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Synthetic Ion Channels

Ion channels perform key tasks in biological systems such as neuronal signaling, muscular control, and sensing. Malfunctions cause serveral serve or common diseases. We synthesize new membrane-bound ion channels and cooperate with biochemical orientated groups to synthesize hybrid channels for studying their function (charge transport) to understand the functionality. A derivatization may include adding permanent charges, filters oder photo switchable groups and leads to the control of key characteristics like selectivity, dwell times and gating.

Foto: Philipp Reiß

  1. Josefine Kahlstatt, Philipp Reiß, Thomas Halbritter, Lars-Oliver Essen, Ulrich Koert,  Alexander Heckel " A light-triggered transmembrane porin", Chem. Comm., 2018, 9623-9626.

  2. Wolfgang Grosse, Georgios Psakis, Barbara Mertins, Philipp Reiß, Dirk Windisch, Felix Brademann, Jochen Bürck, Anne S. Ulrich, Ulrich Koert and Lars-Oliver Essen, "Structure-based engineering of a minimal porin reveals loop-independent channel closure", Biochemistry 2014, 53, 4826-4838.

  3. Philipp Reiß and Ulrich Koert, "Ion-Channels: Goals for Function-Oriented Synthesis", Acc. Chem. Res., 2013, 46, 2773-2780.

  4. Simon Reitz, Menekse Cebi, Philipp Reiß, Gregor Studnik, Uwe Linne, Ulrich Koert and Lars-Oliver Essen "On the Function and Structure of Synthetically Modified Porins", Angew. Chem. 2009, 121, 4947-4951.