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SFB TR84

Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia.

Leading Institution:
Charité - Universitätsmedizin Berlin

Research Network between:
Charité - Universitätsmedizin Berlin
Justus - Liebig -Universität Giessen
Philipps - Universität Marburg
Freie Universität Berlin
Robert-Koch-Institut
Helmholtz Zentrum München
Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Universitätsklinikum Erlangen

Funding and runtime:
Deutsche Forschungsgemeinschaft
01 July 2010 - 31 December 2023

Subproject C10 - Long non-coding RNAs and RNA editing in antibacterial host defense in the lung

Intricate regulatory networks have evolved to gradually adjust antimicrobial immune responses relative to the detected infectious threat. Here we will decipher the roles of long non-coding RNAs (lncRNAs) and posttranscriptional RNA-editing in pulmonary innate immune responses. We will

  • dissect the mechanistic implications of selected microbially-induced lncRNAs in pulmonary immunity
  • identify the molecular basis for the non-redundant function of RNA editing enzymes in alveolar macrophage and dendritic cell differentiation and function, and
  • develop a proof-of-concept interventional approach by targeting major RNA regulators of pulmonary immune responses using novel antisense inhibitors.

Cooperation Partners:
Prof. Dr. Stefan Bauer
Philipps University Marburg
Institut für Immunologie
Hans-Meerwein-Str. 2
35043 Marburg


Prof. Dr. Leif Erik Sander
Charité - Universitätsmedizin Berlin
Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie
Augustenburger Platz 1
13353 Berlin