*Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM & *Decher N. (2018). Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons. Mol. Cell. Neuroci. 88: 330–341.*corresponding authors
Rinné S, Kiper AK, Schlichthörl G, Dittmann S, Netter MF, Limberg SH, Silbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C & *Decher N. (2015). TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. J. Mol. Cell. Cardiol. 81: 71-80. *corresponding author
Putzke C, Wemhöner K, Sachse F, Rinné S, Schlichthörl G, Li XT, Jaé L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Müller R, Daut J & Decher N. (2007). The acid-sensitive potassium channel TASK-1 in rat cardiac muscle Cardiovasc. Res. 75: 59-68.
Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, González W & *Decher N. (2019). The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels. eLIFE. 8: e39476. *corresponding author
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MSP, Sanguinetti MC, Baukrowitz T & *Decher N. (2013). Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition. Nature Chem. Biol. 9: 507-513. *corresponding author
Decher N, Kumar P, Gonzalez T, Pirard B & Sanguinetti MC. (2006). Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation. Mol. Pharmacol. 70: 1204-1211.
Streit AK, Matschke LA, Dolga AM, Rinné S & *Decher N. (2014). RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1. J. Biol. Chem. 289: 26762-26771. *corresponding author
Streit AK, Derst C, Wegner S, Heinemann U, Zahn RK & *Decher N. (2011). RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats. Epilepsia 52: 645-648. *corresponding author
*Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T & Daut J. (2010). RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J. 29: 2101-2113. *corresponding author
Rinné S, Ortiz-Bonnin B, Stallmeyer B, Kiper AK, Fortmüller L, Schindler RFR, Herbort-Brand U, Kabir NS, Dittmann S, Friedrich C, Zumhagen S, Gualandi F, Selvatici R, Rapezzi C, Arbustini E, Ferlini A, Fabritz L, Schulze-Bahr E, Brand T & *Decher N. (2020). POPDC2 a novel susceptibility gene for conduction disorders. J. Mol. Cell Cardiol. 145: 74-83. *corresponding author
Silbernagel N, Walecki M, Schäfer MK-H, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic‑Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L & *Decher N. (2018). The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 32: 6159-6173. *corresponding author
Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K & Wollnik B. (2001). hKChIP2 is a functional modifier of hKv4.3 potassium channels: Cloning and expression of a short hKChIP2 splice variant. Cardiovasc. Res. 52: 255-264.
#Rödström KEJ, #Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Mueller T, *Decher N & *Carpenter EP. (2020). A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature 582: 443-447. *Shared senior and corresponding authors.#Shared first authors.
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ & Baukrowitz T. (2019). A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science. 363: 875-880.
Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Erhlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ & Baukrowitz T. (2011). The pore structure and gating mechanism of K2P channels. EMBO J. 30: 3607-3619.
Popeye Domain Containing Protein 2 (POPDC2) und genetisch-bedingte AV-Blockaden: Mechanistische Untersuchungen zur Modulation kardialer Ionenkanäle durch POPDC2 (Prof. Dr. Niels Decher / DFG)
Untersuchung der differentiellen molekularen krankheits-auslösenden Mechanismen im neuen Arrhythmie-Gen KCNJ5 für die Entstehung verschiedenartiger Herzrhythmusstörungen (Kirsty Vowinkel / Von Behring-Röntgen-Stiftung)
Untersuchung des Aktivierungsmechanismus des TASK-1 Kanals durch Mapping der Bindungsstelle des neu identifizierten und potenten TASK-1 Aktivators JGC-398 (Dr. Aytuğ Kiper / Kempkes-Stiftung)
Identifizierung von einem NCA als hoch potenter TASK-1 Aktivator: Untersuchung der molekularen Grundlagen der Aktivierung für die Entwicklung neuartiger Medikamente gegen pulmonale arterielle Hypertension (Dr. Aytuğ Kiper / Von Behring-Röntgen-Stiftung)
