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Klassifizierung der altersabhängigen Makuladegeneration durch Biomarker

Classification of Age-related Macular degeneration by Biomarkers)

Age-related macular degeneration (AMD) is a widespread disease that poses many challenges in terms of therapy due to its different manifestations and pathomechanisms.

CAMBio is a case-control study to investigate extracellular vesicles and immunological marker profiles ex vivo in aqueous humour samples from AMD patients and controls. The study aims to improve stratification of AMD patients by grouping them based on genetic AMD risk profile in addition to epidemiological and phenotypic classification based on retinal morphology.
The aim of CAMBio is to identify biomarkers and therapeutic target proteins in the aqueous humour that can be used for prospective and early diagnosis as well as pathogenesis and therapy monitoring. In addition, the study offers the opportunity to verify results from basic research on the development of AMD. Based on the findings of the study, new drugs can be developed in a targeted manner in the future and the problem of AMD therapy can be addressed.

Project Partners:
Juliane Schikora
Philipps-Universität Marburg
Augenklinik - Experimentelle Ophthalmologie

Prof. Dr. Diana Pauly
Philipps-Universität Marburg
Augenklinik - Experimentelle Ophthalmologie

Funded by the Freifrau-von-Nauendorf-Stiftung.