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Publikationen Alexander Visekruna

Short-chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells. Luu M, Visekruna A. Eur J Immunol. 2019 Jun;49(6):842-848. doi: 10.1002/eji.201848009. Epub 2019 May 17.

Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. J Clin Invest. 2019 Apr 2;130:1972-1983. doi: 10.1172/JCI98929. eCollection 2019 Apr 2.

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A. Nat Commun. 2019 Feb 15;10(1):760. doi: 10.1038/s41467-019-08711-2.

Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate. Luu M, Weigand K, Wedi F, Breidenbend C, Leister H, Pautz S, Adhikary T, Visekruna A. Sci Rep. 2018 Sep 26;8(1):14430. doi: 10.1038/s41598-018-32860-x.

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites. Unger A, Finkernagel F, Hoffmann N, Neuhaus F, Joos B, Nist A, Stiewe T, Visekruna A, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R, Adhikary T. Front Immunol. 2018 Jun 27;9:1425. doi: 10.3389/fimmu.2018.01425. eCollection 2018.

IL-17 and TNF-? Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation. Alnahas S, Hagner S, Raifer H, Kilic A, Gasteiger G, Mutters R, Hellhund A, Prinz I, Pinkenburg O, Visekruna A, Garn H, Steinhoff U. Front Immunol. 2017 Nov 14;8:1562. doi: 10.3389/fimmu.2017.01562. eCollection 2017.

Functional heterogeneity of gut-resident regulatory T cells. Luu M, Steinhoff U, Visekruna A. Clin Transl Immunology. 2017 Sep 22;6(9):e156. doi: 10.1038/cti.2017.39. eCollection 2017 Sep.

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells. Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A. Front Immunol. 2017 Aug 28;8:1036. doi: 10.3389/fimmu.2017.01036. eCollection 2017.

Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells. Luu M, Jenike E, Vachharajani N, Visekruna A. Oncotarget. 2017 Apr 13;8(32):52678-52689. doi: 10.18632/oncotarget.17079. eCollection 2017 Aug 8.

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Vachharajani N, Joeris T, Luu M, Hartmann S, Pautz S, Jenike E, Pantazis G, Prinz I, Hofer M, Steinhoff U, Visekruna A. Oncotarget. 2017 Jan 10;8(31):50447-50459. doi: 10.18632/oncotarget.14579. eCollection 2017 Aug 1.

c-REL and I?BNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors. Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Huehn J, Schmitz I. J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub 2017 Jun 26.

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M. Nat Commun. 2015 Oct 13;6:8576. doi: 10.1038/ncomms9576.

IKK-induced NF-?B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC. J Exp Med. 2014 Sep 22;211(10):2085-101. doi: 10.1084/jem.20132019. Epub 2014 Sep 15.

Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, Joeris T, Pfefferle PI, Hofer MJ, Steinhoff U. Mucosal Immunol. 2015 Mar;8(2):307-15. doi: 10.1038/mi.2014.68. Epub 2014 Aug 6.
Heterogeneity in the differentiation and function of CD8? T cells. Mittrücker HW, Visekruna A, Huber M. Arch Immunol Ther Exp (Warsz). 2014 Dec;62(6):449-58. doi: 10.1007/s00005-014-0293-y. Epub 2014 May 31.

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. Mittrücker HW, Seidel D, Bland PW, Zarzycka A, Kaufmann SH, Visekruna A, Steinhoff U. Eur J Immunol. 2014 Jun;44(6):1710-5. doi: 10.1002/eji.201343927. Epub 2014 Mar 20.

rKLO8, a novel Leishmania donovani - derived recombinant immunodominant protein for sensitive detection of visceral leishmaniasis in Sudan. Abass E, Bollig N, Reinhard K, Camara B, Mansour D, Visekruna A, Lohoff M, Steinhoff U. PLoS Negl Trop Dis. 2013 Jul 18;7(7):e2322. doi: 10.1371/journal.pntd.0002322. Print 2013.

Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31.

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10.

The role of NF-?B activation during protection against Leishmania infection. Reinhard K, Huber M, Lohoff M, Visekruna A. Int J Med Microbiol. 2012 Oct;302(4-5):230-5. doi: 10.1016/j.ijmm.2012.07.006. Epub 2012 Aug 14.

The proteasome system in infection: impact of ?5 and LMP7 on composition, maturation and quantity of active proteasome complexes. Joeris T, Schmidt N, Ermert D, Krienke P, Visekruna A, Kuckelkorn U, Kaufmann SH, Steinhoff U. PLoS One. 2012;7(6):e39827. doi: 10.1371/journal.pone.0039827. Epub 2012 Jun 29.

A key role for NF-?B transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Visekruna A, Volkov A, Steinhoff U. Clin Dev Immunol. 2012;2012:239368. doi: 10.1155/2012/239368. Epub 2012 Mar 6.

Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease? Lawrenz M, Visekruna A, Kühl A, Schmidt N, Kaufmann SH, Steinhoff U. Mucosal Immunol. 2012 Mar;5(2):129-39. doi: 10.1038/mi.2011.57. Epub 2011 Dec 7.

Reinhard K, Huber M, Wostl C, Hellhund A, Toboldt A, Abass E, Casper B, Joeris T, Herr C, Bals R, Steinhoff U, Lohoff M, Visekruna A. Eur J Immunol. 2011 May;41(5):1388-98. doi: 10.1002/eji.201041056. Epub 2011 Apr 11.

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. Schmidt N, Gonzalez E, Visekruna A, Kühl AA, Loddenkemper C, Mollenkopf H, Kaufmann SH, Steinhoff U, Joeris T. Gut. 2010 Jul;59(7):896-906. doi: 10.1136/gut.2009.203554.

NALP expression in Paneth cells provides a novel track in IBD signaling. Slavova N, Drescher A, Visekruna A, Dullat S, Kroesen AJ, Ritz JP, Buhr HJ. Langenbecks Arch Surg. 2010 Apr;395(4):351-7. doi: 10.1007/s00423-010-0611-8. Epub 2010 Mar 24.

c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Visekruna A, Huber M, Hellhund A, Bothur E, Reinhard K, Bollig N, Schmidt N, Joeris T, Lohoff M, Steinhoff U. Eur J Immunol. 2010 Mar;40(3):671-6. doi: 10.1002/eji.200940260.

Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma. Lauscher JC, Gröne J, Dullat S, Hotz B, Ritz JP, Steinhoff U, Buhr HJ, Visekruna A. Mol Carcinog. 2010 Feb;49(2):121-9. doi: 10.1002/mc.20606.

Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. Hotz B, Visekruna A, Buhr HJ, Hotz HG. J Gastrointest Surg. 2010 Feb;14(2):388-97. doi: 10.1007/s11605-009-1068-3. Epub 2009 Oct 24.