Hauptinhalt

Publikationen

2017

Minimal and RNA-free RNase P in Aquifex aeolicus
A. I. Nickel, B. N. Wäber, M. Gößringer, M. Lechner, U. Linne, U. Tothc, W. Rossmanith, R. K. Hartmann
PNAS. 2017 Oct EE publication. doi: 10.1073/pnas.1707862114

6S RNA in Rhodobacter sphaeroides: 6S RNA and pRNA transcript levels peak in late exponential phase and gene deletion causes a high salt stress phenotype
D. Elkina, L. Weber, M. Lechner, O. Burenina, A. Weisert, E. Kubareva, R. K. Hartmann, G. Klug
RNA Biol. 2017 Jul 10:1-11. doi: 10.1080/15476286.2017.1342933.

Protein-only RNase P function in Escherichia coli: viability, processing defects and differences between PRORP isoenzymes
M. Gößringer, M. Lechner, N. Brillante, C. Weber, W. Rossmanith, R. K. Hartmann
Nucleic Acids Res. 2017 Jul 7;45(12):7441-7454.; doi: 10.1093/nar/gkx405.

Silvestrol: a potential future drug for acute Ebola and other viral infections
A. Grünweller, R. K. Hartmann
Future Virology. 2017 May 12; 5 243-245.  

Silvestrol: Ein pflanzlicher Naturstoff mit antiviraler Wirkung
A. Grünweller, K. Lange-Grünweller, F. W. Schulte, R. K. Hartmann
Pharmakon, 2017; 2, 93-94.

Diverse Applications of Nanomedicine
B. Pelaz B, ... A. Grünweller, ... R. K. Hartmann, ... W. J. Parak
ACS Nano. 2017 Mar 28;11(3):2313-2381. doi: 10.1021/acsnano.6b06040. Epub 2017 Mar 14.

The natural compound silvestrol is a potent inhibitor of Ebola virus replication.
N. Biedenkopf, K. Lange-Grünweller, F. W. Schulte, A. Weißer, C. Müller, D. Becker, S. Becker, R. K. Hartmann, A. Grünweller
Antiviral Res. 2017 Jan;137:76-81. doi: 10.1016/j.antiviral.2016.11.011. Epub 2016 Nov 15.

2016

The conserved dcw gene cluster of R. sphaeroides is preceded by an uncommonly extended 5' leader featuring the sRNA UpsM
L. Weber, C. Thoelken, M. Volk, B. Remes, M. Lechner, G. Klug
PLoS One. 2016 Nov 1;11(11):e0165694. doi: 10.1371/journal.pone.0165694. eCollection 2016.

Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P
N. Brillante, M. Gößringer, D. Lindenhofer, U. Toth, W. Rossmanith, R. K. Hartmann
Nucleic acids research. 2016 Mar; DOI:10.1093/nar/gkw080

RNA binding specificity of Ebola virus transcription factor VP30
J. Schlereth, A. Grünweller, N. Biedenkopf, S. Becker, R. K. Hartmann
RNA biology. 2016 Jun; 13(9); DOI:10.1080/15476286.2016.1194160

RNA-binding of Ebola virus VP30 is essential for activating viral transcription
N. Biedenkopf, J. Schlereth, A. Grünweller, S. Becker, R. K. Hartmann
Journal of virology. 2016 Jun; DOI:10.1128/JVI.00271-16

Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents
P. Mäder, A. S. Blohm, T. Quack, K. Lange-Grünweller, A. Grünweller, R. K. Hartmann, C. G. Grevelding, M. Schlitzer
ChemMedChem. 2016 Jul; 11(13); DOI:10.1002/cmdc.201600127

Chemical modification of nucleic acids as a key technology for the development of RNA-based therapeutics.
A. Grünweller, R. K. Hartmann
Die Pharmazie. 2016 Jan;

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems
P. Kanrai, A. Mostafa, R. Madhugiri, M. Lechner, E. Wilk, K. Schughart, L. Ylösmäki, K. Saksela, J. Ziebuhr, S. Pleschka
The Journal of general virology. 2016 Jul; DOI:10.1099/jgv.0.000542

Bacillus subtilis 6S-2 RNA serves as a template for short transcripts in vivo
P. G. Hoch, J. Schlereth, M. Lechner, R. K. Hartmann
RNA. 2016 Apr; 22(4); DOI:10.1261/rna.055616.115

2015

Distribution of Ribonucleoprotein and Protein-only RNase P in Eukarya
M. Lechner, W. Rossmanith, R. K. Hartmann, C. Thölken, B. Gutmann, P. Giegé, A. Gobert
Molecular biology and evolution. 2015 Sep; 32(12); DOI:10.1093/molbev/msv187

Phenotypic characterization and complementation analysis of Bacillus subtilis 6S RNA single and double deletion mutants
Philipp. G. Hoch, O. Y. Burenina, M. H. W. Weber, D. A. Elkina, M. V. Nesterchuk, P. V. Sergiev, R. K. Hartmann, E. A. Kubareva
Biochimie. 2015 Jan; DOI:10.1016/j.biochi.2014.12.019

Structural and mechanistic characterization of 6S RNA from the hyperthermophilic bacterium Aquifex aeolicus
K. Köhler, E. Duchardt-Ferner, M. Lechner, K. Damm, P. G. Hoch, M. Salas, R. K. Hartmann
Biochimie. 2015 Mar; DOI:10.1016/j.biochi.2015.03.004

Impact of RNA isolation protocols on RNA detection by Northern Blotting
K. Damm, S. Bach, K. M. H. Müller, G. Klug, O. Y. Burenina, E. A. Kubareva, A. Grünweller, R. K. Hartmann
Methods Mol Biol. 2015 ; DOI: 10.1007/978-1-4939-2547-6_4

Improved Northern Blot Detection of Small RNAs Using EDC Crosslinking and DNA/LNA Probes
K. Damm, S. Bach, K. M. H. Müller, G. Klug, O. Y. Burenina, E. A. Kubareva, A. Grünweller, R. K. Hartmann
Methods Mol Biol. 2015 ; DOI:10.1007/978-1-4939-2547-6_5

2014

Playing RNase P Evolution: Swapping the RNA Catalyst for a Protein Reveals Functional Uniformity of Highly Divergent Enzyme Forms
C. Weber, A. Hartig, RK. Hartmann, W. Rossmanith
PLoS Genet. 2014 Aug 7; DOI:10.1371/journal.pgen.1004506

Dissemination of 6S RNA among Bacteria
S. Wehner, K. Damm, R. K. Hartmann, M. Marz
RNA biology. 2014 Oct; DOI:10.4161/rna.29894

Regulation of transcription by 6S RNAs: Insights from the Escherichia coli and Bacillus subtilis model systems
B. Steuten, P. G. Hoch, K. Damm, S. Schneider, K. Köhler, R. Wagner, R. K. Hartmann
RNA Biol. 2014 Apr; DOI:10.4161/rna.28827

Supramolecular membrane-associated assemblies of RNA metabolic proteins in Escherichia coli
P. G. Hoch, R. K. Hartmann
Biochem J. 2014 Feb; DOI:10.1042/BJ20131676

Mechanistic comparison of Bacillus subtilis 6S-1 and 6S-2 RNAs - commonalities and differences
O. Y. Burenina, P. G. Hoch, K. Damm, M. Salas, T. S. Zatsepin, M. Lechner, T. S. Oretskaya, E. A. Kubareva, R. K. Hartmann
RNA. 2014 Jan; DOI:10.1261/rna.042077.113

Orthology Detection Combining Clustering and Synteny for Very Large Data Sets
M. Lechner, M. Hernandez-Rosales, D. Doerr, N. Wieseke, A. Thévenin, J. Stoye, R. K. Hartmann, S. J. Prohaska, P. F. Stadler
PLoS One. 2014 Aug; DOI:10.1371/journal.pone.0105015

Genomewide comparison and novel ncRNAs of Aquificales
M. Lechner, A. I. Nickel, S. Wehner, K. Riege, N. Wieseke, B. M. Beckmann, R. K. Hartmann, M. Marz
BMC Genomics. 2014 Jun; DOI:10.1186/1471-2164-15-522

2013

Von der RNA- zur Protein-Welt
Walczyk, D and Hartmann, R K
q&more 2013;

Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma
U. Weirauch, N. Beckmann, M. Thomas, A. Grünweller, K. Huber, F. Bracher, R. K. Hartmann, A. Aigner
Neoplasia. 2013 Jul; PMC3689241

Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1
M. Thomas, K. Lange-Grünweller, D. Hartmann, L. Golde, J. Schlereth, D. Streng, A. Aigner, A. Grünweller, R. K. Hartmann
Int J Mol Sci. 2013 ; DOI:10.3390/ijms140612273

Structure of an A-form RNA duplex obtained by degradation of 6S RNA in a crystallization droplet
J. Kondo, A. C. Dock-Bregeon, D. K. Willkomm, R. K. Hartmann, E. Westhof
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun; DOI:10.1107/S1744309113013018

U1 Adaptors for the Therapeutic Knockdown of the Oncogene Pim-1 Kinase in Glioblastoma
U. Weirauch, A. Grünweller, L. Cuellar, R. K. Hartmann, A. Aigner
Nucleic Acid Ther. 2013 Jun; DOI10.1089/nat.2012.0407

Pomago: Multiple Genome-wide Alignment Tool for Bacteria
Wieseke, N and Lechner, M and Ludwig, M and Marz, M
Bioinformatics Research and Applications, Lecture Notes in Computer Science. 2013;

The Correlation of Genome Size and DNA Methylation Rate in Metazoans
M. Lechner, M. Marz, C. Ihling, A. Sinz, P. F. Stadler, V. Krauss
Theory Biosci. 2013 Mar; DOI:10.1007/s12064-012-0167-y

2012

3`-UTRs as a source of regulatory RNAs in bacteria
M. Hartmann. RK. Gößringer
EMBO J. 2012 Oct 17; DOI:10.1038/emboj.2012.269

tRNA Processing by Protein-Only versus RNA-Based RNase P: Kinetic Analysis Reveals Mechanistic Differences
L. V. Pavlova, M. Gößringer, C. Weber, A. Buzet, W. Rossmanith, R. K. Hartmann
Chembiochem. 2012 Oct; DOI:10.1002/cbic.201200434

Nuclear RNase P of Trypanosoma brucei: A Single Protein in Place of the Multicomponent RNA-Protein Complex
A. Taschner, C. Weber, A. Buzet, R. K. Hartmann, A. Hartig, W. Rossmanith
Cell Rep. 2012 Jul; DOI: 10.1016/j.celrep.2012.05.021

PEI-complexed LNA antiseeds as miRNA inhibitors
M. Thomas, K. Lange-Grünweller, E. Dayyoub, U. Bakowsky, U. Weirauch, A. Aigner, R. K. Hartmann, A. Grünweller
RNA Biol. 2012 Aug; DOI:10.4161/rna.21165

A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis
B. M. Beckmann, P. G. Hoch, M. Marz, D. K. Willkomm, M. Salas, R. K. Hartmann
EMBO J. 2012 Apr; DOI:10.1038/emboj.2012.23

Characterization of RNase P RNA activity
M. Gössringer, D. Helmecke, R. K. Hartmann
Methods Mol Biol. 2012; DOI:10.1007/978-1-61779-545-9_5

2011

In vivo and in vitro analysis of 6S RNA-templated short transcripts in Bacillus subtilis
B. M. Beckmann, O. Y. Burenina, P. G. Hoch, E. A. Kubareva, C. M. Sharma, R. K. Hartmann
RNA Biol. 2011 Sep; DOI:10.4161/rna.8.5.16151

Archaeal-bacterial chimeric RNase P RNAs: towards understanding RNA
D. Li, M. Gössringer, R. K. Hartmann
Chembiochem. 2011 Jul; DOI: 10.1002/cbic.201100054

The proto-oncogene Pim-1 is a target of miR-33a.
M. Lange-Grünweller. K. Weirauch. U. Gutsch. D. Aigner. A. Grünweller. A. Hartmann. RK. Thomas
Oncogene; DOI:10.1038/onc.2011.278

MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma.
AF. Weirauch. U. Thomas. M. Grünweller. A. Hartmann. RK. Aigner. A. Ibrahim
Cancer Research; DOI:10.1158/0008-5472.CAN-10-4645

RNAcentral: a vision for an international database of RNA sequences
A. Bateman, S. Agrawal, E. Birney, E. A. Bruford, J. M. Bujnicki, G. Cochrane, J. R. Cole, M. E. Dinger, A. J. Enright, P. P. Gardner, D. Gautheret, S. Griffiths-Jones, J. Harrow, J. Herrero, I. H. Holmes, H. D. Huang, K. A. Kelly, P. Kersey, A. Kozomara, T. M. Lowe, M. Marz, S. Moxon, K. D. Pruitt, T. Samuelsson, P. F. Stadler, A. J. Vilella, J. H. Vogel, K. P. Williams, M. W. Wright, C. Zwieb
RNA. 2011 Nov; DOI: 10.1261/rna.2750811

Nukleotidmodifikationen
A.Jäschke, R. Micura, A.Grünweller, R. Hartmann, M. Helm, W. Liebl, L. Merkel, N. Budisa, U. Sundermann, S. Kushnir, F. Schulz
Nachrichten aus der Chemie: Trendbericht Biochemie 2010. 3,

Animal snoRNAs and scaRNAs with Exceptional Structures
M. Marz, A. R. Gruber, Zu. Siederdissen. C. Honer, F. Amman, S. Badelt, S. Bartschat, S. H. Bernhart, W. Beyer, S. Kehr, R. Lorenz, A. Tanzer, D. Yusuf, H. Tafer, I. L. Hofacker, P. F. Stadler
RNA Biol. 2011 Nov; DOI: 10.4161/rna.8.6.16603

Proteinortho: Detection of (Co-)Orthologs in Large-Scale Analysis
M. Lechner, S. Findeiss, L. Steiner, M. Marz, P. F. Stadler, S. J. Prohaska
BMC Bioinformatics. 2011 Apr; DOI: 10.1186/1471-2105-12-124

2010

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites
A. H. Ratje, J. Loerke, A. Mikolajka, M. Brünner, P. W. Hildebrand, A. L. Starosta, A. Dönhöfer, S. R. Connell, P. Fucini, T. Mielke, P. C. Whitford, J. N. Onuchic, Y. Yu, K. Y. Sanbonmatsu, R. K. Hartmann, P. A. Penczek, D. N. Wilson, C. M. Spahn
Nature. 2010 Dec; DOI: 10.1038/nature09547

Northern blot detection of small RNAs.
BM. Grünweller. A. Beckmann, RK. Hartmann
Handbook of RNA Biochemistry. Wiley-VCH. Edited by R.K. Hartmann, A. Bindereif, A. Schön and E.Westhof. DOI: 10.1093/nar/gkq437

A single Arabidopsis organellar protein has RNase P activity
A. Gobert, B. Gutmann, A. Taschner, M. Gössringer, J. Holzmann, R. K. Hartmann, W. Rossmanith, P. Giegé
Nat Struct Mol Biol. 2010 Jun; DOI: 10.1038/nsmb.1812

CHAPTER: Non-Coding RNAs IN: Evolutionary Genomics and Systems Biology
Donath A, Findeiß S, Hertel J, Marz M, Otto W, Schulz C, Stadler PF, Wirth S.
G. Caetano Anolles, eds. Wiley-Blackwell, Hoboken NJ, 2010,

RNA-RNA interaction prediction based on multiple sequence alignments
A. X. Li, M. Marz, J. Qin, C. M. Reidys
Bioinformatics. 2010 Dec; DOI: 10.1093/bioinformatics/btq659

Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis.
R. A. Dalloul, J. A. Long, A. V. Zimin, L. Aslam, K. Beal, Blomberg. L. Ann, P. Bouffard, D. W. Burt, O. Crasta, R. P. Crooijmans, K. Cooper, R. A. Coulombe, S. De, M. E. Delany, J. B. Dodgson, J. J. Dong, C. Evans, K. M. Frederickson, P. Flicek, L. Florea, O. Folkerts, M. A. Groenen, T. T. Harkins, J. Herrero, S. Hoffmann, H. J. Megens, A. Jiang, Jong. P. de, P. Kaiser, H. Kim, K. W. Kim, S. Kim, D. Langenberger, M. K. Lee, T. Lee, S. Mane, G. Marcais, M. Marz, A. P. McElroy, T. Modise, M. Nefedov, C. Notredame, I. R. Paton, W. S. Payne, G. Pertea, D. Prickett, D. Puiu, D. Qioa, E. Raineri, M. Ruffier, S. L. Salzberg, M. C. Schatz, C. Scheuring, C. J. Schmidt, S. Schroeder, S. M. Searle, E. J. Smith, J. Smith, T. S. Sonstegard, P. F. Stadler, H. Tafer, Z. J. Tu, Tassell. C. P. Van, A. J. Vilella, K. P. Williams, J. A. Yorke, L. Zhang, H. B. Zhang, X. Zhang, Y. Zhang, K. M. Reed
PLoS Biol. 2010; DOI: 10.1371/journal.pbio.1000475

Chapter: RNA Interactions of RNA-Infrastructure
Manja Marz and Peter F Stadler
Book, Editor:Lesley Collins, John Wiley & Sons, Inc.

Chapter: Homology Search for Small Structured ncRNAs
Manja Marz, Stefanie Wehner and Peter F Stadler
Book, Editors: A. Schoen, Eric Westhof, Albrecht Bindereif, Roland Hartmann

Aktivtaetsmuster von Brandmaeusen (Apodemus agrarius Pallas, 1771) in urbanen Lebensraeumen.
Marz M, Wolf R
Mittelungen fuer Saechsischen Wirbeltierfreunde. [German]

Temperature-dependent structural variability of RNAs: spliced leader RNAs and their evolutionary history
M. Marz, N. Vanzo, P. F. Stadler
J Bioinform Comput Biol. 2010 Feb;

Bcheck: a wrapper tool for detecting RNase P RNA genes
D. Yusuf, M. Marz, P. F. Stadler, I. L. Hofacker
BMC Genomics. 2010 Jul; DOI: 10.1186/1471-2164-11-432

Northern blot detection of endogenous small RNAs (~14 nt) in bacterial total RNA extracts
B. M. Beckmann, A. Grünweller, M. H. Weber, R. K. Hartmann
Nucleic Acids Res. 2010 May; DOI: 10.1093/nar/gkq437

2009

Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester
S. Cuzic-Feltens, M. H. Weber, R. K. Hartmann
Nucleic Acids Res. 2009 Dec; DOI: 10.1093/nar/gkp775

Expanding RNA silencing approaches by U1 adaptors
A. Grünweller, R. K. Hartmann
Chembiochem. 2009 Jul; DOI: 10.1002/cbic.200900271

Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus
D. Li, D. K. Willkomm, R. K. Hartmann
Nucleic Acids Res. 2009 Jan; DOI:10.1093/nar/gkn915

tRNAdb 2009: compilation of tRNA sequences and tRNA genes
F. Jühling, M. Mörl, R. K. Hartmann, M. Sprinzl, P. F. Stadler, J. Pütz
Nucleic Acids Res. 2009 Jan; DOI: 10.1093/nar/gkn772

The making of tRNAs and more - RNase P and tRNase Z
R. K. Hartmann, M. Gössringer, B. Späth, S. Fischer, A. Marchfelder
Prog Mol Biol Transl Sci. 2009; DOI: 10.1016/S0079-6603(08)00808-8

2008

The putative RNase P motif in the DEAD box helicase Hera is dispensable for efficient interaction with RNA and helicase activity
M. H. Linden, R. K. Hartmann, D. Klostermeier
Nucleic Acids Res. 2008 Oct; DOI: 10.1093/nar/gkn581

Escherichia coli RNase P RNA: substrate ribose modifications at G+1, but not nucleotide -1/+73 base pairing, affect the transition state for cleavage chemistry
S. Cuzic, K. A. Heidemann, J. Wöhnert, R. K. Hartmann
J Mol Biol. 2008 May; DOI: 10.1016/j.jmb.2008.03.042

5'-end maturation of tRNA in aquifex aeolicus
M. Marszalkowski, D. K. Willkomm, R. K. Hartmann
Biol Chem. 2008 Apr; DOI: 10.1515/BC.2008.042

Structural basis of a ribozyme's thermostability: P1-L9 interdomain interaction in RNase P RNA
M. Marszalkowski, D. K. Willkomm, R. K. Hartmann
RNA. 2008 Jan; DOI: 10.1261/rna.762508

2007

Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
T. Christoph, C. Gillen, J. Mika, A. Grünweller, M. K. Schäfer, K. Schiene, R. Frank, R. Jostock, G. Bahrenberg, E. Weihe, V. A. Erdmann, J. Kurreck
Neurochem Int. 2007 Jan; DOI: 10.1016/j.neuint.2006.08.017

RNase P of the Cyanophora paradoxa cyanelle: a plastid ribozyme
D. Li, D. K. Willkomm, A. Schön, R. K. Hartmann
Biochimie. 2007 Dec; DOI: 10.1016/j.biochi.2007.08.004

Function of heterologous and truncated RNase P proteins in Bacillus subtilis
M. Gösringer, R. K. Hartmann
Mol Microbiol. 2007 Nov; DOI: 10.1111/j.1365-2958.2007.05962.x

A 2'-methyl or 2'-methylene group at G+1 in precursor tRNA interferes with Mg2+ binding at the enzyme-substrate interface in E-S complexes of E. coli RNase P
S. Cuzic, R. K. Hartmann
Biol Chem. 2007 Jul; DOI: 10.1515/BC.2007.095

25 years of catalytic RNA: looking younger than ever!
Hammann, C and Hartmann, R K and Marchfelder, A
Biol Chem. 2007 Jul; DOI: 10.1515/BC.2007.086

An important piece of the RNase P jigsaw solved
D. K. Willkomm, R. K. Hartmann
Trends Biochem Sci. 2007 Jun; DOI: 10.1016/j.tibs.2007.04.005

Locked nucleic acid oligonucleotides: the next generation of antisense agents?
A. Grünweller, R. K. Hartmann
BioDrugs. 2007 ; DOI: 10.2165/00063030-200721040-00004

In vivo and in vitro investigation of bacterial type B RNase P interaction with tRNA 3'-CCA
B. Wegscheid, R. K. Hartmann
Nucleic Acids Res. 2007 ; DOI: 10.1093/nar/gkm005

2006

Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo
T. Christoph, A. Grünweller, J. Mika, M. K. Schäfer, E. J. Wade, E. Weihe, V. A. Erdmann, R. Frank, C. Gillen, J. Kurreck
Biochem Biophys Res Commun. 2006 Nov; DOI: 10.1016/j.bbrc.2006.09.037

The precursor tRNA 3'-CCA interaction with Escherichia coli RNase P RNA is essential for catalysis by RNase P in vivo
B. Wegscheid, R. K. Hartmann
RNA. 2006 Dec; DOI: 10.1261/rna.188306

Thermostable RNase P RNAs lacking P18 identified in the Aquificales
M. Marszalkowski, J. H. Teune, G. Steger, R. K. Hartmann, D. K. Willkomm
RNA. 2006 Nov; DOI: 10.1261/rna.242806

Intricacies and surprises of nuclear-mitochondrial co-evolution
D. K. Willkomm, R. K. Hartmann
Biochem J. 2006 Oct; DOI: 10.1042/BJ20061241

Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria
H. Gruegelsiepe, O. Brandt, R. K. Hartmann
J Biol Chem. 2006 Oct; DOI: 10.1074/jbc.M603346200

Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression
M. Gössringer, Far. R. Kretschmer-Kazemi, R. K. Hartmann
J Bacteriol. 2006 Oct; DOI: 10.1128/JB.00756-06

Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences
B. Wegscheid, C. Condon, R. K. Hartmann
EMBO Rep. 2006 Apr; DOI: 10.1038/sj.embor.7400641

2005

Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions
S. Schubert, A. Grünweller, V. A. Erdmann, J. Kurreck
J Mol Biol. 2005 May; DOI: 10.1016/j.jmb.2005.03.011

6S RNA - an ancient regulator of bacterial RNA polymerase rediscovered
D. K. Willkomm, R. K. Hartmann
Biol Chem. 2005 Dec; DOI: 10.1515/BC.2005.144

Highlight: RNA biochemistry
A. Marchfelder, R. K. Hartmann
Biol Chem. 2005 Dec; DOI: 10.1515/BC.2005.138

Studies on Escherichia coli RNase P RNA with Zn2+ as the catalytic cofactor
S. Cuzic, R. K. Hartmann
Nucleic Acids Res. 2005 ; DOI: 10.1093/nar/gki540

Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog
D. K. Willkomm, J. Minnerup, A. Hüttenhofer, R. K. Hartmann
Nucleic Acids Res. 2005 ; DOI: 10.1093/nar/gki334

RNA interference as a gene-specific approach for molecular medicine
A. Grünweller, R. K. Hartmann
Curr Med Chem. 2005 ; PMID: 16375707

2004

Stoppt den Boten - Antisense-, DNA Enzym- und RNA Interferenz-Strategien in der Molekularen Medizin.
Grünweller, A.; Schubert,S. and Kurreck,J.
BIOforum

The tRNA world
R. K. Hartmann, M. Mörl, M. Sprinzl
RNA. 2004 Mar; PMC1370928

2003

Cellular uptake and localization of a Cy3-labeled siRNA specific for the serine/threonine kinase Pim-1
A. Grünweller, C. Gillen, V. A. Erdmann, J. Kurreck
Oligonucleotides. 2003 ; DOI: 10.1089/154545703322617023

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
A. Grünweller, E. Wyszko, B. Bieber, R. Jahnel, V. A. Erdmann, J. Kurreck
Nucleic Acids Res. 2003 Jun; PMCID: PMC162243

Catalysis by RNase P RNA: unique features and unprecedented active site plasticity
T. Persson, S. Cuzic, R. K. Hartmann
J Biol Chem. 2003 Oct; DOI: 10.1074/jbc.M305939200

Antisense inhibition of Escherichia coli RNase P RNA: mechanistic aspects
H. Gruegelsiepe, D. K. Willkomm, O. Goudinakis, R. K. Hartmann
Chembiochem. 2003 Oct; DOI: 10.1002/cbic.200300675

Evaluation of bacterial RNase P RNA as a drug target
D. K. Willkomm, H. Gruegelsiepe, O. Goudinakis, Far. R. Kretschmer-Kazemi, R. Bald, V. A. Erdmann, R. K. Hartmann
Chembiochem. 2003 Oct; DOI: 10.1002/cbic.200300674

The enigma of ribonuclease P evolution
E. Hartmann, R. K. Hartmann
Trends Genet. 2003 Oct; DOI: 10.1016/j.tig.2003.08.007

An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains
R. Feltens, M. Gossringer, D. K. Willkomm, H. Urlaub, R. K. Hartmann
Proc Natl Acad Sci U S A. 2003 May; DOI: 10.1073/pnas.0931462100

2002

A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity
A. Grünweller, A. E. Ehrenhofer-Murray
Genetics. 2002 Sep; PMCID: PMC1462261

Selection of hammerhead ribozyme variants with low Mg2+ requirement: importance of stem-loop II
T. Persson, R. K. Hartmann, F. Eckstein
Chembiochem. 2002 Nov; PMID: 12404631

tRNA maturation in Aquifex aeolicus
D. K. Willkomm, R. Feltens, R. K. Hartmann
Biochimie. 2002 Aug; PMID: 12457559

Potential contact sites between the protein and RNA subunit in the Bacillus subtilis RNase P holoenzyme
C. Rox, R. Feltens, T. Pfeiffer, R. K. Hartmann
J Mol Biol. 2002 Jan; DOI: 10.1006/jmbi.2001.5261

2001

Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis
A. Hansen, T. Pfeiffer, T. Zuleeg, S. Limmer, J. Ciesiolka, R. Feltens, R. K. Hartmann
Mol Microbiol. 2001 Jul; PMID:11454206

Purine N7 groups that are crucial to the interaction of Escherichia coli rnase P RNA with tRNA
C. Heide, R. Feltens, R. K. Hartmann
RNA. 2001 Jul; PMCID: PMC1370148

Distinct modes of mature and precursor tRNA binding to Escherichia coli RNase P RNA revealed by NAIM analyses
C. Heide, S. Busch, R. Feltens, R. K. Hartmann
RNA. 2001 Apr; PMCID: PMC1370109

Correlation between processing efficiency for ribonuclease P minimal substrates and conformation of the nucleotide -1 at the cleavage position
T. Zuleeg, A. Hansen, T. Pfeiffer, H. Schübel, R. Kreutzer, R. K. Hartmann, S. Limmer
Biochemistry. 2001 Mar; PMID: 11258957

NMR spectroscopic evidence for Mn(2+)(Mg(2+)) binding to a precursor-tRNA microhelix near the potential RNase P cleavage site
T. Zuleeg, R. K. Hartmann, R. Kreutzer, S. Limmer
J Mol Biol. 2001 Jan; DOI: 10.1006/jmbi.2000.4299

Chemical synthesis and biological investigation of a 77-mer oligoribonucleotide with a sequence corresponding to E. coli tRNA(Asp)
T. Persson, U. Kutzke, S. Busch, R. Held, R. K. Hartmann
Bioorg Med Chem. 2001 Jan; PMID: 11197345

Nuclear-cytoplasmic translocation of tRNA
C. Kruse, R. K. Hartmann, P. K. Müller
Exp Cell Res. 2001 Jan; DOI: 10.1006/excr.2000.5070

2000

Export and transport of tRNA are coupled to a multi-protein complex
C. Kruse, D. K. Willkomm, A. Grünweller, T. Vollbrandt, S. Sommer, S. Busch, T. Pfeiffer, J. Brinkmann, R. K. Hartmann, P. K. Müller
Biochem J. 2000 Feb; PMCID: PMC1220829

Differential role of the intermolecular base-pairs G292-C(75) and G293-C(74) in the reaction catalyzed by Escherichia coli RNase P RNA
S. Busch, L. A. Kirsebom, H. Notbohm, R. K. Hartmann
J Mol Biol. 2000 Jun; DOI: 10.1006/jmbi.2000.3789

Effects of phosphorothioate modifications on precursor tRNA processing by eukaryotic RNase P enzymes
T. Pfeiffer, A. Tekos, J. M. Warnecke, D. Drainas, D. R. Engelke, B. Séraphin, R. K. Hartmann
J Mol Biol. 2000 May; DOI: 10.1006/jmbi.2000.3655

The 5'-proximal hairpin loop of lbi RNA is a key structural element in repression of D-galactan II biosynthesis in Klebsiella pneumoniae serotype O1
J. M. Warnecke, M. Nitschke, C. E. Moolenaar, E. T. Rietschel, R. K. Hartmann, U. Mamat
Mol Microbiol. 2000 May; PMID: 10844658

Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage
J. M. Warnecke, E. J. Sontheimer, J. A. Piccirilli, R. K. Hartmann
Nucleic Acids Res. 2000 Feb; PMCID: PMC102553

1999

The pravastatin-induced decrease of biliary cholesterol secretion is not directly related to an inhibition of cholesterol synthesis in humans
G. Kallien, K. Lange, E. F. Stange, J. Scheibner
Hepatology. 1999 Jul; DOI: 10.1002/hep.510300119

Microtiter well assays for protein tyrosine phosphatase activities directed against phosphorylated insulin receptor or insulin receptor substrate-1
J. Krützfeldt, A. Grünweller, W. Raasch, M. Drenckhan, H. H. Klein
Anal Biochem. 1999 Jun; DOI: 10.1006/abio.1999.4115

Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis
J. M. Warnecke, R. Held, S. Busch, R. K. Hartmann
J Mol Biol. 1999 Jul; DOI: 10.1006/jmbi.1999.2890

Guanosine 2-NH2 groups of Escherichia coli RNase P RNA involved in intramolecular tertiary contacts and direct interactions with tRNA
C. Heide, T. Pfeiffer, J. M. Nolan, R. K. Hartmann
RNA. 1999 Jan; PMCID: PMC1369743

1998

tRNA is entrapped in similar, but distinct, nuclear and cytoplasmic ribonucleoprotein complexes, both of which contain vigilin and elongation factor 1 alpha
C. Kruse, A. Grünweller, D. K. Willkomm, T. Pfeiffer, R. K. Hartmann, P. K. Müller
Biochem J. 1998 Feb; PMCID: PMC1219084

Production of trypsin by cells of the exocrine pancreas is paralleled by the expression of the KH protein vigilin
C. Kruse, J. Emmrich, E. Rumpel, M. H. Klinger, A. Grünweller, J. Rohwedel, H. J. Krammer, W. Kühnel, P. K. Müller
Exp Cell Res. 1998 Feb; DOI: 10.1006/excr.1997.3891

Newly synthesized cholesterol in human bile and plasma: quantitation by mass isotopomer distribution analysis
K. Empen, K. Lange, E. F. Stange, J. Scheibner
Am J Physiol. 1997 Feb; PMID: 9124362

The contribution of newly synthesized cholesterol to biliary cholesterol in healthy humans
J. Scheibner, K. Lange, K. Empen, E. F. Stange
Z Ernahrungswiss. 1997 Dec; PMID: 9467237

Low background and short exposure times in mapping of DNaseI-hypersensitive sites using digoxigenin-labeled probes
A. Grünweller, P. K. Müller
Anal Biochem. 1997 Apr; DOI: 10.1006/abio.1997.2044

Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity
A. Grünweller, W. G. Purschke, S. Kügler, C. Kruse, P. K. Müller
Biochem J. 1997 Sep; PMCID: PMC1218711

Role of the spacer boxA of Escherichia coli ribosomal RNA operons in efficient 23 S rRNA synthesis in vivo
T. Pfeiffer, R. K. Hartmann
J Mol Biol. 1997 Jan; DOI: 10.1006/jmbi.1996.0744

1997

Newly synthesized cholesterol in human bile and plasma: quantitation by mass isotopomer distribution analysis
K. Empen, K. Lange, E. F. Stange, J. Scheibner
Am J Physiol. 1997 Feb; PMID: 9124362

The contribution of newly synthesized cholesterol to biliary cholesterol in healthy humans
J. Scheibner, K. Lange, K. Empen, E. F. Stange
Z Ernahrungswiss. 1997 Dec; PMID: 9467237

Low background and short exposure times in mapping of DNaseI-hypersensitive sites using digoxigenin-labeled probes
A. Grünweller, P. K. Müller
Anal Biochem. 1997 Apr; DOI: 10.1006/abio.1997.2044

Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity
A. Grünweller, W. G. Purschke, S. Kügler, C. Kruse, P. K. Müller
Biochem J. 1997 Sep; PMCID: PMC1218711

Role of the spacer boxA of Escherichia coli ribosomal RNA operons in efficient 23 S rRNA synthesis in vivo
T. Pfeiffer, R. K. Hartmann
J Mol Biol. 1997 Jan; DOI: 10.1006/jmbi.1996.0744

1996

Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus
S. Kügler, A. Grünweller, C. Probst, M. Klinger, P. K. Müller, C. Kruse
FEBS Lett. 1996 Mar; PMID: 8605996

Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin
C. Kruse, A. Grünweller, H. Notbohm, S. Kügler, W. G. Purschke, P. K. Müller
Biochem J. 1996 Nov; PMCID: PMC1217924

Rp-deoxy-phosphorothioate modification interference experiments identify 2'-OH groups in RNase P RNA that are crucial to tRNA binding
W. D. Hardt, V. A. Erdmann, R. K. Hartmann
RNA. 1996 Dec; PMCID: PMC1369447

Ribonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site
J. M. Warnecke, J. P. Fürste, W. D. Hardt, V. A. Erdmann, R. K. Hartmann
Proc Natl Acad Sci U S A. 1996 Aug; PMCID: PMC38570

Mutational analysis of the joining regions flanking helix P18 in E. coli RNase P RNA
W. D. Hardt, R. K. Hartmann
J Mol Biol. 1996 Jun; DOI: 10.1006/jmbi.1996.0329

1995

Direct linkage of str-, S10- and spc-related gene clusters in Thermus thermophilus HB8, and sequences of ribosomal proteins L4 and S10
T. Pfeiffer, D. Jorcke, R. Feltens, R. K. Hartmann
Gene. 1995 Dec; PMID:8566766

Point mutations in the leader boxA of a plasmid-encoded Escherichia coli rrnB operon cause defective antitermination in vivo
T. Heinrich, C. Condon, T. Pfeiffer, R. K. Hartmann
J Bacteriol. 1995 Jul; PMCID: PMC177098

Precursor of C4 antisense RNA of bacteriophages P1 and P7 is a substrate for RNase P of Escherichia coli
R. K. Hartmann, J. Heinrich, J. Schlegl, H. Schuster
Proc Natl Acad Sci U S A. 1995 Jun; PMCID: PMC41593

Rp-phosphorothioate modifications in RNase P RNA that interfere with tRNA binding
W. D. Hardt, J. M. Warnecke, V. A. Erdmann, R. K. Hartmann
EMBO J. 1995 Jun; PMCID: PMC398413

Kinetics and thermodynamics of the RNase P RNA cleavage reaction: analysis of tRNA 3'-end variants
W. D. Hardt, J. Schlegl, V. A. Erdmann, R. K. Hartmann
J Mol Biol. 1995 Mar; DOI: 10.1006/jmbi.1994.0130

Towards a new concept of gene inactivation: specific RNA cleavage by endogenous ribonuclease P
R. K. Hartmann, G. Krupp, W. D. Hardt
Biotechnol Annu Rev. 1995; PMID: 9704090

Recent approaches to probe functional groups in ribonuclease P RNA by modification interference
W. D. Hardt, J. M. Warnecke, R. K. Hartmann
Mol Biol Rep.; PMID: 8901505

1994

Contribution of structural elements to Thermus thermophilus ribonuclease P RNA function
J. Schlegl, W. D. Hardt, V. A. Erdmann, R. K. Hartmann
EMBO J. 1994 Oct; PMCID: PMC395426

Lead-ion-induced cleavage of RNase P RNA
J. Ciesiolka, W. D. Hardt, J. Schlegl, V. A. Erdmann, R. K. Hartmann
Eur J Biochem. 1994 Jan; PMID: 8307015

1993

Sequence of the gene encoding ribosomal protein L11 from Thermus thermophilus HB8
T. Heinrich, V. A. Erdmann, R. K. Hartmann
Gene. 1993 Dec; PMID: 8294036

Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes
W. D. Hardt, J. Schlegl, V. A. Erdmann, R. K. Hartmann
Biochemistry. 1993 Dec; PMID: 7694652

Gel retardation analysis of E. coli M1 RNA-tRNA complexes
W. D. Hardt, J. Schlegl, V. A. Erdmann, R. K. Hartmann
Nucleic Acids Res. 1993 Jul; PMCID: PMC331454

1992

Identification of the gene encoding transcription factor NusG of Thermus thermophilus
T. Heinrich, W. Schröder, V. A. Erdmann, R. K. Hartmann
J Bacteriol. 1992 Dec; PMCID: PMC207507

Cleavage efficiencies of model substrates for ribonuclease P from Escherichia coli and Thermus thermophilus
J. Schlegl, J. P. Fürste, R. Bald, V. A. Erdmann, R. K. Hartmann
Nucleic Acids Res. 1992 Nov; PMCID: PMC334461

Sequence of the tufA gene encoding elongation factor EF-Tu from Thermus aquaticus and overproduction of the protein in Escherichia coli
R. H. Voss, R. K. Hartmann, C. Lippmann, C. Alexander, O. Jahn, V. A. Erdmann
Eur J Biochem. 1992 Aug; PMID: 1499561

1991

Analysis of the gene encoding the RNA subunit of ribonuclease P from T. thermophilus HB8
R. K. Hartmann, V. A. Erdmann
Nucleic Acids Res. 1991 Nov; PMCID: PMC329053

Comparative analysis of ribosomal protein L5 sequences from bacteria of the genus Thermus
O. Jahn, R. K. Hartmann, T. Boeckh, V. A. Erdmann
Biochimie. 1991 Jun; PMID: 1764514

Analysis of the spc ribosomal protein operon of Thermus aquaticus
O. Jahn, R. K. Hartmann, V. A. Erdmann
Eur J Biochem. 1991 May; PMID: 2029902

Processing and termination of 23S rRNA-5S rRNA-tRNA(Gly) primary transcripts in Thermus thermophilus HB8
R. K. Hartmann, H. Y. Toschka, V. A. Erdmann
J Bacteriol. 1991 Apr; PMCID: PMC207837

1990

Isolation and physical properties of the DNA-directed RNA polymerase from Thermus thermophilus HB8
S. Wnendt, R. K. Hartmann, N. Ulbrich, V. A. Erdmann
Eur J Biochem. 1990 Jul; PMID: 2384094

1989

Structural analysis of prokaryotic and eukaryotic 5S rRNAs by RNase H
S. Lorenz, R. K. Hartmann, S. Schultze, N. Ulbrich, V. A. Erdmann
Biochimie. 1989 Nov-Dec; PMID: 2561346

Thermus thermophilus 16S rRNA is transcribed from an isolated transcription unit
R. K. Hartmann, V. A. Erdmann
J Bacteriol. 1989 Jun; PMCID: PMC209997

Transcription and processing of Bacillus subtilis small cytoplasmic RNA
J. C. Struck, R. K. Hartmann, H. Y. Toschka, V. A. Erdmann
Mol Gen Genet. 1989 Feb; PMID: 2468993

1988

Complete nucleotide sequence of a 23S ribosomal RNA gene from Thermus thermophilus HB8
P. Höpfl, N. Ulrich, R. K. Hartmann, W. Ludwig, K. H. Schleifer
Nucleic Acids Res. 1988 Sep; PMCID: PMC338653

In vitro incorporation of eubacterial, archaebacterial and eukaryotic 5S rRNAs into large ribosomal subunits of Bacillus stearothermophilus
R. K. Hartmann, D. W. Vogel, R. T. Walker, V. A. Erdmann
Nucleic Acids Res. 1988 Apr; PMCID: PMC336509

1987

Sequences implicated in the processing of Thermus thermophilus HB8 23S rRNA
R. K. Hartmann, N. Ulbrich, V. A. Erdmann
Nucleic Acids Res. 1987 Oct; PMCID: PMC306304

An unusual rRNA operon constellation: in Thermus thermophilus HB8 the 23S/5S rRNA operon is a separate entity from the 16S rRNA operon
R. K. Hartmann, N. Ulbrich, V. A. Erdmann
Biochimie. 1987 Oct; PMID: 3126827

The sequence of the 6S RNA gene of Pseudomonas aeruginosa
D. W. Vogel, R. K. Hartmann, J. C. Struck, N. Ulbrich, V. A. Erdmann
Nucleic Acids Res. 1987 Jun; PMCID: PMC340881

Structural analysis of 5S rRNA, 5S rRNA-protein complexes and ribosomes employing RNase H and d(GTTCGG)
S. Lorenz, R. K. Hartmann, N. Piel, N. Ulbrich, V. A. Erdmann
Eur J Biochem. 1987 Mar; PMID: 2434327

1986

Nucleotide sequence of the 5S rRNA from the archaebacterium Halobacterium maris mortui
T. Specht, R. K. Hartmann, N. Ulbrich, V. A. Erdmann
Nucleic Acids Res. 1986 Jun; PMCID: PMC311476

Genomic organization of rDNA in Pseudomonas aeruginosa
R. K. Hartmann, H. Y. Toschka, N. Ulbrich, V. A. Erdmann
FEBS Lett. 1986 Jan; PMID: 3002852

1985

Expression of plasmid encoded Escherichia coli 5S ribosomal ribonucleic acid in Pseudomonas putida
R. K. Hartmann, P. P. Henze, N. Ulbrich, V. A. Erdmann
FEBS Lett. 1985 Sep; PMID:2411598

1984

Reconstitution of 50 S ribosomal subunits from Bacillus stearothermophilus with 5 S RNA from spinach chloroplasts and low-Mr RNA from mitochondria of Locusta migratoria and bovine liver
D. W. Vogel, R. K. Hartmann, M. Bartsch, A. R. Subramanian, W. Kleinow, T. W. O'Brien, T. Pieler, V. A. Erdmann
FEBS Lett. 1984 Apr; PMID: 6201395