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Die besten Publikationen der Klinischen Forschung 2020

 

Institut für Laboratoriumsmedizin und Pathobiochemie

Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, Schmausser-Hechfellner E, Roduit C, Frei R, Lauener R, Divaret-Chauveau A, Dalphin JC, Riedler J, Roponen M, Kabesch M, Renz H, Pekkanen J, Farquharson FM, Louis P, Mills DA, von Mutius E; PASTURE study group, Ege MJ (2020) Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med 26(11):1766-1775

Thysen AH, Waage J, Larsen JM, Rasmussen MA, Stokholm J, Chawes B, Fink NR, Pedersen TM, Wolsk H, Thorsteinsdottir S, Litman T, Renz H, Bønnelykke K, Bisgaard H, Brix S (2020) Distinct immune phenotypes in infants developing asthma during childhood. Sci Transl Med 12(529): eaaw0258

 

Klinik für Innere Medizin, Schwerpunkt für Gastroenterologie

Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman E, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium (2020) Management of patients with increased risk for familial pancreatic cancer. Gut 69(1):7-17

 

Klinik für Innere Medizin, Schwerpunkt für Hämatologie, Onkologie und Immunologie

Röllig C, Kramer M, Schliemann C, Mikesch J-H, Steffen B, Krämer A, Noppeney R, Schäfer-Eckart K, Krause SW, Hänel M, Herbst R, Kunzmann V , Einsele H, Jost E,  Brümmendorf TH , Scholl S, Hochhaus A , Neubauer A, Sohlbach K, Fransecky L, Kaufmann M, Niemann D, Schaich M, Frickhofen N, Kiani A, Heits F, Krümpelmann U, Kaiser U, Kullmer J , Wass M, Stölzel F, von Bonin M, Middeke JM, Thiede C, Schetelig J, Berdel WE, Ehninger G, Baldus CD, Müller-Tidow C, Platzbecker U, Serve H, Bornhäuser M (2020) Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia? Blood 136(7):823-830 

Lubbert M, Grishina O, Schmoor C, Schlenk RF, Jost E, Crysandt M, Heuser M, Thol F, Salih HR, Schittenhelm MM, Germing U, Kuendgen A, Gotze KS, Lindemann H-W, Muller-Tidow C, Heil G, Scholl S, Bug G, Schwaenen C, Giagounidis A, Neubauer A, Krauter J, Brugger W, De Wit M, Wasch R, Becker H, May AM, Duyster J, Dohner K,  Ganser A, Hackanson B, Dohner H, on behalf of the DECIDER Study Team (2020) Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial. J Clin Oncol 38(3):257-270

Cortés J, Diéras V, Lorenzen S, Montemurro F, Riera-Knorrenschild J, Thuss-Patience P, Allegrini G, De Laurentiis M, Lohrisch C, Oravcová E, Perez-Garcia JM, Ricci F, Sakaeva D, Serpanchy R, Šufliarský J, Vidal M, Irahara N, Wohlfarth C, Aout M, Gelmon K (2020) Efficacy and Safety of Trastuzumab Emtansine Plus Capecitabine vs Trastuzumab Emtansine Alone in Patients With Previously Treated ERBB2 (HER2)-PositiveMetastatic Breast Cancer A Phase 1 and Randomized Phase 2 Trial. JAMA Oncol  6(8): 1–7

 

Klinik für Innere Medizin, Schwerpunkt für Kardiologie

Vlacil AK, Schuett J, Ruppert V, Soufi M, Oberoi R, Shahin K, Wächter C, Tschernig T, Lei Y, Liu F, Tietge UJF, Schieffer B, Schuett H, Grote K (2020) Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis. Basic Res Cardiol 115(4):47

 

Klinik für Innere Medizin, Schwerpunkt für Pneumologie

Fehlmann T, Kahraman M, Ludwig N, Backes C, Galata V, Keller V, Geffers L, Mercaldo N, Hornung D, Weis T, Kayvanpour E, Abu-Halima M, Deuschle C, Schulte C, Suenkel U, von Thaler A-K, Maetzler W, Herr C, Fähndrich S, Vogelmeier C, Guimaraes P, Hecksteden A, Meyer T, Metzger F, Diener C, Deutscher S, Abdul-Khaliq H, Stehle I, Haeusler S, Meiser A, Groesdonk HV, Volk T, Lenhof H-P, Katus H, Balling R, Meder B, Kruger R, Huwer H, Bals R, Meese E, Keller A (2020) Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA Oncol 6(5): 714-723

 

Klinik für Neurochirurgie

Lamberink HJ, Otte WM, Blümcke I, Braun KPJ; European Epilepsy Brain Bank writing group; study group; European Reference Network EpiCARE:…, Nimsky C, Carl, B…  (2020) Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. Lancet Neurol 19(9):748-757

 

Klinik für Visceral-, Thorax- und Gefäßchirurgie

Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel (2020) Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International. Gut 69(1):7-17

 

Klinik für Hals-, Nasen- und Ohrenheilkunde

Faughnan ME, Mager JJ, Hetts SW, Palda VA, Lang-Robertson K, Buscarini E, Deslandres E, Kasthuri RS, Lausman A, Poetker D, Ratjen F, Chesnutt MS, Clancy M, Whitehead KJ, Al-Samkari H, Chakinala M, Conrad M, Cortes D, Crocione C, Darling J, de Gussem E, Derksen C, Dupuis-Girod S, Foy P, Geisthoff U, Gossage JR, Hammill A, Heimdal K, Henderson K, Iyer VN, Kjeldsen AD, Komiyama M, Korenblatt K, McDonald J, McMahon J, McWilliams J, Meek ME, Mei-Zahav M, Olitsky S, Palmer S, Pantalone R, Piccirillo JF, Plahn B, Porteous MEM, Post MC, Radovanovic I, Rochon PJ, Rodriguez-Lopez J, Sabba C, Serra M, Shovlin C, Sprecher D, White AJ, Winship I, Zarrabeitia R (2020) Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia. Ann Intern Med 173(12):989-1001

 

Klinik für Kinder- und Jugendmedizin

Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators (2020) Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial. JAMA 324(6):560-570

 

Klinik für Psychiatrie und Psychotherapie

Yang Y, Lueken U, Richter J, Hamm A, Wittmann A, Konrad C, Ströhle A, Pfleiderer B, Herrmann MJ, Lang T, Lotze M, Deckert J, Arolt V, Wittchen HU, Straube B*, Kircher T* (2020) Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study using Semantic Priming. Am J Psychiatry 177(3):254-264, *geteilte Letztautorenschaft

Kamitaki N, Sekar A, Handsaker RE, de Rivera H, Tooley K, Morris DL, Taylor KE, Whelan CW, Tombleson P, Loohuis LMO; Schizophrenia Working Group of the Psychiatric Genomics Consortium: …Nenadic I…, Boehnke M, Kimberly RP, Kaufman KM, Harley JB, Langefeld CD, Seidman CE, Pato MT, Pato CN, Ophoff RA, Graham RR, Criswell LA, Vyse TJ, McCarroll SA (2020) Complement genes contribute sex-biased vulnerability in diverse disorders. Nature 582:577-581

Grasby KL, Jahanshad N, Painter JN, […], Krug A, […], Kircher TTJ, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA) - Genetics working group (2020) The genetic architecture of the human cerebral cortex. Science 367 (6484): eaay6690

 

Klinik für Neurologie

Ruppert MC, Greuel A, Tahmasian M, Schwartz F, Stürmer S, Maier F, Hammes J, Tittgemeyer M, Timmermann L, van Eimeren T, Drzezga A, Eggers C (2020) Network degeneration in Parkinson's disease: multimodal imaging of nigro-striato-cortical dysfunction. Brain 143(3):944-959

Lamberink HJ, Otte WM, Blumcke I, Braun KPJ, Europeam Epilepsy Brain Bank Writing Group…, Knake S, Menzler K… (2020) Seizure outcome and use of antepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. Lancet Neurology 19 (9) 748-757

 

Koordinierungszentrum für Klinische Studien – KKS

Pfisterer J, Shannon CM, Baumann K, Rau J, Harter P, Joly F, Sehouli J, Canzler U, Schmalfeldt B, Dean AP, Hein A, Zeimet AG, Hanker LC, Petit T, Marmé F, El-Balat A, Glasspool R, de Gregorio N, Mahner S, Meniawy TM, Park-Simon T-W, Mouret-Reynier A, Costan C, Meier W, Reinthaller A, Goh JC, L'Haridon T, S. Hay SB, Kommoss S, du Bois A, Kurtz J-E (2020) Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial. Lancet Oncol 21(5):699-709

 

 

Auswahlkriterien:

Originalarbeit, Erst- oder Letztautor und Journal Impact Faktor > 7,5 oder

Originalarbeit, Mitautorenschaft und Journal Impact Faktor > 14