Main Content
2026 - prior to SFB/TRR 425 funding
Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis
Schmidt MF, Feoktistova MA, Panayotova-Dimitrova D, Buhl EM, Boor P, Ruhl T, Waschke J, Tikkanen R, Röcken M, Baron JM, Yazdi AS. Cell Death Discov. 2026 Feb 19;12(1):102. doi: 10.1038/s41420-026-02963-w. PMID: 41714593 Free PMC article.
Collaboration: B03, B04Deep Analysis of Desmoglein-3-Reactive CD4+ T Cells in Pemphigus Vulgaris Reveals a Type 17/Type 2 T-Cell Signature.
Marschall J, Schierhofer LIA, Santos AMS, Hinterseher J, Berg BB, Möbs C, Hertl M, Zimmer CL. J Invest Dermatol. 2026 Apr;146(4):973-985.e6. doi: 10.1016/j.jid.2025.08.039. Epub 2025 Sep 9. PMID: 40930459
Plakoglobin phosphorylation at serine 665 is capable of stabilizing cadherin-mediated adhesion in keratinocytes.
Vielmuth F, Sigmund AM, Egu DT, Hiermaier M, Steinert LS, Moztarzadeh S, Klimkina M, Schikora ME, Rion PM, Schmitt T, Meier K, Ghoreschi K, Horn AK, Radeva MY, Kugelmann D, Waschke J. JCI Insight. 2026 Feb 9;11(3):e190359. doi: 10.1172/jci.insight.190359. eCollection 2026 Feb 9. PMID: 41657310 Free PMC article.
Collaboration: A02, B04, B05, C01, CP4Role of protein kinase C subtype-specific signalling in regulating adhesion in human keratinocytes and skin in pemphigus.
Schmitt T, Haneberg J, Egu DT, Sebastià Morón C, Schmidt E, Hudemann C, Hertl M, Hashimoto T, Waschke J. Br J Dermatol. 2026 Mar 19;194(4):699-710. doi: 10.1093/bjd/ljaf458. PMID: 41239864
Collaboration: A02, B01, B04, B06, CP2Safety, tolerability, pharmacokinetics and pharmacodynamic effects of desmoglein 3 peptide-coupled tolerizing nanoparticles in pemphigus.
Didona D, Hudemann C, Garn H, Krzikalla D, Wang SH, Hinterseher J, Volkmann K, Polakova A, Zakrzewicz A, Feldhoff S, Tikkanen R, Digigow R, Pfützner W, Santos A, Zimmer CL, Hahmann M, Harnisch S, Rösch S, Huguenin S, Eming R, Hahn M, Schauer F, Antiga E, Senatore S, Maglie R, Täubel J, Ghoreschi K, Meier K, Solimani F, Sticherling M, Sollfrank L, Günther C, Steinbrink K, Magnolo N, van Schaick E, Asnaghi V, Zollmann FS, Pohlner J, Hummel J, Sandbrink R, de Min C, Fleischer S, Möbs C, Hertl M. Br J Dermatol. 2026 Jan 6;194(1):86-98. doi: 10.1093/bjd/ljaf311.
The Multikinase Inhibitor Midostaurin Mitigates Loss of Intercellular Adhesion and Skin Blistering in Pemphigus Vulgaris.
Hiermaier M, Egu DT, Sigmund AM, Ernst N, Ludwig RJ, Hertl M, Ghoreschi K, Schmidt E, Hashimoto T, Waschke J. J Invest Dermatol. 2026 Jan;146(1):91-102.e4. doi: 10.1016/j.jid.2025.05.018. Epub 2025 May 29. PMID: 40449656 Free article.
Collaboration: B01, B04, B05, B06, C01, CP4The Tryptophan Metabolite Indole-3-ethanol of Cutibacterium acnes Promotes Skin Barrier Repair via AHR
Han, R., Chen, Y., Xu, J., Worzfeld, T., Wang, J., Xia J. Phenomics. 2026. The Tryptophan Metabolite Indole-3-ethanol of Cutibacterium acnes Promotes Skin Barrier Repair via AHR. . https://doi.org/10.1007/s43657-025-00306-w
