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Publikationen

20 | Morales-Pastor A, Miljuš T, Dieguez-Eceolaza M, Stępniewski TM, Vicente Ledesma, Heydenreich FM, Flock T, Plouffe B, Le Gouill C, Duchaine J, Sykes DA, Nicholson C, Koers EJ, Guba W, Rufer AC, Grether U, Bouvier M, Veprintsev DB, Selent J.
Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R.
Nature communications 2025 16:5265. https://doi.org/10.1038/s41467-025-60003-0

19 | Heydenreich FM, Marti-Solano M, Sandhu M, Kobilka BK, Bouvier M, Babu MM.
Molecular Determinants of Ligand Efficacy and Potency in GPCR Signaling.
Science 2023, 382 (6677), eadh1859. https://doi.org/10.1126/science.adh1859.

18 | Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, Zastrow M von, Inoue A, Kobilka BK.
Membrane Phosphoinositides Regulate GPCR-β-Arrestin Complex Assembly and Dynamics.
Cell 2022, 185 (24), 4560-4573.e19. https://doi.org/10.1016/j.cell.2022.10.018.

17 | Paradis JS, Feng X, Murat B, Jefferson RE, Sokrat B, Szpakowska M, Hogue M, Bergkamp ND, Heydenreich FM, Smit MJ, Chevigné A, Bouvier M, Barth P.
Computationally Designed GPCR Quaternary Structures Bias Signaling Pathway Activation.
Nat. Commun. 2022, 13 (1), 6826. https://doi.org/10.1038/s41467-022-34382-7.

16 | Heydenreich FM, Plouffe B, Rizk A, Milic D, Zhou J, Breton B, Gouill CL, Inoue A, Bouvier M, Veprintsev D. 
Michaelis-Menten Quantification of Ligand Signalling Bias Applied to the Promiscuous Vasopressin V2 Receptor.
Mol. Pharmacol. 2022. https://doi.org/10.1124/molpharm.122.000497.

15 | Hedderich JB, Persechino M, Becker K, Heydenreich FM, Gutermuth T, Bouvier M, Bünemann M, Kolb P.
The Pocketome of G-Protein-Coupled Receptors Reveals Previously Untargeted Allosteric Sites.
Nat. Commun. 2022, 13 (1), 2567. https://doi.org/10.1038/s41467-022-29609-6.

14 | Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE.
GPCR Activation Mechanisms across Classes and Macro/Microscales.
Nat. Struct. Mol. Biol. 2021, 28 (11), 879–888. https://doi.org/10.1038/s41594-021-00674-7.

13 | Harwood CR, Sykes DA, Hoare BL, Heydenreich FM, Uddin R, Poyner DR, Briddon SJ, Veprintsev DB.
Functional Solubilization of the Β2-Adrenoceptor Using Diisobutylene Maleic Acid.
iScience 2021, 24 (12). https://doi.org/10.1016/j.isci.2021.103362.

12 | Latorraca NR, Masureel M, Hollingsworth SA, Heydenreich FM, Suomivuori CM, Brinton C, Townshend RJL, Bouvier M, Kobilka BK, Dror RO.
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
Cell 2020, 183 (7), 1813-1825.e18. https://doi.org/10.1016/j.cell.2020.11.014.

11 | Heydenreich, F. M.; Miljus, T.; Milic, D.; Veprintsev, D. B.
High-Throughput Site-Directed Scanning Mutagenesis Using a Two-Fragment PCR Approach.
Bio-protocol 2020, 10 (01), e3484. https://doi.org/10.21769/BioProtoc.3484

10 | Heydenreich FM, Miljus T, Milic D, Veprintsev DB.
High-Throughput Mutagenesis Using a Two-Fragment PCR Approach.
Sci. Rep. 2017, 7 (1), 6787. https://doi.org/10.1038/s41598-017-07010-4.

9 | Gosztolai A, Schumacher J, Behrends V, Bundy JG, Heydenreich F, Bennett MH, Buck M, Barahona M.
GlnK Facilitates the Dynamic Regulation of Bacterial Nitrogen Assimilation.
Biophys. J. 2017, 112 (10), 2219–2230. https://doi.org/10.1016/j.bpj.2017.04.012.

8 | Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M.
A New Inhibitor of the β-Arrestin/AP2 Endocytic Complex Reveals Interplay between GPCR Internalization and Signalling.
Nat. Commun. 2017, 8 (1), 15054. https://doi.org/10.1038/ncomms15054.

7 | Venkatakrishnan AJ, Deupi X, Lebon G, Heydenreich FM, Flock T, Miljus T, Balaji S, Bouvier M, Veprintsev DB, Tate CG, Schertler GFX, Babu MM.
Diverse Activation Pathways in Class A GPCRs Converge near the G-Protein-Coupling Region.
Nature 2016, 536 (7617), 484–487. https://doi.org/10.1038/nature19107.

6 | Thomsen ARB, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Cell 2016, 166 (4), 907–919. https://doi.org/10.1016/j.cell.2016.07.004.

5 | Isogai S, Deupi X, Opitz C, Heydenreich FM, Tsai CJ, Brueckner F, Schertler GFX, Veprintsev DB, Grzesiek S.
Backbone NMR Reveals Allosteric Signal Transduction Networks in the β1-Adrenergic Receptor.
Nature 2016, 530 (7589), 237–241. https://doi.org/10.1038/nature16577.

4 | Heydenreich FM, Vuckovic Z, Matkovic M, Veprintsev DB.
Stabilization of G Protein-Coupled Receptors by Point Mutations.
Front. Pharmacol. 2015, 6. https://doi.org/10.3389/fphar.2015.00082.

3 | Schumacher J, Behrends V, Pan Z, Brown DR, Heydenreich F, Lewis MR, Bennett MH, Razzaghi B, Komorowski M, Barahona M, Stumpf MPH, Wigneshweraraj S, Bundy JG, Buck M.
Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo.
mBio 2013, 4 (6), 10.1128/mbio.00881-13. https://doi.org/10.1128/mbio.00881-13.

2 | Sun D, Ostermaier MK, Heydenreich FM, Mayer D, Jaussi R, Standfuss J, Veprintsev DB. AAscan, PCRdesign and MutantChecker:
A Suite of Programs for Primer Design and Sequence Analysis for High-Throughput Scanning Mutagenesis.
PLOS ONE 2013, 8 (10), e78878. https://doi.org/10.1371/journal.pone.0078878.

1 | Delley CL, Striebel F, Heydenreich FM, Özcelik D, Weber-Ban E.
Activity of the Mycobacterial Proteasomal ATPase Mpa Is Reversibly Regulated by Pupylation.
J. Biol. Chem. 2012, 287 (11), 7907–7914. https://doi.org/10.1074/jbc.M111.331124.