23.05.2025 SMC motors and switches in genome maintenance and DNA immunity

With Prof. Stephan Gruber from Université de Lausanne, we welcomed another international researcher to our lecture hall.

On 20 May, we welcomed Stephan Gruber to RTG 2937, who is Professor at the Faculty of Biology and Medicine, Department of Fundamental Microbiology. He and his team investigate molecular machines that act on DNA to ensure the integrity of genetic information by maintaining chromosomal DNA and defending against invasive DNA elements such as viruses and plasmids.

SMC and SMC-like complexes are essential for chromosome organization and genome maintenance across the domains of life. Recently, they have also emerged as key players in cellular immunity against foreign DNA. In bacteria and archaea, the Wadjet and Lamassu systems function in anti-plasmid and anti-phage defense, while in humans, the Smc5/6 and Rad50 complexes contribute to antiviral immunity. This dual role presents an intriguing paradox: how can the same, or closely related, complexes preserve chromosomal DNA while also recognizing and restricting extrachromosomal DNA? In the SYNMIKRO lecture hall, Stephan discussed current insights into the role of these complexes in immunity, including how core principles of SMC(-like) function may enable them to differentiate and respond to linear or circular forms of invading DNA. Click here to learn more about the Gruber Lab.

Thank you for the impulses you gave us, Stephan! We hope you enjoyed your stay as much as we did.