Hauptinhalt

tRNA-Prozessierung - RNase P

  • Mechanismus der Katalyse
  • Evolution von RNA-basierten und Protein-Allein-Enzymen
  • Antibiotische Hemmung von RNase P-Enzymen

Aktuelle Publikationen

Nickel. A.I., Wäber, N.B., Gößringer, M., Lechner, M., Linne, U., Toth, U., Rossmanith, W. and Hartmann, R.K. Minimal and RNA-free RNase P in Aquifex aeolicus. Proc. Natl. Acad. Sci. USA, (2017) in press.

Gößringer, M., Lechner, M., Brillante, N., Weber, C., Rossmanith, W. and Hartmann, R.K. Protein-only RNase P function in Escherichia coli: viability, processing defects and differences between PRORP isoenzymes. Nucleic Acids Res 45:7441-7454 (2017).

Walczyk, D., Willkomm, D.K. and Hartmann, R.K. Bacterial type B RNase P: functional characterization of the L5.1-L15.1 tertiary contact and antisense inhibition. RNA 22:1699-1709 (2016).

Walczyk, D., Gößringer, M., Rossmanith, W., Zatsepin, T.S., Oretskaya, T.S. and Hartmann, R.K. Analysis of the Cleavage Mechanism by Protein-Only RNase P Using Precursor tRNA Substrates with Modifications at the Cleavage Site.
J Mol Biol 428:4917-4928 (2016).

Brillante, N., Gößringer, M., Lindenhofer, D., Toth, U., Rossmanith, W. and Hartmann, R.K. Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P. Nucleic Acids Res 44:2323-2336 (2016).

Lechner, M., Rossmanith, W., Hartmann, R.K., Thölken, C., Gutmann, B., Giegé, P. and Gobert, A. Distribution of Ribonucleoprotein and Protein-Only RNase P in Eukarya. Mol Biol Evol 32:3186-3193 (2015).

Kooperationspartner

Prof. W. Rossmanith, Wien; Prof. A. Marchfelder, Ulm; Prof. W. Diederich/Prof. M. Schlitzer/Prof. K. Reuter (Marburg)

Ansprechpartner

M. Gößringer, R.K. Hartmann