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  • Inhalt ausklappen Inhalt einklappen 20212021

    Ramírez D, Mejía-Gutiérrez M, Insuasty B, Rinné S, Kiper AK, Platzk M, Müller T, Decher N, Quiroga J, De-la-Torre P & González W. (2021).
    5-(indol-2-yl)pyrazolo[3,4-b]pyridines as a new family of TASK-3 Channel Blockers: a Pharmacophore-based Regioselective Synthesis.
    Molecules. In Press.

    Wiedmann F, Beyersdorf C, Zhou X-B, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA & Schmidt C. (2021).
    Treatment of atrial fibrillation with doxapram: TASK‑1 potassium channel inhibition as a novel pharmacological strategy.
    Card. Res. In Press.

     *Kiper AK, *Bedoya M, *Stalke S, *Marzian S, Ramírez D, Cruz Adl, Peraza DA, Vera-Zambrano A, Márquez Montesinos JCE, Arévalo Ramos BA, Rinné S, Gonzalez T, Valenzuela C, Gonzalez W & #Decher N. (2021).
    Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels.
    Br. J. Pharmacol. In Press. *shared first authors. #corresponding author.

    *,#
    Decher N, *Rinné S, Bedoya M, González W & Kiper AK. (2021).
    Molecular pharmacology of K2P potassium channels.
    Cell. Physiol. Biochem. 55: 87-107. Invited Review. *shared first author. #corresponding author.

    *Oertli A, *Rinné S, Moss KR, Kääb S, Seemann G, Beckmann BM & Decher N. (2021).
    Molecular mechanism of autosomal recessive long QT-syndrome 1 without deafness.
    Int. J. Mol. Sci. 22:1112. *shared first author.

    Wiedmann F, Rinné S, Donner B, Decher N, Katus HA & Schmidt C. (2021).
    Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system.
    Prog. Biophys. Mol. Biol. 159:126-135.

  • Inhalt ausklappen Inhalt einklappen 20202020

    *Endres D, *Decher N, Röhr I, Vowinkel K, Domschke K, Komlosi K, Tzschach A, Gläser B, Schiele M, Runge K, Süß P, Schuchardt F, Nickel K, Stallmeyer B, Rinné S, Schulze-Bahr E & Tebartz van Elst L. (2020).
    New Cav1.2 Channelopathy with high-functioning autism, affective disorder, severe dental enamel defects, a short QT interval, and a novel CACNA1C loss-of-function mutation.
    Int. J. Mol. Sci. 21: 8611. * shared first author.

    Erlenhardt N, Kletke O, Wohlfarth F, Komadowski MA, Clasen L, Makimoto H, Rinné S, Kelm M, Jungen C, Decher N, Meyer C & Klöcker N. (2020).
    Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.
    Pflügers Archive.  472: 1733-1742.

    Rinné S, Ortiz-Bonnin B, Stallmeyer B, Kiper AK, Fortmüller L, Schindler RFR, Herbort-Brand U, Kabir NS, Dittmann S, Friedrich C, Zumhagen S, Gualandi F, Selvatici R, Rapezzi C, Arbustini E, Ferlini A, Fabritz L, Schulze-Bahr E, Brand T & *Decher N. (2020).
    POPDC2 a novel susceptibility gene for conduction disorders. 
    J. Mol. Cell Cardiol.  145: 74-83. *corresponding author.

    #Rödström KEJ, #Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Mueller T, *Decher N & *Carpenter EP. (2020). 
    A lower X-gate in TASK channels traps inhibitors within the vestibule. 
    Nature  582: 443-447. *Shared senior and corresponding authors.#Shared first author.

    Bustos D, Bedoya M, Ramirez D, Concha G, Zúñiga L, Decher N, Hernandez EW, Sepúlveda FV, Martinez L & González W. (2020).
    Elucidating the structural basis of the intracellular pH sensing mechanism of TASK-2 K2P channel.
    Int. J. Mol. Sci. 21: 532.

  • Inhalt ausklappen Inhalt einklappen 20192019

    Ganjam G, Bolte K, Matschke L, Neitemeier S, Dolga A, Höllerhage M, Hoeglinger G, Adamczyk A, Decher N, Oertel W & Culmsee C. (2019).
    Mitochondrial damage by alpha synuclein causes cell death in human dopaminergic neurons.
    Cell. Death. Dis. 10: 865.

    Vissing J, Johnson K, Töpf A, Nafissi S, Díaz-Manera J, French VM, Schindler RF, Sarathchandra P, Løkken N, Rinné S, Freund M, Decher N, Müller T, Duno M, Krag T, Brand T & Straub V. (2019).
    POPDC3 gene variants associate with a new form of limb girdle muscular dystrophy.
    Ann. Neurol. 86: 832-843.

    Ramírez D, Concha G, Arévalo B, Prent-Peñaloza L, Zúñiga L, Kiper AK, Rinné S, Reyes-Parada M, Decher N, González W & Caballero J. (2019).
    Discovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening.
    Int. J. Mol. Sci. 20: 4014.

    Bedoya M, Rinné S, Kiper AKDecher N, González W & Ramírez D. (2019).
    TASK Channels Pharmacology: New Challenges in Drug Design.
    J. Med. Chem. 62: 10044-10058.

    Ramírez D*, Bedoya M, Kiper AK, Rinné S, Morales-Navarro S, Hernández-Rodríguez EW, Sepúlveda FV, Decher N* & González W*. (2019).
    Structure/activity analysis of TASK-3 channel antagonists based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.
    Int. J. Mol. Sci. 20: 2252. *shared corresponding author

    Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, Gonzalez W, Katus HA, Decher N* & Constanze Schmidt*. (2019).
    Identification of the A293 (AVE1231) binding site in the cardiac two-pore domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site. 
    Cell. Physiol. Biochem. 52: 1223-1235. *shared senior and corresponding author

    Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, González W & *Decher N. (2019).
    The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels.
    eLIFE. 8: e39476. *corresponding author

    Schewe M, Sun H,  Mert Ü, Mackenzie A, Pike  ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ,  Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H,  Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ & Baukrowitz T. (2019). 
    A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. 
    Science. 363: 875-880.

    Key J, Mueller A-K, Gispert S, Matschke L, Wittig I, Corti O, Münch C, *Decher N & *Auburger G. (2019).
    Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons.
    Neurobiol. Dis. 127: 114-130. *shared corresponding authors

    Kuß J, Stallmeyer B, Hain E, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz M-C & Schulze-Bahr E. (2019).
    Familial sinus node disease caused by a gain of GIRK channel function. 
    Circ. Genom. Precis. Med. 12: e002238.

  • Inhalt ausklappen Inhalt einklappen 20182018

    Soufi M, Ruppert V, Rinné S, Mueller T, Kurt B, Pilz G, Maieron A, Dodel R, Decher N & Schaefer JR. (2018).
    Increased KCNJ18 promoter activity as a mechanism in atypical normokalemic periodic paralysis.
    Neurol. Genet. 4: e274.

    Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S,  Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E &  Seebohm G. (2018).
    In vitro analyses of novel HCN4 gene mutations.
    Cell. Physiol. Biochem. 49: 1197-1207. 

    Silbernagel N, Walecki M,  Schäfer  MK-H, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic‑Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L & *Decher N. (2018). 
    The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
    FASEB J. 32: 6159-6173. *corresponding author

    Pott A, Bock S, Berger IM, Frese K, Dahme T, Kessler M, Rinné S, Decher N, Just S & Rottbauer W. (2018).
    Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. 
    J. Mol. Cell. Cardiol.  120: 42–52.

    Henrich MT, Geibl FF, Lee B, Chiu W-H, Koprich JB, Brotchie JM, Timmermann L, Decher N§Matschke LA & §Oertel WH. (2018). 
    A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. 
    Acta. Neuropathol. Commun. 6: 39. §shared last authors

    *Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM & *Decher N. (2018). 
    Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons. 
    Mol. Cell. Neuroci. 88: 330–341.*corresponding authors

  • Inhalt ausklappen Inhalt einklappen 20172017

    Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G & *Decher N. (2017).
    Stress-Kinase Regulation of TASK-1 and TASK-3.
    Cell. Physiol. Biochem.  44: 1024-1037. *corresponding author 

    Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape H-C, Decher N, Meuth SG & Budde T. (2017).
    Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
    J. Physiol.  595: 5875-5893. 

    see also Perspectives by Kim D. (2017). Endocytosis: another pathway in receptor-Gq-TASK signalling.

    *Decher N, Kiper AK & Rinné S. (2017).
    Stretch-activated potassium currents in the heart: focus on TREK-1 and arrhythmias.
    Prog. Biophys. Mol. Biol. 130: 223-232. Invited Review.  *corresponding author

    Ramirez D, Arévalo B, Martínez G, Rinné S, Sepúlveda F, *Decher N & *González W. (2017).
    Side fenestrations provide an `anchor´ for a stable binding of A1899 to the pore of TASK-1 potassium channels.
    Mol. Pharm.  14: 2197-2208. *corresponding authors

    Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N,  Culmsee C & Dolga A. (2017).
    SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.
    Cell. Death Differ.  24: 761-773.

    *Decher NOrtiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B & Schulze-Bahr E. (2017). 
    Sodium permeable and `hypersensitive´ TREK-1 channels cause ventricular tachycardia.
    EMBO Mol. Med. 9: 403-414. *corresponding author

    see also Editorial by Goldstein SA. (2017). Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme

    Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel KRinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N & Schulze-Bahr E. (2017). 
    A mutation in the G-protein gene GNB2 causes familial sinus node and atrioventricular conduction dysfunction.
    Circ. Res.  120: e33-e44.

  • Inhalt ausklappen Inhalt einklappen 20162016

    Ortiz-Bonnin B, Rinné S, Moss R, Streit AK, Scharf M, Richter K, Stöber A, Pfeufer A, Seemann G, Kääb S, Beckmann BM & *Decher N. (2016).
    Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: Identification of novel LQTS3 und BrS mutations.
    Pflügers Archiv. 468: 1375-1387. *corresponding author

    Goldstein M, Rinné S, Kiper AK, Ramírez D, Netter MF, Bustos D, Ortiz-Bonnin B, González W & *Decher N. (2016).
    Functional mutagenesis screens reveal the `cap structure´ formation in disulfide-bridge free TASK channels.
    Sci. Rep.  6:  19492. *corresponding author

    Schindler RFR, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, Schwerte T, Poon K-L, Fang M, Rinné S, Froese A, Nikolaev VO, Grunert C, Müller T, Tasca G, Sarathchandra P, Drago F, Dallapiccola B, Rapezzi C, Arbustini E, Di Raimo FR, Neri M, Selvatici R, Gualandi F, Fattori F, Pietrangelo A, Li W, Jiang H, Xu X, Bertini E, Decher N, Wang J, Brand T & Ferlini A. (2016).
    POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking.
    J. Clin. Invest. 126: 239-253.

  • Inhalt ausklappen Inhalt einklappen 20152015

    Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AKRinné S, Netter MF, Meuth SG, Budde T & *Decher N. (2015).
    An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
    Front. Mol. Neurosci. 8: 63.*corresponding author

    Matschke LA, Bertoune M, Röper J, Snutch TP, Oertel WH, Rinné S & *Decher N. (2015).
    A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking.
    Mol. Cell. Neurosci.  68:293-302. *corresponding author 

    Rinné SKiper AK, Schlichthörl G, Dittmann S, Netter MFLimberg SHSilbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C & *Decher N. (2015).
    TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes.
    J. Mol. Cell. Cardiol. 81: 71-80. *corresponding author

    Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E & *Decher N. (2015).
    Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.
    J. Mol. Cell. Cardiol. 80: 186-195. *corresponding author

    Kiper AKRinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W & *Decher N. (2015).
    Kv1.5 blockers preferentially inhibit TASK-1 channels:  TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
    Pflügers Arch. 467: 1081-1090. *corresponding author

    *Decher N, Kiper AK,  Rolfes C, Schulze-Bahr E & Rinné S. (2015).
    The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias.
    Pflügers Arch. 467: 1055-1067. Invited Review. *corresponding author

    Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HP, Oliver D, Meuth SG & Budde T. (2015).
    Differential phospholipase C-dependent modulation of TWIK-related acid-sensitive K+ (TASK) and TWIK-related K+ (TREK) channels in rat thalamocortical relay neurons.
    J. Physiol.  593: 127-144.

  • Inhalt ausklappen Inhalt einklappen 20142014

    Streit AKMatschke LA, Dolga AM, Rinné S & *Decher N. (2014).
    RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1.
    J. Biol. Chem. 289: 26762-26771. *corresponding author

    §Friedrich C, §Rinné S, Zumhagen S, Kiper AKSilbernagel NNetter MF, Stallmeyer B, Schulze-Bahr E & *Decher N. (2014).
    Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
    EMBO Mol. Med.  6: 937-951. §shared first authors, *corresponding author

    Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S,  Oertel W, Wokosin D, Schumacker P  & Surmeier DJ. (2014).
    Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. 
    Nature Neurosci. 17: 832-840.

    Renigunta V, Fischer T, Zuzarte M, Kling S, Zou X, Siebert K, Limberg MRinné SDecher N, Schlichthörl G & Daut J. (2014).
    Co-operative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1. 
    Mol. Biol. Cell. 25: 1877-1891.

    Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E & Lang F. (2014).
    Up-Regulation of Kir2.1 (KCNJ2) by the Serum & Glucocorticoid Inducible SGK3.
    Cell. Physiol. Biochem. 33: 491-500.

    *Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J & *Preisig-Müller R. (2014).
    A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.
    Pflügers Arch. 466: 1559-1570. *corresponding authors

  • Inhalt ausklappen Inhalt einklappen 20132013

    Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MSP, Sanguinetti MC, Baukrowitz T & *Decher N. (2013).
    Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition.
    Nature Chem. Biol. 9: 507-513. *corresponding author

    see also Editorial by Wulff, H. & Yarov-Yarovoy, V. (2013). Channels: Sticking to nooks and crannies.

    Limberg M, Zumhagen S, Netter MF, Coffey AJ, Grace A, Rogers J, Böckelmann D, Rinné S, Stallmeyer B, *,§Decher N & §Schulze-Bahr E. (2013).
    Non dominant-negative KCNJ2 gene mutations leading to Andersen-Tawil syndrome with an isolated cardiac phenotype.
    Basic Res. Cardiol. 108: 353. *corresponding author, §shared senior authors

    Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R & Galuska SP. (2013).
    Soluble Polysialylated NCAM: A Novel Player of the Innate Immune System in the Lung.
    Cell. Mol. Life Sci.  70: 3695-3708.

    Dolga A, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N & Culmsee C. (2013).
    Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.
    J. Biol. Chem.  88: 10792-10804.

    *Decher NNetter MF & Streit AK. (2013).
    Putative impact of RNA editing on drug discovery.
    Chem. Biol. Drug Des. 81: 13-21. Invited Review. Cover picture. *corresponding author

    see also Commentary by Selwood, DL. (2013). Beyond the Hundred Dollar Genome – Drug Discovery Futures

    Schiekel J, Lindner M, Hetzel A, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D & Daut J. (2013).
    Inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.
    Cardiovasc. Res. 97: 97-105.

    see also Editorial by Mubagwa, K. (2013). Signalling between G-protein-coupled receptors and TASK-1 channels. 

  • Inhalt ausklappen Inhalt einklappen 20122012

    Netter MF, Zuzarte M, Schlichthörl G, Klöcker N & *Decher N. (2012).
    The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.
    Cell. Physiol. Biochem. 30: 1227-1240. *corresponding author

    Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ & *Decher N. (2012).
    A leucine zipper motif essential for gating of hyperpolarization-activated channels.
    J. Biol. Chem. 287: 40150-40160. *corresponding author

    Froese A, Breher SS, Waldeyer C, Schindler RF, Nikolaev VO, Rinné S, Wischmeyer E, Schlueter J, Becher J, Simrick S, Vauti F, Kuhtz J, Meister P, Kreissl S, Torlopp A, Liebig SK, Laakmann S, Müller TD, Neumann J, Stieber J, Ludwig A, Maier SK, Decher N, Arnold HH, Kirchhof P, Fabritz L & Brand T (2012).
    Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.
    J. Clin. Invest.  122: 1119-30.

    see also Editorial by Boukens, BJ & Christoffels VM. (2012).  Popeye proteins: muscle for the aging sinus node.

    Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W & Lang F. (2012).
    Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome.
    FASEB J. 26: 513-522.

  • Inhalt ausklappen Inhalt einklappen 20112011

    Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB & *Decher N. (2011).
    TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.
    Cell. Physiol. Biochem. 28: 613-624.*corresponding author

    Streit AK & *Decher N. (2011).
    A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors.
    Biochemistry (Moscow) 76: 890-899. Invited Review. *corresponding author

    *Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB & Maier SK. (2011).
    Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.
    Cell. Physiol. Biochem. 28: 77-86. *corresponding author

    Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Erhlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ & Baukrowitz T. (2011).
    The pore structure and gating mechanism of K2P channels.
    EMBO J. 30: 3607-3619.

    Streit AK, Derst C, Wegner S, Heinemann U, Zahn RK & *Decher N. (2011).
    RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats.
    Epilepsia 52: 645-648. *corresponding author

    Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ & *Decher N. (2011).
    A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore.
    J. Biol. Chem. 286: 13977-13984. *corresponding author

    Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K & Waldegger S. (2011).
    Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.
    J. Biol. Chem. 286: 2224-2235.

  • Inhalt ausklappen Inhalt einklappen 20102010

    *Decher NStreit AK, Rapedius M, Netter MFMarzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T & Daut J. (2010).
    RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
    EMBO J. 29: 2101-2113. *corresponding author

    see also Editorial by Horn, R. & Reenan, R. (2010). Channels get in an HUFA: RNA editing gets them out of a jam.

    Moreno-Galindo EG, Barrio-Echavarría GF, Vásquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA & Navarro-Polanco RA. (2010).
    Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide.
    Mol. Pharmacol. 77: 751-758.

    Gao YD, Hanley PJ, Rinné S, Zuzarte M & Daut J. (2010)
    Calcium-activated K+ channel (KCa3.1) activity during Ca2+ store depletion and store-operated Ca2+ entry in human macrophages.
    Cell Calcium 48: 19-27.

  • Inhalt ausklappen Inhalt einklappen 20082008

    *Decher N, Gonzalez T, Streit AK, Sachse F, Renigunta V, Soom M, Heineman SH, Daut J & Sanguinetti MC. (2008).
    Structural determinants of Kvß1 induced channel inactivation: a PIP2 modulated hairpin.
    EMBO J. 27: 3164-3174. *corresponding author

    Arechiga IA, Barrio-Echavarria G, Rodriguez-Menchaca A, Moreno-Galindo E, Decher N, Tristani-Firouzi M, Sanchez-Chapula J, Navarro-Polanco R. (2008)
    Kv1.5 Open Channel Block by Antiarrhythmic Drug Disopyramide: Molecular Determinants of Block.
    J. Pharmacol. Sci. 108: 49-55.

  • Inhalt ausklappen Inhalt einklappen 20072007

    Arias C, Guizy M, David M, Marzian S, Gonzalez T, Decher N & Valenzuela C. (2007).
    Kvbeta1.3 Reduces the Degree of Stereoselective Bupivacaine Block of Kv1.5 Channels.
    Anesthesiology 107: 641-651.

    *Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann S, Timothy K, Keating M, Daut J, Sanguinetti M, Splawski I.(2007).
    Impaired Interaction between the slide helix and the C-terminus of Kir2.1: A novel mechanism of Andersen syndrome
    Cardiovasc. Res. 75: 748-757. *corresponding author

    Putzke C, Wemhöner K, Sachse F, Rinné S, Schlichthörl G, Li XT, Jaé L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Müller R, Daut J & Decher N. (2007).
    The acid-sensitive potassium channel TASK-1 in rat cardiac muscle
    Cardiovasc. Res. 75: 59-68.

    see also Editorial by Charpentier, F. (2007). Understanding the cardiac role of K2P channels: A new TASK for electrophysiologists.

    Strutz-Seebohm N, Gutcher I, Decher N, Steinmeyer K, Lang F & Seebohm G. (2007).
    Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and bindung mode.
    Cell. Physiol. Biochem. 20: 791-800.

  • Inhalt ausklappen Inhalt einklappen 20062006

    Decher N, Kumar P, Gonzalez T, Pirard B & Sanguinetti MC. (2006).
    Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.
    Mol. Pharmacol. 70: 1204-1211.

  • Inhalt ausklappen Inhalt einklappen 20052005

    Decher N, Kumar P, Gonzalez T, Renigunta V & Sanguinetti MC. (2005).
    Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels.
    Mol. Pharmacol. 68: 995-1005.

    Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC & Keating MT. (2005).
    Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.
    Proc. Natl. Acad. Sci. USA 102: 8089-8096.

  • Inhalt ausklappen Inhalt einklappen 20042004

    Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC & Keating MT. (2004).
    CaV1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
    Cell  119: 19-31.

    *Decher N, Barth AS, Gonzalez T, Steinmeyer K & Sanguinetti MC. (2004).
    Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents.
    J. Physiol. 557:761-72. *corresponding author

    Best L, Yates AP, Decher N, Steinmeyer K & Nilius B. (2004).
    Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.
    Eur. J. Pharmacol. 489: 13-19.

    Decher N, Chen J & Sanguinetti MC. (2004).
    Voltage-dependent gating of HCN pacemaker channels: Molecular coupling between the S4-S5 and C-linkers.
    J. Biol. Chem. 279: 13859-13865.

    *Decher N, Pirard B, Bundis F, Peukert S, Baringhaus KH, Busch AE, Steinmeyer K & Sanguinetti MC. (2004).
    Molecular basis for block of Kv1.5 channels: Conservation of drug binding sites among voltage-gated K+ channels.
    J. Biol. Chem. 279: 394-400. *corresponding author

  • Inhalt ausklappen Inhalt einklappen 20032003

    *Decher N, Bundis F, Vajna R & Steinmeyer K. (2003).
    KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.
    Pflügers Arch. 446: 633-640. *corresponding author

    *Scherer CR, *Lerche C, *Decher N, Dennis AT, Maier P, Ficker E, Pinto YM, Busch AE, Wollnik B & Steinmeyer K. (2002).
    The antihistamine fexofenadine does not affect IKr currents in a case report of drug-induced cardiac arrhythmia.
    Br. J. Pharmacol. 137: 892-900. *shared first authors

  • Inhalt ausklappen Inhalt einklappen 20012001

    Decher N, Lang HJ, Nilius B, Brüggemann A, Busch AE & Steinmeyer K. (2001).
    DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea pig atrial action potential duration.
    Br. J. Pharmacol. 134: 1467-1479.

    Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K & Wollnik B. (2001).
    hKChIP2 is a functional modifier of hKv4.3 potassium channels: Cloning and expression of a short hKChIP2 splice variant.
    Cardiovasc. Res. 52: 255-264.

    Decher N, Maier M, Dittrich W, Gassenhuber J, Brüggemann A, Busch AE & Steinmeyer K. (2001).
    Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family.
    FEBS Letters. 492: 84-89