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Ausgewählte Publikationen
Till K, Borchers A, The Rho GEF Trio functions in contact inhibition of locomotion of neural crest cells by interacting with Ptk7
Development. 2025 May 1;152(9):dev204446. doi: 10.1242/dev.204446. Epub 2025 May 6. PMID: 40326503
Preußner M, Bischoff M, Önel SF, mir-276a Is Required for Muscle Development in Drosophila and Regulates the FGF Receptor Heartless During the Migration of Nascent Myotubes in the Testis Cells. 2025 Mar 3;14(5):368. doi: 10.3390/cells14050368
Gossen S, Gerstner S, Borchers A, The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells Cells Dev. 2024 Mar;177:203899. doi: 10.1016/j.cdev.2023.203899. Epub 2023 Dec 30.
Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB. (2022). The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x.
Pauli S, Berger H, Ufartes R, Borchers A (2021). Comparing a Novel Malformation Syndrome Caused by Pathogenic Variants in FBRSL1 to AUTS2 Syndrome. Front Cell Dev Biol. 2021 Nov 5;9:779009. doi: 10.3389/fcell.2021.779009. eCollection 2021.
Grund A, Till K, Giehl K, Borchers A (2021). Ptk7 Is Dynamically Localized at Neural Crest Cell-Cell Contact Sites and Functions in Contact Inhibition of Locomotion. Int J Mol Sci. 2021 Aug 28;22(17):9324. doi: 10.3390/ijms22179324
Schwenty-Lara J, Pauli S, Borchers A (2020). Using Xenopus to analyze neurocristopathies like Kabuki syndrome. Genesis. Dec 22:e23404. doi: 10.1002/dvg.23404. Online ahead of print.
Breuer M, Berger H, Borchers A (2020). Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development. Sci Rep. 10(1):16446. doi: 10.1038/s41598-020-73429-x
Kratzer, MC, Becker SFS, Grund A, Merks A, Harnos J, Bryja V, Giehl K, Kashef J and Borchers A (2020). The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development 147 (10), doi: 10.1242/dev.186338
Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmuller J, Nurnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A*, Pauli S* (2020). De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome. Hum Genet Nov;139(11):1363-1379. doi: 10.1007/s00439-020-02175-x. Epub 2020 May 18. (*shared corresponding authors)
Schwenty-Lara J, Nehl D, Borchers A (2020). The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. Hum Mol Genet 29, 305-319.
Kratzer MC, England L, Apel D, Hassel M, Borchers A (2019). Evolution of the Rho guanine nucleotide exchange factors Kalirin and Trio and their gene expression in Xenopus development. Gene Expr Patterns 32, 18-27.
Schwenty-Lara J, Nurnberger A, Borchers A (2019). Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn 248, 465-476.
(2018). Sema3a plays a role in the pathogenesis of CHARGE syndrome. Hum Mol Genet. 2018 Apr 15;27(8):1343-1352. doi: 10.1093/hmg/ddy045. (*shared corresponding authors)
Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A (2017). PTK7 localization and protein stability is affected by canonical Wnt ligands. J Cell Sci 130, 1890- 1903.
Maj E, Kunneke L, Loresch E, Grund A, Melchert J, Pieler T, Aspelmeier T, Borchers A (2016). Controlled levels of canonical Wnt signaling are required for neural crest migration. Dev Biol 417, 77-90.
Podleschny M, Grund A, Berger H, Rollwitz E, Borchers A (2015). A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration. Plos One 10, e0145169.
Schulz Y, Wehner P, Opitz L, Salinas-Riester G, Bongers EM, van Ravenswaaij-Arts CM, Wincent J, Schoumans J, Kohlhase J, Borchers A, Pauli S (2014). CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance. Hum Genet 133: 997-1009.
Wehner P, Shnitsar I, Urlaub H, Borchers A (2011). RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure. Development 138, 1321-1327.
Peradziryi H, Kaplan NA, Podleschny M, Liu X, Wehner P, Borchers A*, Tolwinski NS* (2011). PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J 30, 3729-3740. (*co-corresponding authors)
Shnitsar I, Borchers A (2008). PTK7 recruits dsh to regulate neural crest migration. Development 135, 4015-4024.
Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M (2004). PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430, 93-98.