Main Content

Selected Publications

Schwenty-Lara J, Pauli S, Borchers A (2020). Using Xenopus to analyze neurocristopathies like Kabuki syndrome. Genesis. Dec 22:e23404. doi: 10.1002/dvg.23404. Online ahead of print.

Breuer M, Berger H, Borchers A (2020). Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development. Sci Rep. 10(1):16446. doi: 10.1038/s41598-020-73429-x

Kratzer, MC, Becker SFS, Grund A, Merks A, Harnos J, Bryja V, Giehl K, Kashef J and Borchers A (2020). The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development 147 (10), doi: 10.1242/dev.186338

Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmuller J, Nurnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A*, Pauli S* (2020). De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome. Hum Genet Nov;139(11):1363-1379. doi: 10.1007/s00439-020-02175-x. Epub 2020 May 18. (*shared corresponding authors)

Schwenty-Lara J, Nehl D, Borchers A (2020). The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. Hum Mol Genet 29, 305-319.

Kratzer MC, England L, Apel D, Hassel M, Borchers A (2019). Evolution of the Rho guanine nucleotide exchange factors Kalirin and Trio and their gene expression in Xenopus development. Gene Expr Patterns 32, 18-27.

Schwenty-Lara J, Nurnberger A, Borchers A (2019). Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn 248, 465-476.

Ufartes R, Schwenty-Lara J, Freese L, Neuhofer C, Möller J, Wehner P, van Ravenswaaij-Arts CMA, Wong MTY, Schanze I, Tzschach A, Bartsch O, Borchers A*, Pauli S.* (2018). Sema3a plays a role in the pathogenesis of CHARGE syndrome. Hum Mol Genet. 2018 Apr 15;27(8):1343-1352. doi: 10.1093/hmg/ddy045. (*shared corresponding authors)

Pauli S, Bajpai R, Borchers A. CHARGEd with neural crest defects (2017). Am J Med Genet C Semin Med Genet. 2017 Dec;175(4):478-486. doi: 10.1002/ajmg.c.31584.

Berger H, Wodarz A, Borchers A. PTK7 Faces the Wnt in Developmet and Disease (2017). Front Cell Dev Biol. 2017 Apr 5;5:31. doi: 10.3389/fcell.2017.00031.

Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A (2017). PTK7 localization and protein stability is affected by canonical Wnt ligands. J Cell Sci 130, 1890- 1903.

Maj E, Kunneke L, Loresch E, Grund A, Melchert J, Pieler T, Aspelmeier T, Borchers A (2016). Controlled levels of canonical Wnt signaling are required for neural crest migration. Dev Biol 417, 77-90.

Podleschny M, Grund A, Berger H, Rollwitz E, Borchers A (2015). A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration. Plos One 10, e0145169.

Schulz Y, Wehner P, Opitz L, Salinas-Riester G, Bongers EM, van Ravenswaaij-Arts CM, Wincent J, Schoumans J, Kohlhase J, Borchers A, Pauli S (2014). CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance. Hum Genet 133: 997-1009.

Wehner P, Shnitsar I, Urlaub H, Borchers A (2011). RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure. Development 138, 1321-1327.

Peradziryi H, Kaplan NA, Podleschny M, Liu X, Wehner P, Borchers A*, Tolwinski NS* (2011). PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. EMBO J 30, 3729-3740. (*co-corresponding authors)

Shnitsar I, Borchers A (2008). PTK7 recruits dsh to regulate neural crest migration. Development 135, 4015-4024.

Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M (2004). PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430, 93-98.