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Institute of Molecular Oncology

The focus of our research is the p53 family of tumor suppressor genes. The p53 family is activated by cellular stress, hyperproliferative signals and developmental stimuli. These inputs are integrated within the p53 family in crosstalk with other cellular signalling networks to reach an appropriate cell fate decision. By selective activation of genes this triggers protective mechanisms such as cell cycle arrest, DNA repair, differentiation, senescence or cell death, thereby reinstating homeostasis and preventing the development of cancer.

We are interested in the following questions:

How do p53 and its family members suppress tumorigenesis?

How is the p53 tumor suppressor family inactivated in cancer cells?
How can tumor suppressive functions of the p53 family be reactivated for cancer therapy?

For background information and a more detailed description of our research interest please click the "Research" button!