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Central Projects

  • Central Project 1 - Single cell multiomics and transcriptome analyses

    Holger Garn, Translational Inflammation Research Division and Core Facility for Single Cell Multiomics, UMR

    Project: With the Single Cell Multiomics Core Facility, we offer single-cell analyses based on the Rhapsody Single Cell Analysis System. This includes single-cell partitioning of predefined cell suspensions using a cartridge-based separation system, cell-specific molecular barcoding of relevant molecules (e.g., mRNAs, surface proteins, epigenetic markers), and quantitative analysis of these molecules using deep sequencing, transcriptome analysis, small RNA sequencing, and epigenetic analyses.

  • Central Project 2 - Preclinical disease models of desmosome dysfunction

    Christoph Hudemann, Department of Dermatology and Allergology, UMR
    Christoph Otto, Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, UKW

    Project: CP2 provides (i) preclinical models of pemphigus vulgaris (PV) and inflammatory bowel disease (IBD), (ii) a service platform to promote translational research, and (iii) research participation. We offer validated mouse models that reproduce the induction and effector phases of PV. Furthermore, conditional, gut-specific knockout mouse strains based on the Cre-loxP system exist to investigate the effects of loss of desmosomal integrity on the intestinal barrier and epithelial function in IBD.

  • Central Project 3 - Biobanking from patients with intestinal and skin diseases for research on desmosome-mediated barrier function

    Matthias Goebeler, Department of Dermatology, Allergology and Venereology, UKW
    Benjamin Misselwitz, Department of Internal Medicine II, LMU Munich

    Project: The collection of tissue samples and the capture of contextual, comprehensive clinical metadata from patients with inflammatory, desmosomal skin diseases (pemphigus) or inflammatory diseases of the digestive tract (IBD, EoE) is a central task of TRR 425. LCARS, our open-source data and biobanking platform, will be implemented at all participating centers to automatically capture comprehensive clinical metadata, including patient-reported outcomes (entered via an app), clinical assessments, laboratory values, and endoscopy results.

  • Central Project 4 - The Integrated Research Training Group (IRTG)

    Stefanie Hahner, Department of Internal Medicine 1, UKW
    Wolfgang Pfützner, Department of Dermatology and Allergology, UMR
    Anna Sigmund, Department of Anatomy, LMU

    Project: The Integrated Research Training Group (IRTG) offers a well-structured, comprehensive scientific program to prepare doctoral students and young clinicians/medical scientists, as well as medical students and young doctoral students, for their future roles as independent researchers and project leaders. One of the main goals of the program is to facilitate the translation of new findings on epithelial desmosomal dysfunction at the molecular level into clinical practice and new therapeutic applications.

  • Central Project 5 - Central tasks of the Collaborative Research Centre

    Michael Hertl, Department of Dermatology and Allergology, UMR

    Project: The core function of the administrative central project is to ensure smooth and efficient cooperation and information transfer between the nine institutions and 36 PIs participating in TRR 425, i.e., the financial management of network and equality funds, the coordination of Gerok physician positions, the organization of regular meetings, the Mercator Fellow program, and the monitoring and coordination of research data management.

Cooperation Partners