel
DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method.
J Control Release 111 (2006), 371-381
S. Mao, U. Bakowsky, A. Jintapattanakit, T. Kissel
Self-assembled Polyelectrolyte Nanocomplexes between Chitosan Derivatives and Insulin.
J Pharm Sci 95 (2006), 1035-1048
M. Wittmar, T. Kissel
Biodegradable Brush-like branced polyesters containing a charge-modified poly(vinyl alcohol) bockbone as platform for drug delivery systems: Synthesis and characterization.
Macromolecules 39 (2006), 1417-1424
U. Westedt, M. Wittmar, M. Hellwig, Ph. Hanefeld, A. Greiner, A. K. Schaper, T. Kissel
Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings.
J Control Release 111 (2006), 235-246
J. Schnieders, U. Gbureck, R. Thull, T. Kissel
Controlled release of gentamicin from calcium phosphate - poly(lactic acid-co-glycolic acid) composite bone cement.
Biomaterials 27 (2006), 4239-4249
S. Anabousi, E. Kleemann, U. Bakowsky, T. Kissel, T. Schmehl, T. Gessler, W. Seeger, C.-M. Lehr, C. Ehrhardt
Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant.
J Nanosci Nanotechno 6 (2006), 3010-3016
L.A. Dailey, N. Jekel, L. Fink, T. Gessler, T. Schmehl, M. Wittmar, T. Kissel, W. Seeger
Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung.
Toxicol Appl Pharmacol 215 (2006), 100-108
O. Germershaus, T. Merdan, U. Bakowsky, M. Behe, T. Kissel
Trastuzumab-Polyethylenimine-Polyethylene glycol Conjugates for targeting Her2 Expressing Tumors.
Bioconjugate Chem 17 (2006), 1190-1199
S. Mao, M. Neu, O. Germershaus, O. Merkel, J. Sitterberg, U. Bakowsky, T. Kissel
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/siRNA polyplexes.
Bioconjugate Chem 17 (2006), 1209-1218
T. Kissel
Biomaterials for delivery and targeting of proteins and nucleic acids.
Eur J Pharm Biopharm 63 (2006), 237-239
T. Kissel, S. Maretschek, C. Packhäuser, J. Schnieders, N. Seidel
Microencapsulation techniques for parenteral depot systems and their application in the pharmaceutical industry.
Drugs and the Pharmaceutical Sciences 158 (2006), 99-122
P. Hanefeld, U. Westedt, R. Wombacher, T. Kissel, A. Schaper, J.H. Wendorff, A. Greiner
Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer - Polymer adhesion for stent applications.
Biomacromolecules 7 (2006), 2086-2090
M. Neu, J. Sitterberg, U. Bakowsky, T. Kissel
Stabilized nanocarriers based upon Poly(ethylene imine) for systemic plasmid delivery.
Biomacromolecules 7 (2006), 3428-3438

Publikationen 2005

C.G. Oster, T. Kissel
Comparative study of DNA encapsulation into PLGA microparticles using modified double emulsion methods and spray drying techniques.
J Microencapsul 22 (2005), 235-244
M. Ausborn, O. Lambert, D. Bodmer, F. Nimmerfall, M. Acemoglu, M. Dadsetan, J.M. Andersn, F. Unger, T. Kissel
Poly(ethylene carbonate) Drug Delivery with Surface Eroding Polymers.
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 31 (2004), 31-32
J. Zeng, A. Aigner, F. Czubayko, T. Kissel, J. H. Wendorff, A. Greiner
Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings.
Biomacromolecules 6 (2005), 1484-1488
M. Neu, D. Fischer, T. Kissel
Recent Advances in Rational Gene Transfer Vector Design Based on Poly(ethylene imine) and its Derivatives.
J Gene Med 7 (2005), 992-1009
T. Merdan, K. Kunath, H. Petersen, U. Bakowsky, K. Voigt, J. Kopecek, T. Kissel
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose dependent manner after intravenous injection into mice.
Bioconjugate Chem 16 (2005), 785-792
G. Schliecker, C. Schmidt, S. Fuchs, T. Kissel
Erratum to "Characterization of a homologous series of D,L-lactic acid oligomers a mechanistic study on the degradation kinetics in vitro" [Biomaterials 24 (2003) 3835-3844].
Biomaterials 26 (2005), 827
S. Mao, X. Shuai, F. Unger, M. Wittmar, X. Xie, T. Kissel
Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers.
Biomaterials 26 (2005), 6343-6356
C. Packhäuser, M. Wittmar, T. Kissel
Novel in situ forming implants for bioactive macromolecules based on positively charged nanoparticles: Preparation of insulin-loaded nanoparticles, characterization of depots and investigation of insulin release.
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 32 (2005), 636-637
M. Simon, M. Wittmar, T. Kissel, T. Linn
Insulin containing nanocomplexes formed by self-assembly from biodegradable amine-modified poly(vinyl alcohol)-graft-poly(L-Lactide): Bioavailability and nasal tolerability in rats..
Pharmaceut Res 22 (2005), 1879-1886
O. Germershaus, S. Mao, A. Jintapattanakit, T. Kissel
Pegylated quarternized chitosan as novel gene delivery vector.
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 32 (2005), 606-607
J. Schnieders, U. Gbureck, R. Thull, T. Kissel
Biodegradable Microparticles as Antibiotic Carrier Systems: Modification for Self Setting Bone Cement.
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 32 (2005), 230-231
E. Kleemann, M. Neu, N. Jekel, L. Fink, T. Schmehl, T. Gessler, W. Seeger, T. Kissel
Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI.
J Control Release 109 (2005), 299-316
L.A. Dailey, T. Kissel
New poly(lactic-co-glycolic acid) derivatives: Modular polymers with tailored properties.
Drug Discovery Today 2 (2005), 7-14
M. Wittmar, J. Ellis, F. Morell, F. Unger, J. Schumacher, C. Roberts, S. Tendler, M. Davies, T. Kissel
Biophysical and transfection studies of an amine-modified PVA for gene delivery.
Bioconjugate Chem 16 (2005), 1390-1398
S. Mao, O. Germershaus, D. Fischer, T. Linn, R. Schnepf, T. Kissel
Uptake and Transport of PEG-Graft-Trimethyl-Chitosan Copolymer-Insulin Nanocomplexes by Epithelial Cells.
Pharmaceut Res 22 (2005), 2058-2068
T. Kissel
Lipospheres in Drug Targets and Delivery.
Eur J Pharm Biopharm 61 (2005), 111-112
E. Hann, S. Reinartz, S.E. Clare, T. Kissel, S. Passow, H. Schlebusch, U. Wagner
Development of a delivery system for the continuous endogenous release of an anti-idiotypic antibody against ovarian carcinoma.
Hybridoma 24 (2005), 133-140
J.S. Ellis, M. Wittmar, C.J. Roberts, S.J.B. Tendler, T. Kissel, M.C. Davies
Nanoscale Characterization of poly(vinyl) alcohol-g-poly(lactide-co-glycolide) DNA nanoparticles.
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 32 (2005), 208-209
T.L. Whateley, D. Poncelet, P. Colinet, C. Ward, T. Coakley, O. Alpar, T. Kissel, K. Eichler, G. Rees, D. Bain, J. Taihades, N. Suter
Microencapsulation processes.
European Space Agency SP 1281 (2005), 102-107

Publikationen 2004

I. Behrens, W. Kamm, A.H. Dantzig, T. Kissel
Variation of Peptide Transporter (PepT1 and HPT1) expression in Caco-2 influences substrate transport as a function of Caco-2 origin.
J. Pharm. Sci. 93 (2004) 1743-1754, 2004
D. Fischer, H. Dauzenberg, K. Kunath, T. Kissel
Poly(diallyldimethylammonium chlorides) and their N-ethyl-N-vinylacetamid Copolymer-based DNA-polyplexes: Role of molecular weight and charge desnity in complex formation, stability and in vitro activity.
Int. J. Pharm. 280 (2004) 253-269, 2004
U. Weidenauer, D. Bodmer, T. Kissel
Microencapsulation of hydrophilic drug substances using biodegradable polyesters; Part II: Implants allowing controlled release- A feasibility study using Bisphosphonates.
J. Microencapsulation 21 (2004) 137-149, 2004
G. Schliecker, C. Schmidt, S. Fuchs, J. Sandow, T. Kissel
In vitro and in vivo correlation of buserelin release from biodegradable implants using statistical moment analysis.
J. Controlled Release 94 (2004) 25-37, 2004
X. Shuai, T. Merdan, A. Schaper, F. Xi, T. Kissel
Core-crosslinked Polymaric Micelles as Paclitaxel Carriers.
Bioconjugate Chem. 15 (2004) 441-448, 2004
C.G. Oster, N. Kim, L. Grode, L. Barbu-Tudoran, A.K. Schaper, S.H.E. Kaufmann, T. Kissel
Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination.
J Control Release 104 (2005), 359-377
U. Westedt, L. Barbu-Tudoran, A. Schaper, M. Kalinowski, H. Alfke, T. Kissel
Effects of different application parameters on penetration characteristics and arterial vessel wall integrity after local nanoparticle delivery using a porous balloon catheter.
Eur. J. Pharm. Biopharm. 58 (2004) 161-168, 2004
X. Shuai, T. Merdan, F. Unger, T. Kissel
Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility.
Bioconjugate Chem 16 (2005), 322-329
G. Schliecker, C. Schmidt, S. Fuchs, T. Kissel
Characterization and in vitro degradation of Polytartrate.
Journal of Controlled Release 98 (2004)11-23, 2004
C. Brus, E. Kleemann, A. Aigner, F. Czubayko, T. Kissel
Stabilization of oligonucleotide-polyethylenimine complexes by freeze-drying: physicochemical and biological characterization.
J. Controlled Release 95 (2004) 119-131, 2004
A. Vila, A. Sánchez, K.A. Janes, I. Behrens, T. Kissel, M.J. Alonso
Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice.
Eur. J. Pharm. Biopharm. 57 (2004) 123-131, 2004
C. Brus, H. Petersen, A. Aigner, F. Czubayko, T. Kissel
Physicochemical and biological characterization of polyethylenimine-graft-poly(ethylene glycol) block copolymers as a delivery system for oligonucleotides and ribozymes.
Bioconjugate Chemistry 15 (2004) 677-684, 2004
M. Simon, M. Wittmar, U. Bakowsky, T. Kissel
Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly[(vinyl-3-(diethylamino-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-Lactic acid): A novel carrier for transmucosal delivery of peptides.
Bioconjugate Chemistry 15 (2004) 841-849, 2004
C. Oster, M. Wittmar, F. Unger, L. Barbu-Tudoran, A. Schaper, T. Kissel
Design of Amine-Modified Graft Polyesters for the Effective Gene Delivery Using DNA loaded Nanoparticles.
Pharm. Research 21 (2004) 927-931, 2004
C. Brus, H. Petersen, A. Aigner, F. Czubayko, T. Kissel
Efficiency of polyethylenimines and polyethysenimine-graft-poly(ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation.
Eur. J. Pharm. Biopharm. 57 (2004) 427-430, 2004
E. Kleemann, L. A. Dailey, H.G. Abdelhady, T. Gessler, T. Schmehl, C.J. Roberts, M.C. Davies, W. Seeger, T. Kissel
Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: Investigations of the complex structure and stability during air-jet and ultrasonic nebulization.
J. Controlled Release 100 (2004) 437-450, 2004
L.A. Dailey, E. Kleemann, T. Merdan, H. Petersen, J. Hänze, T. Schmehl, T. Gessler, W. Seeger, T. Kissel
Modified Polyethylenimines as Non Viral Gene Delivery Systems for Aerosol Therapy: Effects of Nebulization on Cellular Uptake and Transfection Efficiency.
Journal of Controlled Release 100 (2004) 425-436, 2004
C. Oster, M. Wittmar, U. Bakowsky, T. Merdan, T. Kissel
Nanocarrier for DNA Delivery by Specifically Engineered Biodegradable Polyesters: Cell Association, Uptake and Transfection.
Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15 - 18 March 2004 11/2003, 2004
J. Schnieders, U. Gbureck, R. Thull, T. Kissel
Spray-drying of Gentamicin crobefate Microparticles and their Processing in Self Setting Bone Cement.
Proc. International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15 - 18 March 2004 11/2003, 2004
C. B. Packhäuser, J. Schnieders, C. G. Oster, T. Kissel
In situ forming parenteral drug delivery systems: An overview.
Eur. J. Pharm. Biopharm. 58 (2004) 445-455, 2004
S. Mao, X. Shuai, F. Unger, M. Simon, D. Bi, T. Kissel
The Depolymerization of Chitosan: Effects on Physiocochemical and Biological Properties.
Int. J. Pharm. 281 (2004) 45-54, 2004
D. Fischer, B. Osburg, H. Petersen, T. Kissel, U. Bickel
Effect of Poly(ethylene imine) Molecular Weight and PEGylation on Organ Distribution and Pharmcokinetics of Polyplexes with Oligodeoxynucleotides in Mice.
Drug Metabolism and Disposition 32 (2004) 983-992, 2004
T. Kissel, C. Packhäuser, J. Schnieders, C. Oster
In situ forming parenteral depot systems for the delivery of bioactive macromolecules.
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 31 (2004) 81-82, 2004
X. Xie, M. Wittmar, T. Kissel
A two-dimensional NMR study of Poly(vinyl dialkylaminoalkylcarbamat-co-Vinyl Acetate-co-Vinyl Alcohol).
Macromolecules 37 (2004) 4598-4606, 2004
G. Winzenburg, C. Schmidt, S. Fuchs, T. Kissel
Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems.
Advanced Drug Delivery Reviews 56 (2004) 1453-1466, 2004
L. Dailey, M. Wittmar, T. Kissel
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles.
J Control Release 101 (2004), 137-149
M. Ausborn, O. Lambert, D. Bodmer, F. Nimmerfall, M. Acemoglu, M. Dadsetan, J.M. Andersn, F. Unger, T. Kissel
Poly(ethylene carbonate) Drug Delivery with Surface Eroding Polymers.
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 31 (2004) 31-32, 2004

Publikationen 2003

I. Behrens, T. Kissel
Influence cell culture conditions the active transport of peptides in Caco-2 monolayers?
Eur. J. Pharm. Biopharm. 19 (2003) 433-442 (O)
D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, T. Kissel
In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
Biomaterials 24 (2003) 1121-1131 (O)
K. Kunath, A. von Harpe, D. Fischer, T. Kissel
Galactose-PEI/DNA complexes for targeted gene delivery: Degree of substitution affects complex size and transfection efficiency.
J. Controlled Release 88 (2003) 159-172 (O)
K. Kunath, T. Merdan, O. Hegener, H. Häberlein, T. Kissel
Integrin targeting using RGD-PEI conjugates for in vitro gene transfer
J. Gene Med. 5 (2003) 588-599 (O)
U. Weidenauer, D. Bodmer, T. Kissel
Microencapsulation of hydrophylic drug substances using biodegradable polyesters, part I: Evaluation of different techniques for the encapsulation of Pamidronate di-sodium salt.
J. Microencapsulation 20 (2003) 509-524 (O)
M. Dadsetan, E.M. Christenson, F. Unger, M. Ausborn, T. Kissel, A. Hiltner, J.M. Anderson
In vivo Biocompatibility and Biodegradation of Poly(ethylene carbonate)
J. Controlled Release 93 (2003) 259-270 (O)
J. Drewe, F. Delco, T. Kissel, C. Beglinger
Effect of intravenous infusions of thiamine on the disposition kinetics of thiamine and its pyrophosphate.
J. Clin. Pharm. Therapeutics 28 (2003) 1-5 (O)
K. Kunath, A. von Harpe, D. Fischer, H. Petersen, K. Voigt, T. Kissel
Low molecular weight polyethylenimine (LMW-PEI) as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high molecular weight PEI (HMW-PEI).
J. Controlled Release 89 (2003) 113-125 (O)
X. Shuai, T. Merdan, F. Unger, M. Wittmar, T. Kissel
Novel biodegradable ternary Copolymer hy-PEI-g-PCL-b-PEG: Synthesis, Characterization and Potential as efficient non-viral gene delivery vector
Macromolecules 36 (2003) 5751-5759 (O)
H. Petersen, K. Kunath, T. Kissel
Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines
J. Controlled Release 87 (2003) 286-288 (O)
H. Petersen, T. Merdan, K. Kunath, D. Fischer, T. Kissel
Poly(ethylenimine-co-L-lactimide-co-succinimide): A biodegradable polyethylenimine derivative with advantageous pH dependent hydrolytic degradation for gene delivery
J. Controlled Release 87 (2003) 283-285 (O)
G. Schliecker, C. Schmidt, S. Fuchs, T. Kissel
Characterization of a homologous series of D,L-lactic acid oligomers: A mechanistic study on the degradation kinetics in vitro
Biomaterials 24 (2003) 3835-3844
G. Schliecker, C. Schmidt, S. Fuchs, T. Kissel
Hydrolytic degradation of Poly(lactide-co-glycolide) films: Effect of oligomers on degradation rate and crystallinity
Int. J. Pharm. 266 (2003) 39-49 (O)
T. Merdan, J. Callahan, H. Petersen, K. Kunath, U. Bakowsky, P. Kopekova, T. Kissel, J. Kopecek
Pegylated polyethylenimine-Fab’ antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells
Bioconjugate Chem. 14 (2003) 989-996 (O)
L.A. Dailey, E. Kleemann, M. Wittmar, T. Gessler, T. Schmehl, C. Roberts, W. Seeger, T. Kissel
Surfactant-free biodegradable nanoparticles for aerosol therapy based upon DEAPA-PVAL-g-PLGA
Pharm. Res. 20 (2003) 2011-2020 (O)
F. Unger, M. Wittmar, T. Kissel
Branched Polyesters of the type PVAL-g-PLGA allow design of rapidly degrading parenteral delivery systems
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 499-500 (A)
T. Merdan, K, Kunath, H. Petersen, U. Bakowsky, T. Kissel
Synthesis and Characterization of novel pegylated Polyethylenimines
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 615-616 (A)
C. Oster, M. Wittmar, U. Bakowsky, T. Kissel
Nanoparticulate DNAa delivery systems based upon novel amine-modified polyesters
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 303-304 (A)
C. Brus, H. Petersen, A. Aigner, F. Czubayko, T. Kissel
Protective effects of polyethylenimines and PEG-derivatives for stabilization of oligonucleotides against enzymatic and mechanical degradation
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 27-28 (A)
E. Kleemann, L.A. Dailey, H. Petersen, H.G. Abdelhady, C.J. Roberts, M.C. Davies, T. Schmehl, T. Gessler, W. Seeger, T. Kissel
Polyethylenimine as non-viral carriers for aerosol gene therapy: Investigations of complex stability and characterization by AFM
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 593-594 (A)
G. Schliecker, C. Schmidt, S. Fuchs, T. Kissel
Polytartrate- Characterization and in vitro degradation
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 473-474 (A)
L.A. Dailey, E. Kleemann, J. Hänze, T. Schmehl, T. Gessler, W. Seeger, T. Kissel
Effects of nebulization on the in vitro transfection of novel non-viral gene delivery vehicles in lung cells
Proc. Intern. Symp. Control. Rel. Bioact. Mater. 30 (2003) 584-585 (A)

Publikationen 2002

T. Jung, W. Kamm, A. Breitenbach, G. Klebe and T. Kissel
Loading of tetanus toxoid to biodegradable nanoparticles from branched and negatively charged poly(sulfobutyl-poly(vinylalcohol)-g-(lactide-co-glycolide)) by protein adsorption: A mechanistic study
Pharm. Res. 19 (8), 1104-1112 (2002)
A. Breitenbach, T. Jung, W. Kamm and T. Kissel
Biodegradable comb polyesters containing polyelectrolyte backbones facilitate the preparation of nanoparticles with defined surface structure and bioadhesive properties
Polymers for Advanced Technologies 13 (10-12), 938-950 (2002)
T. Kissel, Y. Li, F. Unger
ABA-Triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins
Adv. Drug Delivery Rev. 54, 99-134 (2002)
K. Kunath, A. von Harpe, H. Petersen, D. Fischer, K.H. Voigt, T. Kissel, U. Bickel
The structure of PEG-modified poly(ethylene imine) influences biodistribution and pharmacokinetics of their complexes with NF-kB decoy in mice
Pharm. Res. 19, 810-817 (2002)
T. Jung, R. Koneberg, K.D. Hungerer, T. Kissel
Tetanus Toxoid Microspheres consisting of biodegradable poly(lactide-coglycolide)- and ABA-triblock-copolymers: Immune response in mice
Int. J. Pharm. 234, 75-90 (2002)
T. Merdan, K. Kunath, D. Fischer, J. Kopecek, T. Kissel
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells using confocal laser scanning microscopy and inhibitor experiments
Pharm. Res. 19, 140-146 (2002)
H. Petersen, T. Merdan, K. Kunath, D. Fischer, T. Kissel
Poly(ethylenimine-co-L-lactamide-co-succinamide): A biodegradable polythylenimine derivative with an advantageous pH dependent hydrolytic degradation for Gene Delivery
Bioconjugate Chem. 13, 812-821 (2002)
H. Petersen, P.M: Fechner, A.L. Martin, K. Kunath, S. Stolnik, C.J. Roberts, P.M. Williams, S.J.B. Tendler, D. Fischer, M.C. Davies, T. Kissel
Polyethylenimine-graft-Poly(ethylene glycol) Copolymers: Influence of Copolymer Structure on DNAa complexation and biological activities as gene delivery System
Bioconjugate Chem. 13, 845-854 (2002)

Publikationen 2001

D. Fischer, T. Kissel
Histochemical characterization of primary capillary endothelial cells from porcine brains using monoclonal antibodies and FITC-labelled lectins: implications for drug delivery
Eur. J. Pharm. Biopharm. 52, 1-11 (2001)
D. Fischer, T. Bieber, S. Brüsselbach, H.P. Elsässer, T. Kissel
Cationized human serum albumin as a non-viral vector system for gene delivery? Caharacterization of complex formation with plasmid DNA and transfection efficiency
Int. J. Pharm. 225, 97-111 (2001)
K.F. Pistel, A. Breitenbach, R. Zange-Volland, T. Kissel
Brush-like branched biodegradable polyesters, part III: Protein release from microspheres of poly(vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid)
J. Controlled Release 73, 7-20 (2001)
C. Witt, T. Kissel
Morphological characterization of microspheres, films and implants prepared from poly(lactide-co-glycolide) and ABA triblock copolymers: is erosion controlled by degradation, swelling or diffusion
Eur. J. Pharm. Biopharm. 51, 171-181 (2001)
M. Simon, T. Kissel
Nicht-invasive Applikationsrouten für Insulin: Mehr Lebensqualität für Diabetiker?
Pharmazie in unserer Zeit 30, 136-141 (2001)
T. Jung, W. Kamm, A. Breitenbach, K.D. Hungerer, E. Hundt, T. Kissel
Tetanus Toxoid loaded nanoparicles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice
Pharm. Res. 18, 352-360 (2001)
I. Behrens, A.I. Vila Pena, M.J. Alonso, T. Kissel
Uptake and bioadhesive and non-bioadhesive nanoparticles in a human intestinal cell line Caco-2
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 28, 732-733 (2001)
K. Kunath, A.v. Harpe, H. Petersen, D. Fischer, U. Bickel, K. Voigt, T. Kissel
Biodistribution and pharmacokinetics of polyplexes of DNAa and pegylated polyethenimines
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 28, 1133-1134 (2001)
T. Merdan, K. Kunath, D. Fischer, T. Kissel
Elucidating the mechanism of escape of polyethylenimine/ribozyme complexes from the lysosomal compartment
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 28, 1137-1138 (2001)
D. Fischer, H. Alfke, K.J. Klose, T. Kissel
Administration of NF-kB decoy oligonucleotides using polyethylenimine as a nonviral vector system
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 28, 1141-1142 (2001)
A.L. Martin, H. Petersen, M.C. Davies, T. Kissel, C.J. Roberts, S. Stolnik, S.J.B. Tendeler, P.M. Williams
Microscopic investigations of the influence of poly-ethylene glycol on polyethylenimine DNA condensation
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 28, 1153-1154 (2001)
T. Kissel, T. Jung, W. Kamm, A. Breitenbach
Biodegradable Graft Polyesters based on Copolymers of Lactic acid and gylcolic acid grafted onto poly(vinyl alcohol) for oral vaccine delivery
Macromol. Symp. 172, 113-125 (2001)
W. Kamm, J. Hauptmann, I. Behrens, J. Stürzebecher, F. Dullweber, H. Gohlke, M. Stubbs, G. Klebe, T. Kissel
Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenyl-alanine structure: permeability and efflux mechansim in monolayers of a human intestinal cell line (Caco-2
Pharm. Res. 18, 1110-1118 (2001)
I. Behrens, P. Stenberg, P. Artursson, T. Kissel
Transport of lipohilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells
Pharm. Res. 18, 1138-1145 (2001)

Publikationen 2000

A. Breitenbach, D. Mohr and T. Kissel
Biodegradable semi-crystalline comb polyesters influence the microsphere production by means of a supercritical fluid extraction technique (ASES)
J. Controlled Release 53, 53-68 (2000)
A. Breitenbach, Y. X. Li and T. Kissel
Branched biodegradable polyesters for parenteral drug delivery systems
J. Controlled Release 64, 167-178 (2000)
A. Breitenbach, K. F. Pistel and T. Kissel
Biodegradable comb polyesters part II: Erosion and release properties of poly(vinyl alcohol)-g-poly(lactic-co-glycolic acid)
Polymer 41(13), 4781-4792 (2000)
T. Jung, A. Breitenbach and T. Kissel
Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) facilitate the preparation of small negatively charged biodegradable nanospheres for protein delivery
J. Controlled Release 67, 157-169 (2000)
T. Jung, W. Kamm, A. Breitenbach, J. C. Xiao, E. Kaiserling and T. Kissel
Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
Eur. J. Pharm. Biopharm. 50, 147-160 (2000)
Ch. Witt, C. Mäder, T. Kissel
The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers
Biomaterials 21, 931-938 (2000)
K.-F. Pistel, T. Kissel
Effects of salt addition on the microencapsulation of proteins using a W/O/W double emulsion technique
J. Microencapsulation 17, 467-483 (2000)
W. Kamm, A. Jonczyk, T. Jung, G. Luckenbach, P. Raddatz, T. Kissel
Evaluation of absorption enhancement for a potent cyclopeptidic a vb 3-antogonist in a human intestinal cell line (Caco-2)
European Journal of Pharmaceutical Sciences 10, 205-214 (2000)
U. Westedt, G. Schmittmann, A. Papadimitriou, T. Kissel
Adsorption on zinc carbonate stabilizes rhNGF against aggregation during W/O/W-microencapsulation
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 27, 375-376 (2000)
D. Fischer, A.v. Harpe, T. Kissel
PEI-Lactose/DNA Complexes for Targeted Gene Delivery: Relation between Lactose Content, DNA Complexation and Biological Effects
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 27, 838-839 (2000)
I. Behrens, P. Stenberg, P. Artursson, T. Kissel
The Effect of Mucus on the Transpithelial-Transport of Lipophilic Drugs in a Mucus Producing Cell Line HT29-MTX
Proceed. Int. Symp. Control. Rel. Bioact. Mater. 27, 1218-1219 (2000)
F. De Jaeghere, E. Allemann, J. Feijen, T. Kissel, E. Doelker, R. Gurny
Cellular uptake of PEO surface-modified nanoparticles: Evaluation of nanoparticles made of PLA:PEO Diblock and Triblock Copolymers
Journal of Drug Targeting 8, 143-153 (2000)
D. Fischer, A. v. Harpe, T. Kissel
Polyethylenimine: Polymer Structure Influences the Physicochemical and Biological Effects of Plasmid/PEI Complexes
Biomaterials and Drug Delivery toward New Millenium, K.D. Park et al (eds), S. 195-211 (2000)
T. Kissel, H. Petersen, D. Fischer, A. von Harpe, Klaus Kunath
Kationische Blockcopolymere
DE 199 33 024 (2000)
B. Ahlemeyer, D. Fischer, T. Kissel, J. Krieglstein
Staurosporine-induced apoptosis in cultured chick embryonic neurons is reduced by polyethylenimine of low molecular weight used as a coating substrate
Neurosci. Res. 37, 245-253 (2000)
A. v. Harpe, H. Petersen, Y. Li, T. Kissel
Characterization of commercially available an synthesized polyethylenimines for gene delivery
Journal of Controlled Release 96, 309-322 (2000)

Publikationen 1999

W. Graulich, D. M. Nettelbeck, D. Fischer, T. Kissel, R. Müller
Cell type specificity of the human endoglin promoter
Gene 227 (1), 55-62 (1999)
D. Fischer, T. Bieber, Y. Li, H.P. Elsässer, T. Kissel
A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine : Effect of molecular weight on transfection efficiency and cytotoxicity
Pharm. Res. 16, 1272-78 (1999)
B. Ahlemeyer, D. Fischer, T. Kissel, J. Krieglstein
A branched cationic structure of the extracellular matrix inhibited staurosporine-induced apoptosis in chick embryonic neurons.
J. Neurochem. 73, S16B (1999)
A.K. Hilbert, U. Fritzsche, T. Kissel
Biodegradable Microspheres Containing Influenza A Vaccine: Immune Response in Mice
Vaccine, 17 , 1065-1073 (1999)
B. Bittner, T. Kissel
Ultrasonic atomization for spray-drying: a versatile technique for the preparation of protein loaded biodegradable microspheres
J. Microencapsulation 16, 325-341 (1999)
B. Bittner, K. Mäder, C. Kroll, H.-H. Borchert and T. Kissel
Tetracycline-HCl loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: Influence of g -irradiation on radical formation and polymer degradation
Journal of Controlled Release 59, 23-32 (1999)
R. Altenburger, T. Kissel
The human keratinocyte cell line HaCaT: an in vitro cell culture model for cutaneous testosterone metabolism
Pharm. Res. 16, 766-771 (1999)
K.F. Pistel, B. Bittner, H. Koll, G. Winter, T. Kissel
Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: Influence of encapsulation technique and polymer composition on particle characteristics
J. Controlled Release 59, 309-325 (1999)
B. Bittner, Ch. Witt, K. Mäder and T. Kissel
Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: Influence of buffer media on polymer erosion and bovine serum albumin release
J. Controlled Release 60, 297-309 (1999)
A. Breitenbach, G. Nykamp, T. Kissel
Self-assembling colloidal carriers for protein delivery: Nanoparticulate polymer protein conjugates with novel watersoluble biodegradable comb polyolesters
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 26, 159-160 (1999)
D. Fischer, Y. Li, A.v. Harpe, T. Bieber, H.P. Elsässer, T. Kissel
Poly(ethylenimine-co-2-hydroxy ethylenimine) polymers: Relation between Polymer stucture, biocompatibility and transfection efficiency
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 26, 104-105 (1999)
F. De Jaeghere, A. Allémann, J. Feijen, T. Kissel, E. Doelker, R. Gurny
Cellular uptake off nanoparticles made of poly(lactic acid), poly(ethylene oxide) diblock and triblock copolymers
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 26, 727-728 (1999)
T. Jung, A. Breitenbach, W. Kamm, H.-D. Hungerer, E. Hundt, T. Kissel
Oral and nasal administration of tetanus toxoid loaded nanoparticles consisting of novel charged biodegradable polyesters for mucosal vaccination
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 26, 347-348 (1999)
C. Witt, K. Mäder, T. Kissel
Erosion of biodegradable implants prepared by extrusion or compression molding of poly(lactide-co-glycolide) and ABA triblock copolymers
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 26, 232-233 (1999)
O. Schäfer, F. Brink-Spalink, B. Smarsly, C. Schmidt, J.H. Wendorff, C. Witt, T. Kissel, A. Greiner
Synthesis and properties of w –phenylalkyl-substituted poly-(p-xylylene)s prepared by base-induced 1,6-dehydrohalogenation
Macromol. Chem. Phys. 200, 1942-1949 (1999)
T. Kissel
Book Review: "Sterilization of Drugs and Devices: Technologies for the 21st Century" by Fred M. Nordhauser, W.P. Olson (Editors), Interpharm Press, ISBN: 1-57491-060-4
Eur. J. Pharm. Biopharm. 48, 89 (1999)
W. Kamm, P. Raddatz, J. Gante, T. Kissel
Prodrug approach for a IIbb 3-peptidomimetic antagonists to enhance their transport in monolayers of a human intestinal cell line (Caco-2): comparison of in vitro and in vivo data
Pharm. Res. 16, 1527-1533 (1999)
T. Kissel
Biodegradierbare Polymere als Arzneistoffträger
In: Entwicklungen in der pharmazeutisch-technologischen Arzneimittelforschung (R. Gröning, P.C. Schmidt, Hrsg.)
Deutscher Apotheker Verlag Stuttgart, 47-57 (1999)
T. Kissel
2.5 Suspensionen
In: Grundlagen der Arzneiformenlehre/Galenik 2 (Herzfeldt/Kreuter, Hrsg.)
Springer Verlag, 244-262 (1999)
D. Mohr, M. Wolff, T. Kissel
Gamma irradiation for terminal sterilization of 17ß-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticels
J. Controlled Release 61, 203-217 (1999)
P.Bastian, T. Kissel
Maligne Lebererkrankungen: Arterielle Chemo- und Embolisationstherapie mit Hilfe von Trägersystemen
PZ Prisma 6, 235-248 (1999)
C. Witt, T. Traechslin and T. Kissel
Protein Protein release from biodegradable poly(lactide-co-glycolide) matrices: does the swelling of implants influence the in vitro release kinetics?
Special Issue (Prof. Puisieus)
S.T.P. Pharma Sciences 9, 487-495 (1999)
D. Mohr, M. Wolff, T. Kissel
Gamma irradiation for terminal sterilization of 17ß-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticels
J. Controlled Release 61, 203-217 (1999)
D. Fischer, T. Bieber, H.-P. Elsässer, T. Kissel
Nonviral vector systems for gene therapy: tailor-made polyethylenimine derivatives
BIO TECH international (BTi) 11 (5), 8 (1999)
T. Jung, W. Kamm, A. Breitenbach, T. Kissel
Colloidal polymeric vaccine delivery system for the oral and nasal application of Tetanus toxoid
BIO TECH international (BTi) 11 (5), 8-10 (1999)
T. Kissel, A. Breitenbach, W. Kamm, T. Jung
Neue pharmazeutische Zubereitung, enthaltend kolloidale Polymer-Wirkstoff-Assoziate
DE 198 39 515 (1999)
D. Fischer, T. Bieber, H.-P. Elsässer, T. Kissel
Nonviral vector systems for gene therapy: tailor-made polyethylenimine derivatives
BIO TECH international 11 (5), 8 (1999)
T. Jung, W. Kamm, A. Breitenbach, T. Kissel
Colloidal polymeric vaccine delivery system for the oral and nasal application of Tetanus toxoid
BIO TECH international 11 (5), 8-10 (1999)

Publikationen 1998

A. Fahr, T. Kissel
Mikropartikel und Implantate: Arzneiformen zur parenteralen Applikation (17)
In: Pharmazeutische Technologie - Moderne Arzneiformen (R.H. Müller, G.E. Hildebrand, Hrsg.)
2. Auflage, Stuttgart, Wissenschaftliche Verlagsgesellschaft mbH, 243-258 (1998)
T. Kissel, U. Werner
Nasal Delivery of Peptides: An In vitro Cell Culture Model for the Investigation of Transport and Metabolism in Human Nasal Epithelium
Journal of Controlled Release 53, 195-203 (1998)
P.J. Konigsberg, R. Godtel, T. Kissel, L.L. Richter
The development of IL-2 conjugated liposomes for therapeutic purposes
Biochimica et Biophysica Acta (BBA) 1370, 243-251 (1998)
B. Bittner, B. Ronneberger, R. Zange, C. Volland, J.M. Anderson, T. Kissel
Bovine serum albumin loaded poly(lactide-co-glycolide) microspheres: the influence of polymer purity on particle characteristics
J. Microencapsulation 15, 495-514 (1998)
B. Bittner, M. Morlock, H. Koll, G. Winter, T. Kissel
Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics
Eur. J. Pharm. Biopharm. 45, 295-305 (1998)
K. Mäder, B. Bittner, Y. Li, W. Wohlauf, T. Kissel
Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethyleneoxide) B blocks
Pharm. Res. 15, 787-793 (1998)
U.D. Rohr, R. Altenburger, T. Kissel
Pharmacokinetics of the Transdermal Reservoir Membrane System Delivering b -Estradiol: In Vitro/In Vivo-Correlation
Pharm. Res. 15, 877-882 (1998)
R. Altenburger, U.D. Rohr, T. Kissel
Rate Control in Transdermal b -Estradiol Reservoir Membrane Systems: The Role of Membrane and Adhesive Layer
Pharm. Res. 15, 1238-1243 (1998)
T. Laich, T. Kissel
Untersuchung schmiermittelabhängiger Kenngrößen an einer Exzentertablettenpresse ausgerüstet mit einem externen Schmiersystem
Pharm. Ind. 60, 547-554 (1998)
Y. Li, C. Volland, T. Kissel
Biodegradable brush-like graft polymers from poly(D,L-lactide) or poly(D,L-lactide-co-glycolide) and charge-modified, hydrophilic dextrans as backbone - in-vitro degradation and controlled releases of hydrophilic macromolecules
Polymer 39, 3087-3097 (1998)
A. Breitenbach, T. Kissel
Biodegradable comb polyester: Part 1
Synthesis, characterization and structural analysis of poly(lactide) and poly(lactide-co-glycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone
Polymer 39, 3261-3271 (1998)
Y. Li, T. Kissel
Synthesis, characteristics and in vitro degradation of star-block copolymers consisting of L-lactide, glycolide and branched multi-arm poly(ethylene oxide)
Polymer 39, 4421-4427 (1998)
D. Fischer, T. Bieber, Y. Li, H.-P. Elsässer, T. Kissel
Polyethylenimine: Synthesis and in vitro Cytotoxicity of a low molecular weight polycation for gene transfer
European Journal of Cell Biology (Eur. J. Cell Biol.) 75, Supplement 48, 108 (1998)
T. Bieber, D. Fischer, T. Kissel, H.-P. Elsässer
A low molecular polyethylenimene with striking qualities for gene delivery
European Journal of Cell Biology (EJCB) 75, Supplement 48, 107 (1998)
D. Fischer, T. Bieber, Y. Li, H.P. Elsässer, T. Kissel
Cationic Low Molecular Weight Polymers for Gene Transfer: Cytotoxicity and Transfection Efficiency
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 211-212 (1998)
G. Schmittmann, U.D. Rohr, T. Kissel
In Vitro Model for Intramuscular Drug Bioavailability IV: Unstirred Waterlayer Effects on a Porous Membrane
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 25, 457-458 (1998)
R. Bartkowski, T. Lienhoff, V. Armstrong, P. Bastian, Ch. Gärtner, M. Oellerich, T. Kissel
MEGX-test for liver function after chemoembolization or hemihepatectomy – investigations in a rat hepatoma
J. Cancer Res. Clin. Oncol. 124 (Suppl.), R7 (1998)
A. Pansky, P. Hildebrand, M.H. Heim, M. Eberhard, T. Kissel, C. Beglinger
Growth effects of a -interferon but not of bombesin or angiotensin II are mediated by activation of STAT proteins
European Journal of Clinical Investigation 28, 398-406 (1998)
K.F. Pistel, T. Kissel
The influence of additives during microparticulate preparation on the morphology of microparticles
Proc. 2nd World Meeting APV/APGI, p. 499, Paris, 25/28 May 1998
C. Witt, B. Bittner, K. Mäder, Y.X. Li and T. Kissel
Influence of Ph and ionic strength on in vitro degradation and release poly(lactide-co-glycolide) and ABA triblock copolymers
Proc. 2nd World Meeting APV/APGI, p. 527, Paris, 25/28 May 1998
Altenburger, T. Kissel
The human keratinocyte cell line HaCaT: A model system for studying skin metabolism of steroid hormones
Proc. 2nd World Meeting APV/APGI, p. 835, Paris, 25/28 May 1998
T. Laich, T. Kissel
Automatische Anpassung der Schmiermittelmenge durch Regelung eines externen Schmiersystems - Versuche auf einer Exzenterpresse und einer Rundläuferpresse
Pharm. Ind. 60, 896-904 (1998)
M. Lück, K.-F. Pistel, Y. Li, T. Blunk, R.H. Müller, T. Kissel
Plasma protein adsorption on biodegradable microspheres consisting of poly(D,L-lactide-co-glycolide), poly(L-lactide) or ABA triblock copolymers containing poly(oxyethylene) influence of production method and polymer composition
J. Controlled Release 55, 107-120 (1998)
M. Morlock, T. Kissel, Y. Li, H. Koll and G. Winter
Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties
J. Controlled Release 56, 105-115 (1998)
B. Kriwet, E. Walter, T. Kissel
Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an invers emulsion polymerization method for the entrapment of hydrophilic drug candidates
J. Controlled Release 56, 149-158 (1998)
R. Zange, Y. Li, T. Kissel
Biocompatibility testing of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to a central poly(ethylene oxide) B block under in vitro conditions using different L929 mouse fibroblasts cell culture models
J. Controlled Release 56, 249-258 (1998)
M. Roser, D. Fischer, T. Kissel
Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats
Eur. J. Pharm. Biopharm. 46, 255-263 (1998)
P. Bastian, R. Bartkowski, H. Köhler, T. Kissel
Chemo-embolization of experimental liver metastases. Part I: Distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy
Eur. J. Pharm. Biopharm. 46, 243-254 (1998)
B. Ahlemeyer, D. Fischer, T. Kissel, J. Krieglstein
Polyethylenimine of low molecular weight used as extracellular matrix reduced neuronal apoptosis induced by staurosporine
Archiv der Pharmazie 331 (Suppl. 2), 67 (1998)
R. Altenburger, T. Kissel
Biotransformation of b -Estradiol in the Human Kerationocyte Cell Line HaCaT: Metabolism Kenetics and the Inhibitory Effect of Ethanol
Pharmaceutical Research 15, 1684-1689 (1998)

Publikationen 1997

B. Ronneberger, T. Kissel, J.A. Anderson
Biocompatibility of ABA triblock copolymer microparticles consisting of poly(L-lactic-co-glycolic-acid) A-Blocks attached to central poly(oxyethylene) B-blocks in rats after intramuscular injection
Eur. J. Pharm. Biopharm. 43, 19-28 (1997)
M. Morlock, H. Koll, G. Winter, T. Kissel
Microencapsulation of rh-erythropoietin, using biodegradable poly(D,L-lactide-co-glycolide): protein stability and the effects of stabilizing excipients
Eur. J. Pharm. Biopharm. 43, 29-36 (1997)
T. Kissel, R. Koneberg, A.K. Hilbert, K.D. Hungerer
Microencapsulation of Antigens Using Biodegradable Polyesters: Facts and Phantasies
Behring Inst. Mitt. (BIM) 98, 172-183 (1997)
U. Werner, Thomas Kissel, W. Stüber
Effects of peptide structure on transport properties of seven thyrotropin releasing hormone (TRH) analogues in a human intestinal cell line (Caco-2)
Pharm. Res. 14, 246-250 (1997)
T. Laich, T. Kissel
Experimentelle Charakterisierung der Preßkammerbeschichtung auf Rundlauftablettenpressen
Pharm. Ind. 59, 265-272 (1997)
B. Schartel, Ch. Volland, Y.X. Li, J.H. Wendorff and T. Kissel
Dielectric and thermodynamic properties of biodegradable poly(D,L-lactide-co-glycolide) and the effect on the microencapsulation and release of captopril
J. Microencapsulation 14, 475-488 (1997)
W. Kamm, J. Gante, P. Raddatz, T. Kissel
Transport and matabolism of four IIb3-inhibitors in a human intestinal cell line (Caco-2)
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 103-104 (1997)
Y. Li, T. Kissel
Synthesis of biodegradable block and star-block copolymers of LA, LA and PEO by living polymerization
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 132-133 (1997)
R. Zange, Y. Li, T. Kissel
In vitro degradation study and in vitro biocompatibility testing of PEO containing ABA triblock copolymers
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 511-512 (1997)
G. Schmittmann, U.D. Rohr, T. Kissel
In vitro model for intramuscular drug bioavailability III: IVIV correlation of Theophylline
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 513-514 (1997)
A. Breitenbach, T. Kissel
Novel biodegradable comb polyester: L-PLA and D,L-PLG grafted onto water soluble PVA backbone
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 515-516 (1997)
U.D. Rohr, G. Schmittmann, T. Kissel
In vitro model for intramuscular drug bioavailability II: Diffusion model of drug release from both sides of a donor compartment
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 533-534 (1997)
B. Bittner, K. Mäder, Y. Li, T. Kissel
Evaluation of the microenvironment inside biodegradable microspheres from ABA triblock copolymers of poly(L-lactide-co-glycolide) and poly(ethyleneoxide) prepared by spray drying
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 535-536 (1997)
B. Bittner, T. Kissel
Preparation of protein-loaded poly(lactide-co-glycolide) microspheres using an ultrasonic atomizer
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 537-538 (1997)
K. Mäder, B. Bittner, T. Kissel
Direct detection of gamma-sterilization induced free radical formation in PLGA microparticles
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 561-562 (1997)
D. Fischer, R. Zange, T. Kissel
Comparative in vitro cytotoxicity studies of polycations for gene therapy
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 647-648 (1997)
R. Altenburger, U.D. Rohr, T. Kissel
Explanation for the plasma level fluctuations resulting from the transdermal liquid reservoir system delivering -Estradiol
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 695-696 (1997)
K.F. Pistel, M. Lück, R.H. Müller, T. Kissel
Plasma protein adsorption on biodegradable microspheres consisting of polyesters or ABA triblock copolymers
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 765-766 (1997)
M. Lück, K.F. Pistel, T. Kissel, R.H. Müller
Influence of the production method on protein adsorption of biodegradable microspheres
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 937-938 (1997)
D. Mohr, K.H. Nagels, Y. Li, T. Kissel
New hydrophilic biodegradable graft copolymers for improved peptide release
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24, 1019-1020 (1997)
R. Zange, T. Kissel
Comparative in vitro biocompatibility testing of polycyanoacrylates and poly(D,L-lactide-co-glycolide) using different mouse fibroblast (L929) biocompatibility test models
Eur. J. Pharm. Biopharm. 44, 149-157 (1997)
A.G. Shard, M.C. Davies, Y.X. Li, C. Volland, T. Kissel
XPS and SSIMS Analysis Revealing Surface Segregation and Short-Range Order in Solid Films of Block Copolymers of PEO and PLGA
Macromolecules 30, 3051-3057 (1997)
Y. Li, J. Nothnagel, T. Kissel
Biodegradable brush-like graft polymers from poly(D,L-lactide) or poly(D,L-lactide-co-glycolide) and charge-modified, hydrophilic dextrans as backbone-
Synthesis, characterization and in vitro degradation properties
Polymer 38, 6197-6206 (1997)
T. Kissel, A.K. Hilbert, R. Koneberg, B. Bittner
Microencapsulation of antigens for parenteral vaccine delivery systems
In: Antigen Delivery Systems (B. Gander, H.P. Merkle, G. Conrradin, Eds.), Amsterdam, Harwood Academic Publishers GmbH, 159-190 (1997)